How?
I
wrote to myself that there are only 3 distinct ways to undo aging. One
is to change the plasma for an aged individual from young (wrong) by dilution, worthy of human try because NBE can be done by FDA approved TPE modified to NBE. This can be
experimentally shown by parbiosis, another interpretation. Falsifies a plethora of business minded Silicon Valley doctors and professors. Two is by removing aging marks from
DNA, Horvath did the first Bio-clock, implemented by statistically
averaging of methyl marks at certain Cp sites in the DNA, waiting for papers. Three is by copying Dr. Sinclair intelligently.
Another reason is my niece, only second year in prestigious medical school in India, taught that aging is related to TERT and telomere length, a few days ago. Even this generation of Doctors is lost!
Why the marks?
No
one yet knows the exact mechanism of the marks, yet that pattern has a
bioage determination of 98.9 correlation to calendar age. The genetic
marks are consistent with all kind of cells.
Maybe this aging is special to humans!
The
remarkable fact is that there is similarity with the aging clock in all
animals that survived that sixty-three million-year-old catastrophe for
dinosaurs!
Why speculate on how?
The
fact that one way the methyl marks can arise, compatible with Dr.
Sinclair, is that they are remnants of confused RNA proteins constructed
in DNA repair. This is important for expected success from next step –
measuring the expected results when this mouse parbiosis results are
tested in human!
Why not monkeys next?
Not
needed! Unless no experiment can be found for not doing it on humans.
It is safe, extracting plasma and giving it to the aged does not add unusual
risks beyond that needed for blood transfusion.
Expectation?
The
mice experiment made the bioage of mice 0.54(54 %) in mice terms.
Think about it. An 80-year-old become forties. I become 30s. I have
massive needs for performing this! It can lead to a worldwide franchise! This method is one shot, but the extra time is enough to Yamanaka factors.
To human the gain may be smaller, but I will take even 10% (i.e. 10
years) and all but very motivated like me admit the risk , but so what? Timing is today or 5 years from now.
Sinclair's method?
` Independent and done anyway!
- There are basically two. One, currently done by Sinclair and his family is by safe supplements and exercises aping evolution. It seems to give 10 – 20 years. Other is Yamanaka factors. Turns out, from OSKM, only M is deadly. Low level jerked ingestion is safe and effective.
- Sinclair used AAV virus based selection and application of Yamanaka factors. This means the cells can be reconditioned without reverting to pluripotent cells. This can also be done using RNA. This 2020 technology was ready to allow Pfizer and Moderna (derived from modified RNA) vaccines to be built within a week of sequencing the virus. With a month cent. Homegrown, note that astrogenica was done fast in UK similarly. A Critical thing is the usability of RNA for selection. You have seen nothing of the genetic matriculation medicine for slow diseases like cancer. Heart, Alzheimer etc and also brain diseases of the old and aging!
- I honestly believe in this. Can a computer scientist matter? I will and invest and set up Horvath clock assay and plasma donation/use in Delhi.
- The best way of fast notes is to follow research from Stanford.
- I have decided on money and target medical doctors as partners. What is very encouraging is that procedures are genetics based and regular doctors, even medicine faculty know nothing about chemicals involved, have not even heard of Yamanaka factors!
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