Brain advantages of plasmapheresis

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The blood dilution process discussed is FDA approved for autoimmune and called therapeutic plasma exchange, or plasmapheresis.

Irina Conboy said.“We thought that aging could be caused by transient and veryreversible declines in regeneration, such that, even if somebody isvery old, the capacity to build new tissues in organs could berestored to young levels by basically replacing the broken cells andtissues with healthy ones, and that this capacity is regulatedthrough specific chemicals which change with age in ways that becomecounterproductive.

Irina Conboy is a Berkeley scientist who did the original parabiosis work in 2005. Fifteen year later, keeping blood supplies of old and young mice separate, the experiment worked for young (got older) but not for old (did not get significantly younger from young). Wow! Impossible to digest for ALL normal but for me, saved me money and disappointment! The point is nothing is magic in young, the useful proteins in young age, become aged and evil. What to do? Replace blood with reduced concentration and more neutral saline, cells and albumin! In it. The evil proteins don't grow, good part of the fraction grow, and blood gets younger! But blood supplies to all cells and the individual gets younger. You can do this repeatedly some number of times. So I will live till Yamanaka factors become FDA established.

But now why this essay? Blood goes everywhere. But not in the head onto the brain. And my instability is caused in the brain. Further I will grow mentally old. Already my vocabulary is reducing! "What is that word, was at tip of tongue,...". Even for names!

Reduced aging from diluted blood improves brain despite  BBB blood brain barrier! IOn fact it is larger than apoptosis-prevent-killer of senescent cell secretome factors! The dilution of old plasma is more effective for brain rejuvenation than the senolytic ABT 263, even though both act in the periphery – not in the brain. We interpret it as attenuation of blood to brain transfer of the age-elevated factors; and that the senescent cell secretome does not encompass all or the most negative effects of the aged circulation.

Long term, the solutions are Yamanaka/FDA. Short term AMBAR is very encouraging. Alzheimer's Disease inflicted patients did improve their intellectual scores! There may be no improvement in my essential tremors or confusingly similar Parkinson's, but I think my arrangements forced into by instability/Covid-19 give me several years if plasma fails to improve my brain!

Note that consistent to my belief system (Agnostic scientific or Paradigming RDS) gives me unbridled hope of solutions to my slow diseases like heart and diabetes and creeping-slow brain diseases and aging like essential tremors! In conjunction with allopathy for episodic events, aging reduction works wonders without significant risk. It is no different from lots of leeches and blood replacement rather than wait for growth! Haven't heard of risks in that bizarre homeopathy! Heart application then!