Thursday, December 17, 2020

why some prospered


 

 Why some prospered

Central to my thinking is rationalization of why USA prospered, as did Hitler Germany, Apartheid South Africa, Israel and China. While good in eyes of some, USA is micro-corrupt, as is Hitler Germany, Israel and China. So is India before Modi but faltering economy despite since then. No one knows the future, best estimate are forward market! I did some arithmetic, that showed me Forward rupee sinks 2.5% uniformly for next 5 years validated by projections 5 years ago when it depreciated 2.5%. So dollar is expected to be Rs. 85 in 2025. Despite fierce losses in Q1, Modi rate happens in Q3 and Q4. Q2 is tip of bad V.

In each case, the mechanism of markets is reward for innovation. That is so simple but profound. When its comes to external trade, you have no choice but submit to the innovator and buy the stuff! Consider military stuff. China has a huge submarine fleet. Per force, India has to buy 8i aircraft. Several other innovations from the USA, Russia, France and Israel. Pay in dollars for most. Despite being poor! Another is Soft innovation from Hollywood, publishers etc. There is magic Madison Avenue plays on undefined quality, but sane leadership can kill local and ads moronic, not done but simple, every ad subhuman will hate my prescription - can't run a single ad before paying for equal time to competitors! Total control without any management. Third huge area is drugs. YOU GOT TO PAY WHETHER POOR OR NOT.

West prospered despite every stupidity because they developed innovation through invention of patents. I claim that civilized version of laws, despite crushing of virtues, is essentially irrelevant. Virtues are NOT irrelevant because society-wide pursuit is never a prescription of decline. No matter what the ideology, political, social and religious etc - collectively ideologies and politicians leaders are essentially irrelevant. Not that they can make, but they can break. What matters ultimately is the reward structure. The society may be very corrupt - commie Russia, china, Africaan South Africa etc. In many ways, Singapore and UAE are ugly, yet they develop on. It is not just small states but china. Less corrupt societies develop, as can be seen comparing west, in every case it happened top down, and in each case, it declined by corruption at the top. My basic goal is to develop a system like patents and enclosure of the commons i.e. private property - these are not religious prescriptions but society chosen methods and perhaps amenable to societies. This is stark different from most existing ideologies and religions like nature has given rights etc. No ideology can aver that it is good because its axioms are self-evident - basis of all science is experimentation and (true false) lessons from not experimentable systems. To REQUIRE false observations as well is starkly different from most current social science whose predictions can be forgotten like sailers who saw divine worlds or believers in empirical post death experience or UFO abductors!

This approach is fundamental basis of my think. Any system that depends on human will be corrupt regardless, small amounts in the USA is fewer rules (liberty) and humorlessness! People have respect for law, but note small-time violation in New York City with abusive paint-can works and jumping tiles! It is NOT generic superiority but conditioned richer population, large number of well-off law-avoiders, but they call it freedom of lawyers! Ideal law is when violations are detected and punished automatically, by robots and computers. There is no fear of information misuse since guaranteed by proven security software. Missing that humans are used, but only then. The paid software rule is actually a corollary to general way more powerful idea that demand equal space and time for every copyrightable!

A far more powerful and just society results from identifying English/computerese correspeces compactly indicated by noun/object, abstract-noun/object, verb/operation, adjective/type, adverb/type, punctuation/meta object etc. Computer and human language can be the same, even internable through spoken translators that front end software solutions. Robot instructions can be built easily. In fact, my wisdom on insisting on Redmi 8 (now 9) is wise only because it has, unusually for mobiles, an in-built infrared which allows download of control software for TV, camera, ac, microwave, fan, lights today!

A whole slew of companies is built on innovation and prospered immensely by building on innovation from 1980 to 2010. Stage is now set for new crop built on innovation that will uproot and kill innovation last 30 year wave, ready to die as dependent on experience. Innovation kills the experienced! The higher level experienced try hard to save the less experienced but kill the company! Innovation worship implies a fish eat fish world without ethics.

The coming decade is going to be of mechanism operated by speech. Google and Amazon both have the guts of control of mechanisms. Time to build new mechanism with voice control. Robotics comes next - mind you translating speech into commands can be generic and fail-small companies. Forget stem cells! It will be of application of Yamanaka factors to all old-age diseases! Most Indians are not aware of that.

The kisan Andolan of today is so simple to understand - there are wealthy sons of Punjab and Haryana. The manipulated are farmers of rest of India. Every one is terrified of market mechanism which will allow market valuation of bulk produce. Non-contract as evaluated by market at sale time. Farmers of P & H can see the second green revolution happening. They want to kill all benefits for small farmers. There is a simple fix! Center gives MSP rights to states and choice to accept central laws or make their own. Emfubars all commies, congress and AAM aadmi. The P & H wealthy kisans will be hurt forcing their government to set proper MSP! It all depends on whether there is second green revolution. They are likely to be ruined by state MSP prices or the free market. They are likely to continue futile agitation. Furthermore, they CAN be law forced to allow traffic and be fully free to many year agitations. Be prepared to firings.



Friday, November 20, 2020

Nonbeliever religion



Fundament to science is falsifiability, ALL rest is junk  Science answers  Religious questions answered, no need to believe in junk henceforth!


Subsequent life of Universe

https://www.youtube.com/watch?v=uD4izuDMUQ 

Story of earth and solar system

https://www.youtube.com/watch?v=NQ4CUw9RcuA

Life: evolution and aging

https://www.youtube.com/watch?v=9nXop2lLDa4


nonbeliever Arun Arya


Tuesday, November 17, 2020

A new kind of startup - aastartup




Following is a collection of linearized slides. It is directed to healthy retired friends and acquaintances or those who can take early retirement. It believes that heathy  aging till 130 years is possible today, each elongation year healthy. Existing age effects  detrimental  to health can be stopped today!

Not every one gets US citizenship, then returns to their roots and try at business startup. My reason likely matches yours – escape inevitable old age. The singlularity 0f 1+ year extension per year happens in next 50 years, reachable by me.

My contribution and required from all else

===================================

    Me – money in full

    All else – 1 month of toil without pay. Full current pay + 20% for any mutually accepted period thereafter.

    Pay will come from money given by first patients.

    Obviously no one will pay unless convinced got full benefits.

    In any case, some percent of company given to new investors. 20% of amount to people who do not continue.

    Startup partner bioage determination is free ($300-$500).


Why do it so

============

    Every thuggery is based on paying cash to the thug.

    No one will pay money to any one but close friend, known in person many years.

    To lesser friends, people will contribute, risk time only. Every one will risk time if convinced! That requires upfront money to me.

    Paying upfront stock will work if company succeeds.

    If it does not work as expected then just a vacation trip to India and age data!

    Every startup person likes the capital to last long time!


Other methods

==============

It is my claim that Dr. Sinclair has uniquely solved aging mechan ism and all others are subanimals.

    Every other method is subhuman – regardless of experience, knowledge, prestige, fame of the purveyor. Dr. Sinclair is polite, I am not, they are thugs.

    It is possible to objectively measure age benefits of any method, all the bastards can be caught, using Horvath clock, converting aging into science first time in 2019.


What is expected and why

======================

    You must read and understand Dr. Sinclair of Harvard.

    At this time, only Metformin 1gm, Acarbose, Resveratrol 1gm and NMN 1gm per day work.

    NMN must be taken with betaine or vitamin B15.

    NMN must be protected from liver. Eating it fails. Sublingual, nasal drops or iv. In iv form, 500Mg may suffice. NMN is expensive and 95% suppliers are subanimal criminals.

    Iv is very hard unless a nurse – where you come in if a nurse. No iv solutions of NMN are sold or will. I know how to make it.


Expected of you

===============

    If you know “not interested”, send me facebook mail with just “not interested"

    If not interested but lazy, read book first etc, you will get official invite whenever.

    If interested, read book first and decide afterwards. I do not promise another invite. I am going to do it anyway, possibly without a company. Will pay Indian nurse then.


Why start company

=================

    Aging has unlimited patient supply.

    Convincing proof is now possible by externally done bioage.

    I believe hence will make self first victim.

    Benefit happens in one month. If you are convinced, only then offer yourself as beneficiary.

    USA doctors do it in Texas for $1000 per day. No one honestly working can afford it. Only startup persons.


What I bring to table

==================

    Only thing that follows from here is something you can get by Reading Sinclair.The iv solutions of NMN are not sold!

    Like NMN are benficial salts NR, NAD+, NADH.

    Direct NAD+ is better foir ALZHEIMARS and other Brain disorders. So why NMN and not others. I know scientific reason (objective)!

    Aging avoid very new. So much that5 FDA doesnot call Aging a disease, meaningless improvement!


Measuring benefits objectively

===========================

    Salutatory bioage determination is by Horvath clock which measures methylation concentration of several thousand DNA points and reduces them to bioage.

    Determination is human difference free (race, exercise etc). It works for all DNA life like trees and animals!

    Bioage is 3.1 years within calendar age and predicts remaining life as well. Companies in USA do it. So measure before and after any procedure and any moron! You can know how old and years of life remaining! DNA comes from spit or blood lab.

making a business

=============-==

I am starting an Aging undo company. I think  no doctors are taught about aging, in fact even FDA refuses to call Aging a disease. A dream since 5000 years came true in 2019.

10 years from now, aging will be called a disease and doctors will try to monopolise it. I will be there for grandfathering.

Horvath clock is NOT known  in India but common in USA. Going to USA for measuring it is ridiculous.

India based measureing makes "Aging undo" a self-sustained idea. I take all money risk - it is my company. I belive in it and drugs and Horvath clock and will be the first user! The company is formed and run if its cost is 50 % of 1 year plan I will do regardless! I have money, time and will.

Monday, October 19, 2020

Rest of my life


self-link

Proof-theoretic computing science brackets each statement between preconditions and postconditions. The preconditions to  following all require money, management, time,  technology, interest etc. Interest and Time are crucial and the technology for each below has life extension usages. Certain expectations below may be erroneous to accept needed in10 years into the future, but tech developed have life extension uses.

Grim reaper may act today crossing the street. Entire life had me so far planned and acted to make probabilities, not results, flow towards me. Based on that, given my father lived to be 88, and I have taken  steps for another 10 years of healthy life, I expect another 35 years, for making healthy entry into the decade of 2050. There are good facts to ground well the belief that SENS will infuse another 10-25 years to then. Time enogh for another career, for myself this time, and start with great hope that some of the following will succeed.

Constraints

Common to all topics for self

Rationale for thinking so is basic ethics independent development that USA excels in and applies to humans too. It does not depend on ethics or religion! Why should one act ethically? It allows others to be ethical towards you. How does one establish law? By installing detection and punishment systems. Essential to politics is not the past stupidity of law presentation. No emfubar can claim to present a law without detailing detection, punishment and teaching! Otherwise, the politician is a subanimal, forbidden to be in human society without lifelong (hence no experimentation) Expulsion. Expulsion and living restriction are superior to prison and only today possible through face recognition software in public places.

What next

Why invent or develop? Because that is the only way to make money. Who can? Anyone since patent systems are considered stupid! Equally, good and better than patent restrictions is compulsory licensing. Every product is assumed to be made in use of legal steps, on some licence fee is due, to innovators and the government. Vat can be applied and collected. Among other things, the largely anti-competitive tricks to benefit from restrictions actually slow developments! The experience of shen-zen shows that. The number of billionaire in china is not lower. Apart from very fast growth and citizen abuses, the story of China is enormous benefits of compulsory license type of systems. Weak laws against piracy are fueling the rate of growth in India with mild doses of corruption and anti people set conflicts that can not survive for long in a democracy!

But why should anyone buy? Innovation is essentianeeded in some areas. Military is required to use most innovated weapons. Entertainment requires one to innovate in acting, writing, music etc. A copyright is really innovation by the author! Hence, compulsory licensing applies! Propagation of this truth which will make India great and catch up with USA by2050 in free, democratic manner is my politics to then, Prosparity of USA, despite concentrations is solely its intellectual property approach. Livibility springs from freedom and democracy. The unplanned greatness stems from waves of immigrants working for their share of the pie without foreign constraints. As lo

1 aalanguage

Within 10 years, people communication must be free of infrequent errors elided instead. Use is not only think but think well, Insertion of logic into language is required for gen-robot development.Given stress on simplicity, aalanguage will shine for simpler ease.

 It has simple syntax on table primitive, considered simpler than lisp. Semantics is simpler too, using natural language categories of noun, verb, adjective, adverb and names in positional forms. Easy vocabulary arises from reuse of identifier as different part of use `<part of speech> dot expression' syntax, like verb  v. rub, noun n.rub, adjective +.rub etc. Glow yields adverb a.glow etc. Note that dot has higher precedence than juxtaposition. `$.if' converts an identifier into system word. First letter of an identifier indicates the category of the word (a:argument, x:local, o:object, c:constant, t:type, n.noun. <type.texpr> Converts texpr into a value, constant.<expr> evaluates expr once per context.

Currying of a function is `$curry <function> 1+{. <argument name>}'.  The arguments can be set in many ways. So `redball := $curry ball(color:red)(material:steel)' constructs a new, possibly higher order, function which may take shape and size as still free arguments. Unlike lisp, parenthezation has embedded infix precedence with operator precedence identifiers with 1+{%.slash} encode decreasing precedence starting juxtaposition, only dotting higher.

2 voiced programming

Programs without API will c ease to exist as use of very high level API exposed to users will happen, which can be simply and transparently user programmed. Another step will be only voice programming. No language today can! For a simple language like aalanguage this will be quick. The vocabulary will be very contextual with some universal  words.

This is quite a dear subject to me. Mathematicization of languages is due to Chomsky (MIT) who classified and showed the different powers of grammars and introduced the words of context-sensitive and context-free to humans. Actual real formal grammars are simpler than context-free, but have important contextual components.

HARD part, addressed by me and few others lately, is to deal with attributes, the resulting attributed grammar is context sensitive but free of NP-completeness! Modern genetics too requires attributed grammars. Differention of cells is only possible in certain contexts. Magic of crispr cas-9 must limit replacements in some contexts, not everywhere in a DNA! So the goal is to use left-recursion-handling LL-1 parser generators. It can build voice translators into robot commands, do control of genetic translators, compactly encode html, as well as pictures. Givinng self 10 years is needed.

3 aacryption

It is central to my being, replaces (reasons quantum computers) normal encryption with quantum secure methods but efficient. I had painfully built a normal encryption system but if would fail shor capable quantum computers. Unless strongly proven, non-quantum safe is insufficient against even mildly forward looking consumers. However, most non-quantum, systems are quantum-safe if  the modulus of field is hidden and my perfect-prediction method is added. An  intermediary Trent exists now for doing computations. TRUST IS ACHIEVED THROUGH PERFECT-SIGN. THIS REMOVES any NEED FOR GENERATION OF KEYS FROM NAME! it is possible to survive well with records that can be hacked - hacking will always be detected.

This claim is too trivial to write a paper for. Given any tuple, one can get impossible to fake digest by usual means. Included is a length field and name field. Now the tuple [cosumer name, tuple digest] is signed.

Trent comes in for returning consumer 's request by a new encryption system installed on that link! Both asker and target, in their Trent code, are shipped the tuple specifying the new system.

 IBE encryption can be done on a link basis by generating a new system once per new user and a directory with signed entries. Signed entries are needed to prevent consumer targetting by man in the middle. Every user entry is individually signed by the responsible organization.

Quantum security happens by the idea that modulus numbers are not exposed (always greater than half of range) and so can not be factored. Apart from Alice and Bob, we assume exists Trent with whom every one has a private encrypted channel or easily constructed. There are no direct encryption computations but for private messages to Trent.

MY contribution is mainly to see how Trent concept fits into Internet with scheduled and random stoppages. Unlike current net of nets, additional hierarchical nets have to be imposed for not trusting programmers (given NSA and corruption) somewhere and strength against failures. The needs can be met by arranging for personal cloud in a hierarchyical fashion immune to programmers and stoppages somewhere. Personal, company, city, ... etc hierarchical clouds must be fully integrated into current internet, done by a common user level API!

The usage is clear on taking a break and allowing someone else to act for you temporarily, with some but not all powers delegated. We assume that each power is encryption channel to a virtual person . One constrains the acting person by not revealing some encryption keys. Now the acting-instead has a new private channel to which all messages are re-encrypted, the acting-instead does the delegated tasks too. This is what Trent does for any author. The encrypted manuscript is decrypted and re-encrypted for a consumer. This can not be shared with anyone if the machine number is a part checked with. Local key exists only as an internal value computed in a chain of one way arithmetic.

4 mushroom farming

Mushroom farming is deceptively easy - one way starts with the starter log, drills hole in known easy pattern, fill holes by purchased plugs, puts the log apart and cuts the mushrooms on the outside a few times for some part of life, reusing a log till it can and restarting with new log on ending the fertile period.

Difficulty is from making the log and maintaining 60-80 f around the log. It is hard in indo-gangetic planes, hence mushroom farming is not done in plains. Since mushrooms logs/fills can be placed in rundown buildings that trap weather, could a cheap way be found for refrigeration in Indian plains? Turns out that the atmosphere is mostly transparent to certain wavelengths and outer space is very cold, a fact usable in radiative cooling.

Ten years from now, water will be harder to get, number of mouths to feed much larger, vertical water-minimizing farming with mushrooms will be a national political solution. One reason for mushroom is cheap dense protein - no wonder it is called poor man's meat in the west.

5 ageing

Earthian life originated from evolution by natural selection over common DNA - plants, trees, microbes, animal, birds, fishes, even humans. When DNA ages, so do all the life forms. Modern survivors, all, have cellular structures derived from a pluripotent cell that divided and differentiated into specialized cells. Three critical contributions are from a bio-chemist Dr. Sinclair at  Harvard, statistician Dr. Horvath in University of California, and Dr. Yamanaka of Japan. Dr. Yamanaka discovered 4 factors OSKC that will convert any differentiated cell into pluripotent cell. Dr. horvath discovered bio-age to methyl group concentrations at Cp sites or a DNA, and showed that it correlates very well with calendar age. Also, the bio-age worked for all kinds of cells, and is species constant and predictable in species specific ways. Dr. Sinclair showed that ageing can be experimentally and artificially imparted to mice.

    My documentedd efforts have created a need of Horvath clock tests before and after aging interventions which seems to work some! My cuirrent recommendations are a similar test on me, two mehods Yamanaka based and parbiosis-based,  , an d apeing Dr. sinclair. 

Current  numbers for me are 2gm/day metmorphin. 1 gm/day of nmn, 1 gm/day of resveratrol , 1200mg of calcium salt (300 mg-Ca),  4000 IU d3 and 100 micro-gm k2. Last is after MD consult for vastly common oseopenia or more in Indians. I drink 2  fullspoons of Haldi and per week.

I have vastly experimented with self and can reliably distinguish between kholu and sensible doctors. By limiting to parbiosis and Yamanaka, on my own shows some maturity in aging. Aging is not considered a disease, supplement field is littered with sensible sounding sellors of used-car sales type, no oversight agency and method etc My scientific-restricted approach adds wait to my opinions whenever applicable and given my experience that approves of some intererventions, I consider  self capable of guiding equally convinced that interventions are no longer frauds but very difficult to be sane consumer without a practicioner like me.

Although NMN naturally occurs in many food sources, a study found that you would need to consume 100 kg of broccoli, 69 kg of avocado, or 416 kg of beef just to obtain 250 mg of NMN daily.  By restricting self to weekly iv infusion of nmn, I will greatly imrove totality of benefits of overage as opposed to single best gene that resveratrol does. It is by sheer self-experiment and voracious reading that oral nmn was supplemented by betaine, rather than nmn just another hype!

Even today, no one makes an iv solution of nmn since it will immediately attract ambulen chaser lawyers. I can, will and perhaps sell to some friends. It will be done through aaageing company. Prior to chasing parbiosis benefits through plasma insertion, reliable ageing interactions through annual bio-age tests in USA is my first service. Amazon India no longer does it, nor does any one else (and advertizes).

6 Miscellaneous software projects I need, so does possibly the world

Personal spelled English to standard EnglishRather than yell at the monstrosities, Better is spell/type using own phonemes and automatically respell as per standard English

Personal spelled English to standard English

Rather than yell at the english spelling monstrosities, better is spell/type using own phonemes and automatically respell as per standard English, less like error correction and more like learn rules of compounding and derivatives and construct words chosen from english - more semantics and less of syntax correction that ALL spelling checkers are.


Converting spoken transcripts into software macro code

People speak instruictions or may just speak to add to transcipot, Transcript can be broken into macros and varified (neologism) to make useful macros. Documentation can be spoken too. Wonderful use of my aaintuitive system!


Friday, September 25, 2020

undoing ageing

 


 These are truly unique wonderous times. For the first tme in human history, a true scientific path to undoing aging is within reach. Whine philosophy is minimized, scientific means within the capability of legal MD, irrelevant are belief systems of the beneficiary, like allopathic medicine effectiveness is the same for sinners, criminals and upright citizens.

There are many ideas on undoing ageing, referenced in past. I BRIEFLY MENTION THE ONES I WILL FOLLOW. There are other methods that may become more important in futute, so there is no total commitment on way to proceed, except lifelong commitment to evaluate. This attitude can be taken by me as a follower of research, not a researcher, but even here I have to restrict for saving time and reference lookup costs. I am smart enough to know my limitations and that certain references need to be followed, while others can be ignored for being support for simple things or similar or identical to ones already followed.

non-science methods?

All guru, tomes, witnesses are uniformly all bullshit. Have no time to waste even listening, leave interning!

parbiosis?

Veins of mice  of distinct age are sugrically joined to a common circulatory system. The rates of elder mice and younger mice are compared to similar free mice. Recovery from injuries, disease, stress and digestion of the elder mice are found improved.

One does not have to resort to parbiosis ghoulish effects to benefit. The same effects can be obtained by inserting young plasma. Plasma recovery is twice as fast as blood donation, without the fatigue felt after blood donation. This happens because the donated blood is filtered to remove the red cells which are reinserted in the donee. Plasma donation is simpler as blood type distinctions are missing and plasma banking is easier. Plasma can be sold twice a week!

The reason why plasma suffices is that it carries hormones and dissolved organics. What they are,is not known and there is no reason but science, to know. Clearly, the plasma can be enriched, equal to iv add of the chemicals. The whole idea of parbiosis is to undoing ageing, not knowing what ageing is!

One of the most useful effects of Covid is to use plasma in a similar way by transferring anti-bodies to the patient! Delhi has recovery bank blessed by the government. Certainly, the government will not object to repurposing the technology developed!

telomere?

While more developed (Columbia runs an age reduction trial, each member of test coughs up milion dollars), I will not follow because lab scientists have reported failures to now. Additionally, mice have perfect telomeres but live 3 years! The trial above, till results prove me wrong, is snake oil for the gullible!

https://www.prnewswire.com/news-releases/breakthrough-gene-therapy-clinical-trial-is-the-worlds-first-that-aims-to-reverse-20-years-of-aging-in-humans-300963496.html

Yamanaka factors?

Yamanaka-factors revolutionize and ethicize genetics. Determined by very hard experimental work, twenty five chemicals were very smartly  screened to 4 OSKC, which when applied to any DNA convert to its pluripotent form (that is prior to differentiation!)

Most exciting to me is Horvath clock demethylation of the epigenome. Horvath identified 373 sites in human genome DNA (experimentally) and showed that calendar age could be predicted from this biological age (bioage) to  within 3.6 years. You need to measure methyl concentrations at these points. Improvements by US companies has allowed them to claim within 1.6 years. Bioage is very important since it allows science of ageing. Epi-mark are better than DNA-marks! Most importantly, underlying DNA is fixed in the womb. This allows eventual scientific fountain-of-youth.

With proper schedule, the OSK (C only induces cancers) can be used at low amount which reduce ages of differentiated cells without losing the differentiation! Thus drugs can be made for avoiding ageing specific to differentiation.

One can even operate genitically in Cas-9 cuts and restore within the selected context of cas-9. The dajnger is lack of specificity of context which may appear many times. No one has implemented (to my knowledge) additional contexts by surgery. Idea is to remove small chunks through surgery, perform cas-9 updates and surgically replace the amount! The genetic manipulation is now surgically enhanced! This is not useful in the past but very possible in laproscopic surgery!


How Yamanaka factors are the best way.

There’s a preprint from David Sinclair’s Harvard laboratory, posted on BioRxiv but not yet published, with very encouraging news for those of us who think that resetting the epigenetic (methylation) clock is a path to anti-aging.

study from the University of Exeter in England focused on the reverse aging of human genes by focusing on senescent cells and what are called splicing factors. The latter is a type of protein involved helping genes express themselves normally, but as we age, the process of senescence, or a state in which cells stop dividing and slip into a state of growth arrest without dying, causes the cells to be inactive and essentially turn off.

Is Arun finally a mental gone case or harbinger of tidings that are essential to all friends. Answer is believability, in this case the top cetainly conservative science magzine the scientific American over 150 years! 

Aging Is Reversible—at Least in Human Cells and Live Mice https://www.scientificamerican.com/article/aging-is-reversible-at-least-in-human-cells-and-live-mice/

The researchers found that by applying a compound commonly found in wine and foods such as dark chocolate and blueberries called resveratrol, they can actually reverse senescence and cause the splicing factors to reactivate.

Research has indicated that aging is actually an epigenetic process, or in other words it is often fueled by nongenetic forces, such as the environment we live in. A 2016 study published in Cell found that by tweaking genes that turn adult cells back into embryoniclike cells (pluripotent), scientists were able to manipulate the behavior of human skin cells.

The researchers found that by applying a compound called resveratrol, they can actually reverse senescence and cause the splicing factors to reactivate.

One of things I do - 1gm reservatol per day, Rs. 6000 (thousand) for 6 month supply, copying Dr. Sinclaire (Harvard), discoverer of why we age! Redo nmn, nr, or nad when can get prescription for iv or injection form.

Can Science Reverse Aging? https://html.duckduckgo.com/html?q=yamanaka%20ageing


Sunday, September 6, 2020

THE SCIENTIFIC THEORY OF AGING



What does a scientific theory mean? Absent a clear definition, every emfubar, while demonstrably an fubar, will claim science as part of a fubar belief system. Any statement becomes a scientific hypothesis only when it satisfies by negation the falsifiability test of Popper, and positively being a rational skeptic who never ceases a why. Ultimately the infinite regress leads to astronomical evolution which can be continued to about 10-21 second after big bang. What was before that, assumes there was a before, not necessary by any scientific theory. There are many cosmogenies that imply there was a before, but as a basic axiom. One of Cosmogonies in fact says that big bang is when time began. Note that time becomes infinitely slow at the speed of light and that spent by a photon despite coming from eons away is still zero. Neutrinos are matter traveling almost but not nearly light experience time, enough to change flavor in flight unlike photons which have same frequency fixed at creation time.

So what is the theory of Aging? It must be consistent with all known physics, chemistry and biology. It must be provable in the sense that some feature of the theory, on violation speeds up or reduces age. This must be simple enough to be allow performance in peer laboratories without requiring consultation with the author. In other words, experimental evidence can be collected and compared absent the author. This external repeatability is essential to science. I add another test peculiar to me - no external force (like God) may be invoked to explain all life on earth, this is not necessarily a denial of God, just the requirement God concept is not needed. All life can be explained (despite intelligent design pseudo-science) through evolution. This evolution-compatibility is my requirement and holds for Sinclair's theory. It even explains why all life on earth has a DNA basis, why fountain of youth is possible without time travel and why other forms of DNA do not exist. We might never encounter any other DNA.

It is a DNA based theory. The simplest form of consistent Circuits, despite other species based genes, is a fundamental requirement that the protein generated by a repair gene prevents the duplication of the DNA i.e. the cell. This exclusionary behavior is anti-simplistic understand of biology of evolution where replication is assumed to always be reason of existence of any lifeforms. True, but ageing is below a cell which has many species' dependent extra parts to the nucleus DNA molecule which is a giant double helix in all forms. Genes are simply small parts of the giant code. Operations are all done by allowing proteins to form by copying portions of DNA. The two cell level processes are duplicate and apoptosis. Duplication can be prevented internally by shutting of duplication gene while repair is in progress. The cell duplicates by unwind the double helix to 2 one strand parts, each of which forms a double helix by element duplication. The whole process takes time and exclusion circuit prevents duplication while unzip happens. This prevents error in the mother and daughter molecules.

Carefully note that any other DNA molecule, without the exclusion circuit, will fail after each coincidence of an error and replication. Errors happen all the time - x-ray, solar activity, stress, bad food etc. Unless DNA can recover some, the lifetime is milliseconds. Even with amelioration of errors, for animals, lifetime is few days to 300 years - cancers limiting life. EVEN TREES LIVE A FEW THOUSAND YEARS. Errors eventually add up and kill. The problem of ageing is too complicated to be solved by biology alone. But extending biological life can enable time for development of cyborg appendages to complete transfer to silicon life.

The fascinating corollaries to above are


1. The correctness of proof of above theory does not lead to any anti-ageing prescription


2. The systemic environmental interventions are all in the epigenome. underlying the epigenome is pristine DNA, as pristine as birth. Extending age and fountain of youth are the same thing.

 

Here are other possibilities.

HORVATH CLOCK

Distinct, but scientific, is the proof in 2012 by Horvath in California that all DNA genome and epigenome has marker sites whose methylation is strictly increasing and correlates with calendar age. The prediction rules depend on the species but are remarkably stable on mesenchrymal cells. For an individual of a spies, a table can be used to predict bio age TO within about 3 years of the calendar age.  A table can be prepared in advance per species to predict bio age accurately.

The strictly increasing methylation pattern has very few marks at birth. Amazingly, cells sunjected to yamanaka factors become totiplurasl by shedding the epigenome and the methylation marks of the underlying pristine DNA. Even the mesenchymal changes are not preserved. The cell can begin li8ge anew. But it is rarely a single cell! All the cells revert in unison, and what you get is a ball of cancer.

Amazement follows subsequent research. Of the four Yamanaka factors OSKC , the C is always cancer-genic. Of the 3 others, the degree of specialization removed depends on frequency and degree of immersion, more meaning more reversion. This has immediate applications.

1. The degree of age removal can be judged by starting and ending bio age. There are for example telomere based methods which predict a longer life from telomere restoration, but in this case too, the methylation removal happens. One can not cheat the Horvath clock,

 2. A genetic age reversal process follows by OSK based foods and medicine, subjects of future research.

Thursday, August 27, 2020

aaq-capitalism


 One reason that communism flourished is that it was built around Marx researches which had a critical difference from thinkers then, a long researched empirical work to couch in scientific theory but suffers from significant selective bias since many empirical truths were ignored and only supportive facts were retained. In my vernacular, hge was a semi-scientist, a person whose theory is explanatory but inextensible.


I am tired of nuts who consider only public and private as two modes, in between is public-private-partnership my style which interpolates between private models, that were a big failure in South America and Europe. Or the communist public model in the erstwhile Soviet union and satellites. Or offensively successful economically in china which escaped the very anti-progress of Mao to freedom less china today. Without shame for my upbringing, comfortable upper middle class in India with many achievements despite family, surviving as a refugee from the USA but only as a TBI and great oppression by a University to a mentally disabled person. But I gained some clarity after 30 years as a TBI and passage of my father. My parents accepted me after 25 years of escape to a new country and despite my status and illness to a self-chosen minimal  existence and divorce.
America or post-Mao china are examples of my PPP model. Reason underlying my hatred for China, despite great progress, is the simple extinction of liberty. Or non-republican America is a practice of socialism and likely definite extinction of liberty there. It is very common and wrong to advocate American exceptionalism and socialism as solutions in the USA. Even more stupid is libertarian view that US progress is in any way related to Laissez-faire  and weak government. The reason as per me is like this talk here - Well done state capitalism https://www.ted.com/talks/mariana_mazzucato_government_investor_risk_taker_innovator#t-828883 . Even the solution presented here is very good - government must retain a definite fraction of ALL companies and eliminate most taxes. All people without jobs must be paid by the government even as the government sells unemployed labor to companies. Competition must be required in all government jobs, removing all restriction on political membership, and formulate non-discrimination rules. At least 2 persons must be in all rules, one from each collection in politics.


It is wrong to argue privatization without a funding by the government. Clever investment must be needed in this model since the government will starve without taxes. Will enough be generated for the government? Think of the government 20% ownership of all US companies and no taxes! It can be done! Is that ethical - any day better than taxes! Taxes are evil ways and much likelier to be unfair, whoever you are. Note the included destruction of publicity based communists and religion based tax free religionists! You can not hide director level discussions or great corruptions without some director squealing.

Monday, August 17, 2020

Amelioration of Ageing



NAD+ is known miracle chemical. In all humans, it declines continuously in ageing. It is known to be very important in Krebs cycle, which has a circuit of  NAD+ and Na-DH.
 

Na-DH.  NAD+ And NAD Benefits, Side Effects, Dosage And Stacking


The intravenous application of NAD+ is currently the only recommended therapy.


Augmenting either is good enough. NAD+ is made two ways - de novo (from amino acids) and synthesized (from Na-DH) while Na-DH is not made, just a step in the cycle NMN and NR are two precursors, both are made in body from vitamin B3. 

Flushing and Non-flushing (amide) form s of B3 i.e (Niacin,Niacinamide) are equally good. B3 effects, if at all, take 2 years. NMN or NR takes days.
Now there is bio-availability caution. NAD+ is useful inside mitochondria. Getting it there is hard. First difficulty is stomach-blood barrier. Next is Liver barrier. Next is cell-wall barrier from blood. Finally is mitochondrial penetration. There is an extra hard barrier for me - blood-brain barrier to fix ageing error for me - pseudo-Pakinson essential tremor. Past each barrier penetrates a small amount, measure in single digit percent. As you can see, minuscule amounts 0.00000001  percent will reach! one can raise it enormously by eliminating first 2 barriers by directly getting it into blood. Sublingual is one (as heart med, under 5he tongue). I failed in that. Another is nasal spray. Much better is iv or injection. Requires convincing and cooperation of a doctor, even getting injection/iv product.


 

Injection/iv product is very hard to get.
Published experience says iv form of NAD+ is under a day, while NMN lasts a week. USA has a breed called bio-hackers who try things on themselves and often suffer. iv and injectiblke forms of Nad+ are not for sale. One can get them  as powder and make injection forms by sterile water.Very bad idea as clear from this hacker!


more methods

Watch these links, they reflect only two other independent kinown methods  not dependent on exclusion circuit. No other method is known, consistent with all known science, physics, chemistry, biology and evolution. Without mercy, such a method is a religious farce and from a criminal mind.

This independence is great - do all at once, since each is independent!


parabiosis

Parabiosis? https://aaqg-arunarya.blogspot.com/2020/08/to-be-done.html

Parabiosis is surgical joining of two mammals such that their blood systems are joined. Tried successfully on two mice - one young and other old. The repairs in old were like young. Don't get nightmares as the effect survives plasma infusion. A bad idea if just extracting young blood without replacement. Exchanging blood worsens the young. Now what?

Escape from bio-criminal scientists of Nazi Germany is possible by undone experiment that likely will be done eventually by me!  Plasma add is well developed technique where the blood is drawn from a young but distilled to plasma and red blood cells. All the cells are immediately returned to Donor. This technique allows the recovery of donor twice as fast! The red-cell-sans plasma has all the benefits of whole blood! Serum banks in Delhi are made to donations from recovered covid infected. The plasma technique works for most diseases, was in act routinely used before antibiotics.


telomere

Telomere? https://aaqg-arunarya.blogspot.com/2020/08/to-be-done.html

A telomere names the end of DNA like thin fluffy ends. There is progressive shortening on every rebirth of cell. After 30-40 doubling,the size becomes so small that cell wont double any more. The length of Telomere correlates well with bio-age of the species. It is governed by the chemical Telomerase.

Lengthening telomeres for humans correlates to lessening of methyl marks. This is another way developed even more than Sinclair ways. 

Lengthening fully makes cell immortal i.e. cancerous!
One of the largest studies to date on telomeres shed some light on telomeres’ effect on a person’s health. Researchers collected saliva samples and medical records of more than 100,000 participants. Their findings showed that shorter-than-average telomere length was associated with a boost in mortality risk — even after adjusting for lifestyle factors like smoking, alcohol consumption and education that are linked to telomere length.

It stands to reason that if science found a way to increase Telomerase production, telomeres would remain long, lengthening life spans and possibly reducing the risk of some diseases.

In fact, one 2010 study published in Nature performed on rodents seems to confirm that theory. Mice engineered to lack telomerase aged prematurely and became decrepit. But when the enzyme was replaced, they bounced back to health. By reawakening telomerase in human cells where it’s stopped working, normal human aging could be slowed. “This has implications for thinking about telomerase as a serious anti-aging intervention,” said Ronald DePinho, a cancer geneticist who led the study.

However, there are still serious doubts about whether reversing or slowing down aging via telomerase activity is the answer. Because while telomerase does lengthen telomeres, in humans with cancer, the enzyme helps existing tumors grow faster. At this stage, it doesn’t seem we know enough about safely harnessing telomerase to ensure that it works only to lengthen telomeres and doesn’t actually stimulate cancer. Somehow the DNA genome and epigenome lose methyl marks.

 

Sunday, August 16, 2020

ageing



alivebynature discount coupon 4292305
Aging products
pterostilbene better than resveratrol - more bioavailable from putting two methyl groups 200gm=1000gm of resveratrol
pterostilbene https://www.amazon.com/dp/B005ACNW5S
https://www.amazon.com/Strength-Pterostilbene-Capsules-Naturally-Longevity/dp/B07GCBWB83/ref=sr_1_8?dchild=1&keywords=pterostilbene&qid=1597490244&sr=8-8
nmn VERSUS nad+ : BASED ON EXPERIENCE BY UNBOUGHT USERS
bad idea to qualFF nad+, must take in iv form, or nasal spray to bypass liver
nad+ and nmn do same thing - nmn becomes nad+, but nmn injections every week WHILE nad+ every day!
NO iv/injection products BUT atulji sister has agreed to help. Prefer nad+ way because it crosses into brain, will/must improve my parkinson-like shakes now quite bad. Important test for me,  will know after 6 months.
Some references

To be done


Tobe done, whenever


No one can speed me up

Saturday, July 18, 2020

Aging fight: call to arms



I am a scientist, was in bell labs, spoken at Harvard and was assoc prof at university of Massachusetts for many years. I was hit by TBI which I fought as a scientist and had partial recovery in 2020 from TBI after the shock-death of father! Important to give you fast believable intro to me as an atheist scientist who believes in indefinite life, healthy because of current efforts and future age reversal, no longer sci fi!

This is after Nobel-assured research by Dr. Sinclair at Harvard in Aging theory of information. What he has shown is that Horvath clock counts marks in cellular genome DNA and epee-genome IE epi-DNA as well. Aging is simply senescent cells from proteins forgetting where they should repair DNA cuts and/or where to return

https://aaqg-arunarya.blogspot.com/2020/06/aging-proofs-digilog-how.html

DNA does not change after birth - way before that! Epigenome has finite life and genes coding recovery lose proteins to wrong places. Genes make RNA then proteins. Tight coiling of DNA at some places happens due to proteins built by some genes for repair DNA - called gene shutoff. The repair proteins must prevent  generation of new cells while repair. This exclusion circuit is characteristic of all DNA in every life form. The evolutionary advantages are overwhelming, so that only DNA with the atheist scientist who believes in indefinite life, healthy because of future age reversal, no longer sci fi!

In any case, DNA does not change over life while epigenome changes. By stripping away epi-layer, you not only get ageing stop but age reversal!

https://aaqg-arunarya.blogspot.com/2020/07/amelioration-of-ageing.html

Horvath was a bio-statistician. Using primitive of 2012 AI, he managed to get very close bio-age numbers to  the actual calendar age and was very accurate in predicting remaining life for most from age-caused demise. Since then (to 2020) other markers and sites have been used to build other clocks. They cost $300 to $500 in USA, amazon-India used to do them but no longer, in fact no one does them here.

I am starting a company to survive on doing Horvath readings on the side and mouse-test of serious proposals on the side, including novel once. Rs. 10,000 per test is doable and should work at Indian
salaries. Certainly meshes with self-sufficient movement of today. Chemicals can be imported till production happens here. Reading microscopes is where costs are lower.

Horvath clock are absolutely important for scientific investigations in to ageing ideas. I know that metformin+acarbose extend life by about 10 years but the number is vague and can be sharply determined.

I also have a revolutionary idea that will certainly improve modern medicine allopathy. FDA tested drugs are used. There is NO pre-medication test of drug appropriateness! This is done in some cases (penicillin verbal quiz) but not enough! I have determined by experience that while I am not sensitive-penicillin-freak, using it to cure teeth-pain after and during root canal procedures makes me throw up food, while TZ is no longer effective. Ceftum is the answer. Why use sinusitis drug in root canal?

 This double-masked, multicenter, randomized clinical trial compared the efficacy and tolerability of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial maxillary sinusitis. A total of 263 patients with acute bacterial maxillary sinusitis were randomly assigned to receive 10 days of treatment with either cefuroxime axetil 250 mg twice daily (n = 132) or amoxicillin/clavulanate 500/125 mg 3 times daily (n = 131). Patients' responses to treatment were assessed once during treatment (6 to 8 days after the start of treatment), at the end of treatment (1 to 3 days posttreatment), and at follow-up (26 to 30 days after cessation of treatment). Clinical success, defined as cure or improvement, was equivalent in the cefuroxime axetil and amoxicillin/ clavulanate groups at the end-of-treatment and follow-up assessments. Patients in both groups showed improvements in symptoms of acute sinusitis at the during-treatment visit. Treatment with amoxicillin/clavulanate was associated with a significantly higher incidence of drug-related adverse events than treatment with cefuroxime axetil (29% vs 17%), primarily reflecting a higher incidence of gastrointestinal adverse events (23% vs 11%), particularly diarrhea. Two patients in the cefuroxime axetil group and 8 patients in the amoxicillin/clavulanate group withdrew from the study due to adverse events (P = 0.06). These results indicate that cefuroxime axetil 250 mg twice daily is as effective as amoxicillin/clavulanate 500 mg 3 times daily in the treatment of acute sinusitis and produces fewer gastrointestinal adverse events. cefuroxime axetil, amoxicillin/clavulanate, acute sinusitis.

Comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial sinusitis


After patient-intervention(IE by me), another antibiotic eeftum is used, known to some dentists only.. This should never be patient duty. Instead of list of possible side-effects, the physician must use a pre-medicine to know expected side-effects. It can be included in FDA-approval time as a sub-phase to figure out expected side-effects. Double bind tests must determine effectiveness in best adapted patients, the med may still be useful despite overall flunk.

I also have a another revolutionary idea that will certainly improve modern medicine allopathy. FDA trials weigh each participant equally. That is in spite of knowing that effectiveness may depend on ethnicity and sex of the participant. That information must be kept and double-blind results factored by population profile. India can and should establish post FDA approval agency that conducts trials on FDA-approved drugs only that determine efficacy on population profiles!

Monday, July 13, 2020

Amelioration of ageing


Why do we age? Digilog reasons, epigenome fixable.

Methods for fix?

1. Evolution, slowing ageing only, no reversal, needs no medicine. Argues for fasting (creating scarcity condition to use energy for DNA repair using sirtuins, use old proteins in mTOR, use AMPK for correcting metabolism IE diabetes in peripheral tissues), exercise, full sleep and hot/cold. Orthogonal to all else, hence benefits add. Can be done now.

No chemicals available to help. IE wheatgrass, Shilajeet etc are pointless.

2. Telomere Lengthening: Breakthrough Gene Therapy Clinical Trial is the World's First That Aims to Reverse 20 Years of Aging in Human . Likely fraudulent.

3. Yamanaka facto0rs: Ageing g reversal POSSIBLE. Best RESEARCHES IN California, IN SILICON VALLEY. Best place - Stanford.


I can raise about a million dollars. Will risk to start a company that survives by Horvath clock and does mice tests for Ageing on the side. Extra 20 years life extension on the side is prize enough. I think I have 15 to 25 years from evolutionary extension from today from acarbose, metformin, exercise and daily drop of dinner for fasting by hormesis - use diabetes readings for weakly predictive control test.

Why believe and how fast

To be read last!

How do I KNOW that Dr. Sinclair ageing theory of information is right and every other moron to before 2019 wrong!

WHY IS MY ESTIMATE OF 2030 TOO PESSIMISTIC AND 2025 MORE OPTIMISTIC ! As foreseen by me, it will start as a toy of the rich.

Breakthrough Gene Therapy Clinical Trial is the World's First That Aims to Reverse 20 Years of Aging in Humans

Tuesday, July 7, 2020

Who am I - start

BOOK start: self lionk

universe around  me

What is the universe around me - astronomy!

Approach these works like a child and learn to enjoy knowledge.



Cosmology is about every thing after big bang. Cosmogony AT BIG BANG OR BEFORE ( if time existed before 0). Creation of universe in which I am, is NOT the product of any God or intelligent designer. Even excluding the morons, there are many narratives of creation not dependent on these insanity - all important cosmogonies are linked next. None are falsifiable.

It appeared to me that string theory and loop quantum gravity are special in that they serve to unite the two theories of physics that have not united despite every top physicist in last two centuries despite herculean effort by thousands of best scientist in a century. These are quantum mechanics generalized to yield string theory. Loop Quantum Gravity LQG specializes Einstein gravity. These two have no known contradictory phenomena but refuse to mix to any quantum gravity and are perfect descriptions of the very small and astronomy.

Amazingly, scientist have their own, one and only falsifiable cosmogony. Amazing because falsifiable means you can start with nothing, even physics laws and constants.


The genesis of all elements and astronomical features is falsifiabllity complete. Next reference tells you the truth and the scientific theory of creation. (cosmology).

 suggest you download the free book and spend the best 10 hours of life reading it. If you are in true super hurry, I wrote a link. At least it will introduce you to cosmology and introduce NASA some to you.

Cosmology is the result of full-time work by 1000,000 humans for over a century - by far more than any soothsayer moron and done with rational skepticism  - trust no one but the force of logic that only leaves a tiny amount. All the developments in space, so far, are for rational skeptics, for astronomy be they LIGO, valley sized radio telescopes, trip to moon, space telescopes in every part of spectrum, rockets etc. It is stupid to trust a single guru, experience, ancient tomes etc.

What is life 


Know no biology?

What did people, including me, believe before theory of information

 What is the greatest achievement of 2019eatest research ever in human existence, ensures a Nobel prize and will be first thing to learn in biology? This is a start (he he).


Twenty five years of research at Harvard culminating in Dr.Sinclair's ageing theory of information.

When does and should death happen?


Life is about earthiness DNA molecule and its natural intermittent selection evolution after established evolutionary advantage. Every thing alive on earth has a DNA - bacteria, plants, animals and human. They age similarly and the information theory of ageing applies to them, including DNA mthylation at species -specific rates, measurable by Horvath clock, that can provide accurate bio-age and 3.1 year standard deviation prediction of remaining life for human!

Life evolved on earth around DNA because the proto-DNA solved a deep problem that all competing DNA-likes had - there are no exclusion genes, but earth-DNA achieved that by making Repair exclusive to reproduction! This is done by tight coiling (off) of DNA-gene in reproduction and lose winding in repair. Such simplicity gives massive advantages to that DNA, which survives a billion years and has carpet ted earth surface and unimaginable ocean depths.


Apart from extensions to Darwin's theory, this narrative explains Horvath clock in different DNA species of plants, animals, human in cells of all kinds - blood, muscle etc. A Y counter theory will have to explain Horvath clock every where, and commonality of DNA. One can explain Darwin using Watson-Crick DNA and even the latter by Sinclair exclusion behavior. It unites chemistry and biology. No extra reason to believe in his practice regarding reduction in ageing except capability, Horvath tests, needs no money, looks young, father doing well and practicing, plausibility (consistency with evolution). These collectively allow a rational skeptic like me to adopt a follow attitude on anecdotal evidence as I can not afford to wait for statistical proof!


The proofs will not help unless negative, in which case the financial losses end. Not even one suggestion of the guy is dangerous -worst is money loss.


USA is rich, but there can and should be immigration of aged to better shores for elder care like India.


My religion

Here I expect discordant opinion of friends. However, one must be in position of second religion - what if the current belief have to be stopped? In that case, a scientific religion is first choice, even though impossible to unite. The very fact that scientists are in general most trustworthy of all implies to me that they follow an undeclared common religion. Every scientist must never find his/her axioms from history, tomes, inheritance etc. What remains is the universal fact of death. Be it soviets or Americans, no advanced civilization ever accepts stupid organized religions (repeat ALL). Yet the absence does not lead to promiscuous  offshoot uncivilized christian of the dark ages. It requires no belief but in eventual death and a DESIRE TO LEAD A HAPPY LIFE! It is hard to believe a religion can follow from this, but it does, enough to say Hindu is my alternate religion and stoicism underlies my value system.



Saturday, July 4, 2020

Living long


My father lived to be 88, would have lived to 98 (I think0 BUT FOR HIS WEAKNESS RE MANGOES. For men, metformin AND acarbose synergestically work better than each other, while both improve healthy life. Acarbose fails longevity in women. Both benefit from rapamycin, though toxic in long use. As a diabetic on both, I expect to live 15 years beyond my undiabetic life! 98 to 110 with current interventions. NMN targets Sirtuin, Metformin targets AMPk while rapamycin target mTOR pathway.

Researchers have demonstrated that acarbose, a drug used to treat type 2 diabetes, extends life in mice. This should probably be taken as speculative until more studies are run, as another treatment for type 2 diabetes, metformin, has erratic results on life span in rodent studies. Like metformin, the mechanism of action for acarbose involves influencing glucose metabolism, though in a completely different way.




The present meta-analysis aimed to evaluate metformin combined with acarbose compared with monotherapy with either of the two drugs for type 2 diabetes (T2DM). Relevant trials were retrieved through searching PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang and Chongqing VIP information network databases. Heterogeneous and homogeneous data were statistically combined using a random- and fixed-effects model, respectively. For dichotomous and continuous data, the merged effect size was presented as the risk ratio (RR) and weighted mean differences (WMD), respectively, with 95% confidence interval (CI). All included studies were divided into subgroups. A Funnel plot was used to detect publication bias. Review Manager 5.2 software was applied to perform the statistical analyses. Meta-analysis revealed that compared with metformin monotherapy, combined therapy was significantly more efficacious regarding indexes including the total effective rate, fasting blood glucose (FBG), blood glucose levels at two post-prandial hours (2HPG) and hemoglobin A1C (HbA1c). Similarly, combined therapy showed advantages on indexes including FBG, 2HPG and HbA1c over acarbose therapy after 4 months of treatment. In conclusion, the findings of the present meta-analysis suggested that combined therapy of metformin and acarbose appears to be more efficacious than metformin or acarbose monotherapy.


Recognizing that aging can be targeted, the NIH developed the NIA Interventions Testing Program (ITP). The ITP tests diets, drugs, or other interventions to see if they prevent disease and extend lifespan in genetically heterogeneous (outbred) mice (http://www.nia.nih.gov/research/dab/interventions-testing-program-itp). This program is conducted at multiple centers in order to control for laboratory-specific environmental differences, and testing is done in both male and female animals (Miller et al., 2007; Nadon et al., 2008). Major findings of the ITP include that nordihydroguaiaretic acid and aspirin each increase lifespan of male mice (Strong et al., 2008) and acarbose and 17-α-Estradiol extend mouse lifespan preferentially in males (Harrison et al., 2014). Studies of rapamycin (an mTOR inhibitor) have established the most compelling evidence for targeting aging. When rapamycin is administered late in life, it extends lifespan (Harrison et al., 2009; Miller et al., 2011), slows aging in a dose-dependent manner, shows differential effects by sex (Wilkinson et al., 2012), and is synergistic with metformin.


Acarbose "alpha-glucosidase inhibitors" (why it works), 17-α-estradiol, and nordihydroguaiaretic acid (metformin relative) extend mouse lifespan preferentially in males
. 17-α-estradiol is  feminine, why (I think) human women live longer and it does not impact women mice.


Thursday, July 2, 2020

Weltanschauung - who am I - prologue:



Top

Popper https://en.wikipedia.org/wiki/Karl_Popper


who am I - prologue: At 25, I finished my Computer Science PhD.D thesis defense, and stood outside math science tall building with knowledge that the next strong memorial convocation happens with the degree roll for me. I had completed the mercy-less program and I was an employee at Boston doing software for the US army, best I could do, and worst according to my guide, who had become my father and hence took the position as me a misguided young man! His scornful look zeroed my pleasure and I was agitated. The program took me 3.5 years of toil and ended successfully. "What next?" I asked myself, worried by yet another Father I had upset. That fateful afternoon, I decided I will spend the next 4 years of my life (as long as I spent on PhD.) or less, and answer it well to answer my doubts - who am I.

deepest? A life went by. I am 65 about 40 years later and have finally been able to answer it to my satisfaction. How was I to know that this question is deepest in philosophy and touches all aspects of my life. You, my dear reader should read it once to answer it for your own self. Many times to begin to know me. It is unique in how much the question is covered.

writing style: It is written in a particular style, similar to how every intelligent scientist I encountered in the last 40 years whose style I could parse, think, and so do all top professors. I call it Socrates/style. Throughout, phrases with a slash, are mine with detailed semantics as per me and grossly, but not in fine details, without ever being surprising coarsely. In it, a question is asked, constraints on solution are imposed, and then one researches the answer, which might be simple or deepest like what I asked, depth not known. It has no relations to events in my life, most events are much better understood now. Its epistemology, like all science, is falsifiability https://en.wikipedia.org/wiki/Falsifiability. That here can even be the answer to "Who am I" is a 2020 miracle, never before in human existence [I prove it]!

Plethora of sub-questions: The question resolves into many more. For each there is a falsifiable (scientific) answer here. All religions are equally stupid, they are all equal so [I prove it. What is the universe around me - society, people, stars. What is life I have and how valuable - my own, family, friends and soldiers who fight for me. What is death, is there an afterlife, can I influence it? What is ageing, how can I minimize its harmful impact on self and loved once? What is medicine and sickness. How does one minimize its harmful impact? How does one distinguish money-drive salesmen and genuine value adders. How does one escape advertising and use it profitably! How does one escape politics and use it profitably. What is history, baloney and use if well? How to escape those who understand this. What is law and semantics? What is consciousness? Can one make Artificial Intelligence AI to understand and do what lawyers, doctors, teachers, maintain robots, white-collar jobs. How will post-industrial world function? Can robots be conscious? Who, what, how to believe? What makes society around me function. Who am I?

40 years later:  I will answer in subsequent pages. Just the width of sub queries is frightening to all but religious. I consider those beliefs to be uncivilized and support measures to drive them underground. The basis of all questions asked above is science, and lack of any belief in Any book or tome except as detailed by active rational skeptics whose words are treasured as representative of me. Even then, unless old enough to withstand active scientific investigation, else the statements are not a theory but a hypothesis. My great belief in Talib and Sinclair are such that their statements are hypotheses. There are All religions whose every contradictory statement means the converse is likely a hypothesis (Mal/hypothesis)!

what is science: pointless to talk about scientific without knowing what it is. Every religious moron will use the word unscientifically, in fact a collusion between his beliefs and science, not even knowing it is impossible. By Popper definition, generally accepted, science is a collection of falsifiable theories! Not one religious idiot considers religious facts as falsifiable! That is a negative constraint on what science can not be. On the positive side, science is rational skepticism, you only accept testable empiric, never believe unless it meets your logic! If accepted science fails, then your logic is faulty. It never happens with ordinary things. Extremes of size and speed in science force you into quantum mechanics and linear logic. Except quantum phenomena, ordinary propositional logic and predicate calculus suffices. There is nothing more laughable and scornful more than a stupid religious joker applying quantum mechanics to anything.

Who fails the Popper test? Not only do all religions fail, so do many phenomena considered scientific - like multiverse, what happens in a black hole, why is vacuum energy what it is etc. There is an element of rigorous deduction, inviolable known science axioms - limiting to new axioms not tested to today. Even then, it is not science. Science has no claims to be known all ever, it is that ALL religions fail unfalsifiability! ALL sub animal politicians have to become proficient in the art of attractive meaninglessness which can not fail! Said my favorite emfubar Sir - Modi failed Corona, not because he copied west like the US and UK, and failed to follow east like Japan and Sweden (sic) ; but because he failed to follow the Indian way! Not a word about the superior Indian  way! The explanation of Modi errors - so many of them - is simple, he is afraid of Sir. Sir Trump is a failure because he is not properly patriotic enough! Why do you think the intelligent Americans never argue with an Indian brahmin saint ever again?

outline of answers? This text was not possible before 2020 before I read Dr. Sinclair (Harvard) aging theory of information I applied to self as derived digilog theory two weeks after I read and saw some benefit. I tested positively once on  self, will again test on the month mark then life long on the annual mark. I suggest this digilog schedule and its understanding. Best I can suggest is to read and intern his book published in 2019. It is a scientific theory (falsifiable) and not dependent on any authority but sequence of experiments that all can try. I myself have formulated some empirical tests to try the digilog theory. Will be budgeted and done. Unless I could apply myself successfully, writing the rest of the questions is a waste of my time.

Contents Weltanschauung - who am I



Next
contents
Prolog
What is the universe around me - astronomy
Society - What is it around me
People - What is it around me
What is life
My religion
Value of my life
Value of life to family
Importance of friends
Dedication to soldiers
 What is death
Afterlife
Can I influence it?
What is ageing
How can I minimize its impact on self
Impact on loved once
Money-driven salesmen
Advertising  profitably
Escape politics
Politics profitably
What is history
Historical baloney
Abuse of politics
How to escape those who understand this
Non formal law
Semantic genuine value adders
Consciousness
Artificial Intelligence AI
AI - do what lawyers
AI -do what doctors
AI -do what teachers
AI -maintain robots
AI -white-collar
How will post-industrial world function?
Can robots be conscious
Who to believe
What to believe
 How to believe
What makes society around me function
Who am I?

Tuesday, June 16, 2020

The addiction: Heroin or anti-oxidant


mea culpa. International emfubar capitalists spread a web around me using slyly bought doctors causing significant money damage to me in the past! Ros or reactive oxygen series is usefully suppressed in some but harmfully in other cases. Using quote from the Grand master <Through the 1970s and 1980s, Harman and hundreds of other researchers
tested whether antioxidants would extend the lifespan of animals. FALSE. If old habits die hard, the free-radical idea is heroin. The theory was overturned
by scientists within the cloisters of my field more than a decade ago, yet it is still
widely perpetuated by purveyors of pills and drinks, who fuel a $3 billion global
industry. Arlan Richardson and Holly Van Remmen spent about a decade at the
University of Texas at San Antonio testing if increasing free-radical damage or
mutations in mice led to aging; it didn’t.>

I wish this research was published three years ago. Would have saved me lot of money and stupid belief. NMN was ok since it was anti-oxidant. so was coQ10 and even mitoQ. You took for free radicals. Even if I was not suffering a disease, anti-oxidants improved my age!


Mortality in Randomized Trials of Antioxidant Supplements for Primary an d Secondary Prevention: Systematic Review and Meta-Analysis  https://pubmed.ncbi.nlm.nih.gov/17327526/

As for chem-blind nothing like rapamycin, good in infrequent small doses only for higher or frequent doses hurt kidney.damage to ventilator


Now a strong advice, severely effected covid patients, must be given iv resveratrol since damage to ventilator-bound-patient's lungs is not by Covid but cytotkine storm.For long life, resveratrol supplementation has known no evil side-effects and relaxes cytokine by sirt1!

Overexpression of SIRT1 Protects Pancreatic Beta-Cells Against Cytokine Toxicity by Suppressing the Nuclear factor-kappaB Signaling Pathway  https://pubmed.ncbi.nlm.nih.gov/19008341/

Note that resveratrol can be safely added to ordered drugs


Saturday, June 13, 2020

How does Sinclair apply to me

https://blazepress.com/.image/c_fit,h_600,w_600/MTI4OTg1NjQyNTk1MDUzNTM4/self-portrait.jpg

I finished long deliberations 3 days ago. It started with what does proof mean to me. Did David Sinclair meet the burden? He does. Mine thinking is very American! Any support by experience or dead tomes is wrong! There must be repeatable empirical proof in a scientist set conditions, or dependable claim done before other scientists i.e. rational skepticism. Did Dr. Sinclair meet the burden. Experimentally, he did.

But a scientific theory is more - it must be consistent to all physics, chemistry and bio-chemistry so far. It is. Being biological, it must have a believable narrative. David meets the burden fully. Narrative is consistent to evolution - explain all aging (plants bacteria, animals) since all DNA that survives, has the exclusion gene! AMPK, mTOR and Sirutins are simply exclusion gene in mammals. The theory is different enough to label any is-same emfubar historian sub animal.

Beyond being right, what are the reco and why? David talks of improving things for exclusion genes by hormesis (vaccination, Hormesis - Wikipedia  https://en.wikipedia.org/wiki/Hormesis). The theory makes lot of sense to me as it is like Talib! He has analyzed many systems as airplanes and improvements by accidents and uses it in gym. (Talib is a superman like Sinclair is). What a merger.

Meaningfully, for aging, Sinclair advises to be hungry and fasting, to turn on natural preventive circuits in me,  but unlike religious nuts, has no problems with unlimited stuffing when eating. What is more, honest enough to reject multi-day fasts as too hard and not needed. This is very hard for me as diabetic. In my case, each meal is small and there are 3 intermediate meals ( biscuits, fruits and tea) to do slow but continuous nutrition. So protein were moved to breakfast, evening meal is lauki and small chapati, have eliminated night snacks. will do it for a month. Getting up hungry after 3 days. No evil effects so far. Havn't really reduced foods, only rescheduled. Worked so far. Maybe feel or look better in 31 days. If so then  epiClock measurements before and after next month. I am spending 12 straight hours between foods. Incidentally, I do walk 1km in morn and another at evening. Covid has shut the gym and in market for like bull worker. This is self-experimentation with results shared. Best is likely less age look and no decrease in energy.