Amelioration of Ageing

NAD+ is known miracle chemical. In all humans, it declines continuously in ageing. It is known to be very important in Krebs cycle, which has a circuit of  NAD+ and Na-DH.
 

Na-DH.  NAD+ And NAD Benefits, Side Effects, Dosage And Stacking

The intravenous application of NAD+ is currently the only recommended therapy.

Augmenting either is good enough. NAD+ is made two ways - de novo (from amino acids) and synthesized (from Na-DH) while Na-DH is not made, just a step in the cycle NMN and NR are two precursors, both are made in body from vitamin B3. 

Flushing and Non-flushing (amide) form s of B3 i.e (Niacin,Niacinamide) are equally good. B3 effects, if at all, take 2 years. NMN or NR takes days.
Now there is bio-availability caution. NAD+ is useful inside mitochondria. Getting it there is hard. First difficulty is stomach-blood barrier. Next is Liver barrier. Next is cell-wall barrier from blood. Finally is mitochondrial penetration. There is an extra hard barrier for me - blood-brain barrier to fix ageing error for me - pseudo-Pakinson essential tremor. Past each barrier penetrates a small amount, measure in single digit percent. As you can see, minuscule amounts 0.00000001  percent will reach! one can raise it enormously by eliminating first 2 barriers by directly getting it into blood. Sublingual is one (as heart med, under 5he tongue). I failed in that. Another is nasal spray. Much better is iv or injection. Requires convincing and cooperation of a doctor, even getting injection/iv product.

 

Injection/iv product is very hard to get.
Published experience says iv form of NAD+ is under a day, while NMN lasts a week. USA has a breed called bio-hackers who try things on themselves and often suffer. iv and injectiblke forms of Nad+ are not for sale. One can get them  as powder and make injection forms by sterile water.Very bad idea as clear from this hacker!

more methods

Watch these links, they reflect only two other independent kinown methods  not dependent on exclusion circuit. No other method is known, consistent with all known science, physics, chemistry, biology and evolution. Without mercy, such a method is a religious farce and from a criminal mind.

This independence is great - do all at once, since each is independent!

parabiosis

Parabiosis? https://aaqg-arunarya.blogspot.com/2020/08/to-be-done.html

Parabiosis is surgical joining of two mammals such that their blood systems are joined. Tried successfully on two mice - one young and other old. The repairs in old were like young. Don't get nightmares as the effect survives plasma infusion. A bad idea if just extracting young blood without replacement. Exchanging blood worsens the young. Now what?

Escape from bio-criminal scientists of Nazi Germany is possible by undone experiment that likely will be done eventually by me!  Plasma add is well developed technique where the blood is drawn from a young but distilled to plasma and red blood cells. All the cells are immediately returned to Donor. This technique allows the recovery of donor twice as fast! The red-cell-sans plasma has all the benefits of whole blood! Serum banks in Delhi are made to donations from recovered covid infected. The plasma technique works for most diseases, was in act routinely used before antibiotics.

telomere

Telomere? https://aaqg-arunarya.blogspot.com/2020/08/to-be-done.html

A telomere names the end of DNA like thin fluffy ends. There is progressive shortening on every rebirth of cell. After 30-40 doubling,the size becomes so small that cell wont double any more. The length of Telomere correlates well with bio-age of the species. It is governed by the chemical Telomerase.

Lengthening telomeres for humans correlates to lessening of methyl marks. This is another way developed even more than Sinclair ways. 

Lengthening fully makes cell immortal i.e. cancerous!
One of the largest studies to date on telomeres shed some light on telomeres’ effect on a person’s health. Researchers collected saliva samples and medical records of more than 100,000 participants. Their findings showed that shorter-than-average telomere length was associated with a boost in mortality risk — even after adjusting for lifestyle factors like smoking, alcohol consumption and education that are linked to telomere length.

It stands to reason that if science found a way to increase Telomerase production, telomeres would remain long, lengthening life spans and possibly reducing the risk of some diseases.

In fact, one 2010 study published in Nature performed on rodents seems to confirm that theory. Mice engineered to lack telomerase aged prematurely and became decrepit. But when the enzyme was replaced, they bounced back to health. By reawakening telomerase in human cells where it’s stopped working, normal human aging could be slowed. “This has implications for thinking about telomerase as a serious anti-aging intervention,” said Ronald DePinho, a cancer geneticist who led the study.

However, there are still serious doubts about whether reversing or slowing down aging via telomerase activity is the answer. Because while telomerase does lengthen telomeres, in humans with cancer, the enzyme helps existing tumors grow faster. At this stage, it doesn’t seem we know enough about safely harnessing telomerase to ensure that it works only to lengthen telomeres and doesn’t actually stimulate cancer. Somehow the DNA genome and epigenome lose methyl marks.