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I finished long deliberations 3 days ago. It started with what does proof mean to me. Did David Sinclair meet the burden? He does. Mine thinking is very American! Any support by experience or dead tomes is wrong! There must be repeatable empirical proof in a scientist set conditions, or dependable claim done before other scientists i.e. rational skepticism. Did Dr. Sinclair meet the burden. Experimentally, he did.
But a scientific theory is more - it must be consistent to all physics, chemistry and bio-chemistry so far. It is. Being biological, it must have a believable narrative. David meets the burden fully. Narrative is consistent to evolution - explain all aging (plants bacteria, animals) since all DNA that survives, has the exclusion gene! AMPK, mTOR and Sirutins are simply exclusion gene in mammals. The theory is different enough to label any is-same emfubar historian sub animal.
Beyond being right, what are the reco and why? David talks of improving things for exclusion genes by hormesis (vaccination, Hormesis - Wikipedia https://en.wikipedia.org/wiki/Hormesis). The theory makes lot of sense to me as it is like Talib! He has analyzed many systems as airplanes and improvements by accidents and uses it in gym. (Talib is a superman like Sinclair is). What a merger.
Meaningfully, for aging, Sinclair advises to be hungry and fasting, to turn on natural preventive circuits in me, but unlike religious nuts, has no problems with unlimited stuffing when eating. What is more, honest enough to reject multi-day fasts as too hard and not needed. This is very hard for me as diabetic. In my case, each meal is small and there are 3 intermediate meals ( biscuits, fruits and tea) to do slow but continuous nutrition. So protein were moved to breakfast, evening meal is lauki and small chapati, have eliminated night snacks. will do it for a month. Getting up hungry after 3 days. No evil effects so far. Havn't really reduced foods, only rescheduled. Worked so far. Maybe feel or look better in 31 days. If so then epiClock measurements before and after next month. I am spending 12 straight hours between foods. Incidentally, I do walk 1km in morn and another at evening. Covid has shut the gym and in market for like bull worker. This is self-experimentation with results shared. Best is likely less age look and no decrease in energy.
I finished long deliberations 3 days ago. It started with what does proof mean to me. Did David Sinclair meet the burden? He does. Mine thinking is very American! Any support by experience or dead tomes is wrong! There must be repeatable empirical proof in a scientist set conditions, or dependable claim done before other scientists i.e. rational skepticism. Did Dr. Sinclair meet the burden. Experimentally, he did.
But a scientific theory is more - it must be consistent to all physics, chemistry and bio-chemistry so far. It is. Being biological, it must have a believable narrative. David meets the burden fully. Narrative is consistent to evolution - explain all aging (plants bacteria, animals) since all DNA that survives, has the exclusion gene! AMPK, mTOR and Sirutins are simply exclusion gene in mammals. The theory is different enough to label any is-same emfubar historian sub animal.
Beyond being right, what are the reco and why? David talks of improving things for exclusion genes by hormesis (vaccination, Hormesis - Wikipedia https://en.wikipedia.org/wiki/Hormesis). The theory makes lot of sense to me as it is like Talib! He has analyzed many systems as airplanes and improvements by accidents and uses it in gym. (Talib is a superman like Sinclair is). What a merger.
Meaningfully, for aging, Sinclair advises to be hungry and fasting, to turn on natural preventive circuits in me, but unlike religious nuts, has no problems with unlimited stuffing when eating. What is more, honest enough to reject multi-day fasts as too hard and not needed. This is very hard for me as diabetic. In my case, each meal is small and there are 3 intermediate meals ( biscuits, fruits and tea) to do slow but continuous nutrition. So protein were moved to breakfast, evening meal is lauki and small chapati, have eliminated night snacks. will do it for a month. Getting up hungry after 3 days. No evil effects so far. Havn't really reduced foods, only rescheduled. Worked so far. Maybe feel or look better in 31 days. If so then epiClock measurements before and after next month. I am spending 12 straight hours between foods. Incidentally, I do walk 1km in morn and another at evening. Covid has shut the gym and in market for like bull worker. This is self-experimentation with results shared. Best is likely less age look and no decrease in energy.
You may try intermittent fasting simultaneously adjusting yours diabetic pills accordingly thereby eliminating the risk of hypoglycemia...
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