What are prospects of fountain of youth in near future?
At
a forum on Cape Cod earlier this month, Harvard scientist David Sinclair had
the rapt attention of biotech executives and investors as he described treating
20-month-old mice with a molecule to restore their youthfulness. Before
long, the geriatric rodents were outracing 2-month-old mice.
Yes, Sinclair told his audience, “We can turn an
old mouse into a healthy young mouse.”
The Fountain of Rodent Youth feat, outlined in
March in the scientific journal Cell, hasn’t been replicated with humans. But
researchers, who have long scoffed at the anti-aging claims made by companies
pitching dubious products, are warming to the idea that serious science can be
deployed to increase human longevity.
Ambitious efforts are underway in Massachusetts and
beyond to develop the first government-approved drugs to stretch healthy life
spans. Some researchers are scrambling to repurpose a
diabetes medicine to target age-related diseases. Others are working to
boost levels of a key protein to increase blood flow and endurance, or to find
a way to kill “zombie cells” that can send out toxins that cause age-related
maladies.
repurpose a diabetes medicine
metformin. Remember latest
research says insulin, very useful to 35 turns bad after 45! Most current mm
doc were taught wrong!
How long can humans live – some feel not very long!
In the 1960s,
Hayflick found that human cells divide only 40 to 60 times, after which they
stop — even when their division is paused and then allowed to resume.
This discovery, called the Hayflick Limit, indicates that even if a drug like metformin were
effective at suspending aging, the end game stays the same.
Shouldn’t someone, likely to
die, be allowed treatment wished?
So say
conservatives and Trump and US just passed a bill. But it is’nt a simple
issue! Other side has good arguments. It is similar to suicide by suffering
hopeless terminally ill!
Isn’t aging alleviation in
near future by crispr driven gene therapies?
There is no question that if
scientists aren’t careful, CRISPR can induce substantial off-target mutations.
In another study Joung’s lab
submitted to a journal, they show that when “promiscuous” forms of CRISPR were
slipped into mice’s livers, as some genome-editing companies hope to do for some
human metabolic diseases, it edited hundreds of spots in the mouse genome that
it wasn’t supposed to.
Elementary CS has the answer
as I learned in 1976 studying L_systems. Lindenmeyer systems are parallel
context sensitive grammars made type-2 by passage of time which can be viewed
in onary notation. Problem is simple – crispr allows one to edit-replace
sequence of letters of genetic code say CATG to CCAT by changing CAT to CCA,
but it does it everywhere even unintended. Not simple but progress made.
even if a drug like metformin were effective at suspending aging, the end game stays the same
True but error is in assuming that there is no stem cell! Tree cells have shown the way past - a stem cell also divides and the stronger cell lives! That is what transfection does!! I, Arya aaquantum, am still very hopeful of transfection driven anti-aging.
Explored and used interventions?
Metformin
supplementation of three subcycles of krebs cycle
Preventative supplements for gross body objects
Explored, india has advantages
low labor cost
posses real estate
simple operation
Hence 2 week to 2 month medical tourism makes sense - I provide equipment, operator, living, food from dedicated chef - full tour package, turn key basis
Meaningful aging interventions
The three procedures referenced next are
- uniquely addable by me as a non-doctor for upper middle class
- Have existing documented benefits
- Unlikely to have negative effects. Worst is mild benefits!
Thus flooring lazy nincompoops.
- ECP External counterpulsation used to escape stent surgery. My add is reducing costs to enable upper middle class.
- Human Parabiosis - Wikipedia but legally - Doable by upper middle class.
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