Unlike all other things you might have read, and Morons who conflict with me, the first business is to make myself transparent to you and disclose enough to allow you read on or quit:
0. Inputs may cause doctor switch but never perform except after consult with a responsible doctor..
1 Several methods are discussed. My goal is not to0 claim that I, or anyone else has a uniformly believed theory of aging
2. All the methods discussed have empirical evidence in their favor and hence will have to to be explained by rock-hard eventual theory of aging and the benefits at the low end will be there and can only become larger with better theory
3. One consequence of wide read is the sympathetic read of theories, used solely to depend on the sum of benefits of the various methods that is understand why apparently independent methods have been or are implied to be related. In the absence of such dependence seems to allow benefits of procedures to add.
4. There seem to be imminent coming of the Aging singularity - expansion of human age by one year per calendar year. Question that such forecasts (2030 me, 2025 Kurtzweil at Google, lack of criticisms by Drs. Sinclair and de Grey) means that rational people see it in 5-10 years. It will be useless to dead by then or to people who will not be able to afford it, or long life beyond! Individually, even one method gives 5-10 years as empirically found. Given 4 method are likely to become empirically possible, one does not have to blindly depend on Yamanaka factors methods to become possible within 5-10 years! Even 2050 extension is possible without them.
5. Some readers may be confused about lifespan and health span, these are distinct things. Two essential but non-actionable methods are slowly maturing and will happen by 2050 - Yamanaka factors and stem cells. These are both non-actionable and close watch is important for 1000year life and spin-offs that become actionable. But these are not dependent on to life and health expansion to 2050. Ideally they will yield pure increments that have no long term negative consequences. However, there should never be unneeded hurry to benefits from them as soon as they yield benefits due to unknown dangers.
What is aging to me?
Aging relates to looks, performances+ and disease avoidance. Reduction in cell age is sought for maintain of brain performance and disease avoidance and strength for routine tasks, I am not in any strength or stamina business. Means looks, stamina and strength beyond a level are not relevant. Why we age is not interesting beyond a level to understand immediately relevant technologies, beyond are boring.
Why do we genetic-age? DNA is the base of every cell. All alive are an uncountable collection of cells, all derived from the pluripotent cell at the very start. Not only did the cell divide, it also specialized, and became bone, muscle, blood, skin, hair, organs, and all other cell types. It is empirically possible to restore any cell into pluripotent (forgotten specialization) form by the four Yamanaka factors OSKM.
It is possible to theorize that every animal is known collection of cells, each having a center in which DNA lives, evolved into every life or lost life from evolution from a particular DNA molecule that unlike all others DNA like molecules discovered how to fix breaks using special proteins, but also avoided any duplication while the break persisted. This one sentence is my summary of Dr. Sinclair work over 30 years at MIT and Harvard. Establishing this empirically is very hard, good enough for a Nobel Prize!
Along the way was established the chemistry that controlled aging by effecting the DNA. Direct method, TBD is Yamanaka factors. There are 3 classes of chemicals that control the DNA. They are (silent mating-type information regulation) Sirutin, parp (Poly_(ADP-ribose)_polymeraseand and Mtor (mammalian target of rapamycin)
Rather than deep study of aging to understand a gerontologist profession or geriatrician professions, I start by saying that orthogonal to both are Dr. Audrey de Grey ex-department head at Oxford, creator of SENS I publish after 20 year of following and 1-2 man-years chasing aging on the internet with strong skeptical attack personality, and believer and user of aging enzymes for slow in vivo improvements.
Known medical dogmas are dead. A disruptive paradigm sweeps the profession where genetic thinking is essential for all slow aging diseases like heart, diabetes, aging itself and all whack-a-mole approach is vastly inferior to at5tack the root cause through bio-age reduction.
Current improvements are NMN/pterostilbene for sirutins, Metformin/Acarbose for parp but nothing for mtor. About mtor, rapamycin can be deadly as it weakens the immunity (hence used in organ transplant on rejection). Not found any otherwise innocent replacement for rapamycin or reducer of effects.
What are age changes?
Every earthen life is cellular, including me. Intuitively, I expect aging to be cellular! Strongly in my favor are Horovith empirical facts - consistency of methyl marks on Cp sites not only in tissue within a life-form but also across individuals and species! That is empirical proof of similar DNA in species, aging in tissues, and only evolutionary changes in species. In all cases, aging is caused by DNA aging in cells. As cells become senescent, the number of useful cells declines, there is a loss in ability in all tissues and old age grips.
Change in cells. UC San Francisco. Science direct.
All cells have a programmed lifespan by which they are synthesized, multiply, and eventually undergo apoptosis (cell death) when they are no longer functional.
The number of times a cell can divide is bounded by a phenomenon known as the Hayflick limit. This describes the action by which the process of division (known as mitosis) progressively degrades the genetic material, specifically the part of DNA called a telomere.The Hayflick limit dictates that the average cell will divide between 50 to 70 times before apoptosis.
Let us assume a probable model of DNA repair mechanism. A certain life is possible per cell, less than the Hayflick limit from telomere shortening per cell division!
Method linked are
1. Yamanaka factor based medicine and supplements
2. Artificial thymus or white-cell training methods
3. stem cells
4. hibernation based postponing methods
5. TPE based like oil change and aging sharpness keep
6. Evolution justified (Dr. Sinclair tested | FDA tested) NAD+ boosters and blood path lining cells
Of these first 4 are doctor based and people watch methods. Only last 2 used with aging specialist recommendation and MD permission.
All aging specialists are required to track scientific developments in first four methods, also track cancer progress and amelioration of aging diseases. Aging specialty include non-allopathy elements, must be government regulated but not allowed to be closed only to physicians. The first 3 methods are best done by doctors, 4 by chemists, zoologists and genetic engineers. Usefulness but not details of procedures in 5 and 6 should be left to aging specialists. Gerontology and geriatrics have been abused with very limited role in the open future.
I refuse to give any powers over me to physicians. Medical procedures are theirs. When useful and engineering is not medical subject!
What procedures for aging specialists
1. Yamanaka factor based medicine and supplements
Yamanaka designed his factors to convert any specialized cell to become pluripotent - Four enzymes OSKM are enough. M can be removed as it causes cancer. The Other three can be used in live animals with intermittent lower concentration. This allows live genetic reprogramming without any cell losing its specialization it acquired before birth. Yet to be done, it is possible to unage any group of cells that can be selected, selection can be made by aav virus methods or newer mRNA-based methods.
2. Artificial thymus or white-cell training methods
A very medical method rebuilds replacement for anti-viral white cells, that are exhausted not by reducing numbers but losing their function by fat. These can be generated by surgically attaching external thymus like organs or attaching surgically a blob that trains normal immune system cells to attack all objects that have expression of a particular chemical. It not only can be used to target senescent cells but all kinds of cancers too.
3. Stem cells are how top medical institutes and hospitals like AIIMS believe is how medicine goes next. External thymus can be considered a kind of stem cell treatment.
4. hibernation based postponing methods, not discussed but waiting for hibernation break through is the realization that most cryo-postdeath procedures attempt to time-shift patients to the time when the ailment has a proper treatment. Obviously not only can hibernation allow long voyages but also effective undo of aging!
5. TPE based like oil change and aging sharpness keep for brain ailments like Alzheimer and Parkinson from renew of brain (recent magic).
6. Evolution justified (Dr. Sinclair tested | FDA tested) NAD+ boosters and blood path lining cells
Other matters re future world
won't you get bored?
What do you see in philosophy?
Great expansion of Hormesis alternative beyond Talib and ban on Homeopathy.
What happens about investment?
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