Consider the aging undo ways. Better blood flow is by endothelial cell improvement by pterostilbene. One can improve cell energy by targeting the mitochondria, trough NAD+ predecessors and mitoq. One improves blood itself by TPE to reduce proteomics load. Immunity can be reverted to youth levels by reducing fatty white-cells and trained killer cells with enhanced immunity factors. Overall improvement requires genetic improvements by using Yamanaka factor permutation to fix DNA and control over stem cells. Of these ideas, one selects 4 for 50-year gain by 2030.
Senolytic drugs is likely the first big 15-years attack on giving the first 50 years by 2030. Expect 10 from NMN and associates, likely rising to 15 by mib-626 etc by 2030, 10 from my designed plasma substitute designed TPE rising to 15 with 10 year research, 15 from Yamanaka factors supplements & drugs and 15 from senolytic drugs. Of these NMN and associates is done and 15 likely by 2030, Arya replace TPE is done and awaits self test, likely rising to 15, Yamanaka factors supplements are private and public funded furious research in California, and some senolytic are there and more will be available by 2030. If anything, my estimates are probably too pessimistic. Perhaps 50 years by 2025 for the close watchers.
All these attacks
are independent thus likely additive. Another issue is lessening of my circumspection, my thinking of 2030 for 50-year is likely too pessimistic. Perhaps revise it to 2025, great for mother and doctor uncle, they only need to be alive by 2025, Till then confidence in my medical knowledge will be there by self-experiments and there is no need to wait to 2025, important in Covid-times. By 2022 middle, Covid-terror will vanish from herd immunity from 50%+ vaccination and departure of villains like Lady Mamata and Sir Tikat.
Evolution driven natural-like supplements?
NMN and associates target NAD+, the villain could be CD38 evolution to solve cancer problem with aging a solution, and perhaps 10 year research is still needed on this villain.
Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes
Aging affects circadian clock and metabolism and modulates timing of medication
Blood fix like oil change?
TPE with my designed plasma may not work to Parkinson type attack due to BBB. But amyloid were reduced in AMBAR and perhaps other chemicals in the brain might like to keep constant ratio! This is important to me to make India, an important fulcrum of aging and self generated capital.
Artificial disease targeted plasma TPE?
The most severe complications in TPE occur with fresh frozen plasma as the replacement fluid. Almost all studies of TPE for treating SSc used sterilized 5% albumin, which has a much better safety profile because of substantially reduced risk of anaphylactic type events.
Senolytics for Cancer Therapy: Is All That Glitters Really Gold?
Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies. Consequently, senolytic use has been proposed as a potential adjuvant approach to improve the response. Despite the unequivocal promise of senolysis, issues of universality, selectivity, resistance, and toxicity remain to be further clarified. In this review, we attempt to summarize and analyze the current clinical literature involving the use of senolysis in senescent tumor cell models, and to propose tenable solutions and future directions to improve the understanding and use of this novel class of drugs.
Parkinson's efforts - why and how?
Parkinson is important for me because my essential tremors matches better than Alzheimer; I am unlikely to suffer dementia not still have a bad old age, not like Parkinson but still bad. There are two fascinating studies on research. Fundamental to all research, a doctoral thesis for example is finding a new problem in which some progress is possible. Best is research with 2 insights, one to decide if a problem should be selected and another that drops in the course of research. It is the job of guiding professor to provide the first insight, or most of it.
Above describes computer science research. Medical research can be started by lack of reliable answers to patient observations. Two Parkinson research are driven by lack of answers. Why do the Parkinson patients smell different? Why is tandem bike (two persons sharing pedaling) improve symptoms, while pedaling ordinary exercise bikes don't? Another disease that afflicts me is diabetes. Why do patient's with good control have halitosis but symptom free do not? A final one that I learned by spending 40000 bucks and 3 day terror in heart ward is fix heart burn even if you can't fix heart disease and symptoms are identical?
Yamanaka factors drugs and supplements?
Of OSKM, the Oct4 may be redundant, if quality not speed is goal, then SKM suffice, never M which causes cancer! Processes with pulsed S and K at low doses will work.
Drugs?
They require a prescription, sometimes for bureaucratic reasons, obeyed nonetheless. Case in point is metformin, getting a prescription for aging should be easy.
None found.
Supplements?
I use the term in the sense of actual OTC drugs and supplements of food grade and pharmaceutical grade, last suitable for injection or intravenous forms. I consider the mode of usage restricted to doctor or nurse presence in some cases despite no legal requirements, requires warnings.
There are none for Yamanaka factors at this point.
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