The goal is not new - it is present in the oldest extant written telling of Gilgamesh travels in ancient Mesopotamia to cure old age, 4000 years earlier. Since then many frauds have risen.
Why is it not a fraud this time?
The method has been proposed by several scientists not familiar with each other. It uses well-recognized international prize methods. All are available transparently. Not even 1 scientist has refused to hold his method a secret. Such an approach is the reverse of fraud. Every claim is always cross-checked. Speedy claims are ignored. Clearly, no one is being compelled to state anything, and /or unwillingly participate. Everyone is free to state whatever and advance their causes howsoever. The only limit is the permanent ignoration of every claim by a moron.
who ages and why?
Among all the anti-aging interventions, dietary interventions have shown the greatest potential. Calorie restriction, without malnourishing the individual, slows the aging process and expands the average and maximal lifespan in animals of diverse origins. Repeated reports say that restricting food intake in rats extended the median and maximum life span and decreased the onset and severity of chronic diseases. Subsequent findings emphasized that calorie restriction has effects on lifespan in a wide range of organisms. The positive effects of calorie restriction in humans have also been demonstrated in many studies. Calorie restriction while maintaining adequate nutrition has beneficial effects such as protecting against the development of obesity, cardiovascular disease, hypertension, and cancer. In a controlled study, calorie restriction with high levels of physical activity showed a decrease in blood pressure, body weight, serum cholesterol levels, insulin levels, and other anthropometric and physiological parameters. The mechanisms by which calorie restriction induces life-extending properties are not fully understood, but the following four potential target pathways have been suggested: the activation of AMP protein kinase (AMPK) and sirtuins, inhibition of insulin-like growth factor-1 (IGF-1) signaling, and inhibition of the mammalian target of rapamycin (mTOR) by rapamycin. These pathways are the main hypothesized mechanisms of action of calorie restriction that control cell growth, mitochondrial function, and autophagy directly or indirectly. However, despite the proven benefits of calorie restriction, it is a difficult technique to successfully use in humans as it is challenging to apply the treatment long-term since it requires a high level of determination and self-control. This paradox led to the discovery of compounds that imitate the outcome of calorie restriction on health and lifespan without an actual restriction in calorie intake. These compounds were named ‘calorie restriction mimetics’ (CRM).
Composing aging recommendations rationally is my mission and explains why I look for a doctor/Nurse in my team to argue on effects as a devil’s advocate to my research. Beyond the three here and metformin even without TAME (4th), I await TRIIM-X end as 5, low dose rapamycin as 6, lot more like E5 not public yet. The stupidest idea is composing best of each, or try them all sequentially, singly, like 5 Pandavas or six wives.
The three theories, determined by me to be independent, hence composable, are NAD+ boost by NMN and NO from resveratrol as per Dr. Sinclair (and argnin by self); Senolysis through fisetin as per Dr. de Grey; and CaAKG (+ayurveda +vitamins) as per Dr. Kennedy. FDA essentially monitors the safety and efficacy of chemicals, salutary for drugs but useless for drugs and supplements me - critical chemicals like new all aging-related chemicals. For these alone, I do derivations differently, by ethics not law.
Safety is assumed due to low concentration safety from
1 Element of many fruits and vegetables with no credible known dangers
2 At least 20-30 year safe history as a drug or supplement
3 GRAS status in US law
4 Chemical name for a body compound or intermediate
Thus NMN follows from #4, Fisetin from #1, CaAKG from #4, argnin, and resveratrol from #2. This is personal safety and not community safety, for which alone, such arguments can be advanced. For the random communities, I recommend waiting for FDA, unless the inaction risk is greater than aging composition.
Efficacy arises from the fact that I consider these three developers to be like double Noble prize winners who advocate this thread.
Joint efficacy happens from apparent independence of the threads, NAD+ boosts are needed and empirically decrease. The de Grey thread arises from eliminating harmful senescent cells producing SASP and CD38 in particular, buy cancer immunity as a side benefit. The AKG thread is unclear, may work due to effective bookkeeping of methylation marks, thus prolonging cell life. Safety does not end here.
There are unknown dangers from dose size and interactions with other parts of these threads, and wholly different drugs prescribed for other illnesses coincident with aging fixes. These are precisely circumstances when the patient is on their own anyway! Common sense says if the chemicals are safe in low doses and edible, they are likely so in higher doses, unless not natural or so recorded.
I strongly believe in Bayesian statistics and hence am suspicious of FDA clinical tests on new chemicals without a history of use. Most drugs approved post-2000 are cancer suspects! I believe a doctor or a vaccine solves a problem by instantiating more and hence is better avoided unless really needed and healthy disrespect to new chemicals but not foods.
With my thinking, a particular load was lifted after 2 months of self-test. Now I can advise the family to try if as upset with chronic diseases as me provided the risks are more anyway. My work and risks recorded did not crash so far. People who see no death hanging there anyway, or not a decrepitude life should await FDA blessings.
What is aging chemically?
The immense contribution is of Sinclar. Simple and useless except validation of de-aging methods. Each human cell has its DNA in a sack called the nucleolus. It is specialized to the exact kind of cell by an epigenetic covering of the DNA by on and off of genes using methyl group bearing switches. Some switches are permanently on or off according to the specialization expressed. Others can be dynamically on or off according to the protein being made.
Genetics and epigenetics make the DNA an information-bearing molecule that can deliver some proteins through copy by mRNA. With time, the methyl groups lose their elasticity and a cell has more methyl groups no longer capable of on-off. The methyls are part of CpG islands, being sugar C, phosphate bond to next G sugar, a microscope can read the number of such methyl groups. The list can be read by AI to compute a biological age for the cell! Validation follows from equal age of cells in all parts of the human body and predictable changes in all animals in Eutheria. Not only does evolution age all animals by the same method, but different aging details are also species-specific. No fraud can state this in a non-fraudulent way and escape scrutiny!
Amelioration?
Let us divide de-aging in to slow down and reset. Slow down includes temporary resets as well. This means that the body of the subject lives longer after treatment. Reliable reset means becoming younger repeatedly. Cross-effects mean interference of two treatments or one treatment and interference of some medications prescribed for some illness. It is assumed that the aging regime is halted for the duration of other illnesses so that interference happens initially by aging half-life and later by medicine half-life. The safest is to only use GRAS (generally recognized as safe) chemicals. Since repeated aging and reset cycle gives indefinite life, a reliable reset yields indefinite life.
FDA value
I believe that there is conservative safety in my recommendation. From my thinking, the best consequence of the law is that the FDA is Court-reasonable even though I am further conservative in that I worry about cross-interference of drugs and 30 years of age to worry of cancer risk. When required by illness, I only allow modern medicine doctors prescribing drugs with history by request Aging is different on that FDA-wait is stupid and other metrics must be used for safety and effectiveness.
My value?
I determine the GRAS status by assuming that extra concentration of GRAS chemicals is generally, but not always, safe. I believe that there is conservative safety in my recommendations.
Safety: Given that my GRAS status requires known fixed concentrations of drugs FDA-approved before 1990, chemicals in fruits and vegetables, or chemical names already present in body.
Effectiveness: I trust the American system to great academic trust unless wrong as per me.
My value adds: exceeds clever choices, the composition of random great systems can produce immense interference, I compose great systems by ensuring that the chosen systems can be composed by pinpointing the best so that the resultant mixed system is likely to work better than anyone.
Details?
The number of vouched for aging supplements increases every day. One stupid way is to try a random permutation subset of the supplements, hoping for no interaction, possibly even by inexperienced doctor. That is done by many in India, who treat illnesses and cures as buying a product, typically independent in effects. I have contempt for these consumers and call them meta-morons, not only once stupid but repeatedly so. Two cures or medicines can be composed only if the prescriber is a single registered doctor or interactions are precisely thought about and the person runs a self-imposed clinical test, critical for fssai/2012 to know! There is, unfortunately, no credible data like that, side effect web sites indications are not reliable, and if written assurances are sought, most doctors are smart enough to use lawyer language that can include every known/unknown side effect so extensive that any rational patient will never try that drug or supplement! Between lawyers and doctors, the patient is fucked!
Composing aging recommendations rationally is my mission and explains why I look for a doctor/Nurse in my team to argue on effects as a devil’s advocate to my research. Beyond the three groups here (NAD+boost, Senescent forced autophagy by senolytics, and missing reducing chemical AKG) and metformin even without TAME (4th) wait, I await TRIIM-X end as 5, low dose rapamycin as 6, and a lot more like E5 not public yet. Why is spermidine and fisetin both, just 1, or quercetin combo? The stupidest idea is composing best of each, or try them all sequentially, singly, like 5 Pandavas or six wives. There are hard questions even 99% of doctors will not know.
The three theories, determined by me to be independent, hence composable, are NAD+ boost by NMN and NO from resveratrol as per Dr. Sinclair (and not argnin but citrulline by self); Senolysis through fisetin as per Dr. de Grey; and CaAKG (+ayurveda +vitamins) as per Dr. Kennedy. FDA essentially monitors the safety and efficacy of chemicals, salutary for drugs but useless for aging drugs and supplements like me - critical chemicals like new all aging-related chemicals. For these alone, I do derivations differently, by ethics not law.
My principal improvement is to sidestep bio-availability and drug delivery questions by using liposome forms of all chemicals (except NAD+ for BBB entry) thus using supplements except metformin. Liposomes eliminate needed medical services and do even better than injections as they sidestep cell entry. Works for many aging drugs that do not have to be guided by the injection region.
Safety is assumed due to low concentration safety from
1 Element of many fruits and vegetables with no credible known dangers
2 At least 20-30 year safe history as a drug or supplement
3 GRAS status in US law
4 Chemical name for a body compound or intermediate
Thus NMN follows from #4, Fisetin from #1, CaAKG from #4, argnin, and resveratrol from #2. This is personal safety and not community safety, for which alone, such arguments can be advanced. For random communities, I recommend waiting for FDA, unless inaction risk is greater than aging composition.
Efficacy arises from the fact that I consider these three developers to be like double Noble prize winners who advocate this thread.
Joint efficacy happens from apparent independence of the threads, NAD+ boosts are needed and empirically decrease. The de Grey thread arises from eliminating harmful senescent cells producing SASP and CD38 in particular, buy cancer immunity as a side benefit. The AKG thread is unclear, may work due to effective bookkeeping of methylation marks, thus prolonging cell life. Safety does not end here.
There are unknown dangers from dose size and interactions with other parts of these threads, and wholly different drugs prescribed for other illnesses coincident with aging fixes. These are precisely circumstances when the patient is on their own anyway! Common sense says if the chemicals are safe in low doses and edible, they are likely so in higher doses, unless not natural or so recorded.
I strongly believe in Bayesian statistics and hence am suspicious of FDA clinical tests on new chemicals without a history of use. Most drugs approved post-2000 are cancer suspects! I believe a doctor or a vaccine solves a problem by instantiating more and hence is better avoided unless really needed and healthy disrespect to new chemicals but not foods.
With my thinking, a particular load was lifted after 1 month of self-test. Now I can advise the family to try if as upset with chronic diseases as me provided the risks are more anyway. My work and risks recorded did not crash so far. People who see no death hanging there anyway, or not a decrepitude life should await FDA blessings.
The number of vouched for aging supplements increases every day. One stupid way is to try a random permutation subset of the supplements, hoping for no interaction. That is done by many in India, who treat illnesses and cures as buying a product, typically independent in effects. I have contempt for these consumers and call them meta-morons, not only once stupid but repeatedly so. Two cures or medicines can be composed only if the prescriber is a single registered doctor or interactions are precisely thought about and the person runs a self-imposed clinical test, critical for fssai/2012 to know! There is, unfortunately, no credible data like that, side effect web sites indications are not reliable, and if written assurances are sought, most doctors are smart enough to use lawyer language that can include every known/unknown side effect so extensive that any rational patient will never try that drug or supplement! Between lawyers and doctors, the patient is fucked!
Events in 2022
Most important to me, listed in Radom order, are
a. end of my clinical self-experiment in november
b. near end of partial self-experiment by mother and sister
c. expected end of TRIIM-X and my start of HGH-1 with diabetes fix
d. end of MIB-626, hence better NAD+ boost and NO.
e. Success of Sinclair aging test for DNAm and GrimAge of self
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