Heath span 2022

The latest link

What is the current Aging goal in 2022?

Never eat any medicine without a doctor's vetting and supervision. All that follows is for entertainment and a basis for intelligent questioning. I am not a medical doctor. I do hope my work provides some things to discuss and compare answers. My goal is to recover to enable light exercise and be ready to partake in indefinite non-negligible senescence life in the next 5-25 years.

The single largest cause of death and suffering around the world is not cancer or dementia, but aging. This may sound counterintuitive, but when viewed from the perspective of a biologist, the logic is inescapable: the changes that happen in our biology as we get older are the main cause of the diseases that are the world’s biggest killers today.

The good news is that there is currently a revolution quietly underway in the world of aging biology: scientists have discovered dozens of ways to slow - and even reverse - the aging process in the lab. From changing what animals eat to treating them with drugs and even altering their genetic code, the first of these medicines are already making their way into human trials to explore whether the longer, healthier lives seen in animals are possible among us.

Given that I view this effort as a significant addition to healthspan extension, stated in informal terms, likely to be misinterpreted by sub-human extension morons using misquotations, unsaid or unintended meanings, etc. At the same time, I wish to allow useful extensions. Therefore, I have the notion of cannon, which can be enforced by My style encryption that associates a number of digits for every document content and cannon. Every document can be checked for being canon by emailing it to aaa-registered companies. The cannon-service is not restricted to aaa- documents that will have an aaa-registered canon of aaa.  

1. Establish The baseline for future editions. State the unchanging BUT EXTENSIBLE answers to

a.  Why believe in this document?

b. Why are the prescriptions safe?

c. Why are they effective?

d. Why not believe in FDA or FSSAI only?

e. Why not believe in alternates?

f. How to support this work?

g. How to participate in this research?

2. Recommendations on FDA?

I think FDA does proper

1. Safety checking

2. Effectiveness checking 

and does not address hard legal useful answers in

a. Compare supplements and claims

b. Compare alternatives in FDA-approved drugs and quantitative usefulness

c. reliable percent comparison of approved drug side-effects

d. cross-interference of drugs

e. etc.

Leaves them to the wisdom of doctors! The rest of the world can not use the difficulty of training doctors which allows leaving on wisdom. FSSAI should though not be an Indian FDA and compete, it should address FDA shortcomings and be complementary.

3. Recommendations on Drugs basics?

Recommendations by FDA are not applicable to Aging drugs. This is for 2 major and several less important reasons. Aging drugs don’t exist and choice is never between FDA-A and FDA-B Only absurd use in strange diseases can be made, even though an American doctor can then prescribe it for anything. I submit that the FDA mission will not suffer if it allows drugs to be submitted without disease, solely for safety testing, with no comment on effectiveness for anything.

This will allow GRAS-like claims by supplements, still different from GRAS presumed to be safe in allowed mixtures since safety does not imply mixture safety. I assume the GRAS status of all MY recommended drugs since all are present in foods, and the only additional risk is from extra concentration. What is more, unless explicitly found uniformly harmful; by a doctor, and concurrently accepted by other doctors’ silence else deemed controversial, and free of side-effects in other illnesses, although a conservative step in that state is stopping of aging drugs, if on others, unless allowed by the physician.

This also addresses another defect of FDA approval: unknown cross side-effects. All medicines imply some risk and I believe that the risk is not increased by side effects of intermittent supplementation, unless when otherwise sick or reliably opposed.

4. Recommendations on 2022?

All in fruits (GRAS), vegetables (GRAS), chemical names of things in a healthy body, drugs before 1990 (cancer-free).

a. metformin - read up TAME. Dr. Nir Barzelai

b. NAD+ booster, NMN, read up Dr. Sinclair

c. Resveratrol, NO booster, read up Dr. Sinclair (in liposome equals pterostilbene)

d. Fisetin, read up Dr. de Grey

e. Quercetin, read up Dr. de Grey

f. CaAKG, read up Dr. Kennedy

h. CoQ10, read up Mayo

5. Criticality of Liposome

The liposome drug delivery systems possess a significant role in drug formulation in order to improve therapeutics. The liposomal formulations have been targeted to enhance the therapeutic activity with reduced toxicity. The liposomes can be characterized with respect to physical, chemical, and biological parameters. Moreover, the liposomes can be prepared by mechanical method, replacement of organic solvent, a fusion of preformed vesicles; and by the transformation of size. In addition, liposomes possess various applications which include, treatment of respiratory and eye disorders; brain targeting; cancer therapy; antimicrobial therapy; and gene therapy. The present review discusses the mechanism, preparation, and applications possessed by liposomes.

Liposomes are absolutely needed, most recommendations are useless, even perhaps harmful from the chemical or allowed impurities. That is because stomach acid/liver fail raw dosages sharply lower from bioavailability. Only liposomes equal injected liposomes ( injected others are weaker since cell entry problems are still there). Don’t even bother with other forms. In medicine, a weak dose does not mean fewer benefits, it can hurt!