Chemistry of Aging

 

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Contrary to expectation, all life shares the SAME kind of DNA, and have similar, if applicable, modes of aging. There is no need, hence anti-religion, for this to be so. BUT it is so, and lot of research in genetics can be done on models that apply. In fact, non-applicability itself is useful information, subject of research as to why!

Aging is a genetic process, outside medicine, or later a specialty. I am a strong believer and professor! Most current doctors, including currently being trained, know nothing about the chemicals and procedures, except perform them on request, ignorant of why! They are as ignorant as most re stem cells.

I am not interested in learning the biology or chemistry outside its application in aging reversal. To carve out the niche, currently I admit only 3 kinds of method categories, soft methods, Plasma based methods, and medical methods based on Yamanaka factors. Third are most exciting but require FDA equivalent and medicine management. The entire third method is considered outside my current competence. Soft methods are based on parroting successful heroes like Dr. Sinclair. That is the ultimate reason for accept and denial. Plasma based methods are all blood plasma based. Blood is drawn, Preserves are removed, rest of plasma is modified, Preserves are restored and blood restored.

Modifications to Plasma is chemical engineering entrepreneurial, not medicine subject; insist I, including a required court visit. It is not a bureaucratic subject either, beyond open safety rules.

DNA, for later research reasons have 3 genes in human, AMPK, SIRTUIN, and mTOR progenitors. This is the ABC of aging! Genes do not matter, but enzymes do, named as genes. An enzyme protein is needed as catalyst that organic reactions happen in human time scales. It makes sense, without them in reactions, all kind of combination will occur at random and life will not exist. Too slow and then life will not exist as complicated molecules would not form and be useful. By doing the reaction with enzymes gives you the best of worlds, reactions at modifiable speeds, enzymes not routinely found. By genes, you allow them to be transmitted in generations, between generations, despite randomness. It is not complete, there are errors, lots of failed individuals. As long as there is some randomness, evolution happens, speed-ed up to managed speeds by sexual reproduction, randomness happening due to genetic diseases from genetically close unions. I will not have that problem!

I think complex arguments like evolution are justified only for hypothesis formation. Testing is absolutely needed, performed in open, but entrepreneurial nature, not science, drives the chemicals tested (like FDA on supplements). Whether a properly tested product is admitted or conditions imposed will not be considered.

SIRTUIN is nearly universal between all species (all life kingdoms), For humans, there are 8. Their activity includes histone deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. From in vitro studies, sirtuins are implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation[6] and stress resistance, as well as energy efficiency and alertness during low-calorie situations.[7] As of 2018, there was no clinical evidence that sirtuins affect human aging, but I suspect clinical trials of NMN are after this, as is Sirtuin role.

AMPK 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.

The mechanistic target of rapamycin (mTOR),[5] previously referred to as the mammalian target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.[6][7][8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.[9]

mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes.[10] In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.[10][11] As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors.[12] mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton

In terms of copying Dr. Sinclair

NMN affects mitochondria positively. He uses 1gm/day. By experience, Betaine add is absolutely needed(link for NR, applies to all B3 forms like NMN) to replace methyl that NMN uses up.

 Pterostilbene is better resveratrol (more bioavailable). He takes 1gm, equal to 250 mg (I say).  Its chemical relative, resveratrol, received FDA GRAS status in 2007,^[9] and approval of synthetic resveratrol as a safe compound by the European Food Safety Authority (EFSA) in 2016.^[10] Pterostilbene differs from resveratrol by exhibiting increased bioavailability (80% compared to 20% in resveratrol) due to the presence of two methoxy groups which cause it to exhibit increased lipophilic and oral absorption.

Have taken NMN sublingual. Some Positive effects. Now change in NMN and will take in IV. The dosage is likely wrong. Based on LIFESPAN.IO, do it weekly (dosage combined and reduced) rather than NAD+ daily. Need pharmaceutical NMN for that.

Remember my goal - age solution to age diseases (heart problems, essential tremors, diabetes and aging). All can be measured after procedure. Full blood count before and after the procedure. If it fails on me, or is partial, then even that is a research point and science puzzle.