Liposome-2

 

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Essential forward context.

This essay continues this. Don't be stupid to read this essay missing necessary precondition.

Follows from past that for commercial+health reasons, it is safe to limit to bioavailability, protection and ignore targeting reason, I will use liposomal form. These are built at home for cost, independence from commercial availability, and know you are within expiry; never mind you might fail to get the amount of medicine paid for. Targeting can be avoided for vitamins, glutathione, NMN, endolithials and senolytes.

 How does liposome work? It surrounds the drug nano particles with a phospholipid sack. Stomach acid or liver are protected from. It then enters blood. Blood circulates in body within a heart beat.It takes time for the sack to stick to cells. So the sacks end up all over. How do they enter into cells? Of the three things that make the cell membrane (unlike plants, all animals have no wall) are PHOSPHOLIPIDS! Just sticking enters the contents into the cell! The right kind of phospholipid will deliver to the right kind of cell. But we leave targeting for the doctor, all s/he has to tell you the right phospholipid. No doctor needs to oversee these liposomal drugs. Just saving from acid, liver and solubility will give you massive improvements at much lower doses. 

 

I have decided to use sublingual 500 mg NMN/day at the start of liposome experiments and expect 250 mg fast and 100 mg eventually. Rather than MIB-626, I intend to use L-arginine from (3 gm to 0.5 gm) and 50 mg Pterostilbene from 200 mg to 50 [all per day to liposomal goal].

MY BIAS!

I do not think I have any, but quantities are mentioned to allow others to determine their own, experiment with labeled suppliers and dosing schedules. Only if your citizenship allows bio-hacking should you even consider my numbers, only for self, they will change randomly with experimentation, without warning.

Known doses of Dr. Sinclair and FDA accepted numbers are viewed as safe doses. All my doses are for 5'7",70 kg, Indian race person coming from compromised Hygiene/Helminth civilization. Conceptually, I have roman arena gladiator rule of "if it has not killed me, it made me stronger" , "I don't stop tired, only when done" and the Stoic view of life as Aurelius said better than me "Consider the immense gulf before you, and after you, what is the difference between life of 1 day or many human generations. Only this - your life must be just, speech and promises kept to others. You will daily encounter sinners, how can you grudge them anything, for they are stupid and don't know what they miss". To this I add development of can't lie technology, that works in the open through zero knowledge proof, safe even from holders of quantum computers.

As opening referenced in start, I consider blood based rejuvenation as a start, like changing oil of a vehicle - useful but small part of life extension. You raise NAD+, cleanup SASP (not knowing the details of how caused, at this time a black box fix is doable) and fix blood delivery. Liposomal/NMN for NAD+. Liposomal/Fisetin by mayo protocol, every 4 months, Liposomal/Quercetin and strawberry for  senolysis, Liposomal/Pterostilbene and L-arginine for blood lining revive, K2+D3+calcium for bones, Heart drugs and brain-injury drugs. Complex expensive mix, can live carefully only, only in India for now, will rise again as phoenix after life extension and adequate income. Greatly expedited departure if the  massive villain Tikat succeeds. Setting up Aging clinic with MBBS doctor to run by my self-hack in return for my share.

Aging Fundamentals

My logic is simple – aging is the accumulation of senescent cells delivering inflammation chemicals in SASP. The bad things of SASP rise with age and continuously reduce, NAD+ with age. You must do 2 things at once – increase NAD+ and reduce SASP.

First retard every note like – which doctor? Aging and cancers are outside the competence of most current doctors, and specially those specializing in aging. Neither processes inside a cell nor genetics is even remembered by doctors, aging is harder than any cancer! Cell medicine does not mix with traditional medicine, it is not based on germs or viruses. Immune system functioning is central, as is immunotherapy. Messenger RNA drugs are basic. Liposome is not an afterthought, but central to cell medicine, and best made in the kitchen.

2021 shall go down in Human history as the year that Rejuvenation (not Aging) was explained in a form no separate chemistry or Biology is required to understand aging and the understanding is free of ethics and religious nonsense. Medicines work equally well on religious Leaders, politicians, rabid criminals and morons. Anything that has that property, henceforth abbreviated universal applicability, is considered to be science.

That underlies truth and abbreviated TRS for Triaged Rational Skepticism defines me, and scientific living occurs when all facts pass TRS filters. Triage insists on determinable truth in useful time, space, context and money appropriate for the context. Clearly, then God is a meaningless concept unless demonstrable by a TRS test. TRS requires that the test be carried out by concept pushers or their Rishi in a noncontroversial form (super majority) accepted by my Rishis. NOTE THE ABSENCE OF ANY DEMONSTRATION BY ME, God may well exist and control others, not me or my believers who consider such concepts, independent of TRS proof, as irrelevant as continuum hypothesis, await demonstration and pay of appearance costs.

TRS is positive determination of my truth and those I respect. A negative, more general method is to define science as collection of theories that have only falsifiable context appropriate theorems.

Super majority is needed of acceptable (my and others Rishis) jury to tide over undetected bias. Unlike humans, facts have no prevention of repeat trial. The essential problem being dealt with is the reality that not all facts, considered by me, are scientific facts (for which legal facts form the least reliable determination). Admitting possibly erroneous facts rapidly changes the logic to linear logic, which allows quantum logic as well.

The admission of immortality as a feasible fact causes many changes never considered by me. The notion of punishment appropriate for a crime changes drastically in a world that admits immortality. The notion of a logic immune to erroneous facts is needed, and the requirement by me is that the system must distinguish between facts whose negation changes little to those whose negation is drastic.

In classical logic, anything follows a single contradiction.

Scientific immortality, despite mathematical objections to it, is possible if one can posit that there is an upper geographical limit to natural disasters by converting human consciousness by brain download of discrete information and brain-circuit weights and recovering the information to silicon circuits like ml nets. This allows the information duplication, travel at light speed at which time elapse is zero and allows copies to be placed far enough away. All this will likely happen in 1000 years.

So the problem is in the first 1000 years. Different parts of our biological body require different interventions, as Dr Aubrey de Grey believed and solved in high level by him in 2001. He predicts 2036 at solving enough in all 7 fronts. He identified the 7 fronts and high level solved them, created SENS and is easily the saint. Dr. Sinclair discovered resveratrol by 2004. In the decade of 2010, he discovered NMN, MIB-626 by 2021. Dr. Grey funded Drs. Conboy parbiosis in 2005 and does that full time now and greatly supports medical tourism. In the decade of 2010, Drs. Conboy found the immediate lesson of hetrochronic parabiosis wrong and argued correct interpretation to be blood dilution. Dr. Yamanaka took the major step of deriving plenipotentiary cells from any cell in 2007. Dr. Horvath defined methylation and showed correlation by 2011 to calendar age at 0.98 significance level. In 2021, he extended the same table to all eutherians, virtually every land animal bigger than a mm. It proves to me that aging is a cellular epigenetic process. What is common to all such animals? They have a nucleus IE a sac around the DNA, one way for all mRNA. Signal proteins enter the Sac, cause the DNA genes to be copied to mRNA. mRNA exits forever the sac, matches the ribosomes in the cell body outside the sac, unites with them to build the protein that then exits the cell. The mRNA itself dies fast, slow, or exits the cell. Outside are innate immune cells which eat such mRNA. There are adaptable immune cells too, which can be trained, that is how all vaccines work. Some adaptable cells detect bad cells as any that have an mRNA part. In the process, the rest of the mRNA is bad too, and they get trained for killing things showing as rest. That is how mRNA vaccines work, the rest of bad cell is the spike protein for example. Any Covid-19 virus with spike is attacked, no matter what the pathogen evolves to, just hope that the new bastard has a spike too. I, Dr. Arya, have proposed that parts of SASP be attached to mRNA and deliver mRNA drugs to target aging and cancers by quasi-vaccines or mRNA chemotherapeutic drugs.

Throughout 2010 decade, continuing to this day, Yamanaka factors in low concentration, applied transiently, non-cancerous subsets, have worked. This gives doctors a central role in rejuvenation. Another direction are immunotherapy interventions using mRNA drugs and novel mRNA vaccines. Both these technologies complement blood dilution offered by Dr. Conboy. I recommend tracking California for tracking Yamanaka factors, Cancer research for immunotherapy, and Dr. Conboy for dilution, medical tourism for inexpensive solutions. ALL claims to follow above techniques are commercially fraudulent exaggeration and should only follow reliable visiting evaluations acceptable to the major medical figures Dr. deGrey, Dr. Sinclair, Drs. Conboy, Dr. Yamanaka, Dr. Horvath.

Which system is better – Allopathy or modern medicine, Ayurveda, Unani, homeopathy or something else as Chinese medicine. First, the questioner is a moron! Any question so is mad! The proper question is “name the ailment” - what is better. Second, name the dangers of other area treatments! Third, distinguish between treatment and cure. I have a clear-cut position about this. Only treatment is MM. Other systems can damage you by heavy metals. MM is perfect for germ-diseases. If you can bear it, save money by symptomatic OTC drugs. The MM is not able to cure. When it comes to persistent diseases like diabetes, heart, etc.; or cellular like aging and cancers; there is no cure in MM, people will get more or less the same in other methods. The odds are probably better in other systems. Homeopathy is always criminal! Hygiene hypothesis HH considers the cost of external protection to non-adult patient’s immune system. Although public health measures such as sanitation, potable water and garbage collection were instrumental in reducing our exposure to cholera, typhoid and so on, they also deprived people of their exposure to the "old friends" that occupy the same environmental habitats. The rise of autoimmune diseases and acute lymphoblastic leukemia in young people in the developed world was linked to the hygiene hypothesis. If nothing but total lack of infection from Covid-19 in all lower classes has greatly strengthened my belief in HH and helminthic treatment.

Fisitin Mayo protocol

 

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Fisetin is 2019 news. Yet it is caught up still in USA Law, almost as bad as in India. I have decided to go through it. Senolyte maintenance will be Quercetin and strawberries. It is a Flavonoid. All my major goals are done, I have a meaning of life in "Learn to live for Life itself" and I dare to be "happy" at last. Mayo (Same world-famous Mayo Clinic, Minnesota, USA) protocol is two twin/consecutive-dates doses' a month apart

Ref for below

By now, most people with an interest in health are familiar with antioxidants like resveratrol or quercetin. While these compounds have been widely studied, research into a lesser known antioxidant called fisetin is only just beginning in 2019 . Early studies suggest that fisetin is a powerful weapon against aging with a number of other medicinal effects including antioxidant, anti-cancer and anti-inflammatory benefits. If you would like to learn more about fisetin and what it can do for your health, please read on. [Arun: as bio-hacker, I will take it and share my experiences. It is safe from FDA-1 studies to my level of risks. I refuse to wait for FDA-3 after which most likely, it will be open to all]

Ref for below section 6

Follow the risk mitigation strategies outlined in Section 6

• At the current time, the only form and dose that has been tested in phase 1 clinical trials is the so-called "Mayo Protocol"

• The Mayo Protocol consists of taking 20 mg/kg body weight of oral fisetin on two consecutive days and repeating the same dose, one month later

[Arun It means 2 doses of 1400 mg now two days and repeat after a month. Mayo Protocol may be declared unsafe, but is likely safe. It is likely not optimized for efficacy, but that is the price of hurry. Healthy aging is job 1, provided safety is likely! I consider self smarter than any non(aging specialist) and have contempt for gerontologists and geriatricians, IE Dr deGrey effect! Every one not a scientist is aging stupid, politicians and Brahmin especially.

My logic is simple – aging is the accumulation of senescent cells delivering inflammation chemicals in SASP. The bad things of SASP rise and continuously reduce, NAD+ with age. You must do 2 things – increase NAD+ and reduce SASP. NMN+Pterostilbene raise NAD+, Quercetin+coriander clean up senescence. In current state-of-art, NMN => Liposomal(NMN) with separate NO booster, and add to quercetin with Fisetin. I love strawberry which are way better than next Food source (apple), love the idea of boosting medicine by regular eating strawberries!

First retard every note like – which doctor? Aging and cancers are outside the competence of most current doctors, and specially those specializing in aging. Neither processes inside a cell nor genetics is even remembered, aging is harder than any cancer! Cell medicine does not mix with traditional medicine, it is not based on germs or viruses. Immune system functioning is central, as is immunotherapy. Messenger RNA drugs are basic. Liposome is not an afterthought, but central to cell medicine. Liposomal drugs can be easily made at home, and no sense in wasting money to buy them. All they are are enclosure of nanoparticles of drugs by Phospholipids surround. They are useful to control bio-availability and targeting, among others. Every non-soluble vitamin, Glutathione etc. are better absorbed (better is twice to hundred-fold) and saved from stomach acid and liver! The layers are immune! Nano-retention is use of standard mixie and coffee-maker! The phospholipid are bought as a powder. ]

ref for below

Longevity Strategy

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• Created by Michael on 04/26/21

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The cornerstone of our overall approach to take advantage of the amazing opportunity handed to us is to create, apply and constantly improve the most effective "Health & Longevity Strategy" that we can implement at present.

Learn More ...

A Step-by-Step Approach

To split the subject of achieving long-lasting health into manageable parts we have divided our strategy into five pillars that are further broken down into individual building blocks. 

Most processes in our body are highly complex with many interconnections: e.g. our emotional reactions influence our hormones, that in turn affect numerous processes in the body; our toxic burden has an influence on our digestion that can directly affect our brain. 

Although this obviously holds true for the building blocks as well, we structure them in a way that they can be addressed one-by-one. It also allows us to research and improve them individually.

Pillars & Building Blocks

Primary Prevention

• Nutrition
• Physical Activity
• Detoxification
• Sleep
• Advanced Nutrition
• Basic Care
• Protecting the Body
• Preventing Diseases
• Self Testing

Mental Well-Being

• Basic Mental Well-Being
  
  

Health Monitoring

• Blood Panel
• Basic Early Detection
  
  

Integrative Medicine

• Functional Testing
• Heavy Metal Detox

Rejuvenation Therapies

• Risk & Benefit Analysis
  
  

Tools & Resources

• Compound Library
• In-Depth Practical Guides
• Additional Resources

 

Knowledge Pool

The strategy draws knowledge from a wide variety of sources

• Medical Research
• Rejuvenation Research
  
  
• Functional & Integrative Medicine
• Traditional Chinese Medicine
• Ayurveda
• Integrative Dentistry
  
  
• Manual Therapy
  
  
• Preventative Health Assessments
• Precision Medicine

• Nutritional Science
  
  
• Evolutionary / Ancestral Health
• Movement Science
  
• Environmental Medicine
  
  
• Quantified Self
  
  
• Supplementation

• Self Development
  
  
• Meditation & Mindfulness
• Yoga
  
  
• Trauma Release
  
• Dance, Art & Music Therapy
  
  
• Philosophy & Spirituality
• Psychology

 

Liposome

 

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My essay on cell medicine as distinct from Allopathy and more dealing with senescent cells for cancers and aging gave me a tremendous boost to understand liposome. It is worth knowing and doing to increment massively the powers of vitamins and age improving NAD+ supplements. I am sure you know nothing about it. It is a manifold of many many hollow phospholipids, each appropriate for coating some medicine in a phospholipid layer and the coat is used for many things including targeting, protection (stomach acid and liver), improving (by a lot) the bio availability, reduced toxicity and increased permeability across membranes etc. The material can be bought separately, or in some cases made at home. I now do have a calling beyond cell medicine, really included in it, to encourage buy only liposomal medicine or do the procedure at home with simple mixie type machines and espresso coffee maker. Liposome is somewhat new,  1964. It has taken 57 years to today's applications, major recent success in the USA of kitchen making. The only block in Universal application is ignorance.

Intuitively, the idea is to milkify powders. Milk is like an impossible solution of oil and water in the cheese liposome. This mixing gives tremendous power to cream (to fatten). It is really sandwiching insolvent into solvent by constructing a phospholipid layers by two surfaces - a hydrophilic and a hydrophobic bilayer and inserting nanoparticles of insoluble, the whole is then soluble. Within the human body, the medicine is protected from stomach acid and liver but easily bared in right internal tissue which digests the layers. It is a good way to eat insoluble vitamins, glutathiones, aging chemicals like NMN or NR etc. It looks like nanoparticle technology is needed, but that can be achieved easily.

Phospholipids, also known as phosphatides, are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group, and two hydrophobic "tails" derived from fatty acids, joined by a glycerol molecule. Marine phospholipids typically have choline, ethanolamine or serine. Phospholipids are a key component of all cell membranes. The phospholipids are amphiphilic. The hydrophilic end usually contains a negatively charged phosphate group, and the hydrophobic end usually consists of two "tails" that are long fatty acid residues.

Milk exists despite what it is – a suspension of oil (ghee) in water, not normally possible but possible due to cheese part of milk, which acts like a liposome. Now think of suspension of a non-bio available molecule like a vitamin which does not mix well with water as K2 or NMN. Even bigger, like Glutathione. While not bio available in powder form, it will be easily up to 100 times more available in liposome form! Such a material is difficult to survive extended periods in a shop, but the liposome former can be sold separate and special mixie like churning can create an acceptable liposomal variant at home. People don’t, but can in a method I will launch to make liposomal vitamins and drugs at home. Why pay 30-100% increase in cost for a product with suspect goodness. IN A LIPOSOMAL NMN IN AMAZON USA PAGE. MANY CUSTOMERS WERE WORRIED THAT SOME TIMES WHAT THEY BOUGHT WAS CLOUDY, SOME PRODUCTS WERE CLEAR AND SOME CHANGED IN DIFFERENT SAMPLES OF SAME BOTTLE. Helps to understand Liposome semantically! Best form Liposomal form at home to prevent precipitation over time.

What is needed? A utensil and commercially sold liposome precursors like LipoSorb. The utensil is a vacuum driven mixie like. The idea is to use regular mixie for 5 minutes and the advanced for about the same time. Consume liposomal form in a day to, often within a weak. You can get more homie by making own liposomal media from milk!

WHAT IS YOUR INTEREST?

1. Never have I seen a technology, new and experimented in the USA, but missing  and required even more in India. There is a small hassle-factor in kitchen liposome, but the situation is like tailoring, one can buy ready-made, but the art of stitching is taught to all women and unlike the USA, THE ENTIRE GARMENT IS NOT DISCARDED after minor functional defects. Of course, one further this thread in thought and imagine all kinds of self diagnosis appliances and vehicles with a diagnostic port into which the diagnoster is inserted and that determines what to replace to get a target functionality. End of caste of mechanics in shops and workshops! In fact, one can allow internet add-on, which connects to remote mechanics for remote diagnosis, a perfect port for your car.

2. Liposome is excellent for bioavailability and protection from two enemies of all drugs - stomach acid and liver. In most cases, what matters is concentration in circulating blood. One way to get that is intravenous or correctly injected drugs. Other way is under the tongue - sub-lingual method. Third is nasal drops. Even better is Liposomal, the material faces stomach and liver in liposome shield of phospholipids that transparently dissolve in blood circulation. THE METHOD WORKS FOR ALL KIDS OF THINGS AND REQUIRES NANOPARTICLES to be surrounded by phospholipid. It is virtually impossible to do it but for high temperature draw of phospholipids drug powder doable at home with espresso coffee maker! Of course, one can freeze-dry the solution for ready-made liposomal powders! The cavity in liposome must allow one molecule of drug, and different drugs have different ideal liposome. However, somewhat bigger cavities are ok,  perfect mix-match research for, perhaps cranky dreamer, retired like me.

3. Even if I fail generally, singular successes in SUPPLEMENTS AND OTC are usable. I can safely use self body as tester, for the worst case is no different from direct ingestion! Ideal time to test psyllium is constipation and cough powders is when  coughing! Why just take drugs when science and bank balance can benefit?

 (To be continued)

Decentralized democracy for all in all

 

https://image.shutterstock.com/image-illustration/tron-coin-trx-blockchain-cryptocurrency-600w-1028721331.jpg

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Given that lot of what follows attack political comment, true for some, false for others, something else for some, I invent the notation <x> for every x, whose truth value is uncertain for political reasons. Given the universal nature of the essay, it will never complete. Decentralization is considered superior, but sometimes inefficient and then an adoptable centralisation, with unease and checks and balances, and programmed to self-destruct at some democratic point. Both visions of George Orwell were not about left and right, but left/right denunciations of centralisation. Best  think of this a series of independent adoptable ideas.

The best democratic system of all is in the USA. That is not the opinion in less developed world, Vietnam, Chili etc. It will be wrong to even try to transplant the system. Yet the largest democracy in the world is India and likely to dethrone even USA in cumulative economy size, output by 2050, per capita by 2100. That is because there are systemic problems, shared everywhere, but unsolved in US. India is on rolling path under Modi,  the BJP has a depth of competent leader,  opposition indulges in <stupider than thou>. All the deficit of the USA are also unsolved and unaddressed here, too.

Top deficit is the uneducated public, wrongly considered to be adequately educated to take serious decisions. Anyone can raise this point, and any effort to make people more in line with that anyone, immediately lose freedom. Today's India and USA have some freedom, which is the envy of other models. Still I write of freer citizenry in these too, free to commit suicide, what is the ideologue's problem! People make better decisions in groups, the essential justification for democracy. Problems of the commons justifies individual wealth despite the old philosopher cry of "all wealth is by stealing". How can a believer in freedom, democracy and private property talk of a better system? Not just for less developed, but developed as well?

One idea is "educated benefits for uneducated". For every decision identified as important by the government of the day, citizens are required to find one in the educated class recognized by political parliament by consensus votes that eliminates dictatorship of the majority, restores freedom. The citizen is inconvenienced to find a concurrent thinker, but finding one is nearly always possible. The effort in finding one, and of ensuring his solution is similar, will force all voters to discuss issues. Have someone to blame. The educated are periodically relicensed and controlled by votes, also examination both. The exam may be biased, but that will only force the licensed to answer biased and later advise in freedom.

Democracy is restricted by USA type checks and balances, hence do not need further ink.

A very novel idea is "consensus voting". Every significance beating elected can vote the cast vote percentage. This is done in some cases to prevent dictatorship of the majority. I believe in careful drafting of idea, expressed in call for investigation, use of police powers etc. Every winner can invoke police protection, legal investigation etc. The votes once used can never be reused. The reuse of votes, if successful, is forbidden because a political definition of successful is dangerous, although a legally decided determination of success may work. Best forbid it, complainers now have to find sympathetic elected. Many political abuses will happen, <wasting powers> But the bias in defeat of majority dictatorship, can not go beyond launching <useless> investigations. Many political issues can be silenced by consensus note. Every <moron politicin> in India, can ask for <sit> for every matter, solution is consensus vote sit formation. The limits apply to majority also, use up limited supply in investigation of opponents! Every <idiot> politician can waste useful powers for <useless> investigation. Consensus voting can act as a powerful "checks and balances" in all democratic ideas. Autonomy of police must happen like law and election commission.

A basic health difference is in treatment versus cure. Every cure is a treatment that eliminates the root cause such that there is no relapse. Allopathy has no cures for persistent or cellular diseases (cancer or aging), but is very good at treatment. From the viewpoint of public health, a government must provide treatment for all situations, irrespective of remit-relapse situation. It leads to ethically difficult triage situations. Every development level must have instituted triage committees which control health expenses and can be invoked on any patient by any citizen in "anonymous yet consensus voting limited" manner. That is a fundamental improvement in all investigations.

A basic difference is in untriaged hurry (time or cost) and importance/usefulness. By construction, human are intrinsic incapable of differentiating between two, leading to<exploitation|intelligent use> in selling, auction, product placement in stores, online blurbs, advertisement etc. To make money, you can raise the price, or sell more. Price depends on competition and quality-perception. Amount sold depends on need-perception, availability etc. Amount sold depends on price, service, advertisement etc. I thought I had become a smarter buyer in the USA. Not really, USA companies deal with Amount sold method of more money. Indian stores depend on rates, never mind amount, and suffer from no repeat sales, possible in decentralized markets. Advertisement is harder and Balkanized. All USA companies are considered evil. Politics is, like selling, a matter of perception. Perception is by greasing the journalist. Most are smart enough to avoid instant gratification, but honest enough to remember the feeder in the long run. Here is suggested great friendly Press - Feed good stories to chosen journalist by policy leaks and tight-lipped government. To avoid this, all leaks must be investigated, benefits in market of relevant information required, transparent secret communication needed. That can only be done by my encryption that can allow nation-specific open encryption (jointly op enable solely by sender nation only on enforced need for warrant for some time only). Complaints are stronger centralized.

Requirement for all systems - money

Every moron can describe an ideal system. Continuous funding is needed, and I describe every finance less system as dream idealistic system not-worthy/beyond my interest. Tolerable democratic systems are product manufacture and advertisement/selling, dedicated taxes, insurance or charity.All other income can be pooled and allocated by legislative groups. The new idea is dedicated taxes, deliberately away from politician allocation. Nothing short of nationwide referendum tied to elections can instantiate or retire them, and must identify the fraction of taxed activity or income. The reason is to remove the income from politicians without triage with other taxed activities.

Basic to democracy is a period as tax on all mass-media. It is some multiple/fraction of income bearing periods. I predict united squeal from all media when it becomes a serious proposal. It is like a tax, although demonetized. This time is allocated to all significant ideologies represented in Parliament above significance level, numerical population basis. I suspect tremendous cleanup of democracy. It is advisable to limit the time only to expenditure limiting parties, completely elimination for unlimited expense characters. Evolution can be used to determine exact rules.

The goal in above is to encourage politicians to believe without corruptions of money and time-saving in collection. Despite any court judgments, they can be effectuated by expanding free minutes of deficient candidates against well-funded.  The financial interests force non-balkanized politics (non-party candidates get nothing). A party is better off doing concentrated local, not diffuse wide-spread performance.

I believe in nationalized, but decentralized food and and eating powders. I have the practical experience of inevitable natural corruption in edibles by corrupt inspectors, under religious figures in belief that corruption will be lower despite stiff competition between figures! The domains are drawn up with overlap.

Impossibility of inspector management should be accepted. The corruption rates with be lower in services manned by time-bound foreigners with post-service interval, somewhat like IAS in non-resident state. Neither belief in goodness (perception matters more than reality) nor foreigner honesty is the cause. Difficulty of relations is the cause for lower corruption. All inspectors are not same. Qualitative judgment inspections can only be done with multiple overlapping qualitative situations, the totality smaller, factoring out foreigner inspected and quantitative inspections.

What I take and recommend

The latest link

Abstract: A menu of things I take for indefinite life. Missing are three vital information, company, marketeer and dosage schedule. Until this information is given, the reader is at the mercy of marker, and manipulation by sub human marketeers, advertisers, companies and dangers of too little or too much dose, too frequent or too small dosing. It does provide a basis for further study by intelligent googling. So don't use it construct own menu, only on doctor advice.

Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer.

This is an essential reference to the totality of the program. Sole purpose is to learn on chemicals involved and totality. I expect 20 years Horvath age gain, post 2030, by which time, some clinics will offer Drs. Conboy and my procedures commercially and likely hold FDA or FSSAI license.

While there is ample evidence to indicate the health benefits of diets rich in fruits, vegetables, legumes, whole grains and nuts, no specific food has been acknowledged by scientists and government regulatory authorities as providing a health benefit. This applies to all phytochemicals considered useful.

Another severe problem with almost all plants or fruits is a fundamental problem in English of being able to fool people by trace amount as containers of desired chemical, which invariably requires tons of foodstuff to be medically useful, consider this abuse sub human and warn my readers as reading all ad very carefully to ensure enough dose beyond low price.

Every one, suggests 1gm of metformin in divided doses every day, important even if not diabetic. Expect 5-8 years just from this. I am one and also take acarbose with age extension properties.

From Dr. de Grey, I recommend quercetin for senolysis and dhaniya (CORIANDER) for apigenin.

From Dr. Sinclair, mib-626 or NMN, pterostilbene and TMG.

From Drs. Conboy, dilution aging dialysis when done. To eliminate CD38 and TGF-beta1.

From Dr. Arun Arya. mRNA drugs and vaccines when done.

There is a reason for selecting the model pic as cover - since overall food for graceful aging must reduce calories. Best 3 interventions in order of importance are fruits+vegetable, exercise and fasting (calorie restriction better).

Patient directed distributed control

This is the case in civilized world today, but shamefully used by most patients. Can I postulate  a better system and defend it? Yes, solution is here intermixed with defense. Who are the sub human enemies? Sick-unprofessional advertisers, makers and dependent media. Despite current immunity, I advocate later-age prosecution like Nazi and women-rights-enemies of the past along with post-disclosure cigarette companies. The system I advocate, open to improvements, is patient-centric in that some advisor professional must concur with the patient and only that destination is allowed. Controlled by checks and balance democracy. The first point is stupidity of asking or replying to the question of comparison  of any two systems of medicine. The key point to incomparibility agnosticism is comparisons based on evidence and experience for specific ailments. The purpose of requirement of concurrence to a such advocate professional is to force the patient to search for matching opinion in the class of better qualified persons, without constraining the citizen. Advocate professionals are controlled by periodic exams and delicensing.

Now my own choices based on what I know. Open to improvements in stating or choices. Ayurveda or better Allopathized Ayurveda for ignorable minor ailments and exercise. Strict allopathy for all event based medicine. Strict cellular medicine for cell directed ailments, definitely aging. Agreeing with Allopathy distinction, treatment by Allopathy, cure by any method is as good. A system in which tired old sick looking can submit and receive FDA clearance for Aging supplements is not acceptable. Evidence-based only if some agency finds definite group parameters improved.

Baba Ramdev is an advertiser doctor who is controversial stating the advocacy of Ayurveda over Allopathy, correctly criticized by Allopathy professionals. He is however practitioner of Allopathicised Ayurveda in that he uses evidence-based methods, but was shamefully caught in the coronil anti-covid-19 for using a self-beneficial notion of evidence in which all corona-patients ever and aged-over 65 were excluded and could not convince the government of efficacy. Some later version did pass. Should he be believed? For some things, yes. Just as good for cure of persistent diseases. No, for treatments and cell medicine ailments. Use cell medicine when it starts, Allopathy only till then. In many cases, supplements and OTC can be used. Use aggressive Allopathy for cancers.

Clearly, the benefit of and educated proxy, funded by he government, is not to be restricted to medicine. It is an essential part of my "education benefits without education" theory. My belief is a properly educated required proxy for all important decisions. Defined by percent of estimated income, offers vastly improved citizen actions with no problems other than some costs, payable by all developed countries and universally for less developed with my ideas on democracy.

Clarifications + my definitions

 

Controlled by checks and balance democracy:

The list of such professionals, licensed by the government on the basis of some recognized body, which can be removed too, on cause with the concurrence of court system. Laws by transparent checks and balances with forced agreement with supreme court.

Senescence cell doctors

 

Abstract: I believe that Senescence cell doctors are basically distinct from other doctors because they do not need to become jack of all trades and because their fundamental treatment is only related to problems within cells, fundamentally different from physicians who need to understand body function in all random organs effected by differently random diseases, often more than one. Limiting the specialty to cells and strong ties to genetics community and molecular biologists enables Senescence doctors to deal with all eukaryotes. The subject of aging applies to dog, cats, mice etc. as well. The nucleus sack is the basic unification that allows the development and treatment with mRNA drugs and vaccinations to attack cancers of all kinds and aging of all eukaryotes. We must allow all the great scientists mentioned, Dr. de Grey, Dr Sinclair,Drs. Conby and Dr. Horvath as fundamental scientist with MD like opinion value and ability to practice cell medicine’ applied to cancers and aging even though in most cases, they do not have MD credentials. The invited will themselves act responsibly.

Advanced cancers are often considered untreatable anymore, and the focus shifts to control of pain in hospice setting and permission to use any weird technology by the care-givers routinely exploited by moron criminals. This might be acceptable behavior in MD community, but will not be of any senescence cell doctors. That is because both cancers and aging have a cellular basis, and the effort to control ailment in the patient must extend to the very last, even trying theoretically good novel chemicals. Death is no longer a necessary natural event but an admitted shame on the doctors on the state of recuperative art of the time. The ailment must be cellular and that distinction has to be continually refined.

Both aging and cancers are ailments of the cell. Cancers can be researched as one, based on genetic mutation of the effected cells. There is a generalization, which converts remit, post the drugs causing remit fail. THIS MAY BE FOR THE VIRUS TO MUTATE OR TOLERANCE DEVELOPMENT. Only true cancers here.

There is no discovered unification of aging. Certain defects in cells are called hallmarks, with Balkanized work on each. Cell medicine depends on molecular biology and genetics. The unification is mRNA drugs and vaccines, with training the immune system central. There is a hallmark, cell diseases, treatable by mRNA drugs or cousins and vaccines fixing patient immunity. Alternatively, treatment and cure by strengthening immune therapy. The treatment and cure is not by external magic drugs, but by inherent immunity training. Immunotherapy is removed from Allopathy. Some professional organization admits cell medicine professionals, by examination, unless invited.

The persistent diseases of diabetes, heart, osteo-whatsoever etc. are divided into treatment and cure. For cure, all legal systems. For treatment, only Allopathy.

Vaccination against Cancers and for undoing Aging

The Latest link

A completely different disruptive new paradigm path is proposed here to use the machinery (IE mechanism) for mRNA for this purpose. I call it a hypothesis for fails my notion of science theory. But there are arguments to believe it represents likely path to undoing aging. First reference (Follows this) is to learn trivial underlying biology.

Increment to NAD+ is crucial to undoing aging. One basic goal of undoing aging is to increment NAD+ levels to what are in adults. NAD+ declines continuously with age.Synthesis of nicotinamide adenine dinucleotide (NAD⁺) decreases during aging, which is thought to limit the activity of enzymes that require it for their catalytic activity. Studies in animals indicate that replenishment of cellular NAD⁺ can have beneficial effects on aging and age-related diseases, but the situation in humans is less clear. Yoshino et al. report the effects of supplementation with the NAD⁺ precursor nicotinamide mononucleotide in overweight or obese postmenopausal women with prediabetes (see the Perspective by Hepler and Bass). The treatment improved insulin sensitivity in muscle, although a change in NAD⁺ content was not detected. The treatment also increased the expression of platelet-derived growth factor b. The results support potential therapeutic action of NAD⁺ supplementation in humans, but how various NAD+ precursors are processed in specific tissues remains to be fully explored.(science

NAD+ is a basic material used in Krebs cycle. It decrements because senescent cells, hallmarks of aging, are inflamed by NAD+ and generate CD38 poison to reduce NAD+. Every trick to boost NAD+ will fail because eventually CD38, whose concentration increases with age, will overwhelm the trick. Clearly, CD38 levels must be reduced periodically.

One direction being pursued by Group led by Drs. Conboy at UCB is to use Blood dilution and chemical metering to reduce any evil proteins by dialysis type machine. This method will expand graciously with research expanding the evil list to include TGF-beta etc.

The current state of the art is here.

I state a new disruptive paradigm here - use mRNA vaccination idea to remove nonliving proteins much smaller than viruses. The idea here is to train the immune system to recognize the evil proteins and eliminate them in the usual way. For this purpose, we use two properties of biological evolution of DNA and cells of DNA repair and sanctity of DNA by nucleus membrane. This method applies to cancers even when not caused by virus type of things, The paradigm where vaccines work without viruses is novel to all western modern medicine, away from germ theory of causation so strongly tied to it, instead of older systems missing the theory of germs. The idea of vaccinating for cancers and undoing aging seems opposed to modern medicine, since no new germs are postulated.

First, that every evil is legislated against by preventing any direct contact with DNA molecule inside the nucleus sack in eukaryote. All other methods will be destroyed by future evolution interlopers. It is like Dr. Sinclair idea of only surviving DNA to achieve exclusion of repair and replication by making them the opposite sides of logic of epi-gene, shut or not! The signal molecules cause the copy of some part of DNA into mRNA. It is this molecule that exits the eukaryote nucleus sac and can never go back. This mRNA unites with ribosomes of the cell external to the sack, constructs the encoded protein that then exits the cell. The mRNA self-destruct for important proteins to in few hours. They can never reenter the sack, like the perfect surviving solution of Sinclair! Most subsequent evolutionary products can not penetrate and hijack the DNA! 

Somehow, horizontal gene transfer happens, although I state and believe in the theory of lost intermediate eukaryote species sexually compatible with both now incompatible species. This alternate explanation is possible given the low frequency of apparent horizontal transfer, despite the similarities of neighboring sequences in sexually incompatible species. Alternatively, there is still viral transmission theory with symbiotic role.

Second, if mRNA exit the cell, immune system kills them by eating.  But it has to kill only a few that survive self-destruction. The mRNA are copied segments that have a different sugar, becoming Uracil on transcription!

Now comes an irrelevant point as to the recognition by immune system of improper cells - it may be because of memory of all the mRNA. Or any molecule with U is bad. The difference is on the attachment freedom to the evil protein. Whichever, the point is that any molecule that resembles mRNA in part is bad. The immune system killers destroy mRNA analogs and are also trained to consider the rest of the molecule bad too.

This makes the functioning of mRNA vaccines easy to follow. Consider one hypothetical vaccine for Covid-19. The virus feature selected is the spike protein.  A molecule is constructed that joins one mRNA with the protein that

a) is easy to manufacture

b) looks non-toxic

Set of these molecules are tested on mice, human cells or both. The set is reduced usefulness and improved non-toxicity and triaged to a list of candidate for first small human trials. It takes weeks to prepare the candidates, but year to test to convincing levels of safety and efficacy.

My idea is to treat the bad proteins like CD38 to be an expanding list of chemicals of evil for which mRNA vaccines are built and treat cancers as mRNA vaccine for 1 patient! This is possible since building the molecule is measured in weeks and the real time will go in identifying the evil proteins, which will become easier with data per patient helped by recent use principality.

Specifically, knowing the molecule considered evil is smaller than a virus and is assumed small enough to not look for expressed features, which may be shared with useful proteins not to be targeted, An mRNA/evil mix is considered for safety. It will be used for cure, hoping that theoretical predictions are sufficient. Data for several trials is saved on per-patient basis and hopefully will be reusable soon. The data can be exchanged with similar programs.

Immunity period depends on per-protein basis and per-patient basis. It may vary from once a century basis to once-year basis. In any case, some patients will have a very long immune memory. Aged have another severe problem with vaccines - their immunity system is too weak (numerically)  to eat the foreign objects. Hand-in-hand with vaccine solution must be an  immune multiplier. Till that time, the vaccination solutions are for younger cancers and infections.

To summarize, treating by vaccine approach is possible since I fail to see the difference between surface expressed proteins to full proteins in most cases. Sites visited by immune cells exceed that are blood connected. BBB barriers don't exist.

Aging bounty of Covid-19

        Only comparable picture is physicists in 1927. Center is the saint Aubrey de Grey, SENS.

 The latest link

But the scientific community doesn't know what to make of him. In July 2005, the MIT Technology Review challenged scientists to disprove de Grey's claims, offering a $20,000 prize (half the prize money was put up by de Grey's Methuselah Foundation) to any molecular biologist who could demonstrate that "SENS is so wrong that it is unworthy of learned debate." The challenge remains open; the judging panel includes TEDsters Craig Venter and Nathan Myhrvold. It seems that "SENS exists in a middle ground of yet-to-be-tested ideas that some people may find intriguing but which others are free to doubt," MIT's judges wrote. And while they "don't compel the assent of many knowledgeable scientists," they're also "not demonstrably wrong."

Without sounding mean, my life has been unspoken incessant tragedies that made me stronger by the opportunity given because they never killed me. One of the bounties of Covid-19 is mRNA technology polishing, Even a successful company is called Moderna, using RNA as a suffix. RNA is not new, likely older to even first failing DNA a billion years ago. But its use to build new proteins is new, doing it industrially and eliminating kinks, is new. It is a perfect development for Aging.

What aging is, and how does SENS fit within Gerontology and Geriatrics as an engineering approach within great sciences is my ideology of 20 years and counting.

Why is COVID-19 so deadly to the elderly?

What m,RNA is, should be crystal clear after this. The current article is about some of the myriad applications, in the near future, in Aging. That is why you must intern it to be able to judge the technology behind claims of novelty and usefulness of products.

 

Let us abbreviate greatly for new biology novices, even this simplicity was novel to me recently.  Every Eutheria body is collection of trillions of cells, all derived from a single pluripotent cell in the womb and assisted-developed to adult-hood from a single pluripotent cell, about half from both parents from DNA which duplicated by unraveling the double helix. In computer science, every action by a program is a derivation from the start symbol, here is the fertilized zygote and repeatedly derived according to the grammar rules, till all nonterminals become terminals,  the final program. In biology, complete derivation never ends and non-terminals remain as stem cells even at huge long life end. These are reactivated in wounds, just sleep after adulthood. All is done by blood carried signal molecules. It also carries some instructions from specialized organs for hormones. Growth happens by hormones and is stopped so. Hugely extended brain cells called neurons become nerves for analog signals.

For aging, important to consider single cells since the same structure, regardless of organs except brain is found in and aging happens at the cell level, a very recent find. Even if one keeps the structure perfect, aging will happen as cells age. Aging is normal at cell level, and cells avoid death by repeatedly becoming daughter cells. However, telomere at the end of DNA shorten on every division and there is a limit called Hay flick limit on number of divisions, this is about 50.  Classic doctors subscribe to this and believe that undoing aging is a matter of telomeres, expressed by gene within the cell. The first shocker is cancer cells which become infinite lived solely by learning how to use the gene in DNA to infinite divisions. One must be super-careful to avoid cancer in all telomere manipulations. The second shocker is the presence of animals whose telomeres never shorten, but they die all the same! So this possible but unreal story is wrong. Current scientifically established theory is genetic by Dr. Sinclair. It focuses on DNA repair in the nucleolus. By forcing exclusion of repair and duplication rules by error-free perfect means by repair and duplication states logical inverses, One is trivially shut when the other is active. In fact, super centenarians all have robust DNA repairs. Sinclair won the mechanism race by two  repeatable empirical tests, one aged one of a twin pair of twin mice and second by crushing the optical nerve of a mouse and restoring it by topical chemical use (NAD+).

Regardless of chemical needed, a protein is generated either by the DNA lording all, by mRNA which emerge, are grabbed by the right ribosome and protein is built and exits the cell. The messenger RNA (mRNA) is almost a copy of small part of DNA except that it is single strand and contains a U instead of a T – uracil instead of thymine. A signal molecule from outside enters the nucleus, excites the DNA, compelled to emit an mRNA which exits the nucleus. While never encountered in text, all mRNAs are known bad in Blood, immune knows all kinds are bad, (says my evolution part. Hard for nature to preset killers for just all mRNA More likely all Uracil having molecules are bad, needed natural immune complexity there! Whatever rest of the molecule is bad too and that is how the killers learn.) A lot of evolution is simple natural means to solve hard human problems! Just exclusionary DNA repair means all life on earth. Only one kind on earth DNA means likely compatible life in Universe! Many forms that failed evolution lottery on earth will exist in other planets.

The mitochondria generate and release energy in ATP-ADP cycle and have their own 13 unit DNA. Very recently by clever means, mitochondria were fixed by harvests (70%), new DNA for mitochondria, inserted, and replaced, all in living mouse! Holy crap! This technique can be extended to extraction and replacement of ribosomes and in live humans! Another giant step to defeat of aging.

The process that converts signal molecule to DNA to mRNA to protein is the foundation for how the cell functions. The mitochondria probably be segregated to other cells, or is their presence needed by evolution? Reduced NAD+ inflammation with senescent cells might be a reason.

How do mRNA vaccines work

We outlined enough to understand the sequence of steps. From above, I ask as my Socrates brain, after mRNA emerges from the nucleus.

Can it go back, say, for disposal?

Evolution imposes the rule - No going back! Grossly unsafe, all virus kinds will love it. No mRNA allowed returning!

So how disposed?

Self-destruction, minutes for high proteins, hours at most!

What if it emerges from the cell?

The change in at least one sugar is enough to allow target all RNA by immune system.  Additional benefit in Eutheria.

How does mRNA vaccine work?

An mRNA is found to unite with spike protein in Covid-19 case, the compound can't be toxic. Vaccine allow it in blood. If any viruses present, some mRNA sticks. By immunology, all RNA in blood are bad. So they get eaten. Of the rest, some remains in blood and some enter cells. They die inside by self-destruction. Fraction outside are eaten by killers, training them. Later when virus comes, spike-protein launches love to death killers. How train? Remember that mRNA had the spike protein not wanted by vaccine maker. Being partly mRNA, it was bad. Because part of the spike protein was attached, immune cells believe not only mRNA is bad, so is the attached spike protein!

Lesson learned

To kill a virus, one looks for an expressed protein on the surface for which a good mRNA can be found. Next, one uses mice and/or human cell cultures to make candidates by keeping only those which appear safe. Next theory is applied to reject candidates based on harm before. The remainder molecule are triaged to first small human tests. COMES fda-2, ELIDED BY SPUTNIK TO fda-3 AT ONCE. WORKS OFTEN BUT LOWER SAFETY. After all, safe in some humans for some time. Sinopharm, likely example of fail if fda-2 and fda-3 were there. In effect, Seychelles, UAE and many other China vaccine users did the FDA-3 and flunked the vaccine!

Arun Arya generic transform

Nice example of deep understanding of some subject is candidate ideas in Aging of new products and understanding of others. Let us apply the ArunArya transform that will be used to create new kind of programming. For aging, let us keep the protein and mRNA variable. Then the procedure is find the protein, select mRNA for it, train the killer cells and kill them.

Application in Aging

I believe it will be major and many targets. First I pose it and later consider Angel investors. To apply to aging, let us identify the villain. For now, we limit to CD38 and TGF-beta. One way to eliminate them is by filtering blood by concentration meters. A completely different novel technique is to find good mRNA that will attach to the bastards.  Imagine the beauty of the slaughter by natural immune killers trained to kill the bastards, trained by RNA attachments to the bastards. Till a vaccine is developed and tested, drugs can be used for periodic reduction in strength. In other words, new classes by vaccine or drug of senolytics. It will be great to get vaccines for expanding class of bastards - how to expand your life by vaccines and periodic revaccination (100 years?) for some, for healthy age increment purpose. For some, once is good enough, as the immune cells for them retain memory forever. Even that might need slower reactivation. If USA style fish eat fish applies to companies, then maybe we will embark on posthumen form of life even before 1000 years.

Letter seeking help

 

As recounted by Lady Conboy, before 2005, prior to their earth-shattering work, they could not move forward in parbiosis work till fix required funds for research. Beyond the other donnés, stepped up Dr de Grey and solved funding and expertise (suggested and convinced two capable technician fellows to work). Rest is history. It reminded me of Bhama shah. I don’t need one for money. But I do need capable technicians. And someone in our group to sound on by email. Best would be a new doctor uncle. Oh, I miss him.

I did write up my work to a form good enough for me.

It can be edited and extended, in fact should be. IT will be used to ignite shared help calls. The HARDEST part of being a grownup male is to admit you need help, and having doctor uncle meant I did not need help. I do now. Solving funds problem, and tech problem is a good start, that all. Maybe some better ideas. My goal is a company and my need is, a perhaps not meet (email and phone only), partners. No funds needed, best being PPP model with Yogi, or like, delay and use my NMN experience, go for clinical test over 5 people (Too expensive in the USA, NMN still lags NR), … Whose shoulders do I cry on and answer my doubts! Time to build email only groups like class-of-75 with legal statement consequences, ... My proning experience was bad and deflationary. But did fetch help from Hemant & Baldev, gratefully acknowledged,

Tech fi on life after the first thousand from now

 

Latest link

Tech-fi and consistent sci-fi are my invention neologisms. The title "Tech-fi on life after the first thousand from now" indicates that the technology applications will take unspecified time to become profitable, but no new science is postulated. Consistent sci-fi is that the series explores derived possibilities of the raw science imagined, as well as strong believers constitute consistent explored civilizations.  Star Wars and Star Trek are both consistent sci-fi. If current science postulates sufficiently widely a contrary principle, then that branch of sci-fi becomes dead. Jules Verne classics and "back to future" are bad sci-fi, to be passed sci-fantasy, because antigravity and time travel respectively are anti-science. Consistent sci-fi do not include, but do have Star Trek imaginations which while true flights of fancy, are still non-contradictory.

After the first ageless 1000 years, the sane majority of life forms will allow their brains to be blown up to huge sizes using MIT 2010 decade technology developments, transfer their brains on digital memories and weights on huge robotic nets, to enable a recreation of similar net, as nano particles on diamonds, as the brain. Once that is done, light speed travel, and safety against all types of dangers becomes possible, even true immortality assuming correctly that unlimited dangers have very local limits forever. Regardless of length of time in any matter coordinate system, the time elapse for photons is zero! So optical information needs to revert to diamond form only after unlimited travel.

What is an advanced brain?

It can be answered today with some certainty. It is many functional units composed by pipeline. Each unit can be implemented securely by read only functions operating on two kinds of data, write-once and variables, with fixed locations or pointers. The data is separate from code and organized as series of snapshots connected by lists of transactions which each keep an implicit record of what was done, why, and by whom etc. Each function begins with an event which schedules in a set of closures dynamically bound to that function. It terminates in another dynamically bound post-event to which various sanity-checking closures can attach. Closures imply coroutines which can share variables. The entire program is a process which cannot share any variables, but can share write once. The program flow can be normal or automatically instantiated from semi-context-sensitive grammars on events. The semis have singe global nullable non-terminal but nulled just once at the end. It represents time.This models coroutines and machine learning (an opaque functional coroutine) both.

I am predicting that even full first order logic will not be doable by  ml machines. There is nothing intuitive about the logic. Unlike human brain, two independent units can ML-compute a function and the difference, thus operate differently from neural brains. However, complex units will have two levels with one normal circuit level  over ML-level.

To be done.