NMN directly not NR

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I have been interestedin anti-aging and life-extension drugs from a rational stoic (near science)point of view. Difference to (science = rational scepticism) is that statements of scientists are accepted in absence of rational doubts in speech and presentation (very negative whole advertisement) i.e. trust level  improves or reduces based on actions directly or responsibility-wise).

My extensive research on aging has filtered many contextual loves like resveratrol as philosophically ineffective mechanism, also proven by experiment to be ineffective.

Why not, what lessons?

The proponent did not consider transport and sales-business delays, even though the science was solid.

Why was it scientific?

It functions well in natural world at low concentrations where storage is not a problem i.e. red wine. One could do complex medical chase and isolate the core ingredient responsible for the goodness – that is what western medicine is about. One can chase more and find that ultimately within human mitochondria (evolution-shared by rats (mice) and monkeys) what is improved.

What is this about?

Both Nicotinamide Riboside and nicotinamide mononucleotide are NAD+ precursor, and able to increase the NAD+ level. The likely mechanism of nicotinamide mononucleotide uptake is extracellular conversion to nicotinamide riboside (NR). In addition, NMN is more powerful than NR in its anti-aging effects. Of course, the price of NMN is much more expensive. Reference says  here has been very little research conducted on human, and adverse effects of NMN is not known. Always conduct your doctor before taking NMN supplements.
Turns out, mitrochondriac NAD+ declines with age in all humans and animals and is proportional to vitality. What resveratrol did was to boost NAD+.

How does it fall?

Exponentially half life 20 years! 60 is 12% of birth. 80 is 6%. 100 is 3%. Goal is to boost NAD+. Not NaDH directly, no reaction set! Cell energy cycle from Krebs is ATP<=>ADP or  NaDH(v Work) <=> NAD+(^food) or Citric acid.

why not inject nad+ directly?

NAD+ cannot be given directly to the mice because of its toxic effects (serious hyperglycemia … http://sumo.ly/8ahe via @herbnutritional

What does it boost? How to get more of it?

One can suppress the detail of how. Many biological systems have a cycle in chemicals. NAD+ has 2 – de novo and salvage cycle. Critical is salvage about 85%. Food boosts NAD+ to NADH, discharges back to NAD+. Can't boost NaDH directly! The salvage cycle is to a form of vitamin B3 (nicotanamide). As the picture shows, NAMPT interaction is necessary to become NMN.

NR, nicotanamide riboside, trade name niagen, which I feed to mom and dad was near best in past. As the diagram shows, some part becomes NMN. Another just B3 and may get boosted to NMN through NAMPT bottleneck. So there is some benefit in boosting NR concentration. NR costs about $1 per day. Doubling it to $2 is possible but ruins me financially, supporting 2. Cant involve my sisters (have no brother) in a rational-stoic effort absent settled rational-sceptic. Problem is that tests in progress will yield data (preliminary) by Jun 2018. That is likely too late for Dad. So test doses need to be given to him! Cost is secondary with success given low weight and ill-effects very high weights.

Three outcomes are +ve, indifferent and –ve. In consultation with Indian doc treating him, I have established after two years of paper feeding that my proposal has no –ve consequences (mice tests,  proposed dose etc.).

Now doctors say likely waste of money, no benefits, good dad-bhakti! Dad says bad-idea, I will not consume because already quaffing 18 pills a day in 7 occasions (part of diabetes just before a meal, wake, sleep, between meals). He be damned if consuming another speculative benefit, certain high cost to me, another unnecessary pill! So much for son-bhakti!

Back to my narrative. NR is $1 per day. It is likely ½ as effective as NMN. Before Dec 8, 2017 I could buy NMN at $10 per day – extracting it from cows. Then a clever chemist got into act and now NMN direct is $1.50 per day. If NMN is twice as effective than NR, 250 mg per day will be like 500 mg of NR.

I have personally tried 500 mg NR every other day and interspersed it with 500 mg no flushing B3 for 3 months. Now on 250 mg Niagen per day straight for 3 months. I will try 3 month 250 mg/day NMN on me starting april I will see if Dad agrees.

The stoic solution to scepticism re NAD+ is this reference from Scientific American!

The hard part is the skeptical query from father - forget the theory, how will I feel different or show me a proof. Proofr can't be done to June! No reported improved feelings. BUT growth in NAD+ should slow the deterioration! May be try for a month!

My philosophy