There is one link to an internet link farm where the matter
in this write up can be accessed in detail. Humanity is on an exponential curve
that makes reading the future very perilous for all but me – future is not
polynomial extrapolation of the past! How can one predict, even approximately?
By predicting unlike authors – one cannot leave out steps but predict based on
hard philosophical steps in only a reasonable implementation! The future, so
foretold, must happen at the predicted time or faster if someone achieves the
sub-goals faster, with brand new disruptive technology. Enough can be achieved today
to even make slowest lines predicted to be exciting.
Death by desire or rare accidents: Death is a time bound
event to those who take care of themselves and escape accidents. The culprit is
aging and the effects are universal after 80. Several ways exist to give boost,
I use all of them on self. These include religious exercise, metformin, niagen
and coQ10. These give me comfortable 90 to progressively bad 100. Clearly then,
I need a boost within 25 years to 35. Whatever way is found will be expensive (e.g.
niagen or mitoq). One must intersperse the goal; of delayed death WITH FUNDING
THE NEXT INCREASE.
How will that happen? Partly by breakthroughs in
hibernation. Partly by medical breakthrough in DNA repair. But these will add
to vitality while incrementing life span like 5 years! Aging is not
proportional to being wild – there are rare exceptions like well-aged
sedentary, fat smokers. However if one computes expensive but proper genetic
profile, the realised age to genetic predisposition is in fact proportional to
self-care. Smoking and fat are injurious to health despite exceptions.
True first gain in age is unlikely from telomere
manipulation according to my philosophy. I believe strongly that telomere
length is an indicator of cellular age and not a cause of aging. Situation is
like cholesterol and heart disease, improving cholesterol numbers do not affect
the disease events. In general, the curing of indicators does not benefit the
patient! Hibernation seems to truly benefit simple animals only. The benefits
are quite low by the time of complexity of a bear! External counter-pulsation
is an excellent mode to improve vitality but has no longevity benefits.
Rapamycin and friends work for simple animals like yeasts.
That does not exhaust the positive predictively! The
essential ways that enable any live being to live 3000 years and whales to live
300 years is this. Almost any cellular being falls to cancer. That is because
cancer is part of every live body. Cancer cells are not special. They are
normal cells which refuse to die! Normally, healthy surroundings enclose this
cell which dies from lack of food. When the cell survives by infecting near
cells to creation of blood supply, a tumour is produced. If parts of a tumour
go into blood and travel to other parts, metastases of cancer occurs and
eventually the organism dies.
Why do whales and some trees live long despite being much
more likely to be cancerous! When cell divides, it is very useful to have
another cell available in case the division was faulty. The extraordinary
density of cells in whales gives them immunity from cancer formation. In
long-lived trees, the roots continuously send stem-cells, available at divide
time. If the current cell is aged, the division is unlikely to survive. However
not a problem since a stem cell is present!
This trick does not work in higher animals with lot more
specialization. However qn Indian doctor in USA has done amazing work on
transfection. A mouse leg was damaged till it dried to a stumf. A transfection
was done by extracting skin cells, processing them to certain kinds of stem
cells and appending them at certain distance FROM INJURY. Miraculously, the
injury healed and life returned to dying limb..
So I await a transfection miracle in next 25 years.
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