Bio robotic weltanschauun

 

 

Pragmatics is required from readers - while bio robotics is unknown at this point, you are spending time at least reading it and hence must give it some belief even while you compare it to your own Weltanschauung (comprehensive conception or apprehension of the world especially from a specific standpoint)! I refuse any Guru intention beyond this.

Before getting into it, one must use a truth asserting and derivation methods. Science as a set of falsifiable statements investigatives and  empiricism for values. Quantum (IE linear) logic is used for derivations.

Now precise use of some words. A word acquires unexpected meanings once found useful in selling, speeches, theory etc. needed, bior prefix before a word implies as defined in official Bio robotics.

Quite independent of topic, evolution is assumed predefined. Of many such theories is a common one we use - punctuated equilibrium wherever implied. We believe punctuated evolution is why life exists and how bacteria and viruses mutate. Evolution is how companies populate a market. Evolution is how ideas are made. Bio robotics views a paradigm as a punctuation in evolution and disruption as paradigm shift. Every disruption can not be forecast, hence a punctuation in evolution but can be retro-forecast by stupids only.

Basic to Bio robotic Weltanschauung is the belief that humans are nature's robots, an axiomatic external but operable faith that human destiny is cyborg, with conversion of brain information to transmittable bits and brain attachments of any machine as an organ, assumed interfaced to direct brain circuits. The universe is a quantum information construct. Human destiny is to become light transmittable entities interfaced to whatever machine available and paid for. Immortality is a consensus of multiple backups.

Comparison between aged 80+ and bioage 40+

This table from this.

	Chronologically and biologically old (80+)	Chronologically old (80+) but negligibly senescent
Health	Many chronic diseases and partial or full disability	Good health
Appearance	Typical for an old person	Young or middle-aged
Cognitive capacities	Defined by health status	Full capacities
Skills and knowledge	Being gradually reduced accordingly to health status	Constantly increasing
Social/Financial status	Retired (Dependent)	Working (Independent)
Social inclusion	Limited (Absent)	Full inclusion
Exposure to ageism and abuse	Very likely	Unlikely
Life expectancy	115 years	Indefinite
Mood	Likely lower due to age-related factors e.g., poor health, abuse, social isolation, dependence	Not affected by age-related factors, depends mostly on personal achievements

Fig 1. Aging vs negligible senescence. Life expectancy is based on a publication appearing in the journal Nature[14].

asli(R)"Authentic Secure Licensed Inclusion"

 

I love this idea! It greatly expands words-from-phrases, to levels of NASA and beyond. Starting today, I declare a pause on biology depth since de-aging has been developed to actionable levels

Given that in the internet age, it is trivial to build arbitrary bit patterns by photo shop, deep learning and copying images, the goal for asli(R) sounds impossible. Not only will I convince you that it can be done (unless feigning stupidity), but that I still keep the implementation closed and hence can make money some day.

The general arya-method to solve similar problems is to construct a new image in the user that is a combination of writer and user interspersed. All inclusions are verified licensed and in proper place!

The concept of signature is one way. This is done by internet authority digest of the signatured item, encrypted by the licensee private, that follows after the image. If its encryption by licensee public yields the computed digest, we claim asli(R)signature. SHA-384 and asli(R)encryption is suggested.

Every sub-image to be checked asli(R) has a blank left column (or consumer error picture) if the sent sub-image is not licensed else a user chosen image kept encrypted locally. Its license number is also checked against the digest of the letter so far, to asli(R)check for inserted later.

Applications discussed here

Suppose the letter contains a password entry field which could be bank licensed, say in Amazon interaction, which requires another to sign as prime, yet another for registered user. Each of them must be properly licensed. No actor but the licensee needs to check or see the password! In fact once implemented, every company that fails to buy from me can and should be sued for abusing the customer finances by allowing passwords to be stolen! That is a different kind of selling!

Every single cracker on the internet can be embufarred by end-to-end encryption between the consumer and the licensee! I, of course, suggest asli(R)encryption with automatic encryption and decryption of field values. Neither consumer nor licensee need to be aware of encrypt-ions. One variant of asli(R)encryption deals with broadcast (many customers with one common encryption). Note that it cannot be used for funds where every one needs a distinct bank account, but can be used to distribute, examples are magazine issues and restrict audiences for many show dates.

High Level DNBE proposal for Doctor Uncle

Disclaimer

This is a high level DNBE (Democratic Neutral Blood Exchange) proposal for doctor uncle and all other funding people.  He gets links to all the relevant papers (all on internet, so are my explanations) and this write-up written at higher level. And included are links to many years of my past write-ups. There is no need to provide references for every statement to establish references to first empiricist. I can independently assume that everything in older medicine is known to him and can be used in simplified form. He may ask for my papers on things erroneous or unreferenced, but that is what the meeting is about. This is an overall review, claims no biology contribution. 4 of my problems (diabetes, heart, essential tremor and aging) have no non-episodic cure in modern medicine, I am tired of the quality of my life, and I am willing to risk no efficacy, but willing to try DNBE of my design. My metho0d derives inspiration from Dr. Sinclair who calls similar methods level3 (All faults mine).

2005 had Drs. Conboy paper on age-reduction with parbiosis. Two mice, old and new were conjoined by parbiosis, younger aged, aged got younger. It was erroneously assumed to be magic proteins in young blood but 2016 saw a definite debunking by Drs. Conboy, authors of the first paper. Their experiment exchanges blood between young and old mice, that showed equivalent increase in age of the young but very minor improvement in the old. Age-reduction likely was from sharing young organs. Many professors in Stanford and UC Berkeley started companies of magic portions extracted from the young, isolated and made available in huge amount by their companies! Already debunked in 2016. The Conboy team published another fast tracked paper in November 2020, with right development, namely young blood was irrelevant, a neutral replacement was all that was needed for restoring extracted plasma, IE albumin saline solution was all needed. Albumin has no age effects and substitutes for all protein in blood plasma replaced till those in other part of blood flourish in dilute plasma in 24 hours.

I consider Dr. de Grey (PhD, funded 2005 above) to be my hero like you, means not divine but superhuman, unconditional prompt reading of major references. Beyond Conboy are Dr. Sinclair (Harvard NASA) and Dr. Kirprov (first US TPE). Dr. Kirprov participated in 2016 and 2020 papers and also in AMBAR, first human use of NBE. That was a major clinical trial of NBE as solution to Alzheimer. (NBE is like TPE therapeutic plasma exchange and) TPE is FDA approved for auto-immune diseases. That seals safety in me. Yes, I am aware of BBB, the blood-brain-barrier! The beta-amyloid in the brain seems to maintain constant ratios in brain and blood. Drop due to NBE is compensated by brain losing some amyloid. Then Albumin captures it for disposal. Post TPE-procedures, Alzheimer patients scored 40 to 50% extra on psyche tests. They underwent 50% blood replacement for six weeks per week, I want only 1 now! I have also read (new, perhaps shocking, double-checked) that Hippocampus allows neuron generation even in old and this TPE restores creation of new memory, may solve my slow essential tremor loss!

Blood goes everywhere. I believe even repeated TPE of 50% blood is safe. I am not ready for repeated procedures yet, but looks like great improvement in my diabetes, heart and some in essential tremors is expected. Furthermore, I have requested that $1000 worth of NMN (pharmaceutical grade) be bought from the USA. As B3 form, there is no custom duty on it. Unfortunately, no 1/2 kg powder product available on US Amazon, so direct mail-buying not possible (?). Another point is Horvath tests to determine DNA age are not done any-more by Amazon, or in India, so I am looking for 2 day ships of spit into the USA (Boston best), even given USA companies charge $300-500 per test, another $25 to ship. I would be very interested in doing it as service from startup I want. I have included startup ideas in notes.

Furthermore, I am trying two independent bio-age methods at once, plasmapheresis and fix NAD+. Between the two, I expect bio-age reduction of 20 years! I expect a lot, may or mayn't get it, but TPE with a little advanced plasma of my design, (not disclosed here but has another write-up), designed to learn from reported TPE effects. If it works for me, (and I believe in efficacy) I intend to rapidly create a company with major investments ready.

I expect about 10 years from blood based DNBE. The second approach is likely independent, expect another 10 years is NAD+ based, number comes from how much younger Dr. Sinclair looks. Same as that in Krebs cycle with NAD+ uses in many sub cycles. It empirically declines with age! It is a form of Vitamin B3, Path is B3 ⇒ NR ⇒ NMN ⇒ NAD+ which is de Novo path. Reuse cycle is NAD+ ⇒ NaDH ⇒ NAD+ ... One can use NAD+ direct or NaDH direct. The reuse cycle is much bigger than de Novo. One can supplement with B3 (Niacin) direct but full path is too slow.

However, there is a bio availability problem! All food goes to liver first which uses what it can. It reduces the amount for blood-based transfer drastically. Most forms also have a cell entry problem. NMN solves it by becoming NR for a while. So does NAD+ direct. Only NAD+ crosses BBB. Eventually, NAD+ benefits in mitochondria, means energy increase in path inside the cell. That can also be done by Mitoq, a bio-avail form of COQ10. Complexity is further increased by Slc12a8 path for NMN and its bio-avail is not discussed. Some NMN can be absorbed in the entry part of the small intestine, bypassing liver!

Consumer choice is really between NMN/resveratrol(Sinclair) or NR/pterostilbene (better resveratrol) or NMN/ pterostilbene (me). There are complex bio availability, patent, usage-history considerations. To protect from liver, sublingual and nasal inhalation methods have been tried, all without definite FDA blessing. I am now after better but insufficient benefits the plan to use Intravenous methods. How much and food grade of usage is forbidden to state by the USA government bypassing FDA proof. Only FDA accepted is NR obtained in supplement minefield or accept basis prices. Non-empirical experience listing says that NAD+ is best taken intravenous everyday while NMN is every week. How does NMN with DNBE, who knows, my self-test.

Nice thing to self-risk is freedom to choose any paths with no known significant risks including rare deathly risks. The 10-year expectation is how much younger Dr. Sinclair looks and reported Horovith clock assay

I am unhappy about my limitation even if I have money now. I am happy to risk - the worst is nothing will happen, risk ok by me, as every safety precaution will be taken and TPE is approved procedure by FDA, seals safety.

Immunotherapy solution to aging in 10 years if DNBE works, by my way to control apoptosis evaders!

Immunothereapy treatments

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As explained earlier, cancer and aging are closely related. Advances in cancers hugely impact aging. Both are treatments of apoptosis evaders. But immunotherapy of cancers is easier since cancerous cells have an expressed chemical difference to aged cells, they have chemical protein markers and hence can be selected and killed. As I explained earlier, I do not have an answer just then for aging. It requires to be thought.

Applying immunotherapy for aging may be expensive in the near future. Below will give costs. Certainly, it looks to be the expensive forms of aging medication!

Immunotherapy in India as compared to other developed countries:

Countries	Cost (In Rupees)
India	₹1,00,000- ₹4,30,000
United States	₹1,22,44,500.00- ₹1,36,05,000
Canada	₹53,31,830.00- ₹58,60,523.05
Germany	₹8,24,951.46- ₹10,58,254.03

Immunotherapy cost in India is very low as compared to the other countries like US, UK and Singapore.

The above graph shows that there is a huge difference in the cost of immunotherapy in India and other countries.

Let us tell you why there is such a wide difference in the cost between the countries?

• Indian currency: The major reason of this huge difference in immunotherapy cost in India is the currency. The Indian currency is quite low as compared to dollar, euro, etc. Thus, the cost of the treatment is less than compared to other countries.

• Living cost: The living cost in India is almost 65% lower s compared to the other developed countries. Therefore, you can get all the facilities at a very low cost.

• Competition: Well, India is a place where you have abundant choices of hospitals. All these hospitals offer a variety of medical treatment. So, therefore you can choose as per your convenience from a wide range of hospitals.

Let us tell you how such a wide difference in the cost between the countries, is justified?

Consider USA/Canada. There is shown a flood of people on the Canadian border purchasing their drugs in Canada. The Answer is another ad of Canadians buying drugs in the USA because the drugs are not available there. Applies to Mexican border as well except there the additional huge argument is tremendous quality difference of drug versus colored water or worse.

Regardless, can you use it whenever?

Immunotherapy is to train the patient's own immune system to find and kill the bad cells who conveniently have cancer protein expression. This is done by extracting T cells from the patient's blood, reprogramming them in the lab and restoring them in the patient. This will not work with aged cells that have no markers! But something can be done! This is by deep study of the apoptosis path itself, Cell that ignore apoptosis, do so by evading a part of the path.

Apoptosis has an internal path based on mitochondrial signaling, or external signal. Clearly, doing something wrong is far easier than a perfect biological reaction! It took evolution 3 billion years to perfect the first cells with Sinclair DNA break fix. A complex post-apoptosis process must result in perfect suicide of the cell so that it can be garb aged and successfully evicted! Depending on the reason for apoptosis and step not performed, the chemical internals of the cell are different. So if chemical garbage collects in the bad cells only, then it must somehow enter all cells and then kill those who have not done what they should have, otherwise good cells will die too. It is called throwing the baby with used water! This method is possible, but projected costs are astronomical and chasing it further a waste of time. Now the problems are understood, one can intelligently ignore breakthrough news later, cancers and aging.

Virtual cancer (Arya method) to apply Immunotherapy to aging

Here is my idea. The entering chemical in a cell expresses a new protein, after entering a cell, after checking it is wrong in apoptosis and if so, then marking the cell through the cell skin with a virtual cancer expression. Standard cancer immunotherapy happened hereon. Not all senescent cells need to be marked, if only senescent cells of a certain type are marked with some success. Patient may have to ingest some drugs prior to immunotherapy! In fact, the patient may be told about percent expected success depending on percent success of the virtual marker as a fraction of senescent cells if in blood like white cells! In all cases, estimate of marking through MRI etc imaging, is an excellent diagnostic tool. The marks can be different based on cell specialization. The drug may be a cocktail.

Success Rate of immunotherapy in India

The success rate of immunotherapy in India has seen a tremendous increase. The five - year survival rate of immunotherapy has increased from 5.5% in 2012 to 28 % in 2019. While other cancer treatments like chemotherapy, radiation, etc. cannot give this high survival rate at the stage IV cancer, immunotherapy becomes one of the leading choice to get better results.

DNBE

To be done, if DNBE works on me, in a dedicated India/International/Intergalactic Aging Institute facility with first station in Delhi or NOIDA.

Actionable Politics of Aging

 

Actionable is my word that captures me - Actionable aging, actionable politics etc. That is not to minimize 99% of the rest, but often reading great researches, one wonders how it benefits me now or later. Who is doing supportable research application? How is the engineering of applications of great science being done and how can I benefit, provided I understand the risk.

The whole field of aging has forever been the domain of thugs, and will be. An FDA cannot exist that performs the complicated dance between the state, courts, legislation, markets and innovators since risk reduction means expanded extensive, time-consuming testing that will damage non-aging drugs expensively. It is incorrect to try to identify aging chemicals and non-aging chemicals. The only reasonable way is leave the FDA alone and depend on tested and proved medical tourism. In other words, reform but not reincarnate!

This means rules and regulation of the host country but USA inspectors. Some drug trade is conducted along these lines, creating trust in foreign products. It can be extended to service industries too. Dentistry procedures in the USA are quite expensive, but there is no way a citizen can locate trustworthy dentists in India, Thailand etc. It applies to UK and European countries too.

Medical tourism is and maximally strongly opposed by stakeholders in medical services in the USA! Every valid objection can be removed by USA inspectors, not just for the USA but others as well. FDA determinations are not just used in the USA but the entire world.

Hence, my political choice - Controlled medical tourism. It is in conjunction with, and nowhere required to impact national systems directly. One can raise the nefarious nationalist bogey against, trivially fixed by stopping medical tourism to that country! Commies and other moronic objections can be handled so! The essential fear is the continuation of evergreen thuggery, but easy to answer. To consider India, many methods are not considered even as practice of medicine in the west but effects no one in the west! There is a flourishing FDA compliant allopathic wing (called modern medicine mm by me) whose graduates are welcome in the west.

One of the greatest initiative of Dr. de Grey is creation-time support of aging companies which, in my opinion, are the new unicorns of tomorrow, but likely to be ethical too. One such company is Bioviva.

I hope my company will be on that path.

I have identified three actionable paths for aging, soft paths, BNBE, and thymus. I have all methods derived from Yamanaka methods as Doctor territory. There is a fifth method which may or may-not be actionable. It related to the current axiom of medicine that I disagree with, the lengthening of telomere. I do not believe that non-standard aging intervention to lengthen telomere will boost age, I consider them as indicators of age and a side effect to aging intervention just like Horovith aging. Bioviva has an age extension procedure that did lengthen the telomere by about 20 years! There is a clinical trial in progress in Columbia. The team charged a million dollars for being part of the test and I think Columbia was chosen to bypass USA laws, but I will change it some on results and fully when the participant get extended age!

It remains to be seen whether Libella has truly tapped the fountain of youth, but given the dubious nature of their clinical trials, potential participants may want to exercise caution before relocating to Colombia and shelling out $1 million for a chance to live longer.

Here is something to learn and keep in the back of yo0ur mine when diagnosed with unfix-able disease - world has moved to new methods likely unknown to your doctor being immunothereapy, single gene genetic fixes and credible aging improvement methods, called soft-methods and BNBE.

Fixing the thymus

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Disclaimer

Not only does it extend age, but improves immunity against pathogens; that means provide extended health span. Immunotherapy is strengthening bodies own defenses against invaders by T and V cells present in the blood by identification of all invaders, apoptosis-evader or senescent cells. So trained gives you 1000 years. T cells come from the thymus. The adult pluripotent stem cell uses V stem cells, [Very Small Embryonic Like Stem Cells], also referred to as V-Cells. They are also called peripheral blood stem cells, blastomeres or stembios cells. Formed in bone marrow, they are approximately 1/3rd the size of other adult stem cells and are non-tumorigenic.

Previous write-up asked

What is involved in strengthening thymus? Drugs, supplements, plants?

How will I know if some Indian doctor will do Dana Farber fix, when, cost!

Can I request updates and other information?

Before going on, let me first tell you of the wonderful discovery - aging website of the great man Dr de Grey which is collectively far greater than my notes. Here is it. Crucial to view is this summary :

Many research groups have primarily focused on finding possible strategies to rejuvenate the thymus and have developed promising therapeutic approaches. However, few molecules and genes such as KGF, IL-22, IL-7, and Foxn1 have been identified as key players of the mechanistic pathway for endogenous thymic regeneration. Growth factors and hormone therapies were also explored in order to restore age-related or injury-related thymic degeneration, but, despite encouraging results, they have short-term effects and/or require a recurrent administration, which is complicated by their toxic effects on other tissues and organs.

Thymus transplantation represents another promising alternative to complement bone marrow transplantation or to treat congenital thymic anomalies, but T-cell reconstitution following thymus grafting is frequently incomplete and transient, complicated by a skewed T-cell receptor repertoire and an increased occurrence of autoimmunity.

Other master Dr. Sinclair has not been idle. He is raising money to launch a company whose mechanism is novel and expands my horizons as it is a SPAC. God knows what the target is, I hope to launch in May or June provided BNBE works on me!

Now the questions. Nobody knows why thymic atrophy, or involution, occurs, but it happens in all vertebrates, starting really at the age of puberty. Some have suggested that it happens to save energy, since the production of properly qualified T cells is very energy intensive and inefficient, and of course, at puberty, the body begins to devote more energy to reproduction, which might require a trade-off against using energy for immune maintenance.

Drugs for Thymus?

Essentially online or needing prescription. I find entirely appropriate to request a doctor to prescribe them for me, checking me first, to boost immunity. But I have no disease needing drugs.

Supplements for thymus?

Amazon sells many. Pure Thyme Essential Oil 10ml- Thymus Vulgaris is example. It seems to be a fix for cold, flu, lung diseases, asthma, arthritis, cancers etc. It will help against COVID-19? It is best taken with vaccination! Found no one taking it for health span. Dr. Greg Fahy – Rejuvenating the Thymus to Prevent Age-related Diseases.

Plants for thymus?

Plant profile for thymus.

Immunotherapy in India?

What is Immunotherapy? Is Immunotherapy in India used for Cancer Patients?

In fact, wrong thing follow newness of immunotherapy, it is not used as a frontline method of cancer despite it being closest to Ayurveda and Unnani! Somehow, cancer has become associated with immunotherapy. It is to strengthen the inner immunity of the body to fight off infection! There is thing called Hygiene hypothesis that attributes extra immunity of south Asians as due to a whole set of childhood infections solved by no care of the children, unlike the American mothers! Most children survive the little infections and strengthen the immune system. Even in India, the depth of ravages of Corona aligns negatively with citizen income! The Same happens in China and Africa.

Guess what! The death rates were low in all these regions, the biggest victims were in the USA and United Kingdom and Europe, the developed part of the world! Clearly I have different views on some matters, opposite of general sentiment!

I claimed that COVID-19 deaths were independent of political power that be, no one is better or worse, yet most class were either pro-modi or against! Again our class is split, one part believes congress achieved independence, other part believes revolutionaries or Bose-likes. I believe that 1945 labor defeated the Tories and to spite the damn capitalists & Tories and render a socialist world, wanted to get out of being imperial power. Not only British newspapers of the era support me but also that all the British colonies of that era were made independent! Whether they had flowering independence movement or not! It is best to stay quiet and not be killed in dual attack on some issues. God knows how idiotic I sound, when Farmer agitation is opposed by me for non-modi free market rules like the conservatives! But I learned to keep my Trump image quiet. The man's reputations could not be harmed more by his enemies!

Request updates?

Seems to be pointless since the thymus and immunology links I encountered were 2018 end and the world has moved two years ahead! Now one can even have a sane discussion on results, not just venture informed guesses.

Surgical (grafting) direction

As reported here.