SASP : What is it, why important

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My sister reports that my brother-in-law self-experimented, in the USA, with enhanced Haldi and black pepper, and then got ill with an allergic reaction. Now me, self experimenting with great concentrations! What FDA test data do I have and why do I believe there is no interaction between so many chemicals?

SASP stands for Senescence-associated secretory phenotype, beyond lingo means set of chemicals released by senescent cells. It has a hormesis effect of tumor cell suppression but devastates by reducing NAD+ by many chemicals in it, continuously. It has an evolution-based positive effect just after adulthood of prolonging life, say at 30, but only decrepitude effects past 35. Without virus/bacteria control, the human lifespan for most recorded history was 40 years and 80+ age is very modern, last 100 years developed and age 60 age undeveloped. Three major factors in long-age are medicine, cleanliness, and vaccines, enemies of vaccination are meta-moron since they believe in some stupid ideology that allows this stupid derivation or listen to news from meta-morons, possibly pseudo-journalist.

The aging model, generally not useful to know for patients, is by error correction failures in DNA break. People have three sets of enzymes that control cells. These are further sets of sets, SIRT series SIRT1 through SIRT7,  mTOR, and PARP series. All useful chemicals must be absorbed by one before useful things happen. NAD+ and SASP are a distinct higher model that considers only the Krebs cycle and SASP produced by senescent cells. PARP plays a central role and enables the repair of DNA damage caused by alkylating agents and chemotherapeutic drugs.  mTOR is the mammalian target of rapamycin. These should be known to understand why and how the chemicals recommended here operate.

Part of aging is a decline in strength, Eutheria-wide which means a continuous decline in NAD+ necessary in the ATP-ADP cycle for strength. Why does it decline? Aged senescent cells ignore apoptosis and generate SASP. SASP (inflammation+) kill NAD+. That is simplified Aging and an attempt is made to do undo aging by boosting NAD+ and reducing SASP by analyzing main constituents and opposing them.  Many ways exist for raising and reducing. One can boost in many ways and reduce in many ways, I recommend top3 raising and reducing top3. Also, osteoarthritis/osteopenia are fixed by K2/D3 liposome and the heart is boosted by coq10 liposome. What makes me distinct from all professional doctors is eliminating them and their medicine by using only known safe pharmaceutical grade supplements in liposome form, sometimes by sublingual use. The mm doctors are recommended for all treatments, but not for aging and incurable chronic diseases. Naturopathy, Yoga, and my style cell medicine (orthomolecular medicine if applicable) are recommended then.

The opposition to the use of injections only applies to supplements for aging, vitamins, phytochemicals, or GRAS (Generally recognized as safe, FDA designation) pharmaceutical quality chemicals. Where liposomes, particularly sublingual types, are superior to injections (solve the cell entry problem too) and solve the problem of trained interventionists with cost and timing benefits. This novel drug delivery system approach is motivated by devastating scientific attacks on Dr. Linus Pauling, unfairly targetted, by being compared results of oral medications and Dr, Pauling injections of Vitamin C. The unfairness is evident in maximum blood concentrations of vitamin C in differing drug delivery systems, considered wrongly the same by mm doctors despite contrary blood concentration results! Orthomolecular medicine is being revived in my cell medicine, sublingual liposomal supplements are fair comparisons against injections or oral, but not injected liposomes. I believe and self-test liposomal coQ10 on me for heart and other benefits including extended immunity from cancers.

 

Aged cells post adult stage are characterized by senescent cells that do 3 big things, ignore apoptosis chemical orders, make neighbor cells senescent,  and generate SASP which helps some by being tumor suppressant, anticancer, but quickly becomes a major problem since NAD+ is targeted, inflammation occurs with different effects in organs and muscles, and total drain of energy.

 

Surprizing to starters is the fact that telomerase that extends telomeres is part of human DNA and cells can discover its use and become infinite lived as cancers. An Israeli company lengthens telomere but is of marginal help in healthspan!

 

You have to do both, Dr. Sinclair did boost only, and Dr. de Grey only recommended senolytes for reduction! Drop a leg of intervention and aging reappears after a delay, say I, Dr. Arya. SENS claims 5 difficulties in longevity research and difficulty in conjoining separate therapies intelligently (they might not be exclusive) is one of them. Liposome strengthens them both.

The big three boosts for me are Resveratrol, NMN, and NAD+ direct. Why NMN, not NAD+ is based on reported experience with injections, NAD+ every day and NMN only every week. Why NAD+ directs at all – it crosses BBB. Resveratrol is different path from NMN. Safe as found in red grapes. NAD+ occurs in many Krebs cycle reactions. NMN becomes nothing else – it and NAD+ are vitamin B3 forms. Effective because Dr. Sinclair recommends and takes by him, his father, and his brother.

 

The big three reduction chemicals are phytochemical being Apigenin (parsley, celery, onion, orange), Fisetin (strawberries, apples, mangoes), and quercetin (elderberries, onions, apple peels). They are safe because 30+ years of use, they occur in small amounts in fruits and vegetables, I use liposome supplements to have real dosage. Effectiveness as recommended by Dr. de Grey.

 

Link is informative Dr. Sinclair (believe me he is 50).

So what is your belief in human life, Dr. Arya?

For simplicity, I break healthy human life into 20-year portions, age regions accurate only within +/- 5 years based on extensive current reading. First, to age 20 is growing human says evolution. The next 20 years is reproductive stage to 40. Then slow degrade to 60. Then fast degrade of the immune system to 80. Then slow degrade to 100. Then no systematic degrade but a constant probability of death. That is what evolution presented me. I stand ready to challenge evolution.

What is your goal, Dr. Arya?

I think that two things have already happened - medicine to extend life 8+ years and at least 1 reset i.e. another interval of extension by retake of that medicine. That gives me 16 years after that medicine hits the market in 2 to 5 years. My mix will likely, but only self-test will tell, give me freedom from chronic incurable diseases and 5 years. That E5 will pass FDA, I believe, from my trust in, and sayings of Dr. Horvath and Dr. Sinclair and lack of opposition by Dr. de Grey or Drs. Conboy. The chances of another reset research in the next 21 years are overwhelming. There are many works in progress like MIB-626, Yamanaka factors, etc and no acti0onable technology in the next 20 years is unlikely.

My method is a composition of two theories of Aging undo, by Dr. Sinclair and Dr de Grey. Keep in mind this research (challenge #2). I also demand liposomes.

My extortion is quite conservative, imagines cancers, uncontrollable animal marketers, and scientific provided that single-digit greats set is free from self-contradiction. The long experience as food means no known interaction effects. Larger quantities are likely safe as none of the chemicals are sharp and will be likely excreted if, in excess, there is still a risk, for example from direct cell entry, solubility, etc, but that is considered as if I started living on fruits and vegetables, stop on recognized bad effects, daily blood reading, monthly blood tests. I may still be hurt, but then will become a lesson on what not to do. The risk is small, had lovely 65 years, aging will kill me anyway, I have a way to possibly cheat death with no known dangers and so take it after a long analysis.

The key difference to orthomolecular medicine is that huge concentrations are not being claimed to have therapeutic effects on diseases, it is enough to sharpen effects of the normal kind, within normal injected supplements, except the claim is liposomes can be utilized for better or equal effects than injections with many positive effects. (other place details)

Where do Dr. Arya Dual-fix and Dr. Katcher E5 stand?

Gerontology is perhaps the biological discipline that has given rise to the largest number and variety of theories even before the development of modern science. Most theories aimed not only at elucidating the mechanism of aging but also at providing effective interventions to slow aging down. In the late 1950s, the focus of research attention moved to DNA as the likely driver of aging either by expressing a program of aging or by being the target of endogenous and external insults that accumulated damage on the molecule during the lifetime of an organism. Up to this stage, aging was considered as an essentially irreversible process. However, with the discovery of cell reprogramming, early in this century, a view began to emerge that considers aging as a reversible epigenetic process.

The hypothesis proposing the epigenome as the driver of aging was significantly strengthened by the converging discovery that DNA methylation at specific CpG sites could be used as a highly accurate biomarker of age defined by the Horvath clock. The strong correlation between the dynamics of DNA methylation profiles and the rate of biological aging leads to the idea that the epigenetic clock may in fact be the pacemaker of aging or at least a component of it. And it is at this point where epigenetic rejuvenation comes into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backward.

The few initial results already documented seem to suggest that when the clock is forced to tick backward in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. Nevertheless, it would be premature to draw firm conclusions from the scanty experimental results so far documented. What seems to be clear is that epigenetic rejuvenation by cyclic partial reprogramming or alternative non-reprogramming strategies holds the key to both understanding the mechanism by which the epigenome drives the aging process and arresting or even reversing organismal aging.

The key point is a clever synthesis of cumulative damage (in the epigenome only) and reprogrammability using the intact DNA!