Monday, October 4, 2021

Drug delivery systems, beyond medicine

 


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A drug delivery system DDS is taught to all doctors but conscious unknown to 99% for whom it is an education waste and they only use 2, namely pill/capsule and injection.  For what follows, you must remember that no matter what the disease, the human body is a cellular construction and most medicines have to enter cells to have any effect.

Let us follow the sequence from a pill. After swallowing it enters the stomach where acid attacks it. Then if absorbed there or one of the intestines, it enters the bloodstream. there it proceeds to the liver and must be unattached by insulin. When the liver stop ends, it enters blood circulation. Now the targets may be simple cells. Or they are brain cells and medicine must penetrate BBB. Now medicine must enter the cell. If the target is DNA, then it must penetrate the nucleolus. Or it may have to penetrate mitochondria membrane-like CoQ10. If one assumes 10% success per try, one can see that .0001 or 0.00001% medicine is usefully delivered.

Doctors would be defeated nearly always. What saves them is injections. Drug goer directly to the cell. Far better results. Drugmakers know this. They formulate the drug inside their injections as liposomes. Now even cell entry is quick. Also, the liposome is soluble, hence in blood too. Hence get delivered everywhere without cell entry losses. The doctor does not know or care. the medical representative MR presents clinical trials where the injection defeats good drugs in efficacy. The brand wins.

Enter I, set to complement doctors and defeat them well using Liposomal undo aging drugs and my agents who will have shops or pharmaceutical desks and construct liposome encapsulation of whatever powder their doctor prescribed, such that encapsulation is 10-15 minutes. The encapsulated drug is far more efficacious.

Three DDS have been described: pill/capsule, injection and, liposome. A drug may use method4, dissolve under the tongue. It bypasses the stomach. or method5 which is how people snort cocaine. It too provides direct blood entry. There are others. Encapsulation in a liposome eaten does not require pharmaceutical grade and hence iv use of any liposome is a bad idea. But most liposomes enter the cells and hence the drug carried must be pharmaceutical grade.

Depending on the sizes of the liposome and properties of the drug, the liposome form is 4 to 100 times more potent. At least factor of 4 can be assumed For random memory NMN/NAD+ improve factor 4, Fisetin factor 50, k2/D2 factor 4. One can use these numbers to consider amounts needed. ! gm/day NMN from Dr. Sinclair is 250 mg liposome. The Fisetin improvement is enormous, in fact mayo protocol is not needed. Most Indians have poor osteoporosis and osteoarthritis control and 1 year of D3/K2 liposome will solve both issues.

I believe that my dosages are such that potent effects will  be seen by me wit5hin a month even as effects will be measured after one year If it helps me and my sister within a month, then I recommend to my wife and m0other, decision theirs. Recommend to world, as a practitioner in one year. Start October 12 at last with feel November 12. Know for sure October 2022.

Beyond medicine?

Cell medicine, as defined by me, will address issues of chronic aging diseases like diabetes, osteoarthritis, heart, and a lot more for which modern medicine has great treatments but no cure. It has no treatments or cures for cancers and aging. That I have them can be experimentally demonstrated after November 2021 in two months, time frame but no shift in goals. The point is the importance of delivery drug Systems, even better than injections is a liposome, available to all!

Why do you think you can add to the cancer fight?

Apart from liposome drugs like liposomes and Dr. Arya franchise on quick liposome incrementation, why do I think I can add to the fight against Cancer, comes from Linus Pauling and the research institute his legacy in Oregon, he is well known for lifelong advocacy of vitamin-c therapy. Even when alive he was hounded by mm practitioners who developed a huge number of clinical test results against him. 2 decades after death, researchers of his legacy showed him to be wrongly dismissed as an old man once great.

Middle of the 2010+ decade, the researchers discovered the huge difference between a pill and injection. It has to do with a peak concentration in blood. Even if 3 gm (max) drugs are quaffed six times a day, the peak never crosses 200 mg per mole. The peak with injections is 3000. Liposomes can achieve 15000. Doctors as a caste can be defeated. A liposome is even better than injection despite the delay in effect - it even avoids cell entry problems! It works for all pharmaceuticals, not food-grade powders.

How do you think medicine will evolve?

Aging will soon be recognized as a disease, basic to healthspan everywhere. The technique of medicine will shift to cell extraction, fix in the lab, and restoration in organs for all diseased organs. Liposomal drugs will be used for prophylaxis. It will happen in at least my health span!

Dr. Sinclair has mentioned 3 exciting things?

1 working on blood-based Horovith age test, way cheaper than current Rs25000-35000 test, 2 needed for before and after.

2. Knowing if it helps fast within a month you feel the energy from NAD+ you made and SASP reduced by Fisetin

3 Continue testing MIB-626 in FDA2 after excellent FDA1 results. This improves on NMN+ Resveratrol, a better molecule for NAD+ and nitric oxide (I take L-ARGININE for it).

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