As you go along, you must develop pre-undergraduate level knowledge of molecular biology, cell medicine, immunology, and genetics. I advocate a full course to all once in 11 or 12 grade on modern medicine and modern markets about economics and advertisement. I expect the government to force citizens on providing resources to clear 12 standards before being granted citizenship. For my purpose, I assume that every unfamiliar (even unsure) word is looked up with wiki <word> search in the browser.
The principal reason I want you to know CAR T therapy is my belief that it is a cancer therapy part around therapy which all medicine in next 10 years will be built and CAR part is specialized for tough cancers and not crucial to know by non-doctors, but there is an unnamed part (T cell therapy) which is what modern medicine will become, unfortunately devastating all senior clinicians. In other words, avoid doctors without experience in use, in ten years. I call it DDS (Drug Delivery System) therapy for now. T cells are immunological enemies that will attack any molecule like virus-sized or bigger object that has an antigen that matches their slot.
Here is why. The DDS part is to extract part of blood or organ cells by scraping, extract portion or just add some chemical, and replace it at withdrawing site. Currently, that is how works. You can think of it as two-line iv, one for extracting blood for a curing machine which is then returned at other iv like a dialysis machine. The main massive benefit is no fear of rejection. The machine draws T cells in CAR T. They are processed off-line in a lab, and reintroduced later. For some diseases, like aging, or chronic aging-induced, the machine can operate inline. All insertion medicines can be done with a single iv, which means injections or sublingual liposomes. Two iv line with processing head clearly encompasses all critical modalities and is thus universal medicine machine beyond surgeries.
CAR stands for chimeric antigen receptor. It is a chemical of patient-specific cancer. The idea is to extract T cells of the immune system, train them to attack any supermolecule that expresses that antigen, and restore these T cells. Thereafter they will only attack cancer cells and in fact, teach other T cells to recognize the expressed antigen cells as foreign.
You are not a doctor! How can you know what clinicians will encounter!
Fundamentally this speech of a meta-moron is stupid! One can gain massive benefits from USA experience tailored to India's situation. Every meta-decision in a democracy is taken by elected people who even have elected doctors to advise! This is the weak pointless statement of an under-human abuser of personal specialty!
what clinicians will encounter?
Once enough CAR T cells have been made, they will be given back to the patient. A few days before the CAR T-cell infusion, the patient might be given chemotherapy to help lower the number of other immune cells. This gives the CAR T cells a better chance to get activated to fight cancer. This chemotherapy is usually not very strong because CAR T cells work best when there are some cancer cells to attack. Once the CAR T cells start binding with cancer cells, they start to increase in number and can help destroy even more cancer cells.
As CAR T cells multiply, they can release large amounts of chemicals called cytokines into the blood, which can ramp up the immune system. Serious side effects from this release can include:
- High fever and chills
- Trouble breathing
- Severe nausea, vomiting, and/or diarrhea
- Feeling dizzy or lightheaded
- Headaches
- Fast heartbeat
- Feeling very tired
- Muscle and/or joint pain
This treatment can sometimes have serious effects on the nervous system, which can result in symptoms such as:
- Headaches
- Changes in consciousness
- Confusion or agitation
- Seizures
- Shaking or twitching (tremors)
- Trouble speaking and understanding
- Loss of balance
Scared? If not, you understand USA law and lawyers.
The way law works, absence of mention of side-effects or insufficient proof of delivery causes malpractice. Same works for products and tools. No one is required to compute likelihood – if doctors use, then they know, how I do not know. The chance of all for non-cancer will be under 5%, my threshold for unknown medicine. No wonder, top professions, earning wise, are lawyers and doctors.
Your warnings?
Other possible serious side effects of CAR T-cell therapy can include:
- Allergic reactions during the infusion
- Abnormal levels of minerals in the blood, such as low potassium, sodium, or phosphorous levels
- A weakened immune system, with an increased risk of serious infections
- Low blood cell counts, which can increase the risk of infections, fatigue, and bruising or bleeding
What a thinking waste If this fails?
I live even after the Massachusetts government's brutal treatment of a TBI because of the USA federal law of Roosevelt for disability victims. My time is owned by Social security. I seek no charges. It is not a waste. I will feel honored if someone uses it, even without credit.
It gives me a strong idea to do the very difficult discrimination between jihadi meta-morons and honored Muslims by subjecting any suspect to a sequence of questions, discrimination machines sharpened by AI! Both alpha and beta errors can happen, though further investigation can suppress both errors.
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