Tuesday, June 2, 2020

choroquine phosphate repurpose break-through for corona



from chinese, official US translation

https://pubmed.ncbi.nlm.nih.gov/32075365/
[Expert Consensus on Chloroquine Phosphate for the Treatment of Novel Coronavirus Pneumonia]
... Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. It recommended chloroquine phosphate tablet, 500mg twice per day for 10 days for patients diagnosed as mild, moderate and severe cases of novel coronavirus pneumonia and without contraindications to chloroquine.

 https://pubmed.ncbi.nlm.nih.gov/32074550/?from_term=%22COVID-19+drug+treatment%22%5Bnm%5D&from_pos=1
Breakthrough: Chloroquine Phosphate Has Shown Apparent Efficacy in Treatment of COVID-19 Associated Pneumonia in Clinical Studies
Jianjun Gao,, Zhenxue Tian , Xu Yang
 Abstract

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.

Arya
1. unlikely a hype -- too official
2. china did fool the world, emerging late but at least
3. west pharma-scientist  hit but so what? Recommend continue fina ncial support for a month
4. Easy to build after quick ramp up in India
5. Repurpose means known side effects

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