As I delve into NR, not aware of how it started, only
analysis of effects, many
questions came to my mind, answered greatly here.
Why absent empirical data? And I can understand his point about clinical
trials in this area. But it still seems like a big leap from that to the
nutraceuticals industry (here’s
more on the company’s founding). But then “As one scientist recently put it to The New Yorker, the antiaging
science being done at Google-backed Calico Labs is “as self-serving as the
Medici building a Renaissance chapel in Italy, but with a little extra Silicon
Valley narcissism thrown in.””
What is aging?
1. Oxidative Damage
2. Cell DNA Damage
3. Mitochondrial Damage
4. Tissue Glycation
5. Lipofuscin Accumulation
6. Chronic Inflammation
7. Immune System Compromise
8. Neurological Degeneration
9. Declines in Hormone Levels
10.
Susceptibility to
Cancers
11.
Susceptibility to
Cardiovascular Disease
12.
Telomere Shortening
and Damage
13.
Programmed Epigenomic
Changes
14.
Stem Cell Supply Chain
Breakdown
15.
Incorrect protein
folding
16.
Accumulation of
Progerin
17.
Gene mutations leading
to hellicase abnormalities
18.
Increasing mTOR
signaling
19.
Declining hypoxic
response
20.
Micronutrient triage
with aging
Absent empirical data, how can one have any faith in NR?
1.
Quality of people lined up: MIT Lenny
Guarente (planetary aging expert), he’s being advised
by five Nobel Prize winners and two dozen other top researchers.
2.
Width is important! Typical run-of-mill
criminals can not afford by have to lie – means fuck caught! The star
cast, Google calico lab.
3.
People lining up without need!
4.
There are great people who disagree with me! And Barzilai knows about the science of aging. Heis, after all, the director of the Institute for Aging Research at the AlbertEinstein College of Medicine in the Bronx. To me, perfect critic! He
peddles the drug in question, metformin, to me not exclusive!
Why not wait for data? Won’t wait for 2020-2030. Ready to
waste limited money.
How can CDC be shorted? No pharmaceuticals but
nutraceuticals!
Why bad idea?
1.
Criminals an call their stuff (with some
evidence only) just as good!
2.
Cant protect by patents! Any one can copy you.
How can you prevent copy cat criminals?
1 line up many greats
2 Not done, but I will – joint denunciation of competitors
How can non-rigorous studies be done?
1.
No one but I can, motherfuck other protocols
easyu
2.
Mine will be immune. All based on aafiber!
Why is the Elysium methodology bad business?
Whatever they do can be copied!
Bad business, so what?
1
Scientists do not care of profits beyond reasonable
STANDARD.
2 My method can be applied! To do my stuff fast, must use free must-extend-only-free stuff. What if 95% of my stuff was free, only thing making money was sqrt of cloud, method never sold, a user can check by squaring, I was not lying! How the sqrt was done MY BUSINESS only. For aging, a complicated protocol, largely bullshit. The copycats wont know what NOT to copy! For example a useful step may be broken, there might be slow poison – antidote steps. Mind you, be bad idea for pharmaceuticals. But OK for nutraceuticals! The expertise has no legal value!
2 My method can be applied! To do my stuff fast, must use free must-extend-only-free stuff. What if 95% of my stuff was free, only thing making money was sqrt of cloud, method never sold, a user can check by squaring, I was not lying! How the sqrt was done MY BUSINESS only. For aging, a complicated protocol, largely bullshit. The copycats wont know what NOT to copy! For example a useful step may be broken, there might be slow poison – antidote steps. Mind you, be bad idea for pharmaceuticals. But OK for nutraceuticals! The expertise has no legal value!
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