The ASLI Rejuvenation

This is a summary for hard research of 20 years to explain what rejuvenation means to me, why it is true and what will be done by me for self; has only a few reference to other's work and all links are to material which explains in detail the concept referred to or implied. You as reader must chase links for they have the real content that explains this summary. I think that rejuvernation-0 is better handled by rejuvernation doctors different from medical doctors. Only scientfic engineering disposition persons need to bother. To be practical, triage component has to be added to rational skepticism. Triage concept arose from proning disaster, even fleeing criminals often can be made to donate their underwear!

I have advanced far enough in my chosen research over last 20 years to not only understand Dr. Sinclair's theory of Aging and its proof (correct), but to what needs to be done for using it for rejuvenation, the real holy grail in the remaining years, optimistically there, to cheat death  for 1000 years, and know who to track (every emfubar will claim knowledge soon) and how to judge real progress, fundamental to separate wheat from chaff!

Theory of Rejuvenation-0

Rejuvenation-0 is increase NAD+, decrease SASP and cleanup blood flow. Surprisingly useless to rejuvenation-0 beyond emipirical justification, still critical to understand why, Dr. Sinclair's progress sets the bar for every rejuvenation practitioner. He gets the vote from me as to why life ages, humans, animals, bacteria, plants fungi - all we call life will age and why answers are outside medicine, in genetics.

Miracle 1 - Universality of Aging

Every life on earth ages, with no external cause. The crucial discovery is in functioning of the DNA, and the chance discovery by evolution of a repairable DNA, proof against inevitable errors in  duplication coinciding with repair! So fundamental is this trick that it was never rediscovered by evolution again, in fact earth DNA might have come from Mars, and even there from another star by hitching a ride on rock fragments or even the last universal great deed on a destined to doom civilization in another black hole!

Consequences of this lucky break of evolution started with sculpting bacteria, then algae, then sea life, which crawled to land infested with plants who had escaped earlier. The plants evolved to trees, leaves discovered quantum mechanics and photosynthesis began, which released oxygen as a waste product! Changed the planet till 2100 AD centuries, post which race to die like Venus began. The crawling sea life evolved to dinosaurs, who reigned supreme for 500 million years. But it ended 60 million years ago with a giant meteor strike which killed all life bigger than mice. Life recovered, as did evolution, which built humans a million years ago. Also, whales and elephants. All Eutheria - tiny animals to huge, have nucleus around DNA in all cells, the characteristic mark of these animals.

I know I am right by explaining the amazing Horvath determinations, and two wonderful experiments by Dr. Sinclair. Dr. Horvath experimentally divined the age of a cell from any part of the body and for all Eutheria, a common set of tables that correlated Methyl marks in epigenetics of an instance in Cp islands with calendar age to within 0.98. This shows many things, including that aging is an external causeless process. The fact that no child is ever born old, inherits from both parents as they were when young adults, regardless of age of parents means that somehow the pristine DNA is preserved and stripped of methyl marks way before birth (Happens at 4 cells stage!)!  What Dr. Sinclair did was to deliberately age one mice from a twin and in second, crushed and regrew the optic nerve of another rat by clever application of NAD+ boosters. All morons advancing other theories must age one of a twin and regrow one shot like optic nerve! Why do mice things some time work in humans, and can one predict when? They are Eutheria too, as are human cell slides. The slides are closer one way but only chemically so, and mice methods are in vivo. No, I can not predict when it will work or fail, but I know that there is a certain missing reason for failure. The earliest FDA (FDA-1) means all reasons for success are met, but one never knows. Risk-takers at first stage are volunteers, although I would use all convicts sentenced to die, if they agree to volunteer for commuting to life in prison and meet selection protocol. Likely to match one study.

Miracle 2 - Nucleus and adaptive immune system

By now, evolution had another big trick - the DNA for all vertebrate animals that survived and regrew, were trapped in a sac called a nucleolus within a cell. The DNA was isolated. How did proteins arise from genes in the DNA come to be. Through mRNA copies built in nucleus, still transparent to signal molecules, copying signal related genes. The mRNA copies exit the one way nucleus and combines with ribosomes to make the proteins. Thereafter, the mRNA died fast or slow by suicide, or exit the cell. This is where the second part evolution trick is used. All the Vertebrates that survived had an immune system, which was protected by white cells that roamed the blood channels. They had innate training to pick out and eat mRNA cells  There were two types to immune cells, innate and adaptive. Adaptive work, like innate, to eat the mRNA. But more, they remember the rest of the mRNA and develop appetite for that too. I know I am right by explaining how vaccines work, not just in humans but animals too! Guess what they did to lions and other victims of Covid-19 in Indian zoos and safari parks, vaccinated them with human vaccines with dose adjustments by weight! Poor sick lions, became like tired cats! Looks like even though delta-plus can infect after 2 vaccine doses, only mild Covid-19 results. However the spike protein is bio-active!

Why was it a big trick? It saved countless survivors from death by many viruses and bigger who evolved to forms for whom the unprotected DNA was an easy target. Unlike sea creatures, land animals made far easier targets (no water to protect)! As routine in evolution, survivors populate the future. The survivor attackers evolve to newer attacks. But some shields are much better than others, they save not only from one clan, but even from others the attackers will evolve to. Indo-Britrain-American vaccines against Covid-19 are not only effective against last -year versions but also against new bastards -   alpha, delta, delta-plus and lambda. Just pray that the newest version have a related spike too! That protein is the one the immune system is being targeted to eat.

Miracle-3 Liposome escape for intracell medicine

There is no intelligence in biology - the language that treats evolution and bacteria etc. as intelligent beings just is a fiction to make human language dramatic, interesting and normal. In reality, there are just chemicals that mix as per some schedule depending on concentrations etc. Most drugs we use as medicine have to penetrate many defenses, needed for other reasons. Any chemical eaten first has to face stomach acid.  Then it goes to where it stays and gets absorbed if absorbable. Then it enters the blood stream to the liver. Only then it enters the blood. If the target is in the brain, it still has to penetrate the blood-brain-barrier BBB. If the target is mitochondria, it has to penetrate the cell membrane and the mitochondrial skin. Typical rates are in single digit percentages, per obstacle.

The ridiculous numbers are so low and the effect so delayed, faster protected routes are needed. This is injections, may bypass the liver. The iv-forms do. Liposome (liposome-2) provide entry into cell easy and protect from acid, low solubility and liver by surrounding drug nanoparticle by phospholipid sacks. The path is slow but better performance even to injections as cell membrane penetration happens for free. Nothing but ignorance, now past, prevented this from me. Liposomal drugs are dramatic improvements over all eaten drugs. By buying a home liposomal machine and material, amazing self-experimentation will follow! Rest of my life! Can and will finance it in India with the USA SS dole. Wonderful return from money given to me!

What drugs? Liposome is free of rejuvenation, it effects all vitamins seeking protection from stomach and with solution problems. Also, others like glutathione (a blizzard of fairer skin shall drive our ladies bananas, no need to go for whites!). And certainly NAD+ and blood path lining boosters. Even senescence garbage collectors to reduce SASP. Here is 20 year summary, boost NAD+, reduce SASP, cleanup blood channels. That rejuvenates body, to keep organs happy do one of three methods,  intermittent Yamanaka factors at low concentration and subset use; my mRNA drugs and age-reduction vaccines; and filtered or diluted blood, never using any foreign blood. The idea of reduced concentrations applies to Rapamycin too, it will be experimented too by me at 5mg/week, given that no drug company has incentive to test (and potentially be subjected to subhuman liberal flak) and the dosage mentioned is under immunity reduction. I think that India is the right place to organize FDA-like trials for all under incentive drugs and Hygiene or Helminth factors, even ayush drugs. We might escape Nanoparticle disaster in mRNA aging vaccines.

Rejuvenation

Rejuvenation-i does nor indicate sereialization but independence. Rejuvenation-1 methods are concurrent to Rejuvenation-0 and can be used as soon as ready for directed medicine in organ cure.

The purpose of this write-up is not self-propaganda or teaching knowledge. I hope that my notes benefit another reader. It will certainly benefit me. Like vitaDAO of Dr. Grey, the sole incentive for furthering the tasks is to benefit from their products! It finally combines my interest in  understand aging to a realistic doable program, consistent with my limits and my income. No imaginable disability can prevent me from self-experiment with home developed Liposomal drugs. Despite all future evilness, I can declare victory. Lifespan.io has already reviewed scientific projections of alternate scenarios assuming aging is defeated by 2030 (singularity come) and ethics are not every one to their own developments and die if poor. VitaDAO is decentrealised and differently motivated.

Ethics of Rejuvenation is important, but too small to fit here. Some sci-fi has dealt with population control when resources run out, as people do not die. It is being stuck on astronomical escape over a rabid radioactive planet in the TV100. Solution found is death penalty for minor crimes. Artifact solved by shooting 100 to locate usable valley - found and repopulated. Or a buried escape population gone underground from fall out. Solution reverts to death in the ring like Romans. Artifact solved by tech smart people who dig them out with new tools. A death tournament for old in a sci-fi movie. Solution is weak message from people accepting old. Planetary resolution (IE suicide) for all above 60 in a star-trek.Left unresolved as the doubter follows tradition in the end. The strongest point is you can limit population by preventing births, new blood not really needeed when the expirenced work past retirement! How is the top- of any experience based organisation set itself up is left out! Currently, top man retires in 1-2 years, creating log n advancements in n person organization. What if retirement age ends?

Limitations and speculations

Aging covered so far is like keeping a car alive by changing the oil and eliminating any dust contamination. It is best called rejuvenation-0 with NAD+ improvement, blood channel improvement and SASP reduction. I expect 50 years from it giving time to develop for rejuvenation-1. Top 3 are Yamanaka factors, mRNA drugs and dialysis with dilution or filtering.These will give 50 more years. Within a 100 years, we should be capable of artificial organs and novel brain fixes. That is rejuvenation-2. That will likely give 200 years. What then? I am not worried for some thing will crop up. In any case, a pleasant 300 year life.

Pursuit of developments

Death from natural causes can also be predicted, called grim age, from Cp island methylation. 

To those seriously interested, watch for three rejuvenation.1 technologies

1 California for Yamanaka factors based rejuvenation drugs

2 Me for mRNA drugs and antiaging vaccination. Dr. Malone invented mRNA vaccines and remains very concerned with bioactiveproteins killed like spike protein! I am giving many thoughts to industrial scale mice farms like worm farms, be available to all scientists world over. Despite strong ideas, empirical work on mice is needed, and such farms will be useful to all scientists, drug and Food companies. Another track for me is Liposome drugs.

3 Drs. Conboy for blood dilution and filtering by dialysis like machine. Rather than 3/week, once per trimester will be enough for all aged. India can be low cost hub to the USA high-quality high cost machines.

Smart consumer

There will never be a sharp progress border, cutting edge research likely to fail repeatedly, availabity for all politrical issue with pro and con, benefits to chosen of early investors and real contributions very difficult to distinguish from majority thuggish commercial practices. I advcate restriction to explicit recommendation from Dr. DeGrey, Dr. Sinclair, Drs. Conboy (both), Dr. Horvath, Dr. Yamanaka. Whoever (your readings and judgements of issues) if they conflict! Avoid any and all judgements if they prefer to be quiet in full!

0 Links

Liposome-2

 

The Latest link

Essential forward context.

This essay continues this. Don't be stupid to read this essay missing necessary precondition.

Follows from past that for commercial+health reasons, it is safe to limit to bioavailability, protection and ignore targeting reason, I will use liposomal form. These are built at home for cost, independence from commercial availability, and know you are within expiry; never mind you might fail to get the amount of medicine paid for. Targeting can be avoided for vitamins, glutathione, NMN, endolithials and senolytes.

 How does liposome work? It surrounds the drug nano particles with a phospholipid sack. Stomach acid or liver are protected from. It then enters blood. Blood circulates in body within a heart beat.It takes time for the sack to stick to cells. So the sacks end up all over. How do they enter into cells? Of the three things that make the cell membrane (unlike plants, all animals have no wall) are PHOSPHOLIPIDS! Just sticking enters the contents into the cell! The right kind of phospholipid will deliver to the right kind of cell. But we leave targeting for the doctor, all s/he has to tell you the right phospholipid. No doctor needs to oversee these liposomal drugs. Just saving from acid, liver and solubility will give you massive improvements at much lower doses. 

 

I have decided to use sublingual 500 mg NMN/day at the start of liposome experiments and expect 250 mg fast and 100 mg eventually. Rather than MIB-626, I intend to use L-arginine from (3 gm to 0.5 gm) and 50 mg Pterostilbene from 200 mg to 50 [all per day to liposomal goal].

MY BIAS!

I do not think I have any, but quantities are mentioned to allow others to determine their own, experiment with labeled suppliers and dosing schedules. Only if your citizenship allows bio-hacking should you even consider my numbers, only for self, they will change randomly with experimentation, without warning.

Known doses of Dr. Sinclair and FDA accepted numbers are viewed as safe doses. All my doses are for 5'7",70 kg, Indian race person coming from compromised Hygiene/Helminth civilization. Conceptually, I have roman arena gladiator rule of "if it has not killed me, it made me stronger" , "I don't stop tired, only when done" and the Stoic view of life as Aurelius said better than me "Consider the immense gulf before you, and after you, what is the difference between life of 1 day or many human generations. Only this - your life must be just, speech and promises kept to others. You will daily encounter sinners, how can you grudge them anything, for they are stupid and don't know what they miss". To this I add development of can't lie technology, that works in the open through zero knowledge proof, safe even from holders of quantum computers.

As opening referenced in start, I consider blood based rejuvenation as a start, like changing oil of a vehicle - useful but small part of life extension. You raise NAD+, cleanup SASP (not knowing the details of how caused, at this time a black box fix is doable) and fix blood delivery. Liposomal/NMN for NAD+. Liposomal/Fisetin by mayo protocol, every 4 months, Liposomal/Quercetin and strawberry for  senolysis, Liposomal/Pterostilbene and L-arginine for blood lining revive, K2+D3+calcium for bones, Heart drugs and brain-injury drugs. Complex expensive mix, can live carefully only, only in India for now, will rise again as phoenix after life extension and adequate income. Greatly expedited departure if the  massive villain Tikat succeeds. Setting up Aging clinic with MBBS doctor to run by my self-hack in return for my share.

Aging Fundamentals

My logic is simple – aging is the accumulation of senescent cells delivering inflammation chemicals in SASP. The bad things of SASP rise with age and continuously reduce, NAD+ with age. You must do 2 things at once – increase NAD+ and reduce SASP.

First retard every note like – which doctor? Aging and cancers are outside the competence of most current doctors, and specially those specializing in aging. Neither processes inside a cell nor genetics is even remembered by doctors, aging is harder than any cancer! Cell medicine does not mix with traditional medicine, it is not based on germs or viruses. Immune system functioning is central, as is immunotherapy. Messenger RNA drugs are basic. Liposome is not an afterthought, but central to cell medicine, and best made in the kitchen.

2021 shall go down in Human history as the year that Rejuvenation (not Aging) was explained in a form no separate chemistry or Biology is required to understand aging and the understanding is free of ethics and religious nonsense. Medicines work equally well on religious Leaders, politicians, rabid criminals and morons. Anything that has that property, henceforth abbreviated universal applicability, is considered to be science.

That underlies truth and abbreviated TRS for Triaged Rational Skepticism defines me, and scientific living occurs when all facts pass TRS filters. Triage insists on determinable truth in useful time, space, context and money appropriate for the context. Clearly, then God is a meaningless concept unless demonstrable by a TRS test. TRS requires that the test be carried out by concept pushers or their Rishi in a noncontroversial form (super majority) accepted by my Rishis. NOTE THE ABSENCE OF ANY DEMONSTRATION BY ME, God may well exist and control others, not me or my believers who consider such concepts, independent of TRS proof, as irrelevant as continuum hypothesis, await demonstration and pay of appearance costs.

TRS is positive determination of my truth and those I respect. A negative, more general method is to define science as collection of theories that have only falsifiable context appropriate theorems.

Super majority is needed of acceptable (my and others Rishis) jury to tide over undetected bias. Unlike humans, facts have no prevention of repeat trial. The essential problem being dealt with is the reality that not all facts, considered by me, are scientific facts (for which legal facts form the least reliable determination). Admitting possibly erroneous facts rapidly changes the logic to linear logic, which allows quantum logic as well.

The admission of immortality as a feasible fact causes many changes never considered by me. The notion of punishment appropriate for a crime changes drastically in a world that admits immortality. The notion of a logic immune to erroneous facts is needed, and the requirement by me is that the system must distinguish between facts whose negation changes little to those whose negation is drastic.

In classical logic, anything follows a single contradiction.

Scientific immortality, despite mathematical objections to it, is possible if one can posit that there is an upper geographical limit to natural disasters by converting human consciousness by brain download of discrete information and brain-circuit weights and recovering the information to silicon circuits like ml nets. This allows the information duplication, travel at light speed at which time elapse is zero and allows copies to be placed far enough away. All this will likely happen in 1000 years.

So the problem is in the first 1000 years. Different parts of our biological body require different interventions, as Dr Aubrey de Grey believed and solved in high level by him in 2001. He predicts 2036 at solving enough in all 7 fronts. He identified the 7 fronts and high level solved them, created SENS and is easily the saint. Dr. Sinclair discovered resveratrol by 2004. In the decade of 2010, he discovered NMN, MIB-626 by 2021. Dr. Grey funded Drs. Conboy parbiosis in 2005 and does that full time now and greatly supports medical tourism. In the decade of 2010, Drs. Conboy found the immediate lesson of hetrochronic parabiosis wrong and argued correct interpretation to be blood dilution. Dr. Yamanaka took the major step of deriving plenipotentiary cells from any cell in 2007. Dr. Horvath defined methylation and showed correlation by 2011 to calendar age at 0.98 significance level. In 2021, he extended the same table to all eutherians, virtually every land animal bigger than a mm. It proves to me that aging is a cellular epigenetic process. What is common to all such animals? They have a nucleus IE a sac around the DNA, one way for all mRNA. Signal proteins enter the Sac, cause the DNA genes to be copied to mRNA. mRNA exits forever the sac, matches the ribosomes in the cell body outside the sac, unites with them to build the protein that then exits the cell. The mRNA itself dies fast, slow, or exits the cell. Outside are innate immune cells which eat such mRNA. There are adaptable immune cells too, which can be trained, that is how all vaccines work. Some adaptable cells detect bad cells as any that have an mRNA part. In the process, the rest of the mRNA is bad too, and they get trained for killing things showing as rest. That is how mRNA vaccines work, the rest of bad cell is the spike protein for example. Any Covid-19 virus with spike is attacked, no matter what the pathogen evolves to, just hope that the new bastard has a spike too. I, Dr. Arya, have proposed that parts of SASP be attached to mRNA and deliver mRNA drugs to target aging and cancers by quasi-vaccines or mRNA chemotherapeutic drugs.

Throughout 2010 decade, continuing to this day, Yamanaka factors in low concentration, applied transiently, non-cancerous subsets, have worked. This gives doctors a central role in rejuvenation. Another direction are immunotherapy interventions using mRNA drugs and novel mRNA vaccines. Both these technologies complement blood dilution offered by Dr. Conboy. I recommend tracking California for tracking Yamanaka factors, Cancer research for immunotherapy, and Dr. Conboy for dilution, medical tourism for inexpensive solutions. ALL claims to follow above techniques are commercially fraudulent exaggeration and should only follow reliable visiting evaluations acceptable to the major medical figures Dr. deGrey, Dr. Sinclair, Drs. Conboy, Dr. Yamanaka, Dr. Horvath.

Which system is better – Allopathy or modern medicine, Ayurveda, Unani, homeopathy or something else as Chinese medicine. First, the questioner is a moron! Any question so is mad! The proper question is “name the ailment” - what is better. Second, name the dangers of other area treatments! Third, distinguish between treatment and cure. I have a clear-cut position about this. Only treatment is MM. Other systems can damage you by heavy metals. MM is perfect for germ-diseases. If you can bear it, save money by symptomatic OTC drugs. The MM is not able to cure. When it comes to persistent diseases like diabetes, heart, etc.; or cellular like aging and cancers; there is no cure in MM, people will get more or less the same in other methods. The odds are probably better in other systems. Homeopathy is always criminal! Hygiene hypothesis HH considers the cost of external protection to non-adult patient’s immune system. Although public health measures such as sanitation, potable water and garbage collection were instrumental in reducing our exposure to cholera, typhoid and so on, they also deprived people of their exposure to the "old friends" that occupy the same environmental habitats. The rise of autoimmune diseases and acute lymphoblastic leukemia in young people in the developed world was linked to the hygiene hypothesis. If nothing but total lack of infection from Covid-19 in all lower classes has greatly strengthened my belief in HH and helminthic treatment.

Fisitin Mayo protocol

 

The Latest Link

Fisetin is 2019 news. Yet it is caught up still in USA Law, almost as bad as in India. I have decided to go through it. Senolyte maintenance will be Quercetin and strawberries. It is a Flavonoid. All my major goals are done, I have a meaning of life in "Learn to live for Life itself" and I dare to be "happy" at last. Mayo (Same world-famous Mayo Clinic, Minnesota, USA) protocol is two twin/consecutive-dates doses' a month apart

Ref for below

By now, most people with an interest in health are familiar with antioxidants like resveratrol or quercetin. While these compounds have been widely studied, research into a lesser known antioxidant called fisetin is only just beginning in 2019 . Early studies suggest that fisetin is a powerful weapon against aging with a number of other medicinal effects including antioxidant, anti-cancer and anti-inflammatory benefits. If you would like to learn more about fisetin and what it can do for your health, please read on. [Arun: as bio-hacker, I will take it and share my experiences. It is safe from FDA-1 studies to my level of risks. I refuse to wait for FDA-3 after which most likely, it will be open to all]

Ref for below section 6

Follow the risk mitigation strategies outlined in Section 6

• At the current time, the only form and dose that has been tested in phase 1 clinical trials is the so-called "Mayo Protocol"

• The Mayo Protocol consists of taking 20 mg/kg body weight of oral fisetin on two consecutive days and repeating the same dose, one month later

[Arun It means 2 doses of 1400 mg now two days and repeat after a month. Mayo Protocol may be declared unsafe, but is likely safe. It is likely not optimized for efficacy, but that is the price of hurry. Healthy aging is job 1, provided safety is likely! I consider self smarter than any non(aging specialist) and have contempt for gerontologists and geriatricians, IE Dr deGrey effect! Every one not a scientist is aging stupid, politicians and Brahmin especially.

My logic is simple – aging is the accumulation of senescent cells delivering inflammation chemicals in SASP. The bad things of SASP rise and continuously reduce, NAD+ with age. You must do 2 things – increase NAD+ and reduce SASP. NMN+Pterostilbene raise NAD+, Quercetin+coriander clean up senescence. In current state-of-art, NMN => Liposomal(NMN) with separate NO booster, and add to quercetin with Fisetin. I love strawberry which are way better than next Food source (apple), love the idea of boosting medicine by regular eating strawberries!

First retard every note like – which doctor? Aging and cancers are outside the competence of most current doctors, and specially those specializing in aging. Neither processes inside a cell nor genetics is even remembered, aging is harder than any cancer! Cell medicine does not mix with traditional medicine, it is not based on germs or viruses. Immune system functioning is central, as is immunotherapy. Messenger RNA drugs are basic. Liposome is not an afterthought, but central to cell medicine. Liposomal drugs can be easily made at home, and no sense in wasting money to buy them. All they are are enclosure of nanoparticles of drugs by Phospholipids surround. They are useful to control bio-availability and targeting, among others. Every non-soluble vitamin, Glutathione etc. are better absorbed (better is twice to hundred-fold) and saved from stomach acid and liver! The layers are immune! Nano-retention is use of standard mixie and coffee-maker! The phospholipid are bought as a powder. ]

ref for below

Longevity Strategy

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• Created by Michael on 04/26/21

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The cornerstone of our overall approach to take advantage of the amazing opportunity handed to us is to create, apply and constantly improve the most effective "Health & Longevity Strategy" that we can implement at present.

Learn More ...

A Step-by-Step Approach

To split the subject of achieving long-lasting health into manageable parts we have divided our strategy into five pillars that are further broken down into individual building blocks. 

Most processes in our body are highly complex with many interconnections: e.g. our emotional reactions influence our hormones, that in turn affect numerous processes in the body; our toxic burden has an influence on our digestion that can directly affect our brain. 

Although this obviously holds true for the building blocks as well, we structure them in a way that they can be addressed one-by-one. It also allows us to research and improve them individually.

Pillars & Building Blocks

Primary Prevention

• Nutrition
• Physical Activity
• Detoxification
• Sleep
• Advanced Nutrition
• Basic Care
• Protecting the Body
• Preventing Diseases
• Self Testing

Mental Well-Being

• Basic Mental Well-Being
  
  

Health Monitoring

• Blood Panel
• Basic Early Detection
  
  

Integrative Medicine

• Functional Testing
• Heavy Metal Detox

Rejuvenation Therapies

• Risk & Benefit Analysis
  
  

Tools & Resources

• Compound Library
• In-Depth Practical Guides
• Additional Resources

 

Knowledge Pool

The strategy draws knowledge from a wide variety of sources

• Medical Research
• Rejuvenation Research
  
  
• Functional & Integrative Medicine
• Traditional Chinese Medicine
• Ayurveda
• Integrative Dentistry
  
  
• Manual Therapy
  
  
• Preventative Health Assessments
• Precision Medicine

• Nutritional Science
  
  
• Evolutionary / Ancestral Health
• Movement Science
  
• Environmental Medicine
  
  
• Quantified Self
  
  
• Supplementation

• Self Development
  
  
• Meditation & Mindfulness
• Yoga
  
  
• Trauma Release
  
• Dance, Art & Music Therapy
  
  
• Philosophy & Spirituality
• Psychology

 

Liposome

 

The latest link

My essay on cell medicine as distinct from Allopathy and more dealing with senescent cells for cancers and aging gave me a tremendous boost to understand liposome. It is worth knowing and doing to increment massively the powers of vitamins and age improving NAD+ supplements. I am sure you know nothing about it. It is a manifold of many many hollow phospholipids, each appropriate for coating some medicine in a phospholipid layer and the coat is used for many things including targeting, protection (stomach acid and liver), improving (by a lot) the bio availability, reduced toxicity and increased permeability across membranes etc. The material can be bought separately, or in some cases made at home. I now do have a calling beyond cell medicine, really included in it, to encourage buy only liposomal medicine or do the procedure at home with simple mixie type machines and espresso coffee maker. Liposome is somewhat new,  1964. It has taken 57 years to today's applications, major recent success in the USA of kitchen making. The only block in Universal application is ignorance.

Intuitively, the idea is to milkify powders. Milk is like an impossible solution of oil and water in the cheese liposome. This mixing gives tremendous power to cream (to fatten). It is really sandwiching insolvent into solvent by constructing a phospholipid layers by two surfaces - a hydrophilic and a hydrophobic bilayer and inserting nanoparticles of insoluble, the whole is then soluble. Within the human body, the medicine is protected from stomach acid and liver but easily bared in right internal tissue which digests the layers. It is a good way to eat insoluble vitamins, glutathiones, aging chemicals like NMN or NR etc. It looks like nanoparticle technology is needed, but that can be achieved easily.

Phospholipids, also known as phosphatides, are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group, and two hydrophobic "tails" derived from fatty acids, joined by a glycerol molecule. Marine phospholipids typically have choline, ethanolamine or serine. Phospholipids are a key component of all cell membranes. The phospholipids are amphiphilic. The hydrophilic end usually contains a negatively charged phosphate group, and the hydrophobic end usually consists of two "tails" that are long fatty acid residues.

Milk exists despite what it is – a suspension of oil (ghee) in water, not normally possible but possible due to cheese part of milk, which acts like a liposome. Now think of suspension of a non-bio available molecule like a vitamin which does not mix well with water as K2 or NMN. Even bigger, like Glutathione. While not bio available in powder form, it will be easily up to 100 times more available in liposome form! Such a material is difficult to survive extended periods in a shop, but the liposome former can be sold separate and special mixie like churning can create an acceptable liposomal variant at home. People don’t, but can in a method I will launch to make liposomal vitamins and drugs at home. Why pay 30-100% increase in cost for a product with suspect goodness. IN A LIPOSOMAL NMN IN AMAZON USA PAGE. MANY CUSTOMERS WERE WORRIED THAT SOME TIMES WHAT THEY BOUGHT WAS CLOUDY, SOME PRODUCTS WERE CLEAR AND SOME CHANGED IN DIFFERENT SAMPLES OF SAME BOTTLE. Helps to understand Liposome semantically! Best form Liposomal form at home to prevent precipitation over time.

What is needed? A utensil and commercially sold liposome precursors like LipoSorb. The utensil is a vacuum driven mixie like. The idea is to use regular mixie for 5 minutes and the advanced for about the same time. Consume liposomal form in a day to, often within a weak. You can get more homie by making own liposomal media from milk!

WHAT IS YOUR INTEREST?

1. Never have I seen a technology, new and experimented in the USA, but missing  and required even more in India. There is a small hassle-factor in kitchen liposome, but the situation is like tailoring, one can buy ready-made, but the art of stitching is taught to all women and unlike the USA, THE ENTIRE GARMENT IS NOT DISCARDED after minor functional defects. Of course, one further this thread in thought and imagine all kinds of self diagnosis appliances and vehicles with a diagnostic port into which the diagnoster is inserted and that determines what to replace to get a target functionality. End of caste of mechanics in shops and workshops! In fact, one can allow internet add-on, which connects to remote mechanics for remote diagnosis, a perfect port for your car.

2. Liposome is excellent for bioavailability and protection from two enemies of all drugs - stomach acid and liver. In most cases, what matters is concentration in circulating blood. One way to get that is intravenous or correctly injected drugs. Other way is under the tongue - sub-lingual method. Third is nasal drops. Even better is Liposomal, the material faces stomach and liver in liposome shield of phospholipids that transparently dissolve in blood circulation. THE METHOD WORKS FOR ALL KIDS OF THINGS AND REQUIRES NANOPARTICLES to be surrounded by phospholipid. It is virtually impossible to do it but for high temperature draw of phospholipids drug powder doable at home with espresso coffee maker! Of course, one can freeze-dry the solution for ready-made liposomal powders! The cavity in liposome must allow one molecule of drug, and different drugs have different ideal liposome. However, somewhat bigger cavities are ok,  perfect mix-match research for, perhaps cranky dreamer, retired like me.

3. Even if I fail generally, singular successes in SUPPLEMENTS AND OTC are usable. I can safely use self body as tester, for the worst case is no different from direct ingestion! Ideal time to test psyllium is constipation and cough powders is when  coughing! Why just take drugs when science and bank balance can benefit?

 (To be continued)

Decentralized democracy for all in all

 

https://image.shutterstock.com/image-illustration/tron-coin-trx-blockchain-cryptocurrency-600w-1028721331.jpg

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Given that lot of what follows attack political comment, true for some, false for others, something else for some, I invent the notation <x> for every x, whose truth value is uncertain for political reasons. Given the universal nature of the essay, it will never complete. Decentralization is considered superior, but sometimes inefficient and then an adoptable centralisation, with unease and checks and balances, and programmed to self-destruct at some democratic point. Both visions of George Orwell were not about left and right, but left/right denunciations of centralisation. Best  think of this a series of independent adoptable ideas.

The best democratic system of all is in the USA. That is not the opinion in less developed world, Vietnam, Chili etc. It will be wrong to even try to transplant the system. Yet the largest democracy in the world is India and likely to dethrone even USA in cumulative economy size, output by 2050, per capita by 2100. That is because there are systemic problems, shared everywhere, but unsolved in US. India is on rolling path under Modi,  the BJP has a depth of competent leader,  opposition indulges in <stupider than thou>. All the deficit of the USA are also unsolved and unaddressed here, too.

Top deficit is the uneducated public, wrongly considered to be adequately educated to take serious decisions. Anyone can raise this point, and any effort to make people more in line with that anyone, immediately lose freedom. Today's India and USA have some freedom, which is the envy of other models. Still I write of freer citizenry in these too, free to commit suicide, what is the ideologue's problem! People make better decisions in groups, the essential justification for democracy. Problems of the commons justifies individual wealth despite the old philosopher cry of "all wealth is by stealing". How can a believer in freedom, democracy and private property talk of a better system? Not just for less developed, but developed as well?

One idea is "educated benefits for uneducated". For every decision identified as important by the government of the day, citizens are required to find one in the educated class recognized by political parliament by consensus votes that eliminates dictatorship of the majority, restores freedom. The citizen is inconvenienced to find a concurrent thinker, but finding one is nearly always possible. The effort in finding one, and of ensuring his solution is similar, will force all voters to discuss issues. Have someone to blame. The educated are periodically relicensed and controlled by votes, also examination both. The exam may be biased, but that will only force the licensed to answer biased and later advise in freedom.

Democracy is restricted by USA type checks and balances, hence do not need further ink.

A very novel idea is "consensus voting". Every significance beating elected can vote the cast vote percentage. This is done in some cases to prevent dictatorship of the majority. I believe in careful drafting of idea, expressed in call for investigation, use of police powers etc. Every winner can invoke police protection, legal investigation etc. The votes once used can never be reused. The reuse of votes, if successful, is forbidden because a political definition of successful is dangerous, although a legally decided determination of success may work. Best forbid it, complainers now have to find sympathetic elected. Many political abuses will happen, <wasting powers> But the bias in defeat of majority dictatorship, can not go beyond launching <useless> investigations. Many political issues can be silenced by consensus note. Every <moron politicin> in India, can ask for <sit> for every matter, solution is consensus vote sit formation. The limits apply to majority also, use up limited supply in investigation of opponents! Every <idiot> politician can waste useful powers for <useless> investigation. Consensus voting can act as a powerful "checks and balances" in all democratic ideas. Autonomy of police must happen like law and election commission.

A basic health difference is in treatment versus cure. Every cure is a treatment that eliminates the root cause such that there is no relapse. Allopathy has no cures for persistent or cellular diseases (cancer or aging), but is very good at treatment. From the viewpoint of public health, a government must provide treatment for all situations, irrespective of remit-relapse situation. It leads to ethically difficult triage situations. Every development level must have instituted triage committees which control health expenses and can be invoked on any patient by any citizen in "anonymous yet consensus voting limited" manner. That is a fundamental improvement in all investigations.

A basic difference is in untriaged hurry (time or cost) and importance/usefulness. By construction, human are intrinsic incapable of differentiating between two, leading to<exploitation|intelligent use> in selling, auction, product placement in stores, online blurbs, advertisement etc. To make money, you can raise the price, or sell more. Price depends on competition and quality-perception. Amount sold depends on need-perception, availability etc. Amount sold depends on price, service, advertisement etc. I thought I had become a smarter buyer in the USA. Not really, USA companies deal with Amount sold method of more money. Indian stores depend on rates, never mind amount, and suffer from no repeat sales, possible in decentralized markets. Advertisement is harder and Balkanized. All USA companies are considered evil. Politics is, like selling, a matter of perception. Perception is by greasing the journalist. Most are smart enough to avoid instant gratification, but honest enough to remember the feeder in the long run. Here is suggested great friendly Press - Feed good stories to chosen journalist by policy leaks and tight-lipped government. To avoid this, all leaks must be investigated, benefits in market of relevant information required, transparent secret communication needed. That can only be done by my encryption that can allow nation-specific open encryption (jointly op enable solely by sender nation only on enforced need for warrant for some time only). Complaints are stronger centralized.

Requirement for all systems - money

Every moron can describe an ideal system. Continuous funding is needed, and I describe every finance less system as dream idealistic system not-worthy/beyond my interest. Tolerable democratic systems are product manufacture and advertisement/selling, dedicated taxes, insurance or charity.All other income can be pooled and allocated by legislative groups. The new idea is dedicated taxes, deliberately away from politician allocation. Nothing short of nationwide referendum tied to elections can instantiate or retire them, and must identify the fraction of taxed activity or income. The reason is to remove the income from politicians without triage with other taxed activities.

Basic to democracy is a period as tax on all mass-media. It is some multiple/fraction of income bearing periods. I predict united squeal from all media when it becomes a serious proposal. It is like a tax, although demonetized. This time is allocated to all significant ideologies represented in Parliament above significance level, numerical population basis. I suspect tremendous cleanup of democracy. It is advisable to limit the time only to expenditure limiting parties, completely elimination for unlimited expense characters. Evolution can be used to determine exact rules.

The goal in above is to encourage politicians to believe without corruptions of money and time-saving in collection. Despite any court judgments, they can be effectuated by expanding free minutes of deficient candidates against well-funded.  The financial interests force non-balkanized politics (non-party candidates get nothing). A party is better off doing concentrated local, not diffuse wide-spread performance.

I believe in nationalized, but decentralized food and and eating powders. I have the practical experience of inevitable natural corruption in edibles by corrupt inspectors, under religious figures in belief that corruption will be lower despite stiff competition between figures! The domains are drawn up with overlap.

Impossibility of inspector management should be accepted. The corruption rates with be lower in services manned by time-bound foreigners with post-service interval, somewhat like IAS in non-resident state. Neither belief in goodness (perception matters more than reality) nor foreigner honesty is the cause. Difficulty of relations is the cause for lower corruption. All inspectors are not same. Qualitative judgment inspections can only be done with multiple overlapping qualitative situations, the totality smaller, factoring out foreigner inspected and quantitative inspections.

What I take and recommend

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Abstract: A menu of things I take for indefinite life. Missing are three vital information, company, marketeer and dosage schedule. Until this information is given, the reader is at the mercy of marker, and manipulation by sub human marketeers, advertisers, companies and dangers of too little or too much dose, too frequent or too small dosing. It does provide a basis for further study by intelligent googling. So don't use it construct own menu, only on doctor advice.

Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer.

This is an essential reference to the totality of the program. Sole purpose is to learn on chemicals involved and totality. I expect 20 years Horvath age gain, post 2030, by which time, some clinics will offer Drs. Conboy and my procedures commercially and likely hold FDA or FSSAI license.

While there is ample evidence to indicate the health benefits of diets rich in fruits, vegetables, legumes, whole grains and nuts, no specific food has been acknowledged by scientists and government regulatory authorities as providing a health benefit. This applies to all phytochemicals considered useful.

Another severe problem with almost all plants or fruits is a fundamental problem in English of being able to fool people by trace amount as containers of desired chemical, which invariably requires tons of foodstuff to be medically useful, consider this abuse sub human and warn my readers as reading all ad very carefully to ensure enough dose beyond low price.

Every one, suggests 1gm of metformin in divided doses every day, important even if not diabetic. Expect 5-8 years just from this. I am one and also take acarbose with age extension properties.

From Dr. de Grey, I recommend quercetin for senolysis and dhaniya (CORIANDER) for apigenin.

From Dr. Sinclair, mib-626 or NMN, pterostilbene and TMG.

From Drs. Conboy, dilution aging dialysis when done. To eliminate CD38 and TGF-beta1.

From Dr. Arun Arya. mRNA drugs and vaccines when done.

There is a reason for selecting the model pic as cover - since overall food for graceful aging must reduce calories. Best 3 interventions in order of importance are fruits+vegetable, exercise and fasting (calorie restriction better).