Aging fight: call to arms

I am a scientist, was in bell labs, spoken at Harvard and was assoc prof at university of Massachusetts for many years. I was hit by TBI which I fought as a scientist and had partial recovery in 2020 from TBI after the shock-death of father! Important to give you fast believable intro to me as an atheist scientist who believes in indefinite life, healthy because of current efforts and future age reversal, no longer sci fi!

This is after Nobel-assured research by Dr. Sinclair at Harvard in Aging theory of information. What he has shown is that Horvath clock counts marks in cellular genome DNA and epee-genome IE epi-DNA as well. Aging is simply senescent cells from proteins forgetting where they should repair DNA cuts and/or where to return

https://aaqg-arunarya.blogspot.com/2020/06/aging-proofs-digilog-how.html

DNA does not change after birth - way before that! Epigenome has finite life and genes coding recovery lose proteins to wrong places. Genes make RNA then proteins. Tight coiling of DNA at some places happens due to proteins built by some genes for repair DNA - called gene shutoff. The repair proteins must prevent  generation of new cells while repair. This exclusion circuit is characteristic of all DNA in every life form. The evolutionary advantages are overwhelming, so that only DNA with the atheist scientist who believes in indefinite life, healthy because of future age reversal, no longer sci fi!

In any case, DNA does not change over life while epigenome changes. By stripping away epi-layer, you not only get ageing stop but age reversal!

https://aaqg-arunarya.blogspot.com/2020/07/amelioration-of-ageing.html

Horvath was a bio-statistician. Using primitive of 2012 AI, he managed to get very close bio-age numbers to  the actual calendar age and was very accurate in predicting remaining life for most from age-caused demise. Since then (to 2020) other markers and sites have been used to build other clocks. They cost $300 to $500 in USA, amazon-India used to do them but no longer, in fact no one does them here.

I am starting a company to survive on doing Horvath readings on the side and mouse-test of serious proposals on the side, including novel once. Rs. 10,000 per test is doable and should work at Indian
salaries. Certainly meshes with self-sufficient movement of today. Chemicals can be imported till production happens here. Reading microscopes is where costs are lower.

Horvath clock are absolutely important for scientific investigations in to ageing ideas. I know that metformin+acarbose extend life by about 10 years but the number is vague and can be sharply determined.

I also have a revolutionary idea that will certainly improve modern medicine allopathy. FDA tested drugs are used. There is NO pre-medication test of drug appropriateness! This is done in some cases (penicillin verbal quiz) but not enough! I have determined by experience that while I am not sensitive-penicillin-freak, using it to cure teeth-pain after and during root canal procedures makes me throw up food, while TZ is no longer effective. Ceftum is the answer. Why use sinusitis drug in root canal?

 This double-masked, multicenter, randomized clinical trial compared the efficacy and tolerability of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial maxillary sinusitis. A total of 263 patients with acute bacterial maxillary sinusitis were randomly assigned to receive 10 days of treatment with either cefuroxime axetil 250 mg twice daily (n = 132) or amoxicillin/clavulanate 500/125 mg 3 times daily (n = 131). Patients' responses to treatment were assessed once during treatment (6 to 8 days after the start of treatment), at the end of treatment (1 to 3 days posttreatment), and at follow-up (26 to 30 days after cessation of treatment). Clinical success, defined as cure or improvement, was equivalent in the cefuroxime axetil and amoxicillin/ clavulanate groups at the end-of-treatment and follow-up assessments. Patients in both groups showed improvements in symptoms of acute sinusitis at the during-treatment visit. Treatment with amoxicillin/clavulanate was associated with a significantly higher incidence of drug-related adverse events than treatment with cefuroxime axetil (29% vs 17%), primarily reflecting a higher incidence of gastrointestinal adverse events (23% vs 11%), particularly diarrhea. Two patients in the cefuroxime axetil group and 8 patients in the amoxicillin/clavulanate group withdrew from the study due to adverse events (P = 0.06). These results indicate that cefuroxime axetil 250 mg twice daily is as effective as amoxicillin/clavulanate 500 mg 3 times daily in the treatment of acute sinusitis and produces fewer gastrointestinal adverse events. cefuroxime axetil, amoxicillin/clavulanate, acute sinusitis.

Comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial sinusitis

After patient-intervention(IE by me), another antibiotic eeftum is used, known to some dentists only.. This should never be patient duty. Instead of list of possible side-effects, the physician must use a pre-medicine to know expected side-effects. It can be included in FDA-approval time as a sub-phase to figure out expected side-effects. Double bind tests must determine effectiveness in best adapted patients, the med may still be useful despite overall flunk.

I also have a another revolutionary idea that will certainly improve modern medicine allopathy. FDA trials weigh each participant equally. That is in spite of knowing that effectiveness may depend on ethnicity and sex of the participant. That information must be kept and double-blind results factored by population profile. India can and should establish post FDA approval agency that conducts trials on FDA-approved drugs only that determine efficacy on population profiles!

Amelioration of ageing

Why do we age? Digilog reasons, epigenome fixable.

Methods for fix?

1. Evolution, slowing ageing only, no reversal, needs no medicine. Argues for fasting (creating scarcity condition to use energy for DNA repair using sirtuins, use old proteins in mTOR, use AMPK for correcting metabolism IE diabetes in peripheral tissues), exercise, full sleep and hot/cold. Orthogonal to all else, hence benefits add. Can be done now.

No chemicals available to help. IE wheatgrass, Shilajeet etc are pointless.

2. Telomere Lengthening: Breakthrough Gene Therapy Clinical Trial is the World's First That Aims to Reverse 20 Years of Aging in Human . Likely fraudulent.

3. Yamanaka facto0rs: Ageing g reversal POSSIBLE. Best RESEARCHES IN California, IN SILICON VALLEY. Best place - Stanford.

Can You Really Reverse Your Epigenetic Age?

I can raise about a million dollars. Will risk to start a company that survives by Horvath clock and does mice tests for Ageing on the side. Extra 20 years life extension on the side is prize enough. I think I have 15 to 25 years from evolutionary extension from today from acarbose, metformin, exercise and daily drop of dinner for fasting by hormesis - use diabetes readings for weakly predictive control test.

Why believe and how fast

To be read last!

How do I KNOW that Dr. Sinclair ageing theory of information is right and every other moron to before 2019 wrong!

WHY IS MY ESTIMATE OF 2030 TOO PESSIMISTIC AND 2025 MORE OPTIMISTIC ! As foreseen by me, it will start as a toy of the rich.

Breakthrough Gene Therapy Clinical Trial is the World's First That Aims to Reverse 20 Years of Aging in Humans

Who am I - the book

Who am I - the book
self link
   
   
Contents Weltanschauung - who am I

Weltanschauung - Who am I - prologue

Weltanschauung - Who am I - start

Who am I - start

BOOK start: self lionk

universe around  me

What is the universe around me - astronomy!

Approach these works like a child and learn to enjoy knowledge.



Cosmology is about every thing after big bang. Cosmogony AT BIG BANG OR BEFORE ( if time existed before 0). Creation of universe in which I am, is NOT the product of any God or intelligent designer. Even excluding the morons, there are many narratives of creation not dependent on these insanity - all important cosmogonies are linked next. None are falsifiable.

It appeared to me that string theory and loop quantum gravity are special in that they serve to unite the two theories of physics that have not united despite every top physicist in last two centuries despite herculean effort by thousands of best scientist in a century. These are quantum mechanics generalized to yield string theory. Loop Quantum Gravity LQG specializes Einstein gravity. These two have no known contradictory phenomena but refuse to mix to any quantum gravity and are perfect descriptions of the very small and astronomy.

Amazingly, scientist have their own, one and only falsifiable cosmogony. Amazing because falsifiable means you can start with nothing, even physics laws and constants.


The genesis of all elements and astronomical features is falsifiabllity complete. Next reference tells you the truth and the scientific theory of creation. (cosmology).

 suggest you download the free book and spend the best 10 hours of life reading it. If you are in true super hurry, I wrote a link. At least it will introduce you to cosmology and introduce NASA some to you.

Cosmology is the result of full-time work by 1000,000 humans for over a century - by far more than any soothsayer moron and done with rational skepticism  - trust no one but the force of logic that only leaves a tiny amount. All the developments in space, so far, are for rational skeptics, for astronomy be they LIGO, valley sized radio telescopes, trip to moon, space telescopes in every part of spectrum, rockets etc. It is stupid to trust a single guru, experience, ancient tomes etc.

What is life 

Know no biology?

What did people, including me, believe before theory of information

 What is the greatest achievement of 2019eatest research ever in human existence, ensures a Nobel prize and will be first thing to learn in biology? This is a start (he he).


Twenty five years of research at Harvard culminating in Dr.Sinclair's ageing theory of information.

When does and should death happen?


Life is about earthiness DNA molecule and its natural intermittent selection evolution after established evolutionary advantage. Every thing alive on earth has a DNA - bacteria, plants, animals and human. They age similarly and the information theory of ageing applies to them, including DNA mthylation at species -specific rates, measurable by Horvath clock, that can provide accurate bio-age and 3.1 year standard deviation prediction of remaining life for human!

Life evolved on earth around DNA because the proto-DNA solved a deep problem that all competing DNA-likes had - there are no exclusion genes, but earth-DNA achieved that by making Repair exclusive to reproduction! This is done by tight coiling (off) of DNA-gene in reproduction and lose winding in repair. Such simplicity gives massive advantages to that DNA, which survives a billion years and has carpet ted earth surface and unimaginable ocean depths.


Apart from extensions to Darwin's theory, this narrative explains Horvath clock in different DNA species of plants, animals, human in cells of all kinds - blood, muscle etc. A Y counter theory will have to explain Horvath clock every where, and commonality of DNA. One can explain Darwin using Watson-Crick DNA and even the latter by Sinclair exclusion behavior. It unites chemistry and biology. No extra reason to believe in his practice regarding reduction in ageing except capability, Horvath tests, needs no money, looks young, father doing well and practicing, plausibility (consistency with evolution). These collectively allow a rational skeptic like me to adopt a follow attitude on anecdotal evidence as I can not afford to wait for statistical proof!


The proofs will not help unless negative, in which case the financial losses end. Not even one suggestion of the guy is dangerous -worst is money loss.


USA is rich, but there can and should be immigration of aged to better shores for elder care like India.

My religion

Here I expect discordant opinion of friends. However, one must be in position of second religion - what if the current belief have to be stopped? In that case, a scientific religion is first choice, even though impossible to unite. The very fact that scientists are in general most trustworthy of all implies to me that they follow an undeclared common religion. Every scientist must never find his/her axioms from history, tomes, inheritance etc. What remains is the universal fact of death. Be it soviets or Americans, no advanced civilization ever accepts stupid organized religions (repeat ALL). Yet the absence does not lead to promiscuous  offshoot uncivilized christian of the dark ages. It requires no belief but in eventual death and a DESIRE TO LEAD A HAPPY LIFE! It is hard to believe a religion can follow from this, but it does, enough to say Hindu is my alternate religion and stoicism underlies my value system.

Living long

My father lived to be 88, would have lived to 98 (I think0 BUT FOR HIS WEAKNESS RE MANGOES. For men, metformin AND acarbose synergestically work better than each other, while both improve healthy life. Acarbose fails longevity in women. Both benefit from rapamycin, though toxic in long use. As a diabetic on both, I expect to live 15 years beyond my undiabetic life! 98 to 110 with current interventions. NMN targets Sirtuin, Metformin targets AMPk while rapamycin target mTOR pathway.

Researchers have demonstrated that acarbose, a drug used to treat type 2 diabetes, extends life in mice. This should probably be taken as speculative until more studies are run, as another treatment for type 2 diabetes, metformin, has erratic results on life span in rodent studies. Like metformin, the mechanism of action for acarbose involves influencing glucose metabolism, though in a completely different way.

• Studies of this nature take place because the high costs of regulation in medical development, along with the reluctance of regulators to approve anything new these days, make it more cost-effective to find marginal new uses for existing drugs than to go out and develop new therapies or new classes of therapies. It is unfortunate that so much research time is diverted into channels that cannot result in radical breakthroughs or great advances.

The present meta-analysis aimed to evaluate metformin combined with acarbose compared with monotherapy with either of the two drugs for type 2 diabetes (T2DM). Relevant trials were retrieved through searching PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang and Chongqing VIP information network databases. Heterogeneous and homogeneous data were statistically combined using a random- and fixed-effects model, respectively. For dichotomous and continuous data, the merged effect size was presented as the risk ratio (RR) and weighted mean differences (WMD), respectively, with 95% confidence interval (CI). All included studies were divided into subgroups. A Funnel plot was used to detect publication bias. Review Manager 5.2 software was applied to perform the statistical analyses. Meta-analysis revealed that compared with metformin monotherapy, combined therapy was significantly more efficacious regarding indexes including the total effective rate, fasting blood glucose (FBG), blood glucose levels at two post-prandial hours (2HPG) and hemoglobin A1C (HbA1c). Similarly, combined therapy showed advantages on indexes including FBG, 2HPG and HbA1c over acarbose therapy after 4 months of treatment. In conclusion, the findings of the present meta-analysis suggested that combined therapy of metformin and acarbose appears to be more efficacious than metformin or acarbose monotherapy.


Recognizing that aging can be targeted, the NIH developed the NIA Interventions Testing Program (ITP). The ITP tests diets, drugs, or other interventions to see if they prevent disease and extend lifespan in genetically heterogeneous (outbred) mice (http://www.nia.nih.gov/research/dab/interventions-testing-program-itp). This program is conducted at multiple centers in order to control for laboratory-specific environmental differences, and testing is done in both male and female animals (Miller et al., 2007; Nadon et al., 2008). Major findings of the ITP include that nordihydroguaiaretic acid and aspirin each increase lifespan of male mice (Strong et al., 2008) and acarbose and 17-α-Estradiol extend mouse lifespan preferentially in males (Harrison et al., 2014). Studies of rapamycin (an mTOR inhibitor) have established the most compelling evidence for targeting aging. When rapamycin is administered late in life, it extends lifespan (Harrison et al., 2009; Miller et al., 2011), slows aging in a dose-dependent manner, shows differential effects by sex (Wilkinson et al., 2012), and is synergistic with metformin.


Acarbose "alpha-glucosidase inhibitors" (why it works), 17-α-estradiol, and nordihydroguaiaretic acid (metformin relative) extend mouse lifespan preferentially in males. 17-α-estradiol is  feminine, why (I think) human women live longer and it does not impact women mice.

Weltanschauung - who am I - prologue:

Top

Popper https://en.wikipedia.org/wiki/Karl_Popper


who am I - prologue: At 25, I finished my Computer Science PhD.D thesis defense, and stood outside math science tall building with knowledge that the next strong memorial convocation happens with the degree roll for me. I had completed the mercy-less program and I was an employee at Boston doing software for the US army, best I could do, and worst according to my guide, who had become my father and hence took the position as me a misguided young man! His scornful look zeroed my pleasure and I was agitated. The program took me 3.5 years of toil and ended successfully. "What next?" I asked myself, worried by yet another Father I had upset. That fateful afternoon, I decided I will spend the next 4 years of my life (as long as I spent on PhD.) or less, and answer it well to answer my doubts - who am I.

deepest? A life went by. I am 65 about 40 years later and have finally been able to answer it to my satisfaction. How was I to know that this question is deepest in philosophy and touches all aspects of my life. You, my dear reader should read it once to answer it for your own self. Many times to begin to know me. It is unique in how much the question is covered.

writing style: It is written in a particular style, similar to how every intelligent scientist I encountered in the last 40 years whose style I could parse, think, and so do all top professors. I call it Socrates/style. Throughout, phrases with a slash, are mine with detailed semantics as per me and grossly, but not in fine details, without ever being surprising coarsely. In it, a question is asked, constraints on solution are imposed, and then one researches the answer, which might be simple or deepest like what I asked, depth not known. It has no relations to events in my life, most events are much better understood now. Its epistemology, like all science, is falsifiability https://en.wikipedia.org/wiki/Falsifiability. That here can even be the answer to "Who am I" is a 2020 miracle, never before in human existence [I prove it]!

Plethora of sub-questions: The question resolves into many more. For each there is a falsifiable (scientific) answer here. All religions are equally stupid, they are all equal so [I prove it. What is the universe around me - society, people, stars. What is life I have and how valuable - my own, family, friends and soldiers who fight for me. What is death, is there an afterlife, can I influence it? What is ageing, how can I minimize its harmful impact on self and loved once? What is medicine and sickness. How does one minimize its harmful impact? How does one distinguish money-drive salesmen and genuine value adders. How does one escape advertising and use it profitably! How does one escape politics and use it profitably. What is history, baloney and use if well? How to escape those who understand this. What is law and semantics? What is consciousness? Can one make Artificial Intelligence AI to understand and do what lawyers, doctors, teachers, maintain robots, white-collar jobs. How will post-industrial world function? Can robots be conscious? Who, what, how to believe? What makes society around me function. Who am I?

40 years later:  I will answer in subsequent pages. Just the width of sub queries is frightening to all but religious. I consider those beliefs to be uncivilized and support measures to drive them underground. The basis of all questions asked above is science, and lack of any belief in Any book or tome except as detailed by active rational skeptics whose words are treasured as representative of me. Even then, unless old enough to withstand active scientific investigation, else the statements are not a theory but a hypothesis. My great belief in Talib and Sinclair are such that their statements are hypotheses. There are All religions whose every contradictory statement means the converse is likely a hypothesis (Mal/hypothesis)!

what is science: pointless to talk about scientific without knowing what it is. Every religious moron will use the word unscientifically, in fact a collusion between his beliefs and science, not even knowing it is impossible. By Popper definition, generally accepted, science is a collection of falsifiable theories! Not one religious idiot considers religious facts as falsifiable! That is a negative constraint on what science can not be. On the positive side, science is rational skepticism, you only accept testable empiric, never believe unless it meets your logic! If accepted science fails, then your logic is faulty. It never happens with ordinary things. Extremes of size and speed in science force you into quantum mechanics and linear logic. Except quantum phenomena, ordinary propositional logic and predicate calculus suffices. There is nothing more laughable and scornful more than a stupid religious joker applying quantum mechanics to anything.

Who fails the Popper test? Not only do all religions fail, so do many phenomena considered scientific - like multiverse, what happens in a black hole, why is vacuum energy what it is etc. There is an element of rigorous deduction, inviolable known science axioms - limiting to new axioms not tested to today. Even then, it is not science. Science has no claims to be known all ever, it is that ALL religions fail unfalsifiability! ALL sub animal politicians have to become proficient in the art of attractive meaninglessness which can not fail! Said my favorite emfubar Sir - Modi failed Corona, not because he copied west like the US and UK, and failed to follow east like Japan and Sweden (sic) ; but because he failed to follow the Indian way! Not a word about the superior Indian  way! The explanation of Modi errors - so many of them - is simple, he is afraid of Sir. Sir Trump is a failure because he is not properly patriotic enough! Why do you think the intelligent Americans never argue with an Indian brahmin saint ever again?

outline of answers? This text was not possible before 2020 before I read Dr. Sinclair (Harvard) aging theory of information I applied to self as derived digilog theory two weeks after I read and saw some benefit. I tested positively once on  self, will again test on the month mark then life long on the annual mark. I suggest this digilog schedule and its understanding. Best I can suggest is to read and intern his book published in 2019. It is a scientific theory (falsifiable) and not dependent on any authority but sequence of experiments that all can try. I myself have formulated some empirical tests to try the digilog theory. Will be budgeted and done. Unless I could apply myself successfully, writing the rest of the questions is a waste of my time.

Contents Weltanschauung - who am I

Next
contents
Prolog
What is the universe around me - astronomy
Society - What is it around me
People - What is it around me
What is life
My religion
Value of my life
Value of life to family
Importance of friends
Dedication to soldiers
 What is death
Afterlife
Can I influence it?
What is ageing
How can I minimize its impact on self
Impact on loved once
Money-driven salesmen
Advertising  profitably
Escape politics
Politics profitably
What is history
Historical baloney
Abuse of politics
How to escape those who understand this
Non formal law
Semantic genuine value adders
Consciousness
Artificial Intelligence AI
AI - do what lawyers
AI -do what doctors
AI -do what teachers
AI -maintain robots
AI -white-collar
How will post-industrial world function?
Can robots be conscious
Who to believe
What to believe
 How to believe
What makes society around me function
Who am I?