Actionable Politics of Aging

 

Actionable is my word that captures me - Actionable aging, actionable politics etc. That is not to minimize 99% of the rest, but often reading great researches, one wonders how it benefits me now or later. Who is doing supportable research application? How is the engineering of applications of great science being done and how can I benefit, provided I understand the risk.

The whole field of aging has forever been the domain of thugs, and will be. An FDA cannot exist that performs the complicated dance between the state, courts, legislation, markets and innovators since risk reduction means expanded extensive, time-consuming testing that will damage non-aging drugs expensively. It is incorrect to try to identify aging chemicals and non-aging chemicals. The only reasonable way is leave the FDA alone and depend on tested and proved medical tourism. In other words, reform but not reincarnate!

This means rules and regulation of the host country but USA inspectors. Some drug trade is conducted along these lines, creating trust in foreign products. It can be extended to service industries too. Dentistry procedures in the USA are quite expensive, but there is no way a citizen can locate trustworthy dentists in India, Thailand etc. It applies to UK and European countries too.

Medical tourism is and maximally strongly opposed by stakeholders in medical services in the USA! Every valid objection can be removed by USA inspectors, not just for the USA but others as well. FDA determinations are not just used in the USA but the entire world.

Hence, my political choice - Controlled medical tourism. It is in conjunction with, and nowhere required to impact national systems directly. One can raise the nefarious nationalist bogey against, trivially fixed by stopping medical tourism to that country! Commies and other moronic objections can be handled so! The essential fear is the continuation of evergreen thuggery, but easy to answer. To consider India, many methods are not considered even as practice of medicine in the west but effects no one in the west! There is a flourishing FDA compliant allopathic wing (called modern medicine mm by me) whose graduates are welcome in the west.

One of the greatest initiative of Dr. de Grey is creation-time support of aging companies which, in my opinion, are the new unicorns of tomorrow, but likely to be ethical too. One such company is Bioviva.

I hope my company will be on that path.

I have identified three actionable paths for aging, soft paths, BNBE, and thymus. I have all methods derived from Yamanaka methods as Doctor territory. There is a fifth method which may or may-not be actionable. It related to the current axiom of medicine that I disagree with, the lengthening of telomere. I do not believe that non-standard aging intervention to lengthen telomere will boost age, I consider them as indicators of age and a side effect to aging intervention just like Horovith aging. Bioviva has an age extension procedure that did lengthen the telomere by about 20 years! There is a clinical trial in progress in Columbia. The team charged a million dollars for being part of the test and I think Columbia was chosen to bypass USA laws, but I will change it some on results and fully when the participant get extended age!

It remains to be seen whether Libella has truly tapped the fountain of youth, but given the dubious nature of their clinical trials, potential participants may want to exercise caution before relocating to Colombia and shelling out $1 million for a chance to live longer.

Here is something to learn and keep in the back of yo0ur mine when diagnosed with unfix-able disease - world has moved to new methods likely unknown to your doctor being immunothereapy, single gene genetic fixes and credible aging improvement methods, called soft-methods and BNBE.

Fixing the thymus

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Disclaimer

Not only does it extend age, but improves immunity against pathogens; that means provide extended health span. Immunotherapy is strengthening bodies own defenses against invaders by T and V cells present in the blood by identification of all invaders, apoptosis-evader or senescent cells. So trained gives you 1000 years. T cells come from the thymus. The adult pluripotent stem cell uses V stem cells, [Very Small Embryonic Like Stem Cells], also referred to as V-Cells. They are also called peripheral blood stem cells, blastomeres or stembios cells. Formed in bone marrow, they are approximately 1/3rd the size of other adult stem cells and are non-tumorigenic.

Previous write-up asked

What is involved in strengthening thymus? Drugs, supplements, plants?

How will I know if some Indian doctor will do Dana Farber fix, when, cost!

Can I request updates and other information?

Before going on, let me first tell you of the wonderful discovery - aging website of the great man Dr de Grey which is collectively far greater than my notes. Here is it. Crucial to view is this summary :

Many research groups have primarily focused on finding possible strategies to rejuvenate the thymus and have developed promising therapeutic approaches. However, few molecules and genes such as KGF, IL-22, IL-7, and Foxn1 have been identified as key players of the mechanistic pathway for endogenous thymic regeneration. Growth factors and hormone therapies were also explored in order to restore age-related or injury-related thymic degeneration, but, despite encouraging results, they have short-term effects and/or require a recurrent administration, which is complicated by their toxic effects on other tissues and organs.

Thymus transplantation represents another promising alternative to complement bone marrow transplantation or to treat congenital thymic anomalies, but T-cell reconstitution following thymus grafting is frequently incomplete and transient, complicated by a skewed T-cell receptor repertoire and an increased occurrence of autoimmunity.

Other master Dr. Sinclair has not been idle. He is raising money to launch a company whose mechanism is novel and expands my horizons as it is a SPAC. God knows what the target is, I hope to launch in May or June provided BNBE works on me!

Now the questions. Nobody knows why thymic atrophy, or involution, occurs, but it happens in all vertebrates, starting really at the age of puberty. Some have suggested that it happens to save energy, since the production of properly qualified T cells is very energy intensive and inefficient, and of course, at puberty, the body begins to devote more energy to reproduction, which might require a trade-off against using energy for immune maintenance.

Drugs for Thymus?

Essentially online or needing prescription. I find entirely appropriate to request a doctor to prescribe them for me, checking me first, to boost immunity. But I have no disease needing drugs.

Supplements for thymus?

Amazon sells many. Pure Thyme Essential Oil 10ml- Thymus Vulgaris is example. It seems to be a fix for cold, flu, lung diseases, asthma, arthritis, cancers etc. It will help against COVID-19? It is best taken with vaccination! Found no one taking it for health span. Dr. Greg Fahy – Rejuvenating the Thymus to Prevent Age-related Diseases.

Plants for thymus?

Plant profile for thymus.

Immunotherapy in India?

What is Immunotherapy? Is Immunotherapy in India used for Cancer Patients?

In fact, wrong thing follow newness of immunotherapy, it is not used as a frontline method of cancer despite it being closest to Ayurveda and Unnani! Somehow, cancer has become associated with immunotherapy. It is to strengthen the inner immunity of the body to fight off infection! There is thing called Hygiene hypothesis that attributes extra immunity of south Asians as due to a whole set of childhood infections solved by no care of the children, unlike the American mothers! Most children survive the little infections and strengthen the immune system. Even in India, the depth of ravages of Corona aligns negatively with citizen income! The Same happens in China and Africa.

Guess what! The death rates were low in all these regions, the biggest victims were in the USA and United Kingdom and Europe, the developed part of the world! Clearly I have different views on some matters, opposite of general sentiment!

I claimed that COVID-19 deaths were independent of political power that be, no one is better or worse, yet most class were either pro-modi or against! Again our class is split, one part believes congress achieved independence, other part believes revolutionaries or Bose-likes. I believe that 1945 labor defeated the Tories and to spite the damn capitalists & Tories and render a socialist world, wanted to get out of being imperial power. Not only British newspapers of the era support me but also that all the British colonies of that era were made independent! Whether they had flowering independence movement or not! It is best to stay quiet and not be killed in dual attack on some issues. God knows how idiotic I sound, when Farmer agitation is opposed by me for non-modi free market rules like the conservatives! But I learned to keep my Trump image quiet. The man's reputations could not be harmed more by his enemies!

Request updates?

Seems to be pointless since the thymus and immunology links I encountered were 2018 end and the world has moved two years ahead! Now one can even have a sane discussion on results, not just venture informed guesses.

Surgical (grafting) direction

As reported here.

Must read warning

 

Disclaimer

Minimum is consult a doctor

MY logic depends on necessary and sufficient, generally but not always.

I'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. Furthermore, I make no claims. Please practice skepticism and rational critical thinking. You should consult a medicine professional about any serious decisions that you might make about your health. Not fully reading once and not interning can hurt you seriously, even death.

 Your own rational thinking is required only when there is disagreement in professionals or if the professionals state that there is no known method for achieving what is sought or its costs are not achievable etc. Opinions and consultation include research papers from credible journals, or acceptance by government agencies like FDA (Federal U.S. Food and Drug Administration). There are requirements of safety (critical, also certifiable by government GRAS (Generally Recognized as safe)) and efficacy. Both are sufficient but not always necessary.

MEDICINAL VACCINES: 4th actionable mehod

 

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I'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinking. You should consult a professional about any serious decisions that you might make about your health.

I was astonished to so rapid a return on my previous notice, interesting for science reasons only, crystal clear understanding of this! I claimed that cancer and aging are closely related. The First problem in cancer is marking the evil cells. Once marked, somehow killing can be developed. But the cancer cells (also aging) will ignore all apoptosis signals! Fortunately, both cancers and aging take time. While the infected cells ignore apoptosis signals, they in the vast majority of cases do express proteins. These all escape detection by bodies immune cells (T and V), as clear from cancer occurrence! Can happen to anyone, better chances as more age of patient

Normally, cells escaping apoptosis are not detected as foreign invaders and hunted down by immune cells. Sometimes identification takes time, happens and the patient recovers. Best a patient can do is keep cheerful as this cure is probabilistic and odds are against. What if some way could be found to train the immune cells to recognize the cancer apoptosis evaders as foreign, based on the expressed proteins? Likely, healthy cells do not express cancer proteins. Still have to think of how to apply to aging cells!

One way has been done is by planting an aspirin sized body near a lymph node, treatment now tested.

Medicinal vaccination i.e. vaccination cure after the cancer

So this is method 4 to explore! Just a thought for cancer cells and aging cells are likely different here.

What is involved in strengthening thymus? Drugs, supplements, plants?

How will I know if some Indian doctor will do Dana Farber fix, when, cost!

Can I request updates and other information?

This reference will provide a good review of my investigation.

How excited I am on reading that if you had the thymus of a 12-year-old, you would live a thousand years! Thymus declines thereafter and has increasing levels of fat. Every opportunistic disease gets the old, with declining white cells from thymus. Not many doctors know immunotherapy! That is why this vital subject escaped me so far!

Yamanaka factor research start

 

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I'm not a doctor, medical professional, or trained therapist. I'm a researcher and pragmatic biohacking practitioner exercising free speech to share evidence as I find it. I make no claims. Please practice skepticism and rational critical thinking. You should consult a professional about any serious decisions that you might make about your health.

I have actionable supplement methods and TPE based methods with some minor risk. I now turn to Non-actionable methods having exhausted the actionable category. All references next are part of scientific knowledge and must be cleared and suggested by a doctor! The entire third line is based on Yamanaka factors and pulsed use of a subset in living animals. After the research is done, it will be first tested against cancer patients. There is NO reasonable way to handle them in modern medicine, patients are there who will likely benefit, As a scientist, I can say with enormous experience that cancer fix and aging fix go together. Impossible to separate the progress, and hence a population benefiting from the risk. With other methods, I choose knowingly, to benefit aging diseases.

Science, based on very long experience (20 years), is the first in claim of aging versus cancers. This is based on two central experimental (hence scientific) results, one that OSKM factors reprogram any cell to its pluripotent state (magic that purged religious morons out of science, magic as scientists were expecting very complex processing by female cell in fertilization!) and finding that low pulsed ingesting of OSK was tolerated quite well by life. Just cutting out  of M was enough to destroy reversion which meant cancers. These were joined by Horvath work that related methylation at Cp sites to calendar age and death. These convert aging into a science because all procedures can be tested and compared. Every religious and social moron claims to benefit humanity's age benefits provided their methods are followed. There is no distinction between these idiots and my certainty of it will snow in Simla, same day, year 2999; or a loan to me to repay on any dates 2999 to be repaid then (Complicated versions drive income tax officials very angry)!

 Claim I make is that cancer and aging are related. Prior to cancer metastization, a cancer is like local senescence of a cell that ignores all apoptosis signals. It becomes persistent life waste that occupies valuable space and causes senescence-like in neighbors. Exactly what aging does, except that aging does not affect neighbors! There is no way to select intelligently. Surgical removal is not possible as you have to get all, impossible with chaotic growth! Chemotherapy targets a lot of good cells. I have scientific hope that vaccine make RNA methods will allow targeted selection.

My science tells me that medical people will sow up this genetic engineering and drive its price to unreasonable levels. It applies to Cancers and medical intervention makes sense. It applies to aging, and I am dead against Doctors because of other methods. My political belief is that the developed world will try to restrict competition and some, like India and Mexico, will not the blackmailed. However, on defeat, the task of beneficial control will have to allow illegal/quantum tunneling!

Closure for a while

 

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Subject is aging. The Best review found is this. USA government says this. Today is my last essay on BNBE or Beneficial Neutral Plasma Exchange (my new phrase) FOR DILUTING BLOOD AND MORE, for a while. This is because I am committed to BNBE on self but open to medical advice. By my own count, I will be ready middle of May. That gives me enough time.

Why need time?

1. I got the first dose of corona vaccine today. (March 8). Second dose is April 6 or later. After second dose, immunity reaches plateau after 30 days. That is May 6. No need to dawdle then. So May, second week on, depending on TPE availability. Pointless in detail-think about benefits now. The worst case is some pain and failed TPE in its mission. Average expectation is benefit to heart, diabetes and age. In any case, self-imposed isolation ends the second week of may, actually April 30 when may attend a marriage.

2. Three months to set up BNBE, data collection, doctor advice including the cancellation of this project. Note that I am not seeking life extension but improvement in my aging diseases and strongly believe that work in this direction will be done in the USA and available in 3 years. Till then, Yamanaka factor supplements may hit the market. So delay may be useful.

What if average success?

Reopen two fascinating projects for mushroom farming in orchards of UP and high orchard cover with sun-sensitive optical electric panels feeding to State Grid. Both represent paradigm shift, are doable (after repeated experimentation) and represent two of many ideas for doubling income from orchards I own. India will love electricity from non-stealable heights and additional produce to meet growing population with fixed land sizes.

Useful update

Pterostilbene has the remarkable property of being a general broad spectrum antibacterial/bug in some plants over resveratrol!

 

Chemistry of Aging

 

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Contrary to expectation, all life shares the SAME kind of DNA, and have similar, if applicable, modes of aging. There is no need, hence anti-religion, for this to be so. BUT it is so, and lot of research in genetics can be done on models that apply. In fact, non-applicability itself is useful information, subject of research as to why!

Aging is a genetic process, outside medicine, or later a specialty. I am a strong believer and professor! Most current doctors, including currently being trained, know nothing about the chemicals and procedures, except perform them on request, ignorant of why! They are as ignorant as most re stem cells.

I am not interested in learning the biology or chemistry outside its application in aging reversal. To carve out the niche, currently I admit only 3 kinds of method categories, soft methods, Plasma based methods, and medical methods based on Yamanaka factors. Third are most exciting but require FDA equivalent and medicine management. The entire third method is considered outside my current competence. Soft methods are based on parroting successful heroes like Dr. Sinclair. That is the ultimate reason for accept and denial. Plasma based methods are all blood plasma based. Blood is drawn, Preserves are removed, rest of plasma is modified, Preserves are restored and blood restored.

Modifications to Plasma is chemical engineering entrepreneurial, not medicine subject; insist I, including a required court visit. It is not a bureaucratic subject either, beyond open safety rules.

DNA, for later research reasons have 3 genes in human, AMPK, SIRTUIN, and mTOR progenitors. This is the ABC of aging! Genes do not matter, but enzymes do, named as genes. An enzyme protein is needed as catalyst that organic reactions happen in human time scales. It makes sense, without them in reactions, all kind of combination will occur at random and life will not exist. Too slow and then life will not exist as complicated molecules would not form and be useful. By doing the reaction with enzymes gives you the best of worlds, reactions at modifiable speeds, enzymes not routinely found. By genes, you allow them to be transmitted in generations, between generations, despite randomness. It is not complete, there are errors, lots of failed individuals. As long as there is some randomness, evolution happens, speed-ed up to managed speeds by sexual reproduction, randomness happening due to genetic diseases from genetically close unions. I will not have that problem!

I think complex arguments like evolution are justified only for hypothesis formation. Testing is absolutely needed, performed in open, but entrepreneurial nature, not science, drives the chemicals tested (like FDA on supplements). Whether a properly tested product is admitted or conditions imposed will not be considered.

SIRTUIN is nearly universal between all species (all life kingdoms), For humans, there are 8. Their activity includes histone deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. From in vitro studies, sirtuins are implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation[6] and stress resistance, as well as energy efficiency and alertness during low-calorie situations.[7] As of 2018, there was no clinical evidence that sirtuins affect human aging, but I suspect clinical trials of NMN are after this, as is Sirtuin role.

AMPK 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.

The mechanistic target of rapamycin (mTOR),[5] previously referred to as the mammalian target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.[6][7][8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.[9]

mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes.[10] In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.[10][11] As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors.[12] mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton

In terms of copying Dr. Sinclair

NMN affects mitochondria positively. He uses 1gm/day. By experience, Betaine add is absolutely needed(link for NR, applies to all B3 forms like NMN) to replace methyl that NMN uses up.

 Pterostilbene is better resveratrol (more bioavailable). He takes 1gm, equal to 250 mg (I say).  Its chemical relative, resveratrol, received FDA GRAS status in 2007,^[9] and approval of synthetic resveratrol as a safe compound by the European Food Safety Authority (EFSA) in 2016.^[10] Pterostilbene differs from resveratrol by exhibiting increased bioavailability (80% compared to 20% in resveratrol) due to the presence of two methoxy groups which cause it to exhibit increased lipophilic and oral absorption.

Have taken NMN sublingual. Some Positive effects. Now change in NMN and will take in IV. The dosage is likely wrong. Based on LIFESPAN.IO, do it weekly (dosage combined and reduced) rather than NAD+ daily. Need pharmaceutical NMN for that.

Remember my goal - age solution to age diseases (heart problems, essential tremors, diabetes and aging). All can be measured after procedure. Full blood count before and after the procedure. If it fails on me, or is partial, then even that is a research point and science puzzle.