Aging - Arya paradigm

 

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Likely irrelevant, but this is what USA government thinks about aging.

I have spent 20 years, scientifically researching aging, i.e. ignoring EVERYTHING enunciated by non-scientists, and taking what scientists said RDS i.e. skeptically. There is no reason for it to happen in my lifetime, it was to achieve better life when aged, life extension was never a goal. But biological theory of information by Dr. Sinclair has even created that hope, creating a hope being attacked with caution, means likely time-waste knowingly. And now a paradigm of aging connects all my scientific dots into an actionable theory of aging, listing things to do and even a why. All my derivations have a common story that magically, unexpectedly as all derived in isolation, mesh into a single theory and give hence a reason to believe in, and not chase other tricks! Essentially it boils down to what aging is to a person, - blood supply loss to the periphery, poor blood, aged mitochondria and age-methylated epi-genome. Let us fix them all. Not 1, but not many either, 4 to be exact!

Tellingly, regardless of parent's ages, all births have similar low methylation, zero when starting. This means that methylation stripping is part of fertilization and likely that original DNA is somehow preserved. The strip of methylation constrains theories a lot. Likely happens in all eggs and sperm particles, by the cytosine protein. Cytosine necessary for all mating without exception, non-DNA proteins will have some exceptions..

Fixing paths?

Blood supply is by arteries and veins, called paths. The supply is effected by narrowing or death of the paths. There is a cell lining of the path. Resveratrol and Pterostilbene are two ways to benefit the lining cells. ECP creates new paths all over the body and in-effect has wider benefits than heart.

Fixing blood?

Second way is blood itself is aged, effects delivery and usage. It might become more viscous or reduced capacity to carry molecules. Details are not important. There are two large theories of blood. Either young blood carries unaged proteins, or the recovery strength of old blood is reduced. No matter what the age of blood, aged proteins and young proteins always come in relative aging concentrations. Mixing young and old reduces the age of older, but the older is much better off and safer with neutral! Hence, NBE for neutral blood exchange effectively discarding old plasma. I will do it. It has potential for repeat too. Neutral means saline, NMN and albumin.

Fixing mitochondria?

That is what NMN or NR do. Mitoq works too. You can buy NMN+Mitoq too at USA Amazon.

Fixing epi-genome?

Central to immortality. That is what research on Yamanaka factor medicine and supplements in California is all about! When done, usual doctors will learn of FDA results.

Engineering approach?

Do the blood and mitochondria based age improvements based on supplements by aping some good users, it is Dr. Sinclair for me. Wait for prescription for Yamanaka. Will benefits add i.e. they are independent? Looks so, my trial will tell.

FDA permit?

Not a goal now! I view two principal jobs of FDA to be safety and efficacy. My safety is based on plants (resveratrol or pterostilbene) NMN (NMN or NR are vitamin B3 forms in body) and NBE (plasma exchange safer than even 100-year-old blood transfusion). Efficacy proofs for self are resveratrol (botany), pterostilbene (botany), NMN (aping), NR (FDA) and NBE (successor to Berkeley paper on parabiosis).

What causes the Horovith methylation marks?

Irrelevant to know for me. Horovith believes it is from some bookkeeping aspect in DNA. Note that CpG are C-T dense regions of DNA called Islands. Since it matches in tissue, across populations, across species, likely from DNA! In all species, the methylations are stripped in all CpG sites, but not everywhere! Demethylation during early embryogenesis occurs in the preimplantation period. After a sperm fertilizes an ovum to form a zygote, rapid DNA demethylation of the paternal DNA and slower demethylation of the maternal DNA occurs until formation of a morula which has almost no methylation

What else?

Don't trust media, businessmen, corruptible doctors, all advertisers etc. Always spend time on linked papers in top journals only. Always get go ahead from a doctor, don't ever re talk if suggesting a brand! Only universal recommended is k2 (100mcg MK-7) and d3 (1000 -10,000)IU with calcium. Nearly all free radical or ROS (Reactive oxygen species) based advice is bull-shit. D3 is a magic solver for many impossible diseases, hard to overdose on, 25000 IU per week is good.

Self-application of research

Self-application of my research

Believe it or not, David Sinclair is 50 and professor of medicine at Harvard. Based on him

https://aaqg-arunarya.blogspot.com/2021/02/paradigm-changer.html

Don't forget to chase links. It is a huge number of essays linked together. I expect comments making a lot of work free for you!

Self-application and your (reader) applications

Aging - I grow old, weak, frail and disease ridden. There is nothing doable by my immediate family or was by me or medical professionals when my father died. Last years were hard on him, he lived on to 88, but one day he died while we took him to the emergency. A finite life, longer than normal, with no long debilitation at the end is what I can promise to myself, even if any further improvements are in the future. The method I design is open for a specialist to recreate, right now there is no tested method, and my family has refused to trust my medical knowledge, the best I have is a commitment to follow me after my experience at age loss and more important, freedom to screw myself.

Relief from diseases

I have the following diseases with no real fix in allopathy, even though allopathic help will be sought by me on events. These are

1. Diabetes

2. Heart diseases

3. Essential tremor

4 Aging

Aging solution is certain to solve others. Heart was caused third by smoking (Quit 39 years ago), third by diabetes and third by genetics. Diabetes in full genetic, as is essential tremors. Cause is irrelevant. I have four diseases from genes and time. The source is important to decide what kind of intervention, if any, is best. There is precisely one that will certainly defeat all, reducing the biological age of cells involved in each. But there are no off-the-shelf subset mechanisms in biology or chemistry. The aav techniques (adeno-associated virus), that selectively direct a medicine to an activated subset, or RNA technology boosted with applications in rapid vaccine development for Covid-19, do not constitute a solution for non-specialist like me.

For blood aging there are two broad schools of thought: one in which there are regenerative factors in young blood that can be isolated, and another in which aged blood contains regenerative factors that cannot function due to an oversupply of pro-aging factors. I am in the latter camp.

A general age reduction will automatically benefit diseases. So in effect, only solution to aging will work on all. I expect 20 year reduction, which puts me just before diabetes or heart. Great if it works, has not for anyone (unless try anonymously), and requires 10 years from aping Dr. Sinclair (he shows 15) and 10 years from mice experiments at UCB (mice do lot better than10 years, percent wise, Grifol safety data) and mechanism independence (looks so). So the method I will do to self is safe (vitamin B3 chemicals and plasma update) and efficacy (liver damage control, conservative Mice prediction). Results are for me, worst case nothing exciting happens. They will Yamanaka factors medicine within 10 years (my prediction). Looks like Plasma update can be done a few times.

Aasign - Reliable Authentic signatures

 

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Basic are four functions

1 Aaencrypt (key, serial integer,  source string → target string)  also

2 Aadecrypt (key, target string → source string, serial number)

 

Whenever you write a letter and give a serial number for encryption of source and serial  by Aaencrypt app, it returns the target string which you send to the destination. The destination reverses the encrypted serial and reuses the app to get serial number, encrypted to fooling any analyst to preserve even serial number info.

An article is different, here we want authenticated content to go without worry about secrecy. Adding the authenticating code to article content can be auto-checked for all edits or authorship

The method is not for full transparency but responsible transparency i.e. to all who can legally deny any interest in using the method or its variant for encryption or compare to it.

3 Aaauthenticate (article, type publish information → authenticated article)

4 Aacheck (article → okay | error=code, type publish information)

First append publish and authentication information to the article. Aacheck is passed any authenticated article and returns who author are, edition, publication date etc, error if not.

How does authentication work?

Work off the USA standard digest SHA-256 or newer.

How will 'my signatures' work?

Given any text, a standard digest is made to huge integers. The digest-article, listed authors, date, edition, size etc make a virtual group article. Any virtual-group can be digested too. Every group-digest becomes index into a Trent table of integers. The entry is copied and group-digest signature-checked against Trent. If genuine then match exists, is successful and document true, properties as derived from integer or auto-read from document! Simple automation makes it into type-writer cost automatic verifier with all!

But you make no money from Aasign?

Wrong. NSA-proof solution is transparent quantum-resistant computation ONE-WAY (easy in one direction but not the other). The computations can be made transparent reverse-engineering-proof but safe by many Trent and their computations in tested isolated enclosed-hardware only. Verification of some NP-complete and one-way is elementary! The Hard part is with Trent, easy part with you. Online conversations with Trent are end-to-end encrypted! You can/must check every answer Trent gives.

How does perfect forward secrecy PSF work?

 PSF means loss of entire system numbers still keeps every old message/s safe! It is part of the system. Note that any system can be made PFS by exchanging the new random system using the old system first and using the new for one message only!

How does encryption work?

Standard encryption like AES is used for text. My magic is in constructing the key, method disclosure requiring responsible transparency, hence stop here. n*n connections are basic to Aacryption.

 

 

Paradigm changer

 

There are four very significant Paradigm changes I make. I did not think, I would make any 1. These are all recent and very important and each relates to me, thus I have motivation to broadcast as much as I can till the original believers are found. I expose my thinking to convince the originals that my efforts are not in vain, that I am not motivated by any intellectual reasons alone, I am calling on you for self but also that you will benefit so too, and your help be acknowledged too. The help may be from self, your friends to which the links are sent, and not just you, but they will also benefit and be acknowledged as well, recursively.

Paradigm changes ?

The four paradigm changes are

1. How to live for ever, scientifically, Thursday, February 11, 2021

Self-interest is cure my currently insoluble essential tremor, heart and aging. Open contempt to weird plant medicine or non-doctor verified chemicals, unless self checked.

2. How tothink scientifically, Sunday, February 7, 2021

How I think and all above-normal should.

3. How to ethically prosper, ethical self start, Tuesday, November 17, 2020

Needed for unfolding robot world, applicable to far more than aging, applying it my aasign!

4. Aasign for reliable writings.

Trust but verify statistically.

Fallacy why?

Every moron has misused the word 'scientific' since they insist that their thinking is consistent with science. The proper meaning of all the paradigm changes to modern science is no belief ever on anything but self-experiments or description of experiments by scientists where science may be generated and experiments are repeatable. Never trust a putative scientist! Fallacy may happen from false data, false representation of identity, conflict of interest and mis-insertion and mis-deletion.

Why the details?

This is not just identification of error mechanism, but if signatures are in the best practices (transparently proved), then my scientific writings make sense. The biggest Paradigm shift will be historians and explainers prior to my scientific paradigm Paradiming i.e. before me and consistent to my or equal signatures. A new Co-paradigm called Aasign is defined before my paradigms can be reliably learned, even if quantum computers use becomes common.

How will 'my signatures' work?

Given any text, a standard digest is made to huge integers. The digest-article, listed authors, date, edition, size make a virtual group article. Any virtual-group can be digested too. Every group-digest becomes index into a Trent table of integers. The entry is copied and group-digest signature-checked against me. If genuine then match exists, is successful and document true, properties as derived from integer or auto-read from document! Simple automation makes it into type-writer cost automatic verifier with all!

But you make no money from Aasign?

Wrong. NSA-proof solution is transparent quantum-resistant computation ONE-WAY (easy in one direction but not the other). The computations can be made transparent reverse-engineering-proof but safe by many Trent and their computations in tested isolated enclosed-hardware only. Verification of some NP-complete and one-way is elementary! The Hard part is with Trent, easy part with you. Online conversations with Trent are end-to-end encrypted! You can/must check every answer Trent gives.

Actionable undo aging

Self link to latest

This is after 30 years after I woke up without memories, a TBI. It gave me time to reflect on self even as memories returned to six months before the deadly accident. The six months are blank and will remain so. I was an unlucky passenger, suffered, abused by government of Massachusetts, but have unbridled cautious optimism i.e. trust but verify. And rational democratic skepticism and superhuman attitude in paradigm shift when ahead. Something is scientific only if entirely experimental, no other source of truth.

Paradigm shift, no Scientific way ever becomes 3 actionable theories after?

Scientific theory with actionable(by you) undo aging (my claim) represents a paradigm shift. I can expose as fraud age guru theories of all else in 3 steps recommended for self test and brutal suing to true fakir any other guru or recommender by Arun Arya age test. Else the guru is a fraud! Let him draw up a solid pre-sign document, such a Guru will have few chelas (dumb brainless disciples).

Scientific Arun Arya age test of any procedure? Age here.

First get Horvath bioage before procedure, then do the procedure, then test again to post-bio age. If the difference is not twice the calendar age difference or more, the test fails. The factor of 2 hides the zero-errors in Horvath by being tough on the Guru. The procedure cannot extend beyond a decade or the length procedure recommender has been in that business!

Medicine kinds?

As per me there is episodic illness; slow persistent illness like heart, diabetes, cancer; and very slow like lowered intellect, Alzheimer's, Parkinson's, work-stamina, illness-catching and aging. Normal Allopathic doctors are recommended for all episodic diseases and complications from persistent diseases. All very slow diseases and action with aging is co-recommended for very slow diseases. This means all aged and persistent sufferers after a while. It is a better cure to reduce the age of heart cells than try to keep it working by surgery and drugs, after a while.

Why are 3 techniques I state all beneficial and no others?

First is evolution based and self tried chemicals by Dr. Sinclair, aping him with good human logic. Basically boils down to NMN, Resveratrol (200 mg Pterostilbene instead by me) and Metformin

Second is UC Berkley based parabiosis redevelopment, untried in human unless Grifol so considered,

similar but different from blood-letting and leeches. Finally, is work being done on Yamanaka based medicine, food, and supplements in California and Massachusetts.

 

Likely dumb remarks?

Climate concerns kids and long-lifers! You shoot for immortal life!

 

Brain advantages of plasmapheresis

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The blood dilution process discussed is FDA approved for autoimmune and called therapeutic plasma exchange, or plasmapheresis.

Irina Conboy said.“We thought that aging could be caused by transient and veryreversible declines in regeneration, such that, even if somebody isvery old, the capacity to build new tissues in organs could berestored to young levels by basically replacing the broken cells andtissues with healthy ones, and that this capacity is regulatedthrough specific chemicals which change with age in ways that becomecounterproductive.

Irina Conboy is a Berkeley scientist who did the original parabiosis work in 2005. Fifteen year later, keeping blood supplies of old and young mice separate, the experiment worked for young (got older) but not for old (did not get significantly younger from young). Wow! Impossible to digest for ALL normal but for me, saved me money and disappointment! The point is nothing is magic in young, the useful proteins in young age, become aged and evil. What to do? Replace blood with reduced concentration and more neutral saline, cells and albumin! In it. The evil proteins don't grow, good part of the fraction grow, and blood gets younger! But blood supplies to all cells and the individual gets younger. You can do this repeatedly some number of times. So I will live till Yamanaka factors become FDA established.

But now why this essay? Blood goes everywhere. But not in the head onto the brain. And my instability is caused in the brain. Further I will grow mentally old. Already my vocabulary is reducing! "What is that word, was at tip of tongue,...". Even for names!

Reduced aging from diluted blood improves brain despite  BBB blood brain barrier! IOn fact it is larger than apoptosis-prevent-killer of senescent cell secretome factors! The dilution of old plasma is more effective for brain rejuvenation than the senolytic ABT 263, even though both act in the periphery – not in the brain. We interpret it as attenuation of blood to brain transfer of the age-elevated factors; and that the senescent cell secretome does not encompass all or the most negative effects of the aged circulation.

Long term, the solutions are Yamanaka/FDA. Short term AMBAR is very encouraging. Alzheimer's Disease inflicted patients did improve their intellectual scores! There may be no improvement in my essential tremors or confusingly similar Parkinson's, but I think my arrangements forced into by instability/Covid-19 give me several years if plasma fails to improve my brain!

Note that consistent to my belief system (Agnostic scientific or Paradigming RDS) gives me unbridled hope of solutions to my slow diseases like heart and diabetes and creeping-slow brain diseases and aging like essential tremors! In conjunction with allopathy for episodic events, aging reduction works wonders without significant risk. It is no different from lots of leeches and blood replacement rather than wait for growth! Haven't heard of risks in that bizarre homeopathy! Heart application then!

Plasma update for self and AMBAR

 

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What is aging?

Consider improved aging - I admit 3 methods only, Sinclair evolution, plasma update and Yamanaka factors based supplements and medicine. Unless scientific (i.e. experimental) evidence is produced, all other claims are stupid, damn democratic rights, such a person is time waster stupid. Note that this subject is about plasma update, my mistake that parabiosis implied magic proteins in young and its correction.

Similar experiments?

Let us introduce the Spanish company Grifols who make and sell Albutein®, capable of being like albumin in  human blood and their claim that their stuff reduced Alzheimer's and proved their claim with AMBER (Alzheimer Management by Albumin Replacement) clinical tests for FDA and European FDA equivalent. Their process is exactly like my plan - dilute 50% of blood by extracting and discarding the plasma and replacing it with saline and albumin! Except they did it once per week for 6 months and another 6 months of reduced amount. I will add NMN and pterostilbene for self. To bypass liver. Reported and analyzed in this. I consider them just diluting old blood without blood loss by replacing it by saline and ANY albumin rather than their product with UCB proof on mice!

Expect from procedure?

Let use AD for  Alzheimer Disease. In Oldies, AD leads to intellectual losses measured by objective psychological scales. Using these, the measurements improved by making deterioration slower by like 50% slower! Here is efficacy proof missing! Now I can proceed with the strong belief I will benefit, I know Advantages of chemicals I add by Dr. Sinclair! Be very wary, wrong NMN grade will kill you and many other  factors.  

What if it works?

If it works for me, Using FDT, You are welcome to benefit. T expect 20 year benefit from a new one-year program, largely wasting blood and ingesting saline, in an IV in a doctor's clinic. Once self-proven, reduce to 1 month if possible, procedure will cost you $30,000 in the USA, and $10,000 in India with 5* stay and breakfast for 1 month and free trip!

How fresh and why freshness important?

Nov 2020 : Plasma dilution improves cognition and attenuates neuroinflammation in old mice.

Consider technology adoption curve. There is always an early adopter period. It is also in investment. Depending on applications, early period companies barely survive. The period is for all successful technologies. Any moron can tell on success and one can talk of 100-fold growth in hindsight in retrospect. Can you predict forward? Claim you can, after analyzing the technology, how new, how efficacious, how wide the application (population benefitted) and how good the management is in chasing the beneficiaries. The investigators are scientist and aloof from money. Links are all within 6 months. Crucial is the fact no one has done FTD try on humans. There are no reported persons considering the human risks and benefits coldly and logically. Exactly as FDA, issues are safety and efficacy. Safety is vitamins and FDA approved application to auto-immune diseases. Indirect efficacy is effects on mice and AMBAR. So self-risk is low.

Instability difference

Can't forget next!