Why USA thrives

 

It is a colored view of USA, why it thrives, why I love it despite remoteness, why my lessons are central to my self view, weltanschauung, and my politics. The closest I find as ideal is Carnegie who epitomizes "teach a man to fish charity", than "gift him food". He gave a lot to establish free public libraries to many town, but librarians paid by the city government. His perfect man, never knew him by words, but self derived, established a huge school, but run by RSS, and three clinics for homeopathy, Ayurveda and Unani, all free but run by the government of UP as deeded charity. Clearly different from me (all medicines opposed) but so is Carnegie in US, still opposed by all fellow travelers. Rather than destroy, I will add free modern medicine clinic. In fact I may do it from anti-aging wealth!

I could identify my legacy, but this is about why USA thrived. As a superior business man ex-president Trump divined, no matter what your ideology, you will buy some items from USA in at least 4 classes based on innovation, military equipment (else enemy fucks), soft arts like movies, software, books etc (else boring entertainment); space access (else no satellites) and drugs (illness fucks even kills). You will buy them even if you have to eat grass. Modi bought many military items, eventually crushing china. Like a superb tactician, he has switched to self reliance. Farmer agitation has not driven him to USA stupidity (average farmer earns 1.5 times the average, based on competition control (3 laws) and subsidy for MSP like prices on unlimited produce).

The country is not managed! It has become truly universal with time and social equality. It remains a collection with recent hierarchical immigrant communities with mixing (with all the social problems). Inter-operation is competition friendly and must be forced by requiring public explanations to contrary steps, which can then be used in any court. The essential tool is unfettered competition with no steps reliable in courts on books, all capable of being competition attacked.

The USA country is a joy to live for wide reach of successful business and consumer travel on slow dilapidation, still awesome highway system, built in the 50's. India is following the same script with massive growth in highways and rail network. Even my suggestion for double decker trains is being worked on, raising some cross-track bridge path. Railway works on universal electrification of all engines, away from diesel polluters. Rapidly CNG transport and tractor revolution despite arm twisting on paraly burn!

With the falling cost of LFP (LiFePO4/C) batteries, another paradigm change happens in transportation fuel with reusable solar and wind. I am ready to invest in sea based floating solar batteries. H fuel is still sci fi. India and USA both have enormous coast lines. LFP enables electric transport! Economical wind power. Off-grid homes. These move from Sci fi to Rational economics-free speculation RSEF. [A Tesla slide presented during Battery Day revealed the $25,000 EV it plans to sell in three years will use LFP batteries, which makes a lot of sense. ]

Elon Musk is modern miracle man with several paradigm changes under his belt, feeding to themselves. Electric cars, homes and batteries by LFP, boring company city traffic and hyperloop long distance! And then reusable rockets! I summarize them as paradigm changes to fuel, city transport, intercity transport, utility backup and rockets. Achieving Doer rather than me as mere document er. If I succeed in harnessing government help, perhaps I become another 21 century paradigm changer in health span.

Alzheimer's disease and dementia

 

Alzheimer's disease and dementia are certain of some unspecified of my class, could be me. What happens when they do? A link, reachable by clicking title, references AMBAR, the only reference I could find of TPE (Therapeutic Plasma Exchange) on humans. TPE is FDA approved for auto-immune diseases, hence safe with unknown efficacy. My use, based on DRS. Conboy of UC Berkeley, un=recommended (use concerns) by them, but recommended by me for people who have nothing to lose, IE suicide doers and aged on deathbed, but these are psychological states and not diagnose-able as per me. With any sense, you are better off waiting for aging age types or ageotype which will make TPE good for you. Searching for reference I ran into a web link to Dr. Dobri Kirprov, also co-author in Conboy paper, and the TPE expert. My aging world sanes of SENS of Dr. de Grey and Dr. Sinclair has grown to include DRS. Conboy of Berkeley (parabiosis expert) and Dobri Kirprov of San Francisco (TPE expert).

That said, the mental problem is acute for me. I could not help my father. But I can my mother, convince her to take TPE. She does not trust my medicine, despite all belief in me. She has committed to following me, if it benefits me. I am all set but just one problem - I can push the matter for 5 years based on acuity of all my symptoms. In my judgment, she can't. World will change by then, more will be known, why am I interested in becoming an aging doctor, affect others than just me? Perhaps my encryption work will expand to fill all my time, now that quantum computer safe has been provably added! The answer is that for minuscule risk, my mother will follow me after near certain improvement. Do I take the very small risk? Mice and similar experiments are clarinet to buffalo!

The answer came to me after a lot of thinking: talk to the doctor uncle, has always been helpful to every one in the family, me included. He is Prof. G. D. Agrawal kind saint and smart, likely to understand the moral question and understand the medical benefits and issues. Even better, he might just know some TPE doc in Delhi and refer me to him. Covid-19 has done that to Delhi.

Federal Indian govt. in Aging Research

 

The Latest link

Clicking links is req1uired for understanding of rationale for what I say. Particular interest is in what initiatives GOI should take. To be mailed/e-mailed to PM Mr. Modi, CM Yogi, Director IIT Kanpur, class-of-75 hoping some reader will forward properly.

Why should GOI take initiative NOW?

Two aspects are initiative in-this-direction and now. Principal DIRECTION argument is engineering - likely success of California efforts makes it risk known-unknown. Now is from patent restrictions that will hobble Indian efforts soon that will be launched anyway. The efforts also bypass Mexico, likely the beneficiary of California initiatives, which will attract California business of Medical Tourism, as opposed to Greater NOIDA or rest of India, likely to become a center soon. As far as US medicine goes, both Indian and Mexican medicine are Pitts, but Indian Medicine is likely to be better controlled and better destination for Arab and European customers. The amount of sales moment reliable word is out that 10 year healthy health span extension is likely by UP based hospital (Also assuming more interest as Greater Noida soon sees film city and Zaver airport). Whatever I say is likely hot air for all usual doctors, it is all based on genetics/DNA and is paradigm shift beyond germ-theory to Aging undoing by DNA medicine and surgery beyond stem cells, that itself is a new paradigm!

Assuming GOI decides to take initiative now based on some understanding of the aging relative efforts in California, medicine being developed based on 3/4 Yamanaka factors, relevant questions are

1. Can the effort be funded within Indian politics?

My model is the ARPA agency, responsible for nearly all major efforts in the last quarter of century 20 including GPS and internet. It is not Capitalism of that era, and certainly nor Socialism or Worse of that era. The Basic question is development speed despite political reality of uniform funding. Non-uniformity is a must if differential funding of initiatives is done based on how close projects are to stated goals. To avoid bureaucratic slow-downs, project orientation is a must. Project evaluation leaders themselves have a success based bureaucracy within the agency hidden to researchers through infrequent funding visitors who are trusted but verified. There are then two models of doing better than the market - tight study (with trusted but verified visitors) orientation and prize money. Latter is quite common for lesser goals. Both violate the equal spread political reality! India uses a third unequal strategy - event forced development (like road and homes for athletic events or border location). (Bihar argues low development as a reason!).

2. What is the risk level?

One way to argue about risks is the language used by Rumsfeld that drove most public and English grammarians to peals of laughter, when he used known-unknowns etc, being standard lingo in military. Any military unit must consider each episode as unknown force application, but the total damage expected can be estimated even though the intensity of fighting in each episode is unknown.

Applying that to aging is considered funding many places. You don't know which will work, but you can argue that some will work and the returns will justify the effort. Assuming some wastage, the funding may be uniform in the first round but not in subsequent rounds. Each effort, pending experience can be judged from similarity to California work as a start.

The ultimate work goal is instantiating of Medical Tourism for Age undo in India and in UP. It is likely nothing more than FDA approved TPE (therapeutic plasma exchange) repurposed for another benefit, likely safe and worst case, ineffective!

3. Will the funding make a difference?

Yes it will. TPE use for these purposes is novel and likely to be ineffective or too harsh for some patients. A pre-test/diagnose list can be drawn up. Aging organ age-type, also how many procedures, right NBE (I take NMN not NAD+ direct, add based on US experiences, better form, and protect NMN from liver etc)

4. How should the funding be managed?

Through funding visitors, managed internally in cost-effective manner, with rights to continue a project, reduced funding or end of project, protected from all political efforts to influence. The agency worked in the USA because not many politicians could influence the agency of Military! It is fascinating how many academicians repurposed their research to ARPA interests, BUT THAT'S WHAT VISITORS DO.

5 What difference will it make to me?

First, economically change direction not a bit, however sharing results a lot. Following detailed paper that convinced me to spend my money, and benefit from it from likely positive results, is not a science based effort but a risky engineering project which may still fail. In my judgment, the science is solid to the point of known-unknowns (engineering risk) but unknown-unknowns may still arise.

Who writes this, and why?

I am a US Citizen, India resident last 15 years, being IIT Kanpur dept. topper, glorious US experience in Research wing of Bell lab, talk to Harvard, son of illustrious Dr. Arya national disaster chief of India and UN advisor to Gujarat govt after the damaging earthquake. I have recovered some from my devastating TBI accident, work on resuscitating my quantum safe copy free encryption and defeat my aging to become youthful again, no matter the risk.

Prepare for aging procedure

 

Once the intellectual decision is taken, what next. Improvement by TPE (Therapeutic plasma exchange) means some questions. Consistent with our observations. This work improves our understanding of the systemic paradigms of multi-tissue rejuvenation and suggest a novel and immediate use of the FDA approved TPE for improving the health and resilience of older people.

Serious understanding on what exact risks and benefits are?

In exact, I found Conboy interview, essential reading to exact understanding of my belief. Starting 2001, I have chased SENS, of Dr Audrey de Grey. Then he was noticed as a target of MIT Kids after he claimed to be working on Long health span of 1000 years. I learned that he was no light weight, but medical head at Oxford. Computer Scientist who had changed to medicine. Then he was offering a million bucks for lengthening mouse life by 20% or more. I tracked him 20 years. His wife died (he was 10 yr younger), retired from Oxford, moved to the USA. SENS remains, his baby now, and he collects money and thus funds lifespan research over the world. In 2005, he funded doctor pair Irina and Michael at UC Berkeley, and they did the original parabiosis work and paper. He also funded the pairs work in 2020 which also include Mehdipour siblings to watch out in future. Almost every one else interpreted the original work to imply magic proteins in young blood and several doctors from Stanford and UCB formed companies to sell the magic proteins isolated from young blood and medicalized by them. Not Conboy couple who worked on alternate dilution interpretation and proved it Nov, 2020! Other than Dr. Sinclair, only Dr. de Grey gets my full attention re age. They have met and respect each other!

Listing of goals?

Health span. 20 years bioage subtraction. Best safety I can muster. Relief of non-fixable-allopathy diseases. Horvath age post procedure.

Who will be my seconds in TPE?

My father were six brothers and 2 sisters. That is 32 cousins, 12 from mother side. Several became doctors. Four maternal nieces are MD. My ex-wife was MD. She might be tempted to watch me suffer!

Deeper looks at aging?

In fact, a decade ago, a group of prominent scientists penned an open letter describing the SENS strategy as pseudoscience. Say what you will about Aubrey de Grey, but one of his greatest strengths is to challenge conventional thinking. All innovative ideas appear to be lunacy at some point. While Aubrey’s seven strategies of SENS may not all bear fruit, Dr. de Grey is overcoming the inertia that has long kept longevity science subdued. For ex. senolytic drugs have been developed and are in clinical use!

Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin

Heterochronic blood sharing rejuvenates old tissues, and most of the studies on how this works focus on young plasma, its fractions, and a few youthful systemic candidates. However, it was not formally established that young blood is necessary for this multi-tissue rejuvenation. Here, using our recently developed small animal blood exchange process, we replaced half of the plasma in mice with saline containing 5% albumin (terming it a “neutral” age blood exchange, NBE) thus diluting the plasma factors and replenishing the albumin that would be diminished if only saline was used. Our data demonstrate that a single NBE suffices to meet or exceed the rejuvenative effects of enhancing muscle repair, reducing liver adiposity and fibrosis, and increasing hippocampal neurogenesis in old mice, all the key outcomes seen after blood heterochronicity. Comparative proteomic analysis on serum from NBE, and from a similar human clinical procedure of therapeutic plasma exchange (TPE), revealed a molecular re-setting of the systemic signaling milieu, interestingly, elevating the levels of some proteins, which broadly coordinate tissue maintenance and repair and promote immune responses. Moreover, a single TPE yielded functional blood rejuvenation, abrogating the typical old serum inhibition of progenitor cell proliferation. Ectopically added albumin does not seem to be the sole determinant of such rejuvenation, and levels of albumin do not decrease with age nor are increased by NBE/TPE. A model of action (supported by a large body of published data) is that significant dilution of autoregulatory proteins that crosstalk to multiple signaling pathways (with their own feedback loops) would, through changes in gene expression, have long-lasting molecular and functional effects.

Quadruple aging intervention

 

This is after 30 years after I woke up without memories, a TBI. It gave me time to reflect on self even as memories returned to six months before the deadly accident. The six months are blank and will remain so. I was an unlucky passenger, suffered, but have unbridled cautious optimism i.e. trust but verify. And rational democratic skepticism and superhuman attitude in paradigm shift when ahead. Something is scientific only if entirely experimental, no other source of truth.

Paradigm shift, no Scientific to 3 theories here?

Scientific theory with actionable(by you) undo aging (my claim) represents a paradigm shift. I can expose as fraud age guru theories of all else in 3 steps recommended for self test and brutal suing to true fakir any other guru or recommend er by Arun Arya age test. Else the guru is a fraud! Let him draw up a solid pre-sign document, such a Guru will have few chelas (dumb brainless disciples).

Scientific Arun Arya age test of a procedure?

First get Horvath bioage before procedure, then do the procedure, then test again to post-bio age. If the difference is not twice the calendar age difference or more, the test fails. The factor of 2 hides the zero-errors in Horvath by being tough on the Guru. The procedure cannot extend beyond a decade or the length procedure recommender has been in that business!

Medicine kinds?

As per me there is episodic illness; slow persistent illness like heart, diabetes, cancer; and very slow like lowered intellect, Alzheimer's, Parkinson's, work-stamina, illness-catching and aging. Normal Allopathic doctors are recommended for all episodic diseases and complications from persistent diseases. All very slow diseases and action with aging is co-recommended for very slow diseases. This means all aged and persistent sufferers after a while. It is a better cure to reduce the age of heart cells than try to keep it working by surgery and drugs, after a while.

Why are 3 techniques I state all beneficial and no others?

First is evolution based and self tried chemicals by Dr. Sinclair, aping him with good human logic. Basically boils down to NMN, Resveratrol (200 mg Pterostilbene instead by me) and Metformin

Second is UC Berkley based parabiosis redevelopment, untried in human unless Grifol so considered,

similar but different from blood-letting and leeches, wait for me! Finally, is work being done on Yamanaka based medicine, food, and supplements in California and Massachusetts.

 

Likely dumb remarks?

Climate concerns kids and long-lifers! You shoot for immortal life!

Aging - Arya paradigm

 

The Latest link

Likely irrelevant, but this is what USA government thinks about aging.

I have spent 20 years, scientifically researching aging, i.e. ignoring EVERYTHING enunciated by non-scientists, and taking what scientists said RDS i.e. skeptically. There is no reason for it to happen in my lifetime, it was to achieve better life when aged, life extension was never a goal. But biological theory of information by Dr. Sinclair has even created that hope, creating a hope being attacked with caution, means likely time-waste knowingly. And now a paradigm of aging connects all my scientific dots into an actionable theory of aging, listing things to do and even a why. All my derivations have a common story that magically, unexpectedly as all derived in isolation, mesh into a single theory and give hence a reason to believe in, and not chase other tricks! Essentially it boils down to what aging is to a person, - blood supply loss to the periphery, poor blood, aged mitochondria and age-methylated epi-genome. Let us fix them all. Not 1, but not many either, 4 to be exact!

Tellingly, regardless of parent's ages, all births have similar low methylation, zero when starting. This means that methylation stripping is part of fertilization and likely that original DNA is somehow preserved. The strip of methylation constrains theories a lot. Likely happens in all eggs and sperm particles, by the cytosine protein. Cytosine necessary for all mating without exception, non-DNA proteins will have some exceptions..

Fixing paths?

Blood supply is by arteries and veins, called paths. The supply is effected by narrowing or death of the paths. There is a cell lining of the path. Resveratrol and Pterostilbene are two ways to benefit the lining cells. ECP creates new paths all over the body and in-effect has wider benefits than heart.

Fixing blood?

Second way is blood itself is aged, effects delivery and usage. It might become more viscous or reduced capacity to carry molecules. Details are not important. There are two large theories of blood. Either young blood carries unaged proteins, or the recovery strength of old blood is reduced. No matter what the age of blood, aged proteins and young proteins always come in relative aging concentrations. Mixing young and old reduces the age of older, but the older is much better off and safer with neutral! Hence, NBE for neutral blood exchange effectively discarding old plasma. I will do it. It has potential for repeat too. Neutral means saline, NMN and albumin.

Fixing mitochondria?

That is what NMN or NR do. Mitoq works too. You can buy NMN+Mitoq too at USA Amazon.

Fixing epi-genome?

Central to immortality. That is what research on Yamanaka factor medicine and supplements in California is all about! When done, usual doctors will learn of FDA results.

Engineering approach?

Do the blood and mitochondria based age improvements based on supplements by aping some good users, it is Dr. Sinclair for me. Wait for prescription for Yamanaka. Will benefits add i.e. they are independent? Looks so, my trial will tell.

FDA permit?

Not a goal now! I view two principal jobs of FDA to be safety and efficacy. My safety is based on plants (resveratrol or pterostilbene) NMN (NMN or NR are vitamin B3 forms in body) and NBE (plasma exchange safer than even 100-year-old blood transfusion). Efficacy proofs for self are resveratrol (botany), pterostilbene (botany), NMN (aping), NR (FDA) and NBE (successor to Berkeley paper on parabiosis).

What causes the Horovith methylation marks?

Irrelevant to know for me. Horovith believes it is from some bookkeeping aspect in DNA. Note that CpG are C-T dense regions of DNA called Islands. Since it matches in tissue, across populations, across species, likely from DNA! In all species, the methylations are stripped in all CpG sites, but not everywhere! Demethylation during early embryogenesis occurs in the preimplantation period. After a sperm fertilizes an ovum to form a zygote, rapid DNA demethylation of the paternal DNA and slower demethylation of the maternal DNA occurs until formation of a morula which has almost no methylation

What else?

Don't trust media, businessmen, corruptible doctors, all advertisers etc. Always spend time on linked papers in top journals only. Always get go ahead from a doctor, don't ever re talk if suggesting a brand! Only universal recommended is k2 (100mcg MK-7) and d3 (1000 -10,000)IU with calcium. Nearly all free radical or ROS (Reactive oxygen species) based advice is bull-shit. D3 is a magic solver for many impossible diseases, hard to overdose on, 25000 IU per week is good.

Self-application of research

Self-application of my research

Believe it or not, David Sinclair is 50 and professor of medicine at Harvard. Based on him

https://aaqg-arunarya.blogspot.com/2021/02/paradigm-changer.html

Don't forget to chase links. It is a huge number of essays linked together. I expect comments making a lot of work free for you!

Self-application and your (reader) applications

Aging - I grow old, weak, frail and disease ridden. There is nothing doable by my immediate family or was by me or medical professionals when my father died. Last years were hard on him, he lived on to 88, but one day he died while we took him to the emergency. A finite life, longer than normal, with no long debilitation at the end is what I can promise to myself, even if any further improvements are in the future. The method I design is open for a specialist to recreate, right now there is no tested method, and my family has refused to trust my medical knowledge, the best I have is a commitment to follow me after my experience at age loss and more important, freedom to screw myself.

Relief from diseases

I have the following diseases with no real fix in allopathy, even though allopathic help will be sought by me on events. These are

1. Diabetes

2. Heart diseases

3. Essential tremor

4 Aging

Aging solution is certain to solve others. Heart was caused third by smoking (Quit 39 years ago), third by diabetes and third by genetics. Diabetes in full genetic, as is essential tremors. Cause is irrelevant. I have four diseases from genes and time. The source is important to decide what kind of intervention, if any, is best. There is precisely one that will certainly defeat all, reducing the biological age of cells involved in each. But there are no off-the-shelf subset mechanisms in biology or chemistry. The aav techniques (adeno-associated virus), that selectively direct a medicine to an activated subset, or RNA technology boosted with applications in rapid vaccine development for Covid-19, do not constitute a solution for non-specialist like me.

For blood aging there are two broad schools of thought: one in which there are regenerative factors in young blood that can be isolated, and another in which aged blood contains regenerative factors that cannot function due to an oversupply of pro-aging factors. I am in the latter camp.

A general age reduction will automatically benefit diseases. So in effect, only solution to aging will work on all. I expect 20 year reduction, which puts me just before diabetes or heart. Great if it works, has not for anyone (unless try anonymously), and requires 10 years from aping Dr. Sinclair (he shows 15) and 10 years from mice experiments at UCB (mice do lot better than10 years, percent wise, Grifol safety data) and mechanism independence (looks so). So the method I will do to self is safe (vitamin B3 chemicals and plasma update) and efficacy (liver damage control, conservative Mice prediction). Results are for me, worst case nothing exciting happens. They will Yamanaka factors medicine within 10 years (my prediction). Looks like Plasma update can be done a few times.