It is weird but used by smart people and requires understanding, despite stupidities as per you. First is to adopt evolution, whether you believe or not (IE an emfubar moron, but said softly) for it forms the basis of cladistics classification of life, and you will not understand why evolution never discovered other way to build DNA and why vertebrates had a feature essential to life (immune system) as complex as us.
Never mind the enormous naming of cladistics. Very few are relevant to top level biology, essential to understand rejuvenation. You need to understand some, to answer the trivial question of why this way, and not another. Further, a very number of unsavory morons will seek to establish their way as the right one, often in fake but devilishly clever sale methods. As a general rule, the mention of any trademarked terms is a definite clue to a commercial emfubar, not intellectual discussion! Avoid when possible such characters, forever, once identified, avoiding discussion in sweet irrelevant talk!
The classifications essential are
Eukaryote to understand the generality of Dr. Sinclair DNA theory, IE why it applies to all life
Vertebrate to understand immune system and mRNA
Thymus the small gland in the chest that forms part of the immune system, undergoes involution that ends in youth after making it a useless fat blob, and is the people killer aged 65 to 80 years (90%) in the entire species, irrespective of economic or technology development. Fascinating story of immune system and vaccines.
Immune system
There is growth of a vast new area in medical therapy called immunotherapy in the last six years that is closely tied to vaccines, cancers, aging and largely unknown to doctors as it is closely linked to mRNA, applicable to cancer, aging and cures for persistent illnesses.
All vertebrates have the cell DNA min the nucleus sac within a cell. A signal molecule causes the responsive gene sequence to be copied into one-sugar different mRNA which one way exits the nucleus sac. After uniting with a rbosome, it forms the protein that exits the cell. The mRNA itself dies by self fast or slow, In in some cases it exits the cell. Outside are innate B cells that are preprogrammed to eat mRNA, But some immune systems have T cells. They eat mRNA but also mark the remainder as evil and foreign. They develop appetite for things expressing this sequence too,
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Tthe essential story is outlined here, otherwise you can not understand why it took me 20 years of research and why best science work in rejuvenation that is far more than sci-fi, and a tech-fi as per me. To summarize, rejuvenation extends my life to 300 years, First two, called rejuvenation1/2 consist of 4/3 steps each
rejuvenation1.1: NAD+ boost, Otherwise NAD+ and strength continuously decline with age
rejuvenation1.2: SASP reduction by senolytes, otherwise some cancer gets you, or SASP use up NAD
rejuvenation1.3: Blood vessel toning, else external skin shrinks and folds
rejuvenation1.4: Fix bones else osteoarthritis to osteoporosis
rejuvenation2.1: YAMANAKA factor drugs and supplements
rejuvenation2.2: Dialysis like Drs, Conboy filters and dilution
rejuvenation2.3: Aging vaccines and mRNA drugs
This is just a summary so far. You are programmed to die in next year to 15 years from now, 90% of you. 40 of us will be in 80s. 2 or 3 will cross 100. I want to be one. I will if I take 7 steps above, most certainly one if TRIIM develops fast as it might, given Dr. Greg Fahy leads the charge. He is the ONLY doctor who has met my test - decrease some reputable Bioage (decrease as much as calendar age or more), He did 1.4 years gain in 1 year elapse, in 2018, in FDA clinical trial on males aged 50 to 65. This time, both sexes, 40 to 80, much bigger sample. He operates on the thymus. This is rejuvenation 1..3. I fight wi6th self on thymus supplements as built out of calf thymus extracts. Kill the calf or harvest thymus - to be found.
Steps taken by Dr. Fahy
For the purpose of TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) here is the paper.
Reversal of epigenetic aging and immunosenescent trends in humans
First published: 08 September 2019
Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological age. Here, we use four such age estimators to show that epigenetic aging can be reversed in humans. Using a protocol intended to regenerate the thymus, we observed protective immunological changes, improved risk indices for many age-related diseases, and a mean epigenetic age approximately 1.5 years less than baseline after 1 year of treatment (−2.5-year change compared to no treatment at the end of the study). The rate of epigenetic aging reversal relative to chronological age accelerated from −1.6 year/year from 0–9 month to −6.5 year/year from 9–12 month. The GrimAge predictor of human morbidity and mortality showed a 2-year decrease in epigenetic vs. chronological age that persisted six months after discontinuing treatment. This is to our knowledge the first report of an increase, based on an epigenetic age estimator, in predicted human lifespan by means of a currently accessible aging intervention.
Thymus Regeneration by Immuno-restoration by IGH-1
Insulin Mitigation by DHEA and metformin.
Every one benefitted, some by 6.5 years. No one published real death data, Grim age improved. Results summarized next.
A primary concern in this study was whether increased levels of a
mitogen (IGF-1) might exacerbate cancerous or precancerous foci in the
prostate. Both of these changes should be detectable by measuring PSA or
percent free PSA levels. However, PSA, percent free PSA, and the ratio
of PSA to percent free PSA, an overall index of prostate cancer risk,
improved significantly by day 15 of treatment and remained favorably
altered to the end of 12 months (Figure 1a–c).
A brief spike in PSA at 6 months in two volunteers was rapidly reversed
and, after volunteer consultation, was interpreted as reflecting sexual
activity close to the time of PSA testing. No change in testosterone
levels was observed
Growth Hormone
HGH (encouages IGF-1) has been taken by some Silicon Valley billionaires. Based on their experience, the drawbacks of HGH were realized (causes mild diabetes, may cause cancer). The trial dismisses cancer fears and contains anti-diabetes.
Evolution view
All vertebrates suffer from programmed involution. Why? Why does evolution be against long life for anyone? A minority view, those willing to an opinion point to enormous energy in making T cells. This happens with rising expense for sexual maturity. So the evolution survivor inherit sexual maturity over T cells! How recapture energy for some residual T cells? HGH of course with drawbacks filled. Many HGH dangers are not evident.
AN effective warning! However, while muscle mass and bone applications attract all fears and no proof of anti-aging ( diabetes itself reduces life), only Thymus benefits are believed by me as a bio-hacker who prints out warnings as well. This is the only effective test known, being repeated, even though I believe in mayo protocol for SASP and that Dr. Sinclair is 10 years bioage younger (known), good blood channels and all this due to his diet and efforts.
Fact is HGH causes lot more trouble as aging fix, bad idea used so, but the only bioage reversal can not be swept under the rug! For all my fears, based on a minority theory of programmed reduction, I do believe it as a shot, but only as a biohacker.
