aaging: Arun Arya paradigm
on Aging
When a paradigm
changes, the new is rarely even comprehensible to the old, it is a
restart which demolishes seniority. (Paradigm is used generally). It
swings to the young new. Historically, it changes because all believers in the old paradigm grow old and die, while professors teach the new! It is not unusual for the paradigm changer
to be sensible and to transfer real power to a semi-senior young,
rather than the old guard.
Since I use this word so much, let me introduce the sub-paradigm concept motivated by programming. Use of procedures and functions was a very successful sub-paaradigm that persisted unchanged even while structured programming, object orientation and api-based sub-paradigm rose. Now comes a true paradigm change of functional programming! Old style programmers were not confused by sub-paradigms but will be devastated by functional programming.
Politics example?
This happened with
Modi who became CM of Gujarat, primarily at that point to solve
infra-party conflicts. He won, prospered his state and prospers the
country today. He represents a paradigm just as Nehru did. Rahul does
not understand and never will.
Medicine example?
The germ theory of
disease underlies modern medicine. Also called allopathy to raise
Ayurveda etc as equal alternatives (they are not and homeopathy is
criminal). Most diseases of century 20 were bacteria based and mm
theory prospered. Now we must deal with virus based diseases and
likes of heart and brain diseases. Further is Aging, also considered
a disease. The reasons are subtle changes in cells, mitochondria and
DNA. It is more genetics based. New medicine will deal with stem
cells and cell fixing. New mm is a new paradigm. In old, causation
was bacterial. Lot of effort has gone into identification and killing
off suspected agents. FDA was a golden way to evaluate medicine. New
efforts are on in-vivo genetic changes, strengthening of white
cells, reinsertion of cells after extraction and processing and
infusion of plasma. The greatest challenge is to extract and reinsert
brains. It can be done with heart. Current FDA and its interpolations
are stupid for evaluating new agents
Arya test?
It is like a Turing
test. Can any organism achieve biological
immortality, if isolated from all other life forms?
Perhaps for lower life. Cancer cells are immortal. Higher animals
like jelly fish are immortal. It has a massive advantage of being
able to revert to child form. This is death of the old form and not
included since memories are not preserved, and it is more like
rebirth, not included.
If at all awake,
there is new technology which can enable a digital brain readout in the next few hundred years (channel rhodopsin
. TED,
This is from MIT) and will fund its own growth through mental and brain disease
alleviation. If
so, immortality can be achieved through robot life. Is the new
robot the same as old? Is the person after quantum gates transfer the
same? There is a philosophical argument possible. I skip that, since
I know that death is like endless sleep that I was in pre-birth, one
every day without dreams and one I was in while TBI. It is a boring
philosophical topic.
Physics example
There was pre-newton
understanding, representing a paradigm. Several thousand years of
seniority. There was a paradigm change that the Christian church has not
gone over. This was followed by the Einsteinian paradigm. Confluent was
quantum physic's paradigm change with Planck. Now the church is screwed
and has bowed out of reality, evolution and all. This was supplanted
by Feynman/Dirac paradigm change. Suddenly one could make sense of
particle zoo!
Cosmology
The Universe was understandable to church till Galileo paradigm. This was changed in the
American astronomer Hubble paradigm. It forced belief into the big bang
model. I believe (minority) that Galactic
rotation curves indicate that the theory of gravity follows Dutch
physicist Erik
Verlinde's Gravity and also independent
observation to indicate that dark matter is real. Or it might happen that the bullet cluster is special. BUT consider the fate of two shining examples of dark matter!
Understanding?
What does it mean to
understand anything? The paradigm theory provides a barometer.
Paradigms change with time as new technology allows finer data that
may well conflict with current paradigm Or the current theory is
found to fit experiment in worse ways. Can a paradigm be inviolate.
My thoughts since no thinker has asked this question. It means
something that opposes science a big way - unless something is
falsifiable, it is not science. No wonder doctors keep changing their
mind, they can only tell a patient the current results. Lack of change prohibits new experiments! Yet one thing can seem to
be certain - mathematics. It matters not what current belief or
experiments are. Even that fails in quantum physics. Things can
happen without any classical (read logical) reason. There are two
things in particular that can behave as quantum resources. One is
entanglement and the other is simultaneous states.
Many states is that
if a particle goes right, it will also go left with some probability
at the same time, there is no way to prevent going left. You can not
prevent a particle in a well of energy, with some it will go out with
some probability, It is how photosynthesis works, any leaves can, but
best chemical engineers can't. Entanglement can be used to build
tamper-proof internet. This is how tomorrow works, no sci-fi
involved. These are only two uses.
The protein folding
problem is fundamental to new medicine, Existing computers, no matter
how much faster, can not solve it. But quantum computers can. Google
has claimed quantum supremacy. The protein folding problem is
solvable for them with more qubits.
So even
understanding is a difficult problem. Is general P solvable? Can't,
but quantum computers may, but they can't. There is no way to tell the
answer in general. Don't feel bad because same was even before,
undecidability is itself undecidable on deterministic ordinary
computers!
… when you’ve solved biology, and you know how
it all works, will that be disappointing at all? To have no more
mystery about the mind, or why we do things?
The premise of the question is that the mystery would go away. But
I don’t know if the premise is correct.
We know lots and lots about water, but does that erase the
meditative quality of sitting on a beach and watching the waves? We
know a heck of a lot about how stars work, through fusion of hydrogen
and the creation of all the elements and so forth. But does that make
it so nobody wants to look at the night sky? I think there are many
kinds of wonder. And some are untouched, if not enhanced, by science.
Aging?
It seems that
'creatures age without tampering' except that jellyfishes are
immortal but for useful point of no memories transmitted. Suppose I
could be immortal jellyfish style. Record all memories preservable.
Then proceed to renew my body, set up the environment so that the
recording is available to renewed me, am I immortal? Why should I
leave bad memories for next me? Perhaps some mine and others
obtained. Or all as sold? Or just enough to be me! All kind of
questions disappear with Yamanaka factor based renew. Done every
dozen years, I go to renew self, spending say a month in a company
hospital. Since robotics is everywhere, I get government dole. The Government sets up a tribunal for each death (only accidental).
Lessons are learned and implemented to avoid a repeat, research if
tribunal can't decide.
What will hospitals
do?
They will use RNA
based selections of right DNA cells. Then OSK factors will be
administered to pull back age of some cells. Same repeated for all
cells. The brain part is different. The neurons form undecidable
analog circuits. So no engineering is done. Something much better is
done. Like body parts, independent neural net governed extensions are
available for direct brain control. The control is fused to the
brain, useless till some commands become part of the brain. The rest
are picked with time. All this before download happens, in a few
hundred years.
Why will they do it?
To earn money per
procedure from the government.
Will private
property live?
It will because of
tragedy of commons.
So how will this
come about?
Increasing free time
to workers, decided between unions and the government for employers.
Consolidation of unions to two - free enterprise and socialist.
Brutal firing of commies and long imprisonment.
Politics?
Don't know or care.
Competition between at least two raised to constitution and made part
of checks and balances. Strong anti-monopoly checks and balances. The
government must be minimal, with less the role as possible. Strong
support for son-of-soil employment. Poor states have no dole
provision. State parts have the right to secede and join on unanimous
wish (seceder and absorber). No uniform laws in family matters except
number of husbands and wives, marriage and divorce and other
population count matters.
