Digilog - new paradigm shift in Aging

A paradigm shift is a revolution that destroys ALL old methods and concepts and by definition, destroys experience. As a member of computer science, I have witnessed several paradigm shifts and destruction of all my friends but me, who smartened up fast, changed to academia and sincerely busied myself in research, redoing all with each shift.

This is my first piece and tells what was a(later) and why this is a paradigm shift. Digilog  is my neologism for this new paradigm, portmanteau from digital+analog, the generation is by Dr. David Sinclair who calls it theory of information, who along with Dr. Aubrey de Gray are the only doctors who make sense, and are both originally non-MD! In other words, digilog will hopefully force ALL MD to retire from AGEING, and destroys gerontology and geriatrics, both being staffed by inconsequential now till they learn and start using digilog concepts.

The first surprise is that perpetual youth and end of Aging are the same thing! That is because end of Aging is like jellyfish. second: It will work because it depends on Yamanaka factors (Nobel prize) that convert any cell to its pluripotent form. Right things are not as any per any religion, but evolution. Aging is from Cellcide from analog epienome transcription errors on broken digital DNA.

https://www.youtube.com/watch?v=IEz1P4i1P7s

50 min long. MOST valuable video you will ever watch - Socrates-video not capable of summarizing.  Either you become convinced, or remain stupid - maximum strong words from me. It is falsifiable, hence a scientific theory. It treats Aging as a disease, not a source for any ethics. It works on all animals, easy for  evolutionist as me. Healthy things it propagates have zero value beyond your own health! Hopefully, you will NEVER abuse word natural again - death is NOT natural but consequence of bad life choices, not following empirical techniques  and lack of knowledge. I think it will be wish-death by 2030 (corona ends 2020 with CQP)!

Tremendous concept of Horvath clock and sane blood tests feedback. (Later)

HCQ etc

Much flip-flop on HCQ. I believe it was being administered to Dharavi residents as a prophylactic. Perhaps other slums too. Haven't heard about the outcome. Sir Mohoni
10:42 AM

HCQ and phosphate are different despite sharing quinine - HCQ is Trump baby, chinese scientists are equal to best west, never-mind USA now; but Govt captive.

I am NOT a professional chemist, the phosphate ion makes it acidic while HCQ is a base pH from OH-.

a study in The Lancet Rheumatology has found that hydroxychloroquine decreases the acidity in compartments in the cell membrane. Since many viruses use the acidity of these compartments to breach the membrane and set off the process of replicating copies of itself, the reduction of acidity can potentially inhibit viral replication. In 2005, the drug was used to treat SARS, but it failed to decrease the viral load in mice. HCQ probably works for very few.

Rajasthan doing HCQ for police. I suspect non-bjp folks but HCQ is failed Trump baby! These govt. not acting on results!

I suspect virus does penetrate compartments but then gets killed by quinine or phosphate or both.

I read somewhere that the US is administering four times the dosage that we are, and that has caused the reported complications and deaths - Sir Mohoni

 
US problem of plenty! If x is good, 4x should work miracles!

choroquine phosphate repurpose break-through for corona

from chinese, official US translation

https://pubmed.ncbi.nlm.nih.gov/32075365/
[Expert Consensus on Chloroquine Phosphate for the Treatment of Novel Coronavirus Pneumonia]
... Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. It recommended chloroquine phosphate tablet, 500mg twice per day for 10 days for patients diagnosed as mild, moderate and severe cases of novel coronavirus pneumonia and without contraindications to chloroquine.

 https://pubmed.ncbi.nlm.nih.gov/32074550/?from_term=%22COVID-19+drug+treatment%22%5Bnm%5D&from_pos=1
Breakthrough: Chloroquine Phosphate Has Shown Apparent Efficacy in Treatment of COVID-19 Associated Pneumonia in Clinical Studies
Jianjun Gao,, Zhenxue Tian , Xu Yang
 Abstract

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.

Arya
1. unlikely a hype -- too official
2. china did fool the world, emerging late but at least
3. west pharma-scientist  hit but so what? Recommend continue fina ncial support for a month
4. Easy to build after quick ramp up in India
5. Repurpose means known side effects

More vitamin D

First regurgitating what written 1 month back as end this missive. Did not stress it much as most of folk were engineers at MIT etc. Now the claim is also made by MGH doc. Harmless waste of money if not as good. Suggest consider 60000 IU. Per week or 15 days of vitamin D3. Talk to doctor first. D sold as sachet once/month 60000 IU. Use it per week.

Overdoses not possible. AN ortho doc told me re medical education 40 years back, they wrote prescriptions for 500,000 IU per week! Alternately, remove shirt and sit in Sun in India (no shirt) for 30 min per day!

Talk to doc ASAP. Most of us are 65+ and need D3 fast!

Vitamin D deficiency may be linked to more severe cases of COVID …

 

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths.

https://pubmed.ncbi.nlm.nih.gov/32377965/?from_term=vitamin+d+coronavirus&from_pos=2

https://pubmed.ncbi.nlm.nih.gov/32268052/?from_term=vitamin+d+coronavirus&from_pos=4 

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D vitamin

https://www.foxnews.com/science/vitamin-d-levels-covid-19-mortality-rates

The researchers also found a strong correlation between vitamin D levels and cytokine storm, which is a hyperinflammatory condition caused by an overactive immune system.

"Cytokine storm can severely damage lungs and lead to acute respiratory distress syndrome and death in patients," Ali Daneshkhah, a postdoctoral research associate at Northwestern's McCormick School of Engineering, said in a statement. "This is what seems to kill a majority of COVID-19 patients, not the destruction of the lungs by the virus itself. It is the complications from the misdirected fire from the immune system."

Arya

1. Eating d3 as part of [k2, d3, ca]

2. explains low rates in india etc high italy, france, usa etcbecause melatonin - we brown/black

3 anyway good although oteoporosis/penia common from lack of ca and no k2 in diet like chinese or japanese, addind d good as overdose NOT a problem - jusst wasted money and d cheap

My universe and earth

My universe and earth: why written and why to be read

https://aaqg-arunarya.blogspot.com/2016/11/birth-of-aaqgs-aaroon-aryan-quantum.html

Why written? Like greatest ever book “meditations” by highest stoic and roman emperor Aurelius, two thousand years ago, I write this as a personal journal. Two score years ago, I was a new minted doctor of computer science at the age of 25 at the University of Rochester at New York in USA, finished serving the greatest computer scientist of all Prof. Jerome Feldman, and I was finally free to deal with rest of Life. How?

A content life​? Like my doctorate, rest of life made sense only if there was a sequence of overriding objectives. It had to begin with “who I am and what drives the society around me” and gave myself 5 years, like gave 4 years to get a doctorate. Actually 40 years to be finally comfortable, what this book is about. And has finally allowed me the next question “how to live long enough, healthy enough, to ask myself the next question”! Again five years to find an answer, it matters not if answer is no (stoicism) or can’t keep schedule – extend then”

Acknowledge debts? I TRUST NO ONE INCLUDING MY GREAT PARENTS, GREATNESS NOW EVIDENT. I am eldest only son with three accomplished sisters, all great engineers., each of them a topper LIKE ME and all great engineers.scientist in their own right. The youngest is Anshulie (IAS) who broke all existing records of academics AND sports in IIT Roorkee formed from Thompson college built 150 years ago by the British as the first science college in asia. My parents genes and our upbringing.

What is a scientist? A rational skeptic, who ensures that some credible scientist has verified every fact in a theory which must be verifiable. To escape deep philosophical problems, every scientific truth must be a theory (i.e. verifiable), others are mythical stories. That must be the first question! Every religious statement is dead on this ground. So are many pseudo-science account of multi-verse. Only one known is story from Smolin that is verifiable, equals a theory. I want to read more. But not more myth and no fiction but science fiction.

Why read this? Certain not because of me, I don’t care! Because it raises questions and never unanswerable, but hard enough that it is worthwhile to look at some one else solution to get a skeleton. On your skeletons, build the muscles and a skin you like, to be changed whenever. Or do what I do, important enough to generate a new theory of system organization – start from a solution, filling its blanks, adding new ways replacing the deleted. Every iteration yield a new complete new solution. In software, the method starts from a working system designed to be modified and modify it to a complete new solution! Legacy solutions are not disasters if written with further developments in mind! In software sense (AI WILL EXCEED HUMANS), my own BELIEF IS THAT ASPECT MERGING OF LEGACY CODE WITH AI SOLUTIONS IS THE NEXT PARADIGM SHIFT IN SOFTWARE.

D vitamin

https://www.foxnews.com/science/vitamin-d-levels-covid-19-mortality-rates

Abstract Background Large-scale data show that the mortality of COVID-19 varies dramatically across populations, although the cause of these disparities is not well understood. In this study we investigated whether severe COVID-19 is linked to Vitamin D (Vit D) deficiency. Method Daily admission, recovery and deceased rate data for patients with COVID-19 from countries with a large number of confirmed patients (Germany, South Korea (S. Korea), China (Hubei), Switzerland, Iran, UK, US, France, Spain, Italy) as of April 20, 2020 were used. The time-adjusted case mortality ratio (T-CMR) was estimated as the number of deceased patients on day N divided by the number of confirmed cases on day N-8. The adaptive average of T-CMR (A-CMR) was further calculated as a metric of COVID-19 associated mortality in different countries. Although data on Vit D level is not currently available for COVID-19 patients, we leveraged the previously established links between Vit D and C-Reactive Protein (CRP) and between CRP and severe COVID-19, respectively, to estimate the potential impact of Vit D on the reduction of severe COVID-19. Findings A link between Vit D status and COVID-19 A-CMR in the US, France, and the UK (countries with similar screening status) may exist. Combining COVID-19 patient data and prior work on Vit D and CRP levels, we show that the risk of severe COVID-19 cases among patients with severe Vit D deficiency is 17.3% while the equivalent figure for patients with normal Vit D levels is 14.6% (a reduction of 15.6%). Interpretation Given that CRP is a surrogate marker for severe COVID-19 and is associated with Vit D deficiency, our finding suggests that Vit D may reduce COVID-19 severity by suppressing cytokine storm in COVID-19 patients. Further research is needed to account for other factors through direct measurement of Vit D levelsThe researchers also found a strong correlation between vitamin D levels and cytokine storm, which is a hyperinflammatory condition caused by an overactive immune system.

"Cytokine storm [ why kids die] can severely damage lungs and lead to acute respiratory distress syndrome and death in patients," Ali Daneshkhah, a postdoctoral research associate at Northwestern's McCormick School of Engineering, said in a statement. "This is what seems to kill a majority of COVID-19 patients, not the destruction of the lungs by the virus itself. It is the complications from the misdirected fire from the immune system."

Arya

1. Eating d3 as part of [k2, d3, ca]
2. explains low rates in india/africa etc high italy, france, usa etc because melatonin - we brown/black
3. anyway good although osteo-porosis/penia common from lack of ca and no k2 in diet like chinese or japanese, adding d good as overdose NOT a problem - just wasted money and d cheap

FALSIFIABLE Creation theory

(Falsifiable = Scientific) theory of creation

It is possible to create theories of unfalsifiable creation for morons, about 90% of people, the remainder being agnostic, if not stated atheists. All human cultures have done so. Can there be a theory of creation which is testable? I believed not possible and delved into Cosmogonies (many) that at least looked like science in the limit - top being strings (now branes) and LCQ where every thing is quantized, space and time too. Both lead to rigorous deductions but alas are unfalsifiable IE not science. Both postulate a multiverse.

But Lee Smolin changed that - a very boring speaker with the first falsifiable theory. The standards he sets are so high, that ALL other stories are small and stupid in comparison!

Is cosmological natural selection a theory? Yes, because it is testable. Whatever the theory, it has to meet these goals as per me -

1. Explain physical constants and their values
2.  Physical laws and their genesis
3. How is the theory falsifiable and why not falsified already
4. Where did space, matter, time come from?
5. How does science arise in the limit?

If you have even of iota of doubt about these issues the rest of this write-up is a waste. If you are dumb enough to think that ANY theory of creation can answer these or is listed in any set of tomes, you are a hopeless gone-case and the rest is a waste of time. Only if you are a rational skeptic, not a rational Stoic like I was for 35 years, and think it can't be done without some belief, go on please.

The essential theory is based on evolution, carving the values of constants over eons till they reach a universe which has human life; other beings find their sets in the multiverse. Because space and time are created in big bang in all universes, there is no problem of all universes share or not the same space-time, or not!

The Key to magic in the Smolin model is black holes in the chain that leads to us. Moment a black hole forms, it is provably cut off the parent! It is not magic but the derivable consequence of collapse of large stars. All matter that falls in a black hole falls to its center. When two black holes approach each other, their mutual dance leads to an eventual merge. More mass for center of joint new black hole.

 How does science arise in the limit?

It need not as Sir Smolin's theory assumes no new science and is consistent with current science.

Does Arya agree?

There is a hole, why did compaction at the center bounce to produce a new big bang?
I postulate new quantum physics with a maximum space density equivalent. When the density limit is exceeded, you get a bounce IE new big bang. Left for undone physics of quantum gravity.

Where did space, matter, time come from?

Time appears to be universal. Space-time appears to be emergent from quantum gravity
QG and not fundamental.

Explain physical constants and their values

Physical laws and their genesis evolution, death and rebirth cycle are postulated (for QG) to be slightly different per finite cycle. A chain of finite sized universe, each a black hole,  exists for our universe. Amount of matter per universe grows (likely) till the current universe which will never collapse! All the former parents may have finite lives or not, black holes must merge to our mass in the chain.

How is the theory falsifiable and why not falsified already

The universe of beings in our universe must have sentient life to subject the universe to logical and falsifiable evidence  tests IE scientific inquiry. Such a universe will likely produce life (at 13.7 billion years) ONLY IF IT IS ABOUT as common as the average composition of the universe. At this time, most stars made from big bang materials (First generation) stars have died (mostly H & He) after fusion to iron. Stars die in explosions,  in turn spreading their guts in their galaxy. In turn galaxies merge to become larger, as did Milky Way. Clusters of enriched gases had one with the solar system. Evolution produced life in one that was called the Solar system on a planet called earth.

It is falsifiable because it claims similarity in chemical constituents of universe and life. Every part of the story can be checked by astronomy which has components far away in time too. It has not been falsified already because quantum gravity has never developed despite the best human efforts.

God was never invoked in this narrative. Pointless to argue about unneeded deity. This world has a billion nonbelievers and does fine. Deity not needed for ethics. Explains my agnosticism - deity not needed, ALL believers without science (IE rational skeptic falsifiable) are stupid since 2020.

Excellent hour+

https://www.youtube.com/watch?v=fORZASxZMEQ&feature=youtu.be&fbclid=IwAR1_U6_sG46MJBU1zDUaZOcyx90PJyQO_DPNzW0DU-Aj-1jU0C3U9OQpJHY

Sir Smolin says.