5G- 21st century revolution begins

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I have talked about NMN + metformin, the joint revolution to human ageing, NMN is already at prices affordable to upper middle class around the world and metformin is dirt cheap everywhere. 5G is new tech, available advanced countries by 2019, extensive by 2020 and world wide by 2021. If you guessed ‘successor to 4G’ in phones, faster than 4G, you are right. So what? Better phones for sure. But 5K is like internet, say I! At most 2 years from start of another internet! So far, to me, Internet defines 21^st – business, communication etc.

It is what else that happens, is why 21^st century revolution begins. Basically, 5G is communication at 10 gigabit range. What can happen at that speed?

All local information becomes pointless. Much worse for libraries, photo-albums, CD etc.! Large TB level USB solid state only will remain.

Essential for self-driving cars, virtual reality, smart cities and networked robots.

Enables remote weapons. Why build expensive local computation in each fire and forget weapon? Just do computation remotely and communicate with bomb encrypted!

A surgeon with virtual reality equipment and haptic gloves, which sense motion and pressure, could operate on a patient on the other side of the world via a robot.

Remote surgery has been possible for a while, but 5G speeds should eliminate all delays and lag. That means the surgeon could get instant feedback via the gloves.

"With 5G and the new networkingarchitecture we're building, we're hoping to get this delay down to just thespeed of light," said Mischa Dohler, a professor of wirelesscommunications at King's College.

Dohler, who moonlights as a composer and pianist, also plans to digitize his piano skills and teach people remotely to master the instrument. Why record the music when can record and reproduce the play? You can already modulate your voice as per another singer, so as to sound as good! (Expensive but doable, I intend to buy a unit and make it available as cloud connected franchise!) Within 3 years, one can make citizen-movie – substituting only one character in movie to the buyer! I can imagine vast sales with just the heroine replaced by the lady-buyer and my franchisee providing blue frame acting studio and post-acting integration on the cloud (otherwise very expensive)!

Like Netflicks and Amazon, one can consider self-production of replacement films (Shot with few blue-clad replaceable characters!)

I am ready with great ideas – use 0f 5G and low-cost start. A Bangalore techie started flipkart in 2012! 2020 here I come. Can even enjoy the wealth!

Start of Anti-aging revolution

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Everything that follows is based on hard biology, without any apology to those influenced at all by religion or spiritualism, even if my presentation attacks their belief. Don’t then read-on.

A human robot is managed by brain. All feelings are either converted to nerve signals, or generate hormones. Biology is by evolution by punctuated natural selection. The being is constructed by epigenetic envelope over DNA.

Aging is by cellular damage accumulation in all life – plant or human. Wrongly I believed that compensation of missing DNA products would lead to better age. Old belief leads to healthier life but has no age extension benefits. Dr. Sinclair changed my paradigm. To extend age, one starts from proven methods, determine their molecular pathways, identify the molecules one tries to help, find the genes helped by the helper and thus consider the effects. Metformin and NMN are anti-insulin perhaps, effecting the mTor molecular pathway!

This summary of why think so, explains to me why Ayurveda is unlikely to help! If there was ANY herb/combination, I view our continuous history of several thousand years and say to self – if there was any plant or combination that had +ve aging effects, it would safely be discovered by now! Our ancestors even discovered the good effects of Shilajit by unscientific blind empiricism since it has +ve strength properties and no –ve side effects! Clearly then NMN is not a plant or animal product as it was discovered in west with several thousand year old non-vegetarian history over all kinds of animals or in Africa with cannibalism in past!

Why does it work?

It increases NAD+, better than NR which suffers from NAMPT bottleneck.

Epistemology?

Here means who to believe! Bastard criminal sellers (i.e. most US Marketeers) means that there is NO way to discover truth – if there were, it would already be abused elsewhere! What then? My esteemed brother-in-law had the same question in 1998 when I sang re Java, writing me off as victim of Clever US Marketeers! So I was forced to examine my own epistemology. I claim general scientific view. Which means rational skepticism! In other ords, ALL the excellent reviews were bull shit, simply extensive ads. All the endorsers could be liars. Videos photo-shopped. So on. The devil was not ordinary but US sellers, who have to be respected for their bull-shit!

My belief is twofold – try it on self-first for 3 months, and try only because Dr. Sinclair has been followed by me since 1998, discovered Reservetrol, sold his company for billion dollars, hence has NO economic reason to lie, sells nothing and consults to NASA re HEALTH of astronaut going to mars, has PhD from MIT, tenured MD faculty at Harvard! He looks 30 and claims to feed his father, living proof of small trial, NMN behind $2000 per month cost till 6 months ago, tolerable only to motivated billionaire.

One thing all agree on – no ill-effects. Only thing I lose 3 months from now is NMN has NO benefit!

Aging properties of NMN?

Big question is – how do know after 3 months (no death needed) that NMN indeed helped aging. Interestingly, I can!

What if NMN works?

Living to 150 or more as a vegetable is not my goal! There are 3techniques to enable me to a worthwhile life – ECP, HOT, parabiosis! These are extra to NMN vitality. I can usefully chase women for next 100 years! By then transfection would develop for 1000 year boost!

Aging characteristics of NMN

Who knows in detail! What will convince me that my money is not being wasted on a supplement without FDA testing? It can be done!

Earlier research by Brown-u says 2 things

1 calorie-restriction works thru m-Tor molecular pathway

2 Anything that reduces Insulin, but also sugar, is good for you if done without insulin or making the pancreas make more by suphonyl-urea drugs! These include metformin acting on liver and acarbose type drugs interfering in sugar absorption in stomach. Both have claims to improving longevity. I happen to believe (unlike most existing doctors fully complacent of new research, dependent on studies on big samples).

There is one reason to explain lack of studies, NMN around for ages, the users at 500 mg per day paid $2000 per month!  Sinclair MD did, himself and father! Reportsenergy-level for both is 20 years lower age. He could, being a billionaire. Empirically proved it on mice. Fountain of youth for mice. Safe for humans.

Apart from being diabetic, I am also an exercise freak, excellent with NMN. What is more, even better than Dr. Sinclair, the sublingualroute is as good as injecting, possible for NMN. 500 mg is like 1000 mg dose!

90% of my fasting sugars are within 100-110. If they are 90% within 90-100, NMN has proven graceful aging properties for me after 3 months. Exercise route for this is estimated to 400 cal per day (1.5 hours of brutal exercise). I test every day and meter zero errors are irrelevant! Three months later, post experiences! NMN is advertised on eBay for Rs. 20,000 per month for 500 mg but only edible, as capsules!

 In a novel experment in mice, MitoQ was shown to protect against insulin resistance.  All these studies were reviewed in a 2011 paper by Smith and Murphy.  Historically, there is a strong correlation of life extension drugs and the ability to enhance stress resistance.  “Together these findings show that MitoQ is protective against pathological changes in a number of animal models of mitochondrial oxidative damage that are relevant to human diseases.”

Aging – Sinclair view over all others

https://www.youtube.com/watch?v=hgQM9l8RWCw

Sinclair is an MD, faculty in Harvard medicine, MD-PhD with MIT. His views are minority but being adopted explosively fast.

What is the basis of fame?

Yeast, made of very simple cells in a colony, suffers from aging! What is more, it can be studied fast. Using yeast, he found aq number of genes related to Sir genes. 7 are found in human, called Sirtuins, of which Sirt1 is the most prominent.

One entire line of medicine is focussed on anti-oxidants. Another attempts to understand two techniques, applicable to many species that have demonstrated benefits but are difficult to adopt – calorie restriction (hunger) and exercise (tiring). Both have molecular basis that may be amenable to much easier adoption, or even act as to increase the effectiveness of these two techniques.

Cutting through the chemistry thicket is the block diagram above. Of the three pathways, two are benefitted by metformin and nmn (nicotinamide mono nuclide). Upto last year, nmn was $2000 year per month of recommended dose. Two great things have happened since

1 Direct synthesis of nmn has been discovered

2 Sublingual administration of nmn is shown to be possible and effective so that stomach penetration losses can be avoided (sharply reducing required dosage) and 4 or more divided doses  per day is feasible.per day are feasible

THIS MEANS, STARTING JUNE 15, IN usa, A 500 MG/DAY DOSE PER DAY, DIVIDED INTO 4 OR MORE SUBLINGUAL SUBDOSES IS POSSIBLE FOR ANNUAL $500.

What does it mean to oxidant-guy like you?

Above indicates a tectonic shift in my thinking away from anti-oxidants to helper molecules. Why?

1 Beliveable partial empirical proof. The doctor takes his drugs as does his father. Doc claims feels like 30 when 60 (looks so too in video linked!) and wears no makeup! Father in 70’s claims feels 50’s.

2. Metformin (10,000,000) records and nmn (3 year human, countless mice) is safe.

3. Program is easy, super-easy for me who needs metformin for diabetes! 500 mg of nmn as four or 5 sublingual sub-doses, 4 times a week, supplement day 300 kcal exercise. Two dinners off per week. Age ninety, here I come, expecting to make 2050 decade, current tech, despite diabetes and heart triple bypass! Plenty of time to acquire boost and live past current expectation.

4 Plausible narrative, experiment worthy, low risk. Results can be visible within 3 months! So blow $200, limited risk.

Three ingredients of belief in my epistemology (absent credible attacks) are sho benefit, show safety and affordable! All met. Further requirement is short interval (3 month). If no visible benefits in 3 months then bye bye.

How come you trust him so much?

1 Experiments on himself and loved

2 Critical of own Reservetrol (sold for 750 million dollars. Empirical disaster from sales process losses and stomach barrier!

3 Avoids the glamourous but FDA-avoid route to FDA welcome to test

4 Hard won NASA commission to supervise health of Long-term astronauts to Mars

Why deaths – road, medical, crime etc – aaquantum scholarly research

There are commonalities deducible from hard statistics, not chosen. First rod then medicine Finally crime. Suggest from statistics is that causes can be divided into controllable and uncontrollable factors; different degrees of loss of liberty in remedial steps is involved; politicians, lawyers and law enforcement and philosophers who do not consider liberty-loss in suggestions upfront and fail to identify this consequence of trade-off up front are motherfucker criminals.

They must be severally punished in my ideology which only respects limited “no law, no crime” i.e. forbid of retroactive crime, not prohibited but subject to “prohibited, unless necessary” like “guilty, unless innocent” philosophy. This allows criminalization of slave-owners, tax-cheats, cigarette companies, nazi, apartheiders etc.

Deaths happen in road accidents for many reasons. Following is 2018 report on Yamuna expressway to agra (HT may 25, delhi). Sleep drivers = 45%. Drinking = 14%. Speeding = 19%. Traffic rules violations = 11% Mechanical 11%. Aaquantum style human = 90%, mechanical 10% (tyre burst, bad mechanics, damaged warning, highway layout,…). Sleepy drivers, speeding, violators and drunk are easy to fix and catch, difficult to enforce. Mechanical are difficult to catch, easy to fix but are only 10 % of total. They also are 90% of intellectual conversations. This is a simple example from many of why I consider intellectuals pointless! That is 90% of class-of-75 !!!!!!!!!!!!!!!!!!

In medicine, death happens for many reasons. Following is report. Why do people die normally? Diet? To say that it’s little known that key crops are getting less nutritious due to rising CO₂ is an understatement. It is simply not discussed in the agriculture, public health or nutrition communities. At all.

You can find true data of choice from here.

Everyone has unique risk factors and causes of demise. Risks do not add as they come with inner correlation. Risks are divide-able into fixed and fixable. Factors like age, sex, genetics etc. are fixed.

Fixable (me) are divisible into two – measurable and statistical. There are varying costs, pain and error rates of measures. The proper investigation method is Very subjective and experience+SKILL dependent with inverted-U (quality vs. experience). Perfect for AI robot or my current mehod od scepticism unless confirmed by sens or Cochrane collaboration (not even mm doctors say so) or journals sceptically, only if peer reviewed.

These methods work for diabetes treatment as death analysis as buying-decisions and indicate an underlying epistemology certainly shared as it evolves.

Inside of a nucleus

Following story had an electric effect on me – it tells of real problems in working with quantum computers, likely to become common-place by 2030, and the basics of what quantum computers can and cannot do, for realistic reasons, not perfect QC capabilities!

Here is my take away.

1.       QC are programmed by comparing answers against tractable normal cases in boundary condition

2.       That match requires deep analysis of noise, artificially added and slowly removed. Unsaid but obvious is that a fixed point algorithm was used. Noise add to some problem can be, while others cannot be removed so.

3.       Generalization of boundary problems is assumed to work. This might be true – say deuterium to tritium etc., but may or may not in heterogeneous systems.

4.       The problem of latency between the users and cloud-based services is severe. Latency and crytion-trust are two fundamental limitations of cloud computing. One can drastically reduce internet latency by in-house QC for example.

5.       Real world programmers will likely not be motivated as these scientists.

Strange moons of Saturn

https://phys.org/news/2018-05-history-saturn-small-moons.html#nRlv

Just look at them, how come so weird!

Martin Jutzi and Adrien Leleu, both members of the NCCR PlanetS, took the challenge of calculating the formation process of the small inner moons of Saturn. The first, simple tests worked well. "But then, we took the tidal forces into consideration and the problems piled up," remembers Adrien Leleu. "The conditions close to Saturn are very special," confirms Martin Jutzi. Since Saturn has 95 times more mass than Earth and the inner moons orbit the planet at a distance of less than half the distance between Earth and Moon, the tides are enormous and pull almost everything apart. Therefore, Saturn's inner moons couldn't have formed with these peculiar shapes by gradual accretion of material around a single core. An alternative model called pyramidal regime suggests that these moons were formed by a series of mergers of similar sized little moonlets.

Read more at: https://phys.org/news/2018-05-history-saturn-small-moons.html#jCp

Take away is that sometimes astronomical bodies are formed by merger in special situations (Saturn tides).