Sinclair is an MD, faculty in Harvard medicine, MD-PhD with MIT. His views are minority but being adopted explosively fast.
What is the basis of fame?
Yeast, made of very simple cells in a colony, suffers from aging! What is more, it can be studied fast. Using yeast, he found aq number of genes related to Sir genes. 7 are found in human, called Sirtuins, of which Sirt1 is the most prominent.
One entire line of medicine is focussed on anti-oxidants. Another attempts to understand two techniques, applicable to many species that have demonstrated benefits but are difficult to adopt – calorie restriction (hunger) and exercise (tiring). Both have molecular basis that may be amenable to much easier adoption, or even act as to increase the effectiveness of these two techniques.
Cutting through the chemistry thicket is the block diagram above. Of the three pathways, two are benefitted by metformin and nmn (nicotinamide mono nuclide). Upto last year, nmn was $2000 year per month of recommended dose. Two great things have happened since
1 Direct synthesis of nmn has been discovered
2 Sublingual administration of nmn is shown to be possible and effective so that stomach penetration losses can be avoided (sharply reducing required dosage) and 4 or more divided doses per day is feasible.per day are feasible
THIS MEANS, STARTING JUNE 15, IN usa, A 500 MG/DAY DOSE PER DAY, DIVIDED INTO 4 OR MORE SUBLINGUAL SUBDOSES IS POSSIBLE FOR ANNUAL $500.
What does it mean to oxidant-guy like you?
Above indicates a tectonic shift in my thinking away from anti-oxidants to helper molecules. Why?
1 Beliveable partial empirical proof. The doctor takes his drugs as does his father. Doc claims feels like 30 when 60 (looks so too in video linked!) and wears no makeup! Father in 70’s claims feels 50’s.
2. Metformin (10,000,000) records and nmn (3 year human, countless mice) is safe.
3. Program is easy, super-easy for me who needs metformin for diabetes! 500 mg of nmn as four or 5 sublingual sub-doses, 4 times a week, supplement day 300 kcal exercise. Two dinners off per week. Age ninety, here I come, expecting to make 2050 decade, current tech, despite diabetes and heart triple bypass! Plenty of time to acquire boost and live past current expectation.
4 Plausible narrative, experiment worthy, low risk. Results can be visible within 3 months! So blow $200, limited risk.
Three ingredients of belief in my epistemology (absent credible attacks) are sho benefit, show safety and affordable! All met. Further requirement is short interval (3 month). If no visible benefits in 3 months then bye bye.
How come you trust him so much?
1 Experiments on himself and loved
2 Critical of own Reservetrol (sold for 750 million dollars. Empirical disaster from sales process losses and stomach barrier!
3 Avoids the glamourous but FDA-avoid route to FDA welcome to test
4 Hard won NASA commission to supervise health of Long-term astronauts to Mars
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