Looks like real singularity, after intensive research, when marketed - USA first. Likely after FDA trial, in 1-2 years. To bio-hackers as me, buy+consume after FDA-1
It is not open, but that means that the intellectual property to my speculations is mine. One never needs to admit that Katcher has solved a complicated math problem. The context of the bio-logical canvas is such that fairly simple theories have difficult proofs, required in open decentralized research. Sinclair's aging theory is one such gem. By tying aging to Epi-genome error correction, he did two great things
1. 1 Converted human aging to all-life aging
2. 2 Pre-2021 could anticipate the applicability of Horvath tables to Eularians. That is true science theory proof – not only does it describe things known when developed but has a prescient view of what happens in experiments done later. Einstein was validated yet again when gravity waves were found 7 decades after his demise.
3. Without knowing E5, here is what it really is. The story of young blood use is likely to confuse all who will try to understand E5, needed for many new types of research. That is one way to benefit from the work. Sinclair had a much better approach to his disruptive workbook royalties and greatly improved life, at Harvard and in Sidney. I do not think money drives Katcher, but it drives people who invested in him. I think his answer would be even smaller than mine!
The bottom is Drs. Conboy link, more believed than Dr. Katcher spiel! In any case, I have written to Dr. Sinclair, Dr. de Grey, and Drs. Conboy, beseeching them for clarification.
Young blood does not reverse aging in old mice, UC Berkeley study finds
Insight 1: The DNA molecule has subsequences, both useful and evil. The epigenome sits over and shuts the evil ones off.
Insight 2: DNA marks (methyl) are not only markers of aging, but consequences of use! Removing them not only reduces bio age but makes you actually younger. The following story got to me (how?) that in the womb babies start with zero methylation, methylation advances at a normal pace, but is reset again to zero at birth! We undergo age reversal once anyway!
Insight 3: DNA never changes but epigenetic cover turns the gene off and on. Signal molecules in blood are the only way DNA information causes proteins to be built.
Insight 4: Katcher's work on breast cancer is essential to prevent cancers that will arise from poor reverse engineering.
In other words, the young blood base is simply a cover to confuse all the subsequent scientists. All kinds will cleverly look for signals and proteins till cows come home! Use of young blood is a feint!
There is in every cell a part that creates telomerase protein. It is needed since its sustained use is precisely cancer and it may happen anywhere. Part of the aging fix must be the determination of signal molecules for all kinds of cancers. I suspect that one large class can be shut off by e5 component, thus many cancers can be fixed. Katcher was the inventor of one cancer fix, whatever it is, it works to kill all those needing that telomerase. All? Unlikely!
The aging fix cannot be expected to be protective for all cancers. But a class of fixes can progressively cover most or even all cancers. That will happen only when E5 is exposed.
Very long but informative
The interviewer is the chief spokesperson for lifespan.io.
https://youtu.be/B3--k8ORQVo
Does it work
And my complaint - temporary halt to newer things. Very good short
https://www.youtube.com/watch?v=8d-q7jHP3AM
It gave me lot of information. He believes 8 year cycle of redo for most humans since he says aging is accumulation of breaks in DNA, implicitly validating Sinclar work. Not asked and wont answer either on how many 8-year chunks are possible, theoretically if f is fraction of damages fixed, some power of f. Probably 10-12 i.e. 100 years. One must assume Yamanaka factors pefected in 100 years. So the singularity has come! Maybe Hbot good for fix of immune system only. Beyween E5 and Hbot, 100 years seem possible now.
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