My comments are in italic.
It is worth examining this since it will have theoretically similar performance to HHP-HBOT and have lower cost as ordinary air can be used instead of oxygen expense. It matters not that the HHP-HBOT effort may be faster. A quick design of the simulation machine says that the costs are returns on the machine, attendant (rs 20000 per annum including benefits) and electricity, thus price of Rs10 per day of 2hr sessions can be achieved per 4 patients per day every 10 machines, attached to a hospital as shop. The attendant can run a shop filled by many machines, reducing the cost by that factor. Such machines will be useful for persistent diseases targeted for repeated treatment. These abstracts say that divers encounter HHP with ordinary air and a machine proposed have reasonable chance to work.
1. Abstract
Many cross-sectional studies have tried to assess the in vivo effect of oxidative stress on organismal aging in general and on telomere length dynamics specifically. Here we followed telomere length dynamics over a 12-month interval, in divers exposed to intense hyperbaric oxygen in comparison with an age-matched control group. Both groups were exposed to extreme physical activity, as well. Among the divers following the oxidative stress, significant telomere elongation was observed in granulocytes and naïve T cells, but not in memory T cells and B cells. Telomere length in granulocytes was mildly elongated in the control group as well, a finding that may relate to the extreme physical activity to which they were exposed. While telomere elongation in naïve T cells may be attributed to telomerase activation, we suggest that in granulocytes the elongation results from undifferentiated hematopoietic cells carrying longer telomeres that repopulate the peripheral hematopoietic compartment. This event might be accompanied by enhanced cell division within the repopulating pool. Since the aging of mammalian tissues can be attributed in part to the reduction in the replicative potential of self renewing cells, enhanced cell turnover under conditions of hyperbaric oxidative stress might be directly relevant to tissue and organismal aging.
Research highlights
► Telomere elongation in granulocytes and naïve T cells in divers exposed to oxidative stress. ►No telomere elongation in memory T and B cells in divers exposed to oxidative stress. ►Telomere elongation in naïve T cells may be attributed to telomerase activation. ► Oxidative stress may lead to repopulation of the peripheral hematopoietic compartment.
2. Abstract
Many cross-sectional studies have tried to assess the in vivo effect of oxidative stress on organismal aging in general and on telomere length dynamics specifically. Here we followed telomere length dynamics over a 12-month interval, in divers exposed to intense hyperbaric oxygen in comparison with an age-matched control group. Both groups were exposed to extreme physical activity, as well. Among the divers following the oxidative stress, significant telomere elongation was observed in granulocytes and naïve T cells, but not in memory T cells and B cells. Telomere length in granulocytes was mildly elongated in the control group as well, a finding that may relate to the extreme physical activity to which they were exposed. While telomere elongation in naïve T cells may be attributed to telomerase activation, we suggest that in granulocytes the elongation results from undifferentiated hematopoietic cells carrying longer telomeres that repopulate the peripheral hematopoietic compartment. This event might be accompanied by enhanced cell division within the repopulating pool. Since the aging of mammalian tissues can be attributed in part to the reduction in the replicative potential of self renewing cells, enhanced cell turnover under conditions of hyperbaric oxidative stress might be directly relevant to tissue and organismal aging.
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