Aging and Parkinson – Arun on cutting edge

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Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

Must understand else like clarinet in front of buffalo!

At present there is no guaranteed and proven protocol for living as long as possible. What can be done is a proposed protocol for living as long as possible in a very healthy condition, which is what I suggest here. These are actionable notes to self and being made available to others to hopefully benefit them. Two problems I have are <pre-descent Parkinson and Aging, source irrelevant. I consider aging a disease, not a natural condition. I do not believe that in 2018, one deals with hitherto sane and logical concept of life. I am positing 150 year improvement using metformin, NMN, rapamycin and stem cells. These are chemicals available now – there is no science fiction involved.

There is critical understanding required of epistemology i.e. who to believe! 99,9 % doctors are expected to pooh-pooh this essay. Any philosophical derivation will conflict with all they have been taught, and life-extension has been a dear wish of most humans so far, with all saints so far medical charlatans! So what is different now? Why believe? What is the –hurry? Why doctor’s don’t believe?

Why believe?

The most important essay in your life!. Why so? Before and after of metformin+Niacianamide therapy.
Non-Sinclair anecdotal test by another docter

The results achieved by Professor David Andrew Sinclair in his quest for reversing aging have moved from the exceptional to the phenomenal. This brief essay lists the evidence and suggests what may be the best value for money route to implementing an effective lowest-cost protocol for delivering similar or the same results.

Roughly

NMN is provableyouth-giver to mice, that can be experimentally see able to roughly doubletheir life

Mice biologyroughly scales as 0.5 times the human effort

Dr. Sinclair is 50,looks 30 and claims to feel so. Feeds his father in seventies who claims feelslike fifties. There is thus anecdotal evidence. The fellow is known to behonest and unlikely to be fooled by statistical efforts

What is hurry?

The FDA studies with start producing results by 2021. My father is close to death! Parkinson will descend fast perhaps!

Why docter’s don’t believe?

Such claims earlier have been all false.  There is no philosophical rationale that does not conflict with their instruction, Better safe than sorry.

What is different in 2018?

Dr. Sinclair could pay before, the $1000 per month per person cost for speculative medicine. Direct synthesis of NMN was discovered at $1000 per year! So anecdotal Dr. Sinclair experience is affordable by me. Results and philosophy good enough to try Phase-3 FDA trials in US and Japan.

What is rationale behind your belief?

Remedy for anydisease must do three things

Prevent more damage
Restore chemicals not generated or obtained
Repair or restore the diseased cells

For speed, abbreviated <prevent, restore, rejuvenate>

For Parkinson <no drug, levodopa, no drug>. For aging <no drug, anti-oxidant, no drug>. I have concluded <NAD+, levodopa, stem> for Parkinson, <NAD+, antioxidant, stem> for aging. Turns out stem cell therapy needed for even age 150 years to treat heart disease, Alzheimer’s,  Parkinson’s and cancers. All these diseases expected. SCIIT concept essential!

In 2015, Parkinson has been successfully attacked in Bangalore by iPS like cells. Bedridden for 2 years, Parkinson’s patient back on his feet, says Times of India. There is NO miracle or cocktail of drugs! Beyond religious stupidity is straight forward medicine, possible now! SCIIT is one of the ways to develop a world class facility to serve patients!

What is the hope?

New method constructed to turn skin cells into pluripotent stem cells . It is dated Jul 6, 2018 .  Up till now, reprogramming has only been possible by introducing so called Yamanaka modifications to cells, themselves derived from aborted babies.

Term genetic chemists use is reprogramming. I was amused by discussion of errors in CAS-9 manipulations by bio-chemists that were trivial and predictable to compiler/macro-processor writer like me dealing with formal languages and translation and expert in application of dynamic programming to code sequences for optimal code!

What is a stem-cell?

-       - Embryonic stem cells.

-        -Tissue-specific stem cells.

-        -Mesenchymal stem cells.  Also abbreviated MSC. Aleady somewhat specialized.

-        -Induced pluripotent stem cells. Abbreviated iPS cells. Like extracted from early stage growing in womb, capable of any specialisation. It is magical that since 2011, it is possible to build them from skin cells!

What is special about you?

I am a diabetic. Life extension is very hard to measure! I cannot imagine life-extension without curing my diabetes (metformin!). I test sugar levels daily 4 times!

  I am not out to sell or convert, this documentations might benefit a friend, may benefit from issues raised and exposes my errors. I admit lack of consensus, admit error in assuming aging .

Life-extension to me is more than extending life to suffer longer. It implies healthy life with great looks to very close to death. Anti-oxidants will do so in practise. ECP, HOT and parbiosys effect perceptions. From accumulation of DNA damage, hence fixable, by providing missing anti-oxidants, switching paradigms to helper molecules in fasting and exercise – only two natural ways to longer life, possibly impossible from calorie restriction directly due to loss in disease fighting of frail bodies.

Part of being strong agnostic who denies spirituality; all emotions are simple chemical signals to or within brain; unless handled locally. Given that Aging is universal, it must be cell based as life. Mitochondrial elements of cell perform energy production. It is these whose energy kreb cycle is crucial. That can be approximated by three – citric and ATP cycles age-decline too, but handled by coQ10 and Shilajit for Quality of life QOL and neither have aging increment benefit. Nad+ effects both cellular respiration and aging! The Aging part from the fact that it is on the molecular pathways through which exercise and fasting effects occur! The QOL beneficial effects of CoQ10 still occur. So do alpha lipoic acid, reservetrol and Glutathione (skin lightening anti-oxidant) etc. but none have anti-aging properties – only improve health.

With metformin and nmn, my quest for anti-aging ends, and I am a willing test-subject, motivated to try therapy from $1000 per month of Dr. Sinclair to $1000 per year today, affordable by me. The actual costs may be less for me, for Dr. Sinclair was not taking his 500 mg sublingually and the same positive effect may be possible with lesser dosage.

The self trial is 4-5 50mg doses, sublingually with 5 days medication and 2 day off per week with weekly health indicators and diary. I am particularly interested in diabetes and heart health. I can raise funds to establish ECP and HOT facilities and an apartment in a complex to establish a medical tourist retreat for friends and relatives. There is no reason to not expand onto HOT into treatment for Aging Film Stars and likes!