So far I have explained
2. The rationale behind my choice of Metformin/mitoq/NMN
– just these. More research on SKQ1,c60 and rapamycin.
2.
Reasons for irrelevance of modern medicine (awake
allopathy), let alone discounted Ayurveda or criminal Homeopathy. Very few mm
have any interest in rational life-extension (if possible), very new things (reasonable
NMN is 2018, never human tested but anecdotal, only mice). Perhaps all my notes
are destined to waste paper in best of worst case (worst of worst case means
lots of money too).
3.
Mice make reasonable human model. This means
that safety and dosage (mg per kg wt.)can be extrapolated. Reason why for me is
belief in anecdotal pronouncements by Dr. Sinclair! Note that it does not apply
to 99.99% human MD, institute, experience etc. The reason why this Doc
satisfies my rational scepticism is
a.
He became a billionaire by past efforts (invention)
of resveratrol, abandoned on account of bio-availability
b.
He claims to have been on it when unreasonable
expensive ($2000 Per month)
c.
Claims to feed his father too
d.
Claims benefits
e.
Mice verified
f.
Has developed the idea of Sirtuins (1-7) that
explain the anti-aging
Point is that it is unlikely he
suffers judgment lapses from benefits – the Elysium recommendations are
different and latter is staffed even better reputation! Alas, all of them are
regular research professors who COULD (no reason to doubt their word) be bought
by conflict of interest. No amount of proof by them can convince, my simple
response is “Show and pass Dr. Sinclair filter first”! NASA has chosen him for health
of its astronauts to Mars and not only is he likely without conflict of
interest but likely to follow genuine developments in aging!
4.
Not only does above satisfy my urge to extreme
caution in difficult areas like aging, when most of my friends are advised to
await empirical studies (phase 2 have started, take 2 years). Not followed by
me after Parkinson damage is ongoing, NMN likely to help as it can cross
blood-brain).
5.
I am a chicken when it comes to C60! It is known
that quantum dots can cross the blood-brain barrier and destroy unholy protein
clumps (Parkinson and Alzheimer’s). However the dots are not available in mg
quantities! One can use C-60 that is Buckminster fullerene from C. It is also
nano-medicine form of C that also crosses blood-brain barrier. Here I will wait
for others because we have no mice results on safety of C60.
Why does mitoq work?
Mitoq is wittigified version of coQ10. It allows
coQ10 molecule to tunnel through mitochondrial wall without losses. It is explained
by greatly positive form of the molecule and negatively charged mitochondria!
Adding the alkene group through wittig ,makes coQ10 very positive. Same can be
done to c60, Let us add a COOH group. The new form has some better properties
Interested in fullerene: Research: We recommend anyone considering C60 to do
their own research. Below are a few links to help you get started.
The proposed mechanism indicates that C60 has the ability to acquire
positive charge by absorbing protons (positively charged hydrogen atoms) and
this complex could enter the mitochondria, leading to a decrease in reactive
oxygen species production. https://www.hindawi.com/journals/bmri/2013/821498/
Computer simulations have shown that C60 has the ability the pass
through lipid membranes, enter the cell, and alter its functions. https://www.ncbi.nlm.nih.gov/pubmed/18654548
2017 review from Royal Society of Chemistry Journal. https://www.sesres.com/wp-content/uploads/2017/07/Edison-Castro-Fullerenes-in-Bio-Med.pdf
FDA Compliance: The consumption of C60 and the above statements
have not been evaluated by the Food and Drug Administration. This product
is not intended to treat any disease.
6.
Note that FDA does not prevent self-tests. I
will go to c60 if and when my condition deteriorates. It may turn out that c60
products are better used in early stages. That is a risk I knowingly take.
Better mice safety studies will unchicken me.
No comments:
Post a Comment