Article https://www.longecity.org/forum/topic/72402-coq10-vs-mitoq-vs-pqq-vs-c60oo-for-mitochondrial-health/
SKQ1's (greatly recommend read) anti-aging cousins are the antioxidants MitoQ and C60 (also
sometimes called C60oo and other silly names) which
is derived from olive oil.
MitoQ and SKQ1 deliver to the Mitochondria chemical foot soldiers that
fight ROS, MitoQ delivers CoQ10, and SKQ1 delivers Plastoquinone.
C60 is a little different, it's an antioxidant molecule that your
mitochondria absorbs by osmosis.
Why is SKQ1 worth your attention when C60 and MitoQ are highly
accessible?
SKQ1 directly targets the mitochondrial membrane, MitoQ is also targeted
to the mitochondria, C60 is not, your Mitochondria absorb it by osmosis
(hopefully!)
MitoQ cannot be regarded as a mitochondria-targeted form CoQ or CoQ
precursor since it cannot replace CoQ in its master function...
The big problem that MitoQ has is that VERY little of the CoQ10
actually gets delivered to the inside of the mitochondria, perhaps as low
as 1% - 2% according to a 2014 paper out of the University of Toronto:
CoQ10 has low oral bioavailability due to its lipophilic nature,
large molecular weight, regional differences in its gastrointestinal
permeability and involvement of multitransporters. Intracellular delivery and
mitochondrial target ability issues pose additional hurdles. To maximize CoQ10
delivery to its biopharmaceutical target, numerous approaches have been
undertaken.
Whereas SKQ1 delivers Plastoquinone directly to the
interior of the Mitochondria. To quote author and doctor Josh Mitteldorf
But no animal study has ever succeeded in extending life span with
CoQ10. Perhaps its value is limited by bioavailability. Only a small
portion of ingested CoQ10 makes its way from the stomach into the bloodstream,
and a much tinier portion actually reaches the mitochondria where it is needed.
This is the issue that Skulachev has addressed in such an innovative way with
his molecule, which his friends and students have affectionately dubbed SkQ.
Plastoquinone is better than CoQ10. Skulachev initially used CoQ10 but
A/B testing it with Plastoquinone in animal experiments discovered that
Plastoquinone is a more effective antioxidant.
Regarding C60, one of the masterminds behind
the anti-aging forum Longecity clarified C60 is NOT currently theorized to
promote rejuvenation, only to slow aging
I would not say that MitoQ and C60 are useless, there's significant
anecdotal evidence and some clinical evidence that they are very helpful in
restoring and maintaining health but SkQ1 is the clear leader in terms of
safety and economics thanks to the tiny dose of it needed to achieve the kind
of effect that the others might have. The tiny dosage also
makes it highly non-toxic, which is a concern with the other Mitochondrial
antioxidants.
Potency
These results suggest that under the conditions used SkQ1 protects
mitochondria from oxidative damage as an antioxidant when added at extremely
low concentrations.
...extremely low, nanomolar concentrations of the mitochondria-targeted
plastoquinone derivative SkQ1... were shown to prolong the lifespan of male and
female Drosophila melanogaster by about 10%...
SKQ1 as a Nootropic (improves cramming/cognition/focus)?
A lot of Biohackers are at this point wondering if SKQ1 would work as a
performance enhancing Nootropic or smart drug for otherwise
healthy people that just want more energy or motivation.
It's hard to say at this point, there have been no human trials
conducted demonstrating an effect on cognition. I could find no meaningful or
credible anecdotal reports from Biohackers who tried it and experienced classic
Nootropic effects.
However, the Mitochondria are the fundamental energy generation system
of the body; optimizing your Mitochondria is quintessential performance
enhancement; more energy, better mood, memory, immunity, resilience or hotter
sex. Anything that improves your Mitochondria will make you better but we
are probably a few years off from real SKQ1 Nootropics, for the
time being at least SKQ1 is quite expensive, if you're interested in hacking
your Mitochondria for performance enhancement, you'll want to use the Mitochondrial supplements I list here.
Skq1 Antibiotic
A 2017 in vitro study out of Lomonosov Moscow State University
observed that SKQ1's targeting made it a highly effective antibiotic:
Mitochondria-targeted antioxidants are known to alleviate mitochondrial
oxidative damage that is associated with a variety of diseases...
Therefore, SkQ1 may be effective in protection of the infected
mammals by killing invading bacteria.
Skq1 Parkinson/ Alzheimer's
Neuro-protective for Parkinson - No results found for neuroproteoctive
skq1
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