Wednesday, May 3, 2017

Classic Anti-aging Research



One epistemological way out of very vast thicket of publications on aging is to require, by ignoring howsoever good, the literature from NUTS who do not start their gems with transparent simple description of their epistemology, and use that to select the articles. Another is look at their prescriptrions to follow, the individual importanmces, and allow the reader to judge if the readers and
their doctors will allow the filtered prescription, perhaps after consultation.

Main take-away from my writing is this - Deep careful literature search + reading says aging is an unnatural disease from accumulation of damage that weakens our body to fight opportunistic diseases. Aging is not natural! It can be fixed starting 10 years and done by mid-2040's if greats, by 2040-2150 if me. You must get to 2040 your own way - 90-100 year for me, 95-105 for friends. Weight lifting 90s is possible if start now - reading and accepting needed discipline. Making a joke of doers is certainly a PJ, I can sympathize with naysayers, still there is a definite chance to cross singularity, It is not if but when! Will you live bad life for long then? Age reduction (perpetual youth) is only in some models!

My own method is TOTAL ignoration od ALL traditional medicine, consideration, of certains like homeopathy to be criminal, and total trust in certain subset of allopathy, namely acute diseases and some chronic diseases by default awaiting research; acute being defined by short duration urgent care. That certain parts of other systems are valuable is recognized, but must await allopathic approval (I think quality mm do fast) and every person celebrating the anecdotal success is ignored as a nut - why aren't allopaths investigating, or perhaps will? It delays neem, haldi etc, but only for some time, makes GOI the villain! Even Ramdev is researching in state-of-art lab and likely will do first rate work on use of herbal medicine for cure!

A very valuable reference

Rest is my view on Kurzweil presciption. Quite a character!

Two greats

There are various types of damage that the body does to itself as a side effect of the way the body works. Damage is always happening, and right now there is only so much that we can do to minimize that rate, and there’s only so much accumulated damage that we can tolerate. But our work revolves around repairing that ongoing damage. It’s just like a car. As carefully as we drive it and as diligently as we keep it oiled, sooner or later the engine will give out and it will stop running. But if a mechanic keeps replacing the broken parts, it can last forever. Vintage cars were not designed to last more than ten or 15 years, but preventive maintenance, so long as it’s comprehensive, can completely transcend any such limits.
– Aubrey de Grey, SENS Research Foundation, oxford gerontology chief
Our bodies are a bit like a house, we inhabit them, and if you don’t maintain the house it’s not going to last for very long, and if you do maintain the house it can last indefinitely. There are some houses that are thousands of years old. The only difference between a house and this house I inhabit is we understand how a house works because we built it. We don’t fully understand this house yet. But that understanding is increasing exponentially.
– Ray Kurzweil, Google life-extension chief

EXPLORING ANTI-AGING STRATEGIES

The body is a complex machine. Like any machine, it wears down over time during its normal course of operations. This is a process of decay and accumulation of damage, so combating aging is simply a technical repair and maintenance problem. There are various types of damage that the body does to itself.

1. Admit you don't know, goto Blue zone where long-life live, perhaps environmental or dietary (For 7 years)

BLUE ZONES

Blue Zone research details lifestyle commonalities that communities with high life expectancies share. The top 5 places are:
  • Sardinia (Italy)
  • Okinawa (Japan)
  • Loma Linda (USA)
  • Nicoya Peninsula (Costa Rica)
  • Icaria (Greece)
  • Gives you 7 year extra life!
2.  gene vector research

Gene Therapy In America, the CEO of biotech startup BioViva recently made headlines (AAQGS-LIKELY CRIMINAL/false) by claiming that she is the first person to be successfully rejuvenated by gene therapy. This claim is extremely dubious and results haven’t been submitted for peer-reviewed publication, but it’s another indication of how close we are. Pioneering gene therapy very dangerous.

3 Two bridge strategy

By deGrey and Kurtzweil, Bridge 2 is called singularity. BriDge1 is 5-15 yeRS AWAY. nORMAL HUMAN AND FORECASTERS ARE STUPID IN PREDICTING EXPONENTIAL  MOORE'S LAW  WHERE 95% PROGRESS IS MADE IN LAST PERIOD.!


deGrey - mid 2020's, Kurtzweil 2020, Me 2060

4 Multi-bridge strategy

me - indefinite life in phases with different problems and solutions. Bridge in 2060. Next in 2150 using hibernation. Final in 6000 using spintronics. To b2 - usual docs. to b3 - hibernation. to b4 - stem cell codivision or vat-brain organ- radio-interface. Beyond b5: antifragilee transfer to electronics/spintronics.

Bridge 1 strategyS

COENZYME Q10 FOR THE CELL’S MITOCHONDRIA

SPIRULINA (To DO)


 RC claims it is the most important vitamin to take and that there is tremendous amounts of research and consensus that it helps prevents cancer and others.

NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+) (A variant of vit B3)

Australian and US researchers hope the anti-ageing compound NAD could be trialed on humans as early as next year, following a key breakthrough that saw the ageing process reversed in mice. Two-year-old mice were given NAD over a week, moving back the key indicators of ageing. by NR or NMN. damage to mitochondria accumulates over the years and is one of the main contributors to the negative effects of aging.

LIFE EXTENSION

HUMAN GROWTH HORMONE (HGH)


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