Aging characteristics of NMN

Who knows in detail! What will convince me that my money is not being wasted on a supplement without FDA testing? It can be done!

Earlier research by Brown-u says 2 things

1 calorie-restriction works thru m-Tor molecular pathway

2 Anything that reduces Insulin, but also sugar, is good for you if done without insulin or making the pancreas make more by suphonyl-urea drugs! These include metformin acting on liver and acarbose type drugs interfering in sugar absorption in stomach. Both have claims to improving longevity. I happen to believe (unlike most existing doctors fully complacent of new research, dependent on studies on big samples).

There is one reason to explain lack of studies, NMN around for ages, the users at 500 mg per day paid $2000 per month!  Sinclair MD did, himself and father! Reportsenergy-level for both is 20 years lower age. He could, being a billionaire. Empirically proved it on mice. Fountain of youth for mice. Safe for humans.

Apart from being diabetic, I am also an exercise freak, excellent with NMN. What is more, even better than Dr. Sinclair, the sublingualroute is as good as injecting, possible for NMN. 500 mg is like 1000 mg dose!

90% of my fasting sugars are within 100-110. If they are 90% within 90-100, NMN has proven graceful aging properties for me after 3 months. Exercise route for this is estimated to 400 cal per day (1.5 hours of brutal exercise). I test every day and meter zero errors are irrelevant! Three months later, post experiences! NMN is advertised on eBay for Rs. 20,000 per month for 500 mg but only edible, as capsules!

 In a novel experment in mice, MitoQ was shown to protect against insulin resistance.  All these studies were reviewed in a 2011 paper by Smith and Murphy.  Historically, there is a strong correlation of life extension drugs and the ability to enhance stress resistance.  “Together these findings show that MitoQ is protective against pathological changes in a number of animal models of mitochondrial oxidative damage that are relevant to human diseases.”

Aging – Sinclair view over all others

https://www.youtube.com/watch?v=hgQM9l8RWCw

Sinclair is an MD, faculty in Harvard medicine, MD-PhD with MIT. His views are minority but being adopted explosively fast.

What is the basis of fame?

Yeast, made of very simple cells in a colony, suffers from aging! What is more, it can be studied fast. Using yeast, he found aq number of genes related to Sir genes. 7 are found in human, called Sirtuins, of which Sirt1 is the most prominent.

One entire line of medicine is focussed on anti-oxidants. Another attempts to understand two techniques, applicable to many species that have demonstrated benefits but are difficult to adopt – calorie restriction (hunger) and exercise (tiring). Both have molecular basis that may be amenable to much easier adoption, or even act as to increase the effectiveness of these two techniques.

Cutting through the chemistry thicket is the block diagram above. Of the three pathways, two are benefitted by metformin and nmn (nicotinamide mono nuclide). Upto last year, nmn was $2000 year per month of recommended dose. Two great things have happened since

1 Direct synthesis of nmn has been discovered

2 Sublingual administration of nmn is shown to be possible and effective so that stomach penetration losses can be avoided (sharply reducing required dosage) and 4 or more divided doses  per day is feasible.per day are feasible

THIS MEANS, STARTING JUNE 15, IN usa, A 500 MG/DAY DOSE PER DAY, DIVIDED INTO 4 OR MORE SUBLINGUAL SUBDOSES IS POSSIBLE FOR ANNUAL $500.

What does it mean to oxidant-guy like you?

Above indicates a tectonic shift in my thinking away from anti-oxidants to helper molecules. Why?

1 Beliveable partial empirical proof. The doctor takes his drugs as does his father. Doc claims feels like 30 when 60 (looks so too in video linked!) and wears no makeup! Father in 70’s claims feels 50’s.

2. Metformin (10,000,000) records and nmn (3 year human, countless mice) is safe.

3. Program is easy, super-easy for me who needs metformin for diabetes! 500 mg of nmn as four or 5 sublingual sub-doses, 4 times a week, supplement day 300 kcal exercise. Two dinners off per week. Age ninety, here I come, expecting to make 2050 decade, current tech, despite diabetes and heart triple bypass! Plenty of time to acquire boost and live past current expectation.

4 Plausible narrative, experiment worthy, low risk. Results can be visible within 3 months! So blow $200, limited risk.

Three ingredients of belief in my epistemology (absent credible attacks) are sho benefit, show safety and affordable! All met. Further requirement is short interval (3 month). If no visible benefits in 3 months then bye bye.

How come you trust him so much?

1 Experiments on himself and loved

2 Critical of own Reservetrol (sold for 750 million dollars. Empirical disaster from sales process losses and stomach barrier!

3 Avoids the glamourous but FDA-avoid route to FDA welcome to test

4 Hard won NASA commission to supervise health of Long-term astronauts to Mars

Why deaths – road, medical, crime etc – aaquantum scholarly research

There are commonalities deducible from hard statistics, not chosen. First rod then medicine Finally crime. Suggest from statistics is that causes can be divided into controllable and uncontrollable factors; different degrees of loss of liberty in remedial steps is involved; politicians, lawyers and law enforcement and philosophers who do not consider liberty-loss in suggestions upfront and fail to identify this consequence of trade-off up front are motherfucker criminals.

They must be severally punished in my ideology which only respects limited “no law, no crime” i.e. forbid of retroactive crime, not prohibited but subject to “prohibited, unless necessary” like “guilty, unless innocent” philosophy. This allows criminalization of slave-owners, tax-cheats, cigarette companies, nazi, apartheiders etc.

Deaths happen in road accidents for many reasons. Following is 2018 report on Yamuna expressway to agra (HT may 25, delhi). Sleep drivers = 45%. Drinking = 14%. Speeding = 19%. Traffic rules violations = 11% Mechanical 11%. Aaquantum style human = 90%, mechanical 10% (tyre burst, bad mechanics, damaged warning, highway layout,…). Sleepy drivers, speeding, violators and drunk are easy to fix and catch, difficult to enforce. Mechanical are difficult to catch, easy to fix but are only 10 % of total. They also are 90% of intellectual conversations. This is a simple example from many of why I consider intellectuals pointless! That is 90% of class-of-75 !!!!!!!!!!!!!!!!!!

In medicine, death happens for many reasons. Following is report. Why do people die normally? Diet? To say that it’s little known that key crops are getting less nutritious due to rising CO₂ is an understatement. It is simply not discussed in the agriculture, public health or nutrition communities. At all.

You can find true data of choice from here.

Everyone has unique risk factors and causes of demise. Risks do not add as they come with inner correlation. Risks are divide-able into fixed and fixable. Factors like age, sex, genetics etc. are fixed.

Fixable (me) are divisible into two – measurable and statistical. There are varying costs, pain and error rates of measures. The proper investigation method is Very subjective and experience+SKILL dependent with inverted-U (quality vs. experience). Perfect for AI robot or my current mehod od scepticism unless confirmed by sens or Cochrane collaboration (not even mm doctors say so) or journals sceptically, only if peer reviewed.

These methods work for diabetes treatment as death analysis as buying-decisions and indicate an underlying epistemology certainly shared as it evolves.

Inside of a nucleus

Following story had an electric effect on me – it tells of real problems in working with quantum computers, likely to become common-place by 2030, and the basics of what quantum computers can and cannot do, for realistic reasons, not perfect QC capabilities!

Here is my take away.

1.       QC are programmed by comparing answers against tractable normal cases in boundary condition

2.       That match requires deep analysis of noise, artificially added and slowly removed. Unsaid but obvious is that a fixed point algorithm was used. Noise add to some problem can be, while others cannot be removed so.

3.       Generalization of boundary problems is assumed to work. This might be true – say deuterium to tritium etc., but may or may not in heterogeneous systems.

4.       The problem of latency between the users and cloud-based services is severe. Latency and crytion-trust are two fundamental limitations of cloud computing. One can drastically reduce internet latency by in-house QC for example.

5.       Real world programmers will likely not be motivated as these scientists.

Strange moons of Saturn

https://phys.org/news/2018-05-history-saturn-small-moons.html#nRlv

Just look at them, how come so weird!

Martin Jutzi and Adrien Leleu, both members of the NCCR PlanetS, took the challenge of calculating the formation process of the small inner moons of Saturn. The first, simple tests worked well. "But then, we took the tidal forces into consideration and the problems piled up," remembers Adrien Leleu. "The conditions close to Saturn are very special," confirms Martin Jutzi. Since Saturn has 95 times more mass than Earth and the inner moons orbit the planet at a distance of less than half the distance between Earth and Moon, the tides are enormous and pull almost everything apart. Therefore, Saturn's inner moons couldn't have formed with these peculiar shapes by gradual accretion of material around a single core. An alternative model called pyramidal regime suggests that these moons were formed by a series of mergers of similar sized little moonlets.

Read more at: https://phys.org/news/2018-05-history-saturn-small-moons.html#jCp

Take away is that sometimes astronomical bodies are formed by merger in special situations (Saturn tides).

Graceful aging: aaquantum scholarly research

What are prospects of fountain of youth in near future?

At a forum on Cape Cod earlier this month, Harvard scientist David Sinclair had the rapt attention of biotech executives and investors as he described treating 20-month-old mice with a molecule to restore their youthfulness. Before long, the geriatric rodents were outracing 2-month-old mice.

Yes, Sinclair told his audience, “We can turn an old mouse into a healthy young mouse.”

The Fountain of Rodent Youth feat, outlined in March in the scientific journal Cell, hasn’t been replicated with humans. But researchers, who have long scoffed at the anti-aging claims made by companies pitching dubious products, are warming to the idea that serious science can be deployed to increase human longevity.

Ambitious efforts are underway in Massachusetts and beyond to develop the first government-approved drugs to stretch healthy life spans. Some researchers are scrambling to repurpose a diabetes medicine to target age-related diseases. Others are working to boost levels of a key protein to increase blood flow and endurance, or to find a way to kill “zombie cells” that can send out toxins that cause age-related maladies.

Arun aaquantum notes

repurpose a diabetes medicine

metformin. Remember latest research says insulin, very useful to 35 turns bad after 45! Most current mm doc were taught wrong!

How long can humans live – some feel not very long!

In the 1960s, Hayflick found that human cells divide only 40 to 60 times, after which they stop — even when their division is paused and then allowed to resume. This discovery, called the Hayflick Limit, indicates that even if a drug like metformin were effective at suspending aging, the end game stays the same.

Shouldn’t someone, likely to die, be allowed treatment wished?

So say conservatives and Trump and US just passed a bill. But it is’nt a simple issue! Other side has good arguments. It is similar to suicide by suffering hopeless terminally ill!

Isn’t aging alleviation in near future by crispr driven gene therapies?

There is no question that if scientists aren’t careful, CRISPR can induce substantial off-target mutations. In another study Joung’s lab submitted to a journal, they show that when “promiscuous” forms of CRISPR were slipped into mice’s livers, as some genome-editing companies hope to do for some human metabolic diseases, it edited hundreds of spots in the mouse genome that it wasn’t supposed to.

by crispr driven gene therapies?

Elementary CS has the answer as I learned in 1976 studying L_systems. Lindenmeyer systems are parallel context sensitive grammars made type-2 by passage of time which can be viewed in onary notation. Problem is simple – crispr allows one to edit-replace sequence of letters of genetic code say CATG to CCAT by changing CAT to CCA, but it does it everywhere even unintended. Not simple but progress made.

Arun aaquantum view
even if a drug like metformin were effective at suspending aging, the end game stays the same
True but error is in assuming that there is no stem cell! Tree cells have shown the way past - a stem cell also divides and the stronger cell lives! That is what transfection does!! I, Arya aaquantum, am still very hopeful of transfection driven anti-aging.

Explored and used interventions?

Metformin
supplementation of three subcycles of krebs cycle
Preventative supplements for gross body objects

Explored, india has advantages

low labor cost
posses real estate
simple operation

Hence 2 week to 2 month medical tourism makes sense - I provide equipment, operator, living, food from dedicated chef - full tour package, turn key basis

Meaningful aging interventions

The three procedures referenced next are
- uniquely addable by me as a non-doctor for upper middle class
- Have existing documented benefits
- Unlikely to have negative effects. Worst is mild benefits!
Thus flooring lazy nincompoops.

- ECP External counterpulsation used to escape stent surgery. My add is reducing costs to enable upper middle class.

- HOT Hyperbaric oxygen therapy - Mayo Clinic commonly used by aging film stars. My add is reducing costs to enable upper middle class.

- Human Parabiosis - Wikipedia but legally - Doable by upper middle class.

Collectively, the mechanisms are disjoint - improved blood flow through angiogenesis, high pressure yoga-like and stem cells. Doing all three should benefit me visibly and empirically documentable. 99.99 readers will view it skeptically and move on! Tough luck!
- 

aaquantum scholarly research

This page is intended to be the end-product of evolutionary developments, imagined to be very substantial but not even penned yet. To be a scientist means to me to be rational skeptic

First requirement is integrity and it will happen as soon as my IBE is done.

Next is skeptic nature of enquiry into decompositions. The whole may be an AND of components or an OR or a NOT. If an OR, single failure does not demolish the theory. Skeptic enquiry may sharpen the region of applicability.  Second order paradoxes are removed without eliminating recursion by requiring that all dependents range over previously defined elements only! Goedel is automatically eliminated - consistency and completeness of a language can not be constructed within! In other words (all x)F and (exist x)F are illegal, one must say (all x in X)F and (exist x in X)F where X are predefined! I call it aaquantum typed logic.

By goal, completeness in not an objective or perhaps even possible. Nor is full consistency - a mechanical way to test arbitrary derivations as being consistent. However, one can define consistency as those sentences derived by consistent applications of consistent axioms. Similarly complete. Skeptical enquiry is required for all statements independent of accepted sets.

This pragmatic outline suffices to constrain my behavior to an aaquantum stoic, free from all known paradoxes, unconstrained but rationally accepting stoic, pragmatic to live, with limited shared effort. The tools are finally here - internet, IBE, middle class comfort. Fuck the legal stupids, entirely new ideology can be constructed, as subset of current law till the end. The goal is simple enough - an aaquantum-stoic can not be cheated - politically, seller, friend, colleague, law etc!

aaquantum means discussed evolution, enforcement without appeal to good nature, responsible crime abatement etc. Different laws of 'guilty unless proved innocent' apply to specified minority: repeat offenders, celebrities and inspectors where honey traps can be officially used.