Tuesday, May 16, 2017

Dr. Arya self-imposed copyright laws


1 It is free, I say what I like. No incentives or disincentives.
2. Hope brief (certain) useful (to me at least) researched (references)
3 I don’t distinguish between charging adster help, product sellers, donation seekers, product sellers, criminals and thugs. ANY law agency that seeks to impose that distinction by necessity is a criminal violator of my natural rights and will be searched for unnatural punishment for life, everywhere.
4 Only legitimate way to charge for information is to sell the key to an encrypted copy that works only on one copy and forbid availability in any other key or none. I will accept the copyright of my jurisdiction and forced armed neutrality to avoid all other personal cases in all other jurisdictions.

A legitimate copy can be referenced, requiring a veracity-checker to obtain a copy somehow.

Disclaimer: 
The information on this page and in the book, and the references cited are for information purposes only, and are not intended to treat, diagnose or prescribe for any illness or condition. For your specific diagnosis and treatment, consult with your doctor or health care provider. Only a Legally recognized Doctor can take responsibility!

Disclaimer: 
The information on this page and in the book, and the references cited are for information purposes only, and are not intended to treat, diagnose or prescribe for any illness or condition. For your specific diagnosis and treatment, consult with your doctor or health care provider. Only a Legally recognized Doctor can take responsibility!



Disclaimer: The information on this page and in the book, and the references cited are for information purposes only, and are not intended to treat, diagnose or prescribe for any illness or condition. For your specific diagnosis and treatment, consult with your doctor or health care provider. Only a Legally recognized Doctor can take responsibility!


Thursday, May 11, 2017

Big bang common misconceptions



If you need big bang science info, you are stupid anyway and waste of following effort. Assume you understand science reasons andare  normal human. In that case you certainly have misconceptions clarified today.  But first “why care?”, a philosophy-science reason why it matters.

So now you know why cosmology is so important to me – the very purpose to agnostic science life. Misconceptions next, summarizing the source.

Reason why certain you have misconception is because the red shift essential to astronomy has two parts – Doppler effect and general theory of relativity,

1.       Space routinely spreads apart at velocities greater than light! That means that two distant points visible to us are moving apart at super luminous speeds in an effect NOT forbidden by special relativity!

2.       If we draw a sphere of points velocity of light away, we get the Hubble sphere. Yet we can see universe outside! This is because the points outside were in Hubble-sphere of the past! Due to super luminous spread of space, can be still visible!

3.       The red-shift of galaxies receding at light speed is about 1.5. There are thousands of objects with red shift more than that! The redshift of a disappearing object is infinity, happens in reducing infinite  time series that terminates in finite time!

4.       The big bang was not a bomb that went off in the center of the universe and hurled matter outward into a pre-existing void. Rather it was an explosion of space itself that happened everywhere, similar to the way the expansion of the surface of a balloon happens everywhere on the surface. But the bomb model is one of the many! Similarly, time could have a beginning or continuous existence.
5.       In my aqgs-model, time extends to –ve infinity, with big-bang-big-crunch devastations to reset the qubit-information and entropy, till an infinite universe is reached, hopefully with at least one seed of life, technologically capable of crushing entropy in the infinite phase. It may be our destiny to spawn such gods.

6.       People often assume that as space expands, everything in it expands as well. But this is not true. Expansion by itself—that is, a coasting expansion neither accelerating nor decelerating—produces no force. Photon wavelengths expand with the universe because, unlike atoms and cities, photons are not coherent objects whose size has been set by a compromise among forces. A changing rate of expansion does add a new force to the mix, but even this new force does not make objects expand or contract.

7.       WRONG: The universe is 14 billion years old, so the radius of the observable part is 14 billion light-years. RIGHT: Because space is expanding, the observable part of our universe has a radius of more than 14 billion light-years. 

8.       WRONG: Yes. Expansion causes the universe and everything in it to grow. Consider galaxies in a cluster. As the universe gets bigger, so do the galaxies and the overall cluster. The edge of the moves outward. RIGHT: No. The universe grows, but coherent objects inside it do not.


Astrophysics is very counter-intuitive challenging fun subject. These are just from general relativity. Next throw-in quantum mechanics!

Wednesday, May 10, 2017

Better Know terms 2017



From a forbes article comes this survey. It is useful for it filters useful things from a meaningful empirical perspective and saves on googling.

Not just 3, I think all are important to ANYONE claiming to be literate in 2017, and a discardible OIE, if a politician!
IoT: It has started. Intuitively internet of things, likely even more revolutionary than internet. Needs me to finish so that hacking criminality can be killed. On it, you can quiz appliances at home, start and stop them, chest surgical add can talk to doctor device , operate car entry remotely etc.

The Internet of Things: Evolution or Revolution?

 

API: a set of functions and procedures that allow the creation of applications which access the features or data of an operating system, application, or other service.

Application programming interface - Wikipedia


AI: Artificial intelligence - Wikipedia


AR: Augmented reality - Wikipedia


VR: Virtual reality - Wikipedia


MR: Mixed reality = VR/AR Part of AR is opaque and used as a screen for VR.
Machine learning: same as deep Learning.
Deep learning: Learning without being taught, no low level algorithms! Deep learning algorithms transform their inputs through more layers than shallow learning algorithms. At each layer, the signal is transformed by a processing unit, like an artificial neuron, whose parameters are 'learned' through training. Revolution in AI!

Deep learning - Wikipedia


Neural nets: Architecture for deep learning.
NVIDEA marvel:
Intel Xeon Phi processor: Intel reply to Nvidea.
Microsoft FPGA: for deep learning.
Block chain: Distributed self-organizing database, right now currencies and coupons, As revolutionary as deep learning, a m ajor new concept.

Bots: Internet bot - Wikipedia

An Internet Bot, also known as web robot, WWW robot or simply bot, is a software application that runs automated tasks (scripts) over the Internet. 

Drones:       The Best Drones of 2017 | PCMag.com

A high-quality drone is a serious investment. We've flown them all, and these are the top performers in our tests.

Autonomous vehicles:

An autonomous car (also known as a driverless car, auto, self-driving car, robotic car) is a vehicle that is capable of sensing its environment and navigating without human input. Many such vehicles are being developed, but as of May 2017 automated carspermitted on public roads are not yet fullyautonomous.

Autonomous car - Wikipedia



A model for century 21


Marx had mistaken ideas about 19th. Lenin and Mao extended the wrong creed but creditable effort. Hitler found support in anti-Semitism and extreme right, imposing mistaken-burden on every nationalist that followed, even if open to international cooperation. Simple aaqgs-point is this – nationalism is ultimately adopted by those who admit their ideology is NOT a universal truth, every nation has its own best strategy, it is strongly aaqgs-supported because it is fundamental devolution.
European union is too early for it pretends that its component nations can see national interest being best served by a union of economies and laws. It served a purpose once, but no more. It will again serve a purpose but aaqgs-says never a social union, nationalism will rise and devastate even the economic union.

SAARC is my central interest and is ready for economic union and social devolution using aaqgs-adhar. One can view SAARC as a collection of states of the old nations, each component with own passport linked to aaqgs-adhar. Fundamental difference to current adhar is maintenance of privacy on top of all the benefits. Public release and hacking has no deleterious effort. One never uses adhar directly, only a year valid exponential of the usual adhar modified by an unknown exponent function. A number of privacy features follow, the single bio-map of adhar is kept, but the year long adhar (or even weekly) adhar of no one is same or computable! Fucked are all businesses, US spy-agencies, hacker-thugs and similar criminals.

A number of criminal-motherfuck schemes have been designed using aaqgs-adhar. For example, corrupt railway sellers and reservation TTI can be emfubarred in court-satisfactory ways. The scheme is very very general, adhar is wonderful but new, not used for privacy attacks yet, but will be very soon and THOSE abuses have been wrongly solved in more capable west by not creating adar equivalents! Indian supreme court has forbidden forced use of adhar for benefits. A likely salutary judgment on plain adhar (WRONG judicial reason likely. It will justify even on aaqgs-adar!)
The main point is that aaqgs-adhar will support regional passport schemes as well as economic  union with social-devolution with none of the problems of plain adhar.

Gig economy

One rather basic point is “What about jobs”. Modi considers wrongly that India is blessed with demographic abundance. Current problem is “what jobs requires a human  because better than a program”. Reasoin is simple – whole groups of jobs are set to vanish – autonomy- driving, sharing economy, 3D printers, medicine cafes etc. Critical is US-India tech gap is 1 year! Uber, Lyft, Airnbnb etc are in India, as is amazon. The new businesses are MORE reliable and better than the past!


In US, the concern is rapidly increasing class of useless. India US rule of thumb is 1$ = 2R service, 1$=50R manufactured. In PPP terms, India & japan lost 70% value over 2000-2016, while eu gained 12% and Germany 35%.


Programming

Remains a lone bright spot. However, the speed of development is so high, that working lives is of 25 years, then uselessness. Structured programming died by 1990. Early object orientation by 2000. Visual programming by 2010. Android programming now. It will die by 2020. What next? Million dollar question, my answer is Giant database based AI. Nvidia makes a product avaible combining IBM and Google terabyte databases. Essential for AI based on neural nets. Voice interfaces have just begun and will sweep the market by 2020. Already, you can get amazon or “OK, Google” products, voice enabled TV remotes etc. Quickly, cloud based interfaces will appear in ALL consumer products.

No sale of un enabled products, no programming jobs for people incapable of voice api, standardized later! Clearly aaqgs-forecast is different!


Thursday, May 4, 2017

Acute and chronic diseases




I have always wondered why application of scientific method fails in medicine for chronic diseases. Essentially, the trust in advice of allopaths in chronic diseases is low. Scientific methodology i.e. measurement and animal models are employed by Ramdev in state-of-the-art facility to position Ayurveda successfully as cutting edge plantation based medicine. But why will he & modern medicine practitioners get poor results?
There are at least two flaws, applicable to mm and Ramdev both – short term positives and placebo-nocebo effects.
  1. Episodic versus historical statistics.
  2. 1.The failure is systemic and will require CHANGE in methods of data collection and analysis (historical not episodic statistics). Placebo is curing from believed proper care and nocebo is reporting expected side-effects! It is particularly true in transient diseases – very common in acute care requirement. The number of patients who THINK homeopath-criminals are particularly good at curing colds is legion! Further cleverer studies can usually remove the effect. Another famous homeopath-exposure-method is for a group to drink the most potent medicine of a system by liters!
  3. Short term positives – well known to addiction therapists. If you feed an alcoholic wine to one trying to quit, addict feels better for a short time, even though very injurious long term! Same is likely in insulin in diabetes-2. A standard prescription across many religions is periodic fasting. Under doctor care, does it work? Trying, detox diet is much easier and may work – fasting with green tea, stevia lemonade and watermelon. Goal is crushing of hunger pang, not speed since it looks like this periodic fasting benefits many systems and can be continued for life. There are many pain-suppressing medicines and drugs. It is common for physician at border to prescribe alleviations in guise of cures. Patient feels better, praises the doctor, moves away from border, continues the prescriptions, and the disease returns! Can blame the moving away, lost contact, even medicine admixtures! But not the motherfucker thug! I call it short term positives. A drug may prove to be short-term beneficial but long-term cancerous. Hence very important to suffer whenever medicine that fixes is under 50 years old, unlessokayed by a physician with enormous practice and reputation od being conservative; or rquired for emergency purposes.
    Ayurveda has the concept of kiaya-kalpa where fasting is carried out with one thing allowed – lemonade, skim-milk etc. Since total disrespect to Ayurveda, why only one? May be my kaya-kalpa will happen with these, more than 1, we shall see!
    So I am original nut not following strict mm or Ayurveda solely widely read rational skeptic conservatively experimenting with self. Unreasoned detractors, please lay off for your own good.

In other words, hundreds of empirical flawed experiments, published in peer-reviewed journals, likely mean nothing!

Wednesday, May 3, 2017

Classic Anti-aging Research



One epistemological way out of very vast thicket of publications on aging is to require, by ignoring howsoever good, the literature from NUTS who do not start their gems with transparent simple description of their epistemology, and use that to select the articles. Another is look at their prescriptrions to follow, the individual importanmces, and allow the reader to judge if the readers and
their doctors will allow the filtered prescription, perhaps after consultation.

Main take-away from my writing is this - Deep careful literature search + reading says aging is an unnatural disease from accumulation of damage that weakens our body to fight opportunistic diseases. Aging is not natural! It can be fixed starting 10 years and done by mid-2040's if greats, by 2040-2150 if me. You must get to 2040 your own way - 90-100 year for me, 95-105 for friends. Weight lifting 90s is possible if start now - reading and accepting needed discipline. Making a joke of doers is certainly a PJ, I can sympathize with naysayers, still there is a definite chance to cross singularity, It is not if but when! Will you live bad life for long then? Age reduction (perpetual youth) is only in some models!

My own method is TOTAL ignoration od ALL traditional medicine, consideration, of certains like homeopathy to be criminal, and total trust in certain subset of allopathy, namely acute diseases and some chronic diseases by default awaiting research; acute being defined by short duration urgent care. That certain parts of other systems are valuable is recognized, but must await allopathic approval (I think quality mm do fast) and every person celebrating the anecdotal success is ignored as a nut - why aren't allopaths investigating, or perhaps will? It delays neem, haldi etc, but only for some time, makes GOI the villain! Even Ramdev is researching in state-of-art lab and likely will do first rate work on use of herbal medicine for cure!

A very valuable reference

Rest is my view on Kurzweil presciption. Quite a character!

Two greats

There are various types of damage that the body does to itself as a side effect of the way the body works. Damage is always happening, and right now there is only so much that we can do to minimize that rate, and there’s only so much accumulated damage that we can tolerate. But our work revolves around repairing that ongoing damage. It’s just like a car. As carefully as we drive it and as diligently as we keep it oiled, sooner or later the engine will give out and it will stop running. But if a mechanic keeps replacing the broken parts, it can last forever. Vintage cars were not designed to last more than ten or 15 years, but preventive maintenance, so long as it’s comprehensive, can completely transcend any such limits.
– Aubrey de Grey, SENS Research Foundation, oxford gerontology chief
Our bodies are a bit like a house, we inhabit them, and if you don’t maintain the house it’s not going to last for very long, and if you do maintain the house it can last indefinitely. There are some houses that are thousands of years old. The only difference between a house and this house I inhabit is we understand how a house works because we built it. We don’t fully understand this house yet. But that understanding is increasing exponentially.
– Ray Kurzweil, Google life-extension chief

EXPLORING ANTI-AGING STRATEGIES

The body is a complex machine. Like any machine, it wears down over time during its normal course of operations. This is a process of decay and accumulation of damage, so combating aging is simply a technical repair and maintenance problem. There are various types of damage that the body does to itself.

1. Admit you don't know, goto Blue zone where long-life live, perhaps environmental or dietary (For 7 years)

BLUE ZONES

Blue Zone research details lifestyle commonalities that communities with high life expectancies share. The top 5 places are:
  • Sardinia (Italy)
  • Okinawa (Japan)
  • Loma Linda (USA)
  • Nicoya Peninsula (Costa Rica)
  • Icaria (Greece)
  • Gives you 7 year extra life!
2.  gene vector research

Gene Therapy In America, the CEO of biotech startup BioViva recently made headlines (AAQGS-LIKELY CRIMINAL/false) by claiming that she is the first person to be successfully rejuvenated by gene therapy. This claim is extremely dubious and results haven’t been submitted for peer-reviewed publication, but it’s another indication of how close we are. Pioneering gene therapy very dangerous.

3 Two bridge strategy

By deGrey and Kurtzweil, Bridge 2 is called singularity. BriDge1 is 5-15 yeRS AWAY. nORMAL HUMAN AND FORECASTERS ARE STUPID IN PREDICTING EXPONENTIAL  MOORE'S LAW  WHERE 95% PROGRESS IS MADE IN LAST PERIOD.!


deGrey - mid 2020's, Kurtzweil 2020, Me 2060

4 Multi-bridge strategy

me - indefinite life in phases with different problems and solutions. Bridge in 2060. Next in 2150 using hibernation. Final in 6000 using spintronics. To b2 - usual docs. to b3 - hibernation. to b4 - stem cell codivision or vat-brain organ- radio-interface. Beyond b5: antifragilee transfer to electronics/spintronics.

Bridge 1 strategyS

COENZYME Q10 FOR THE CELL’S MITOCHONDRIA

SPIRULINA (To DO)


 RC claims it is the most important vitamin to take and that there is tremendous amounts of research and consensus that it helps prevents cancer and others.

NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+) (A variant of vit B3)

Australian and US researchers hope the anti-ageing compound NAD could be trialed on humans as early as next year, following a key breakthrough that saw the ageing process reversed in mice. Two-year-old mice were given NAD over a week, moving back the key indicators of ageing. by NR or NMN. damage to mitochondria accumulates over the years and is one of the main contributors to the negative effects of aging.

LIFE EXTENSION

HUMAN GROWTH HORMONE (HGH)


Saturday, April 29, 2017

Work on Metformin

  1. How much metformin per day. How many doses. 2550 mg limit, 2000 mg preferred, 1000 mg for non-diabetics. Metformin should be given in divided doses with meals and should be started at a low dose, with gradual dose escalation, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient.
  2. Contraindicated for whom, answers before clinical data from mechanism of digestion and excretion.
    To determine dose, 500 and 1500 mg doses are being tried. Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine and does not undergo hepatic metabolism (i.e. shit). Means kidney better be good. Likely in age 80+ or patients before. Ensure adequate urine clearance. Other contraindication on clinical use data. Best wait pioneering use, ie to 2025. I must for use it for diabetes! Fasting means elimination of Teneligliptin.
Special Populations i.e. Patients with Type 2 Diabetes In the presence of normal renal function, there are no differences between single or multiple dose pharmacokinetics of metformin between patients with type 2 diabetes and normal subjects (see Table I), nor is there any accumulation of metformin in either group at usual clinical doses, or race/gender differences in type-2 diabetic effects. Can safely await clinical data.
So major testable contraindication is renal insufficiency. Other common sense no go are congestive heart failures, known allergies to metformin, and metabolic acidosis with insulin emergency fix.


Can people with type 2 diabetes live longer than those without? 

Clinical and observational studies have shown an increased risk of cardiovascular events and death associated with sulphonylureas versus metformin. However, it has never been determined whether this was due to the beneficial effects of metformin or detrimental effects of sulphonylureas. The objective of this study was therefore to compare all-cause mortality in diabetic patients treated first-line with either sulphonylurea or metformin monotherapy with that in matched individuals without diabetes.

METHODS:

retrospective observational data from the UK Clinical Practice Research Datalink (CPRD) from 2000. Subjects with type 2 diabetes who progressed to first-line treatment with metformin or sulphonylurea monotherapy were selected and matched to people without diabetes. Progression to all-cause mortality was compared using parametric survival models that included a range of relevant co-variables.

RESULTS:

We identified 78,241 subjects treated with metformin, 12,222 treated with sulphonylurea, and 90,463 matched subjects without diabetes. This resulted in a total, censored follow-up period of 503,384 years. There were 7498 deaths in total, representing unadjusted mortality rates of 14.4 and 15.2, and 50.9 and 28.7 deaths per 1000 person-years for metformin monotherapy and their matched controls, and sulphonylurea monotherapy and their matched controls, respectively. With reference to observed survival in diabetic patients initiated with metformin monotherapy, adjusted median survival time was 15% lower in matched individuals without diabetes and 38% lower in diabetic patients treated with sulphonylurea monotherapy.

CONCLUSIONS:

Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls. Those treated with sulphonylurea had markedly reduced survival compared with both matched controls and those receiving metformin monotherapy. This supports the position of metformin as first-line therapy and implies that metformin may confer benefit in non-diabetes. Sulphonylurea remains a concern.