Patient directed distributed control

This is the case in civilized world today, but shamefully used by most patients. Can I postulate  a better system and defend it? Yes, solution is here intermixed with defense. Who are the sub human enemies? Sick-unprofessional advertisers, makers and dependent media. Despite current immunity, I advocate later-age prosecution like Nazi and women-rights-enemies of the past along with post-disclosure cigarette companies. The system I advocate, open to improvements, is patient-centric in that some advisor professional must concur with the patient and only that destination is allowed. Controlled by checks and balance democracy. The first point is stupidity of asking or replying to the question of comparison  of any two systems of medicine. The key point to incomparibility agnosticism is comparisons based on evidence and experience for specific ailments. The purpose of requirement of concurrence to a such advocate professional is to force the patient to search for matching opinion in the class of better qualified persons, without constraining the citizen. Advocate professionals are controlled by periodic exams and delicensing.

Now my own choices based on what I know. Open to improvements in stating or choices. Ayurveda or better Allopathized Ayurveda for ignorable minor ailments and exercise. Strict allopathy for all event based medicine. Strict cellular medicine for cell directed ailments, definitely aging. Agreeing with Allopathy distinction, treatment by Allopathy, cure by any method is as good. A system in which tired old sick looking can submit and receive FDA clearance for Aging supplements is not acceptable. Evidence-based only if some agency finds definite group parameters improved.

Baba Ramdev is an advertiser doctor who is controversial stating the advocacy of Ayurveda over Allopathy, correctly criticized by Allopathy professionals. He is however practitioner of Allopathicised Ayurveda in that he uses evidence-based methods, but was shamefully caught in the coronil anti-covid-19 for using a self-beneficial notion of evidence in which all corona-patients ever and aged-over 65 were excluded and could not convince the government of efficacy. Some later version did pass. Should he be believed? For some things, yes. Just as good for cure of persistent diseases. No, for treatments and cell medicine ailments. Use cell medicine when it starts, Allopathy only till then. In many cases, supplements and OTC can be used. Use aggressive Allopathy for cancers.

Clearly, the benefit of and educated proxy, funded by he government, is not to be restricted to medicine. It is an essential part of my "education benefits without education" theory. My belief is a properly educated required proxy for all important decisions. Defined by percent of estimated income, offers vastly improved citizen actions with no problems other than some costs, payable by all developed countries and universally for less developed with my ideas on democracy.

Clarifications + my definitions

 

Controlled by checks and balance democracy:

The list of such professionals, licensed by the government on the basis of some recognized body, which can be removed too, on cause with the concurrence of court system. Laws by transparent checks and balances with forced agreement with supreme court.

Senescence cell doctors

 

Abstract: I believe that Senescence cell doctors are basically distinct from other doctors because they do not need to become jack of all trades and because their fundamental treatment is only related to problems within cells, fundamentally different from physicians who need to understand body function in all random organs effected by differently random diseases, often more than one. Limiting the specialty to cells and strong ties to genetics community and molecular biologists enables Senescence doctors to deal with all eukaryotes. The subject of aging applies to dog, cats, mice etc. as well. The nucleus sack is the basic unification that allows the development and treatment with mRNA drugs and vaccinations to attack cancers of all kinds and aging of all eukaryotes. We must allow all the great scientists mentioned, Dr. de Grey, Dr Sinclair,Drs. Conby and Dr. Horvath as fundamental scientist with MD like opinion value and ability to practice cell medicine’ applied to cancers and aging even though in most cases, they do not have MD credentials. The invited will themselves act responsibly.

Advanced cancers are often considered untreatable anymore, and the focus shifts to control of pain in hospice setting and permission to use any weird technology by the care-givers routinely exploited by moron criminals. This might be acceptable behavior in MD community, but will not be of any senescence cell doctors. That is because both cancers and aging have a cellular basis, and the effort to control ailment in the patient must extend to the very last, even trying theoretically good novel chemicals. Death is no longer a necessary natural event but an admitted shame on the doctors on the state of recuperative art of the time. The ailment must be cellular and that distinction has to be continually refined.

Both aging and cancers are ailments of the cell. Cancers can be researched as one, based on genetic mutation of the effected cells. There is a generalization, which converts remit, post the drugs causing remit fail. THIS MAY BE FOR THE VIRUS TO MUTATE OR TOLERANCE DEVELOPMENT. Only true cancers here.

There is no discovered unification of aging. Certain defects in cells are called hallmarks, with Balkanized work on each. Cell medicine depends on molecular biology and genetics. The unification is mRNA drugs and vaccines, with training the immune system central. There is a hallmark, cell diseases, treatable by mRNA drugs or cousins and vaccines fixing patient immunity. Alternatively, treatment and cure by strengthening immune therapy. The treatment and cure is not by external magic drugs, but by inherent immunity training. Immunotherapy is removed from Allopathy. Some professional organization admits cell medicine professionals, by examination, unless invited.

The persistent diseases of diabetes, heart, osteo-whatsoever etc. are divided into treatment and cure. For cure, all legal systems. For treatment, only Allopathy.

Vaccination against Cancers and for undoing Aging

The Latest link

A completely different disruptive new paradigm path is proposed here to use the machinery (IE mechanism) for mRNA for this purpose. I call it a hypothesis for fails my notion of science theory. But there are arguments to believe it represents likely path to undoing aging. First reference (Follows this) is to learn trivial underlying biology.

Increment to NAD+ is crucial to undoing aging. One basic goal of undoing aging is to increment NAD+ levels to what are in adults. NAD+ declines continuously with age.Synthesis of nicotinamide adenine dinucleotide (NAD⁺) decreases during aging, which is thought to limit the activity of enzymes that require it for their catalytic activity. Studies in animals indicate that replenishment of cellular NAD⁺ can have beneficial effects on aging and age-related diseases, but the situation in humans is less clear. Yoshino et al. report the effects of supplementation with the NAD⁺ precursor nicotinamide mononucleotide in overweight or obese postmenopausal women with prediabetes (see the Perspective by Hepler and Bass). The treatment improved insulin sensitivity in muscle, although a change in NAD⁺ content was not detected. The treatment also increased the expression of platelet-derived growth factor b. The results support potential therapeutic action of NAD⁺ supplementation in humans, but how various NAD+ precursors are processed in specific tissues remains to be fully explored.(science

NAD+ is a basic material used in Krebs cycle. It decrements because senescent cells, hallmarks of aging, are inflamed by NAD+ and generate CD38 poison to reduce NAD+. Every trick to boost NAD+ will fail because eventually CD38, whose concentration increases with age, will overwhelm the trick. Clearly, CD38 levels must be reduced periodically.

One direction being pursued by Group led by Drs. Conboy at UCB is to use Blood dilution and chemical metering to reduce any evil proteins by dialysis type machine. This method will expand graciously with research expanding the evil list to include TGF-beta etc.

The current state of the art is here.

I state a new disruptive paradigm here - use mRNA vaccination idea to remove nonliving proteins much smaller than viruses. The idea here is to train the immune system to recognize the evil proteins and eliminate them in the usual way. For this purpose, we use two properties of biological evolution of DNA and cells of DNA repair and sanctity of DNA by nucleus membrane. This method applies to cancers even when not caused by virus type of things, The paradigm where vaccines work without viruses is novel to all western modern medicine, away from germ theory of causation so strongly tied to it, instead of older systems missing the theory of germs. The idea of vaccinating for cancers and undoing aging seems opposed to modern medicine, since no new germs are postulated.

First, that every evil is legislated against by preventing any direct contact with DNA molecule inside the nucleus sack in eukaryote. All other methods will be destroyed by future evolution interlopers. It is like Dr. Sinclair idea of only surviving DNA to achieve exclusion of repair and replication by making them the opposite sides of logic of epi-gene, shut or not! The signal molecules cause the copy of some part of DNA into mRNA. It is this molecule that exits the eukaryote nucleus sac and can never go back. This mRNA unites with ribosomes of the cell external to the sack, constructs the encoded protein that then exits the cell. The mRNA self-destruct for important proteins to in few hours. They can never reenter the sack, like the perfect surviving solution of Sinclair! Most subsequent evolutionary products can not penetrate and hijack the DNA! 

Somehow, horizontal gene transfer happens, although I state and believe in the theory of lost intermediate eukaryote species sexually compatible with both now incompatible species. This alternate explanation is possible given the low frequency of apparent horizontal transfer, despite the similarities of neighboring sequences in sexually incompatible species. Alternatively, there is still viral transmission theory with symbiotic role.

Second, if mRNA exit the cell, immune system kills them by eating.  But it has to kill only a few that survive self-destruction. The mRNA are copied segments that have a different sugar, becoming Uracil on transcription!

Now comes an irrelevant point as to the recognition by immune system of improper cells - it may be because of memory of all the mRNA. Or any molecule with U is bad. The difference is on the attachment freedom to the evil protein. Whichever, the point is that any molecule that resembles mRNA in part is bad. The immune system killers destroy mRNA analogs and are also trained to consider the rest of the molecule bad too.

This makes the functioning of mRNA vaccines easy to follow. Consider one hypothetical vaccine for Covid-19. The virus feature selected is the spike protein.  A molecule is constructed that joins one mRNA with the protein that

a) is easy to manufacture

b) looks non-toxic

Set of these molecules are tested on mice, human cells or both. The set is reduced usefulness and improved non-toxicity and triaged to a list of candidate for first small human trials. It takes weeks to prepare the candidates, but year to test to convincing levels of safety and efficacy.

My idea is to treat the bad proteins like CD38 to be an expanding list of chemicals of evil for which mRNA vaccines are built and treat cancers as mRNA vaccine for 1 patient! This is possible since building the molecule is measured in weeks and the real time will go in identifying the evil proteins, which will become easier with data per patient helped by recent use principality.

Specifically, knowing the molecule considered evil is smaller than a virus and is assumed small enough to not look for expressed features, which may be shared with useful proteins not to be targeted, An mRNA/evil mix is considered for safety. It will be used for cure, hoping that theoretical predictions are sufficient. Data for several trials is saved on per-patient basis and hopefully will be reusable soon. The data can be exchanged with similar programs.

Immunity period depends on per-protein basis and per-patient basis. It may vary from once a century basis to once-year basis. In any case, some patients will have a very long immune memory. Aged have another severe problem with vaccines - their immunity system is too weak (numerically)  to eat the foreign objects. Hand-in-hand with vaccine solution must be an  immune multiplier. Till that time, the vaccination solutions are for younger cancers and infections.

To summarize, treating by vaccine approach is possible since I fail to see the difference between surface expressed proteins to full proteins in most cases. Sites visited by immune cells exceed that are blood connected. BBB barriers don't exist.

Aging bounty of Covid-19

        Only comparable picture is physicists in 1927. Center is the saint Aubrey de Grey, SENS.

 The latest link

But the scientific community doesn't know what to make of him. In July 2005, the MIT Technology Review challenged scientists to disprove de Grey's claims, offering a $20,000 prize (half the prize money was put up by de Grey's Methuselah Foundation) to any molecular biologist who could demonstrate that "SENS is so wrong that it is unworthy of learned debate." The challenge remains open; the judging panel includes TEDsters Craig Venter and Nathan Myhrvold. It seems that "SENS exists in a middle ground of yet-to-be-tested ideas that some people may find intriguing but which others are free to doubt," MIT's judges wrote. And while they "don't compel the assent of many knowledgeable scientists," they're also "not demonstrably wrong."

Without sounding mean, my life has been unspoken incessant tragedies that made me stronger by the opportunity given because they never killed me. One of the bounties of Covid-19 is mRNA technology polishing, Even a successful company is called Moderna, using RNA as a suffix. RNA is not new, likely older to even first failing DNA a billion years ago. But its use to build new proteins is new, doing it industrially and eliminating kinks, is new. It is a perfect development for Aging.

What aging is, and how does SENS fit within Gerontology and Geriatrics as an engineering approach within great sciences is my ideology of 20 years and counting.

Why is COVID-19 so deadly to the elderly?

What m,RNA is, should be crystal clear after this. The current article is about some of the myriad applications, in the near future, in Aging. That is why you must intern it to be able to judge the technology behind claims of novelty and usefulness of products.

 

Let us abbreviate greatly for new biology novices, even this simplicity was novel to me recently.  Every Eutheria body is collection of trillions of cells, all derived from a single pluripotent cell in the womb and assisted-developed to adult-hood from a single pluripotent cell, about half from both parents from DNA which duplicated by unraveling the double helix. In computer science, every action by a program is a derivation from the start symbol, here is the fertilized zygote and repeatedly derived according to the grammar rules, till all nonterminals become terminals,  the final program. In biology, complete derivation never ends and non-terminals remain as stem cells even at huge long life end. These are reactivated in wounds, just sleep after adulthood. All is done by blood carried signal molecules. It also carries some instructions from specialized organs for hormones. Growth happens by hormones and is stopped so. Hugely extended brain cells called neurons become nerves for analog signals.

For aging, important to consider single cells since the same structure, regardless of organs except brain is found in and aging happens at the cell level, a very recent find. Even if one keeps the structure perfect, aging will happen as cells age. Aging is normal at cell level, and cells avoid death by repeatedly becoming daughter cells. However, telomere at the end of DNA shorten on every division and there is a limit called Hay flick limit on number of divisions, this is about 50.  Classic doctors subscribe to this and believe that undoing aging is a matter of telomeres, expressed by gene within the cell. The first shocker is cancer cells which become infinite lived solely by learning how to use the gene in DNA to infinite divisions. One must be super-careful to avoid cancer in all telomere manipulations. The second shocker is the presence of animals whose telomeres never shorten, but they die all the same! So this possible but unreal story is wrong. Current scientifically established theory is genetic by Dr. Sinclair. It focuses on DNA repair in the nucleolus. By forcing exclusion of repair and duplication rules by error-free perfect means by repair and duplication states logical inverses, One is trivially shut when the other is active. In fact, super centenarians all have robust DNA repairs. Sinclair won the mechanism race by two  repeatable empirical tests, one aged one of a twin pair of twin mice and second by crushing the optical nerve of a mouse and restoring it by topical chemical use (NAD+).

Regardless of chemical needed, a protein is generated either by the DNA lording all, by mRNA which emerge, are grabbed by the right ribosome and protein is built and exits the cell. The messenger RNA (mRNA) is almost a copy of small part of DNA except that it is single strand and contains a U instead of a T – uracil instead of thymine. A signal molecule from outside enters the nucleus, excites the DNA, compelled to emit an mRNA which exits the nucleus. While never encountered in text, all mRNAs are known bad in Blood, immune knows all kinds are bad, (says my evolution part. Hard for nature to preset killers for just all mRNA More likely all Uracil having molecules are bad, needed natural immune complexity there! Whatever rest of the molecule is bad too and that is how the killers learn.) A lot of evolution is simple natural means to solve hard human problems! Just exclusionary DNA repair means all life on earth. Only one kind on earth DNA means likely compatible life in Universe! Many forms that failed evolution lottery on earth will exist in other planets.

The mitochondria generate and release energy in ATP-ADP cycle and have their own 13 unit DNA. Very recently by clever means, mitochondria were fixed by harvests (70%), new DNA for mitochondria, inserted, and replaced, all in living mouse! Holy crap! This technique can be extended to extraction and replacement of ribosomes and in live humans! Another giant step to defeat of aging.

The process that converts signal molecule to DNA to mRNA to protein is the foundation for how the cell functions. The mitochondria probably be segregated to other cells, or is their presence needed by evolution? Reduced NAD+ inflammation with senescent cells might be a reason.

How do mRNA vaccines work

We outlined enough to understand the sequence of steps. From above, I ask as my Socrates brain, after mRNA emerges from the nucleus.

Can it go back, say, for disposal?

Evolution imposes the rule - No going back! Grossly unsafe, all virus kinds will love it. No mRNA allowed returning!

So how disposed?

Self-destruction, minutes for high proteins, hours at most!

What if it emerges from the cell?

The change in at least one sugar is enough to allow target all RNA by immune system.  Additional benefit in Eutheria.

How does mRNA vaccine work?

An mRNA is found to unite with spike protein in Covid-19 case, the compound can't be toxic. Vaccine allow it in blood. If any viruses present, some mRNA sticks. By immunology, all RNA in blood are bad. So they get eaten. Of the rest, some remains in blood and some enter cells. They die inside by self-destruction. Fraction outside are eaten by killers, training them. Later when virus comes, spike-protein launches love to death killers. How train? Remember that mRNA had the spike protein not wanted by vaccine maker. Being partly mRNA, it was bad. Because part of the spike protein was attached, immune cells believe not only mRNA is bad, so is the attached spike protein!

Lesson learned

To kill a virus, one looks for an expressed protein on the surface for which a good mRNA can be found. Next, one uses mice and/or human cell cultures to make candidates by keeping only those which appear safe. Next theory is applied to reject candidates based on harm before. The remainder molecule are triaged to first small human tests. COMES fda-2, ELIDED BY SPUTNIK TO fda-3 AT ONCE. WORKS OFTEN BUT LOWER SAFETY. After all, safe in some humans for some time. Sinopharm, likely example of fail if fda-2 and fda-3 were there. In effect, Seychelles, UAE and many other China vaccine users did the FDA-3 and flunked the vaccine!

Arun Arya generic transform

Nice example of deep understanding of some subject is candidate ideas in Aging of new products and understanding of others. Let us apply the ArunArya transform that will be used to create new kind of programming. For aging, let us keep the protein and mRNA variable. Then the procedure is find the protein, select mRNA for it, train the killer cells and kill them.

Application in Aging

I believe it will be major and many targets. First I pose it and later consider Angel investors. To apply to aging, let us identify the villain. For now, we limit to CD38 and TGF-beta. One way to eliminate them is by filtering blood by concentration meters. A completely different novel technique is to find good mRNA that will attach to the bastards.  Imagine the beauty of the slaughter by natural immune killers trained to kill the bastards, trained by RNA attachments to the bastards. Till a vaccine is developed and tested, drugs can be used for periodic reduction in strength. In other words, new classes by vaccine or drug of senolytics. It will be great to get vaccines for expanding class of bastards - how to expand your life by vaccines and periodic revaccination (100 years?) for some, for healthy age increment purpose. For some, once is good enough, as the immune cells for them retain memory forever. Even that might need slower reactivation. If USA style fish eat fish applies to companies, then maybe we will embark on posthumen form of life even before 1000 years.

Letter seeking help

 

As recounted by Lady Conboy, before 2005, prior to their earth-shattering work, they could not move forward in parbiosis work till fix required funds for research. Beyond the other donnés, stepped up Dr de Grey and solved funding and expertise (suggested and convinced two capable technician fellows to work). Rest is history. It reminded me of Bhama shah. I don’t need one for money. But I do need capable technicians. And someone in our group to sound on by email. Best would be a new doctor uncle. Oh, I miss him.

I did write up my work to a form good enough for me.

It can be edited and extended, in fact should be. IT will be used to ignite shared help calls. The HARDEST part of being a grownup male is to admit you need help, and having doctor uncle meant I did not need help. I do now. Solving funds problem, and tech problem is a good start, that all. Maybe some better ideas. My goal is a company and my need is, a perhaps not meet (email and phone only), partners. No funds needed, best being PPP model with Yogi, or like, delay and use my NMN experience, go for clinical test over 5 people (Too expensive in the USA, NMN still lags NR), … Whose shoulders do I cry on and answer my doubts! Time to build email only groups like class-of-75 with legal statement consequences, ... My proning experience was bad and deflationary. But did fetch help from Hemant & Baldev, gratefully acknowledged,

Tech fi on life after the first thousand from now

 

Latest link

Tech-fi and consistent sci-fi are my invention neologisms. The title "Tech-fi on life after the first thousand from now" indicates that the technology applications will take unspecified time to become profitable, but no new science is postulated. Consistent sci-fi is that the series explores derived possibilities of the raw science imagined, as well as strong believers constitute consistent explored civilizations.  Star Wars and Star Trek are both consistent sci-fi. If current science postulates sufficiently widely a contrary principle, then that branch of sci-fi becomes dead. Jules Verne classics and "back to future" are bad sci-fi, to be passed sci-fantasy, because antigravity and time travel respectively are anti-science. Consistent sci-fi do not include, but do have Star Trek imaginations which while true flights of fancy, are still non-contradictory.

After the first ageless 1000 years, the sane majority of life forms will allow their brains to be blown up to huge sizes using MIT 2010 decade technology developments, transfer their brains on digital memories and weights on huge robotic nets, to enable a recreation of similar net, as nano particles on diamonds, as the brain. Once that is done, light speed travel, and safety against all types of dangers becomes possible, even true immortality assuming correctly that unlimited dangers have very local limits forever. Regardless of length of time in any matter coordinate system, the time elapse for photons is zero! So optical information needs to revert to diamond form only after unlimited travel.

What is an advanced brain?

It can be answered today with some certainty. It is many functional units composed by pipeline. Each unit can be implemented securely by read only functions operating on two kinds of data, write-once and variables, with fixed locations or pointers. The data is separate from code and organized as series of snapshots connected by lists of transactions which each keep an implicit record of what was done, why, and by whom etc. Each function begins with an event which schedules in a set of closures dynamically bound to that function. It terminates in another dynamically bound post-event to which various sanity-checking closures can attach. Closures imply coroutines which can share variables. The entire program is a process which cannot share any variables, but can share write once. The program flow can be normal or automatically instantiated from semi-context-sensitive grammars on events. The semis have singe global nullable non-terminal but nulled just once at the end. It represents time.This models coroutines and machine learning (an opaque functional coroutine) both.

I am predicting that even full first order logic will not be doable by  ml machines. There is nothing intuitive about the logic. Unlike human brain, two independent units can ML-compute a function and the difference, thus operate differently from neural brains. However, complex units will have two levels with one normal circuit level  over ML-level.

To be done.