Texas businessman with a family history
of dementia recently announced he would award $4 million in prize
money to researchers who search through published scientific
studies and knit the findings together into a unified explanation of how
Alzheimer’s works.
No millionaire or prize is needed for
motivation since age-sickness will strike me – it is not familial chances.
Reviewed by Neha
Pathak, MD on August 22, 2018 [all except text in [] ]
[ WebMD pronouncements, good or bad
are as good as conventional medicine doctors average, which is very good for
lay persons, both as what to do and judge anything different as perturbations
based on referenced arguments.
After several years of hard skeptical
but rational research, I am ready to summarize my learning, as I do here. The
goal, as Dr. Sinclair puts it, it is not people living longer, but extending
their youth. Even if later empirical tests prove a lack of age increase,
unlikely but possible, the reader and implementer gains enormously from the
quality of life!
The solution is some cocktail of vitamin
B3 forms and supplements metformin, MK7+D3+Ca,
and CoQ10
(direct or mitochondria
entering). The forms of B3 are niacin (flushes) or nicotinamide (non-flush
niacin), NR (2 steps
to NAD+), NMN(1
step to NAD+), NAD+ or NADH
(REDUCED NAD+).
Why a cocktail?
The forms vary
enormously on costs, bioavailability and cells improved! The goal is NAD+in each case as an essential part of Kreb cycle in every cell. All forms of B3,
or any other aging intervention must target NAD+! There is age-long
diminish of NAD+, it is a reliable measure of bio-age, even better than
telomeres!
Bioavailabity?
Me: It is the essential difference
between a doctor and biochemist. Just because a chemical is found in a
particular plant means nothing and is the principal difference between
nutritionist and a subhuman passing as capitalist sellor, advisor, company,
doctor, biochemist etc. In each case, the subhuman will be incapable of
referencing the right material or reference bad or controversial matter. One
who does is a scholar. One who does not is a subhuman! In argument, one or both
scholars may differ and be wrong, a subhuman is always criminal, whether right
or wrong. It is possible to detect subhumans without deep knowledge of any
subject and I suggest they should be treated as criminals.
Bioavailabity is to
get the chemical in usable shape at the right place. In current case, the
chemical may have transportation losses, aging losses, blood entry losses in
stomach, blood-brain barrier interface losses, cell-wall penetration losses and
losses from entry into mitochondria. Reserveratrol is excellent example, you
get it in red grapes which has to eaten by tonnes or hundred of gallons as red
wine. Glutathione is another skin lightening anti-oxidant, very poor
bioavailability unless given as drip! NMN is another, easy bioavailability for
mice (in drink) but very poor in humans. They must either take it in drip or
sublingually.
Sublingual is
possible in some cases, like NMN, when the molecule is small, it is like IV
direct. Another matter is easy intra-muscular (like insulin injections) or
intravenous (requires training)
Niacin/nicotinamide
do not significantly become NAD+, but crosses into brain and helps
Parkinson/Alzheimer patients. Only NR crosses into cells but NAD+ and NMN
spontaneously become NR! NADH crosses to brain, as does NAD+.
There is a war
between believers in NR, NMN, NAD+ and NADH. It is empirically known that
they effect different cells differently. Which is why I think of a cocktail
depending on who to help.
No matter what form, IV route is
best. USA costs are $1000 per day i.e. $13,000 (10 day) to $30,000
(28 day) per treatment Me: Ideal for Indian medical tourism! I start with
drip (B3 cocktails), ECP and HOT. It is $1500 in premium coach for USA-India
back and forth. Great use of my real estate assets and cost or quality uncompetable medical tourism.
International airport near Greater Noida will be ready by 2022! I can also pay
for eScooter fare to IG airport at palam.
Beyond that, there is sublingual
glutathione, self-injectable
nmn etc as product ideas.
]
How Vitamins Can Help
Older adults have different needs
when it comes to vitamins and minerals. For example, the right amount of
calcium can help fend off osteoporosis in women. Vitamin D, which helps your
body take in and use calcium, also helps prevent bone loss and broken bones in
older adults.
It’s sometimes hard to know exactly
what you need. But if you have a balanced diet, you’re probably doing OK. If
you’re still concerned, Robin Foroutan, a nutritionist from New York, suggests
you ask your doctor if supplements might help.
Before you head to the store,
though, it’s important to know the term “supplements” includes not only
vitamins and minerals, but also herbs and other botanicals, amino acids,
enzymes, and other things. Some are so-called specialty products like
probiotics or fish oils.
Before you take anything, talk with
your doctor and read labels.
What Might I Need?
You can find these in foods or on
the supplement aisle:
Calcium. “There really should be no reason that people should be
calcium deficient,” says Angel Planells, a dietitian from Seattle. Known for
the role it plays in making your bones stronger, calcium is found in dairy
products like milk and yogurt. Women -- especially those who are likely to have
osteoporosis -- may think about taking calcium supplements. But talk to your
doctor first.
Vitamin D. This nutrient, made by the body from sunshine, helps you
take in calcium and phosphorus, so it’s key for healthy bones and teeth. Older
adults don’t make it as well, so supplements can help make you less likely to
have bone loss and broken bones.
[
Most Indians and westerns elders develop Osteoporosis, even if
adequately supplied with calcium and D3. Japanese much less for their diet has
natto (soybean -> k2). Like K1 a quinone, but not heart enemy like K1.
Probiotics in human gut do convert some k1 to k2 in some cases (K1 essential
for blood clotting, why heart enemy). Available as MK-4 (only japan allows) or
MK-7 (empirically better than MK-4. Ideally supplement with k2, if calcium and
d3).
Fascinating
was hospital dietician (after food poisoning admit) who was not clear on
vitamin k2 last month! Try in your place!
My theory is k2 by supplements essential
menaquinone like MK7, PREVENT wrong deposit of Calcium in blood-vessels where
they cause arthritis, kidney stones etc! MK7+D3+Ca essential
for strong bones to avoid the topmost Osteoporosis problem
post age 90, essential before for comfortable aging. As my mother says, hell is
on earth, with slip in bathroom and 3 month elevation of cast legs, confined to
a bed!
]
Vitamin B12. This is important for keeping blood cells and nerve cells
healthy. Aging affects how well you take in and use B12 from foods, so if
you’re over 50, it’s probably best to get your B12 from supplements and
B12-fortified foods like cereals, as well as foods that are rich in it,
like meat, low-fat dairy, and fish.
[ Very
cheap in India in Modicare, stupid if not used as supplement, anecdotal helps]
Folate. This helps prevent anemia. Spinach, beans, peas, oranges,
fortified cereals, and enriched breads can have it.
B6. This helps your metabolism and immune system. You can get
it in fortified cereals and soy products, as well as organ meats and whole
grains.
Your body also needs these:
Vitamin C. Oranges, right? (And red and green bell peppers, along
with other vegetables and fruits.) It may help protect you from cataracts, help
wound healing, and possibly lower your odds of having certain kinds of cancer.
Magnesium. Among other things, it helps keep your blood pressure and
blood sugar levels steady. It’s also good for your bones. You can get it in
nuts, spinach, and dairy products, and it’s used to fortify some breakfast
cereals. Experts aren’t sure how well it works as a supplement.
And here are some popular items you
can find in the supplements aisle that you might talk with your doctor about:
Probiotics. Gut health is also very important for your immune system.
Some studies show that probiotics -- living organisms like those found in
yogurt -- help prevent some types of diarrhea and ease symptoms of irritable
bowel syndrome.
Coenzyme Q10. Also called coQ10, this is made naturally in your body and
found in most body tissues. It may help your immune system work better.
Melatonin. A hormone released mostly at night, it’s believed to help
you fall asleep. The science on it is promising.
