Sunday, January 14, 2018

NMN directly not NR



Freshest Link

I have been interestedin anti-aging and life-extension drugs from a rational stoic (near science)point of view. Difference to (science = rational scepticism) is that statements of scientists are accepted in absence of rational doubts in speech and presentation (very negative whole advertisement) i.e. trust level  improves or reduces based on actions directly or responsibility-wise).

My extensive research on aging has filtered many contextual loves like resveratrol as philosophically ineffective mechanism, also proven by experiment to be ineffective.

Why not, what lessons?

The proponent did not consider transport and sales-business delays, even though the science was solid.

Why was it scientific?

It functions well in natural world at low concentrations where storage is not a problem i.e. red wine. One could do complex medical chase and isolate the core ingredient responsible for the goodness – that is what western medicine is about. One can chase more and find that ultimately within human mitochondria (evolution-shared by rats (mice) and monkeys) what is improved.

What is this about?

Both Nicotinamide Riboside and nicotinamide mononucleotide are NAD+ precursor, and able to increase the NAD+ level. The likely mechanism of nicotinamide mononucleotide uptake is extracellular conversion to nicotinamide riboside (NR). In addition, NMN is more powerful than NR in its anti-aging effects. Of course, the price of NMN is much more expensive. Reference says  here has been very little research conducted on human, and adverse effects of NMN is not known. Always conduct your doctor before taking NMN supplements.
Turns out, mitrochondriac NAD+ declines with age in all humans and animals and is proportional to vitality. What resveratrol did was to boost NAD+.


How does it fall?

Exponentially half life 20 years! 60 is 12% of birth. 80 is 6%. 100 is 3%. Goal is to boost NAD+. Not NaDH directly, no reaction set! Cell energy cycle from Krebs is ATP<=>ADP or  NaDH(v Work) <=> NAD+(^food) or Citric acid.

why not inject nad+ directly?

NAD+ cannot be given directly to the mice because of its toxic effects (serious hyperglycemia … http://sumo.ly/8ahe via @herbnutritional

What does it boost? How to get more of it?

One can suppress the detail of how. Many biological systems have a cycle in chemicals. NAD+ has 2 – de novo and salvage cycle. Critical is salvage about 85%. Food boosts NAD+ to NADH, discharges back to NAD+. Can't boost NaDH directly! The salvage cycle is to a form of vitamin B3 (nicotanamide). As the picture shows, NAMPT interaction is necessary to become NMN.

NR, nicotanamide riboside, trade name niagen, which I feed to mom and dad was near best in past. As the diagram shows, some part becomes NMN. Another just B3 and may get boosted to NMN through NAMPT bottleneck. So there is some benefit in boosting NR concentration. NR costs about $1 per day. Doubling it to $2 is possible but ruins me financially, supporting 2. Cant involve my sisters (have no brother) in a rational-stoic effort absent settled rational-sceptic. Problem is that tests in progress will yield data (preliminary) by Jun 2018. That is likely too late for Dad. So test doses need to be given to him! Cost is secondary with success given low weight and ill-effects very high weights.

Three outcomes are +ve, indifferent and –ve. In consultation with Indian doc treating him, I have established after two years of paper feeding that my proposal has no –ve consequences (mice tests,  proposed dose etc.).

Now doctors say likely waste of money, no benefits, good dad-bhakti! Dad says bad-idea, I will not consume because already quaffing 18 pills a day in 7 occasions (part of diabetes just before a meal, wake, sleep, between meals). He be damned if consuming another speculative benefit, certain high cost to me, another unnecessary pill! So much for son-bhakti!

Back to my narrative. NR is $1 per day. It is likely ½ as effective as NMN. Before Dec 8, 2017 I could buy NMN at $10 per day – extracting it from cows. Then a clever chemist got into act and now NMN direct is $1.50 per day. If NMN is twice as effective than NR, 250 mg per day will be like 500 mg of NR.

I have personally tried 500 mg NR every other day and interspersed it with 500 mg no flushing B3 for 3 months. Now on 250 mg Niagen per day straight for 3 months. I will try 3 month 250 mg/day NMN on me starting april I will see if Dad agrees.

The stoic solution to scepticism re NAD+ is this reference from Scientific American!

The hard part is the skeptical query from father - forget the theory, how will I feel different or show me a proof. Proofr can't be done to June! No reported improved feelings. BUT growth in NAD+ should slow the deterioration! May be try for a month!

My philosophy

Saturday, January 13, 2018

Building aalan – 2 block-chain


Latest link

This project is special in that I view new syntax more necessity and a virtual clientele who would be there when it is offered as a product. It expands Go in 3 directions I consider crucial

1.       Multiple-inheritance
2.       Non-deterministic programming
3.       Built-in block-chain

It removes in-build memory management. Rust idea of language supported reference counting and help in avoiding reference loops is very important. So is language provide block-chain for all applications. Unit the ability of separating intentions from executions, letting robots do them progressively more, automating continuously is basic reason for new syntax, not just library improvements. From python comes the idea of infinitely extensible language whenever the syntax is not needed, and from Go the point of brevity.

NO language provides ANY of these 3 despite the need for them! Reason is simple, MI requires new algorithms only I know, even though easy to do in slow interpreted languages, non-deterministic programming is limited to compilers area, while block-chains are only being done by deep pockets even though the goal is to kill the deep pockets. Quickly the world will consist of deep pocket users of block-chain attempting murderous first-mover patent attacks, from which India will be lot safer than USA.

This is about block-chain and its presentation for any application, not just crypto-currency. All bold nouns can be safely replaced by homogenous chains. The aalan world has Clients conversing with Agents who talk to miners. An agent is smart enough to code and decode. All the Miners maintain a transcript in local private order. At the same time, they are involved in a statistically fair tournament. Whenever one wins, the win is broadcast as a transaction. Let us assume that there is a global unique number (originating miner. Serial) of every transaction. The victory transaction has an ordered list of the winner. Now everyone defers to this order! A miner can have some extra items which are moved to next block. Some missing ones, are gotten from known miners. I assume that the item itself has encrypted text such that a miner can’t understand. Note that I describe the supermedioum block chain free of miner contention. In normal block-chain, contention winner is recognised as competent to extend current hash-block.

That contention serves no purpose is the major point in my favor. The miners win round-robin every period and then broadcast their block. Every one rejects even one block with ANY error of double spend or undirected points. Every one, when their time, send their block time signatured by self. Eliminating contention saves enormously on electricity! It is provably fair! No-one can cheat without without cheat creating blocks of every miner. Any lesser speed is useless!

Once a block is complete in a miner, he send the block to a local cloud. Per miner, many lists of client are kept. The agent chooses which list per transaction. The local cloud is a reliable Ethernet connected net or fast multiprocessor (super medium). The entire block is broadcast. Decryption only happens in the selected representative for client. No miner can make sense of encryption.

A suspicious client is welcome to act as own agent!

Let us walk through two application – loyalty points and smart contract.

Loyalty points – Agent accepts money and gives loyalty points.  Miner does the duplication, so ALL miners get the same message. Super medium does the duplication, so all representatives get the same copy. If message is (A give n points to B) every one ensures A has n points. If so all subtract the amount from A and add to B. Here Agent is A and customer B. If B cashes some loyalty points, B gives to A. A starts infinity and B starts 0.

Smart contract - smart contract is a computer protocol intended to digitally facilitate, verify, or enforce the negotiation or performance of a contract. Smart contracts allow the performance of credible transactions without third parties. These transactions are track able and irreversible. Smart contracts were first proposed by Nick Szabo in 1994. New institutions, and new ways to formalize the relationships that make up these institutions, are now made possible by the digital revolution. I call these new contracts "smart", because they are far more functional than their inanimate paper-based ancestors. No use of artificial intelligence is implied.

  • Subject of the contract
The program must have access to goods or services under contract to lock and unlock them automatically.
  • Digital signatures
All the participants initiate an agreement by signing the contract with their private keys.
  • Contract terms
Terms of a smart contract take the form of an exact sequence of operations. All participants must sign these terms.
  • Decentralized platform
The smart contract is deployed to the block-chain of this platform and distributed among the nodes of the platform.
They can be used in untold number of ways.
1.       Elections
2.       Logistics (Businessman – goods/warehouse customer)
3.       Titles (owner contract customer)
4.       Contract (provider service customer)
5.      
Among fuckable are most government servants, lawyers middlemen politicians … Lets privatize them all!

A transaction tax can be imposed on goods as well as smart contracts. NO corruption is possible! Depending on political will, different taxation rates can be applied depending on who does this type of transaction more!


My philosophy


Friday, January 12, 2018

“Where do we live” and “where to die"



Must click links

We are in the local cluster of Laniakea super cluster, which has a star sol in a galaxy milky way; on a planet called earth. In aalan


Virgo supercluster is a neighbour, rather than us! You could extend it to the pc in front of you. And pregnant science says - our universe is in multiverse.

This madness is science, which has toexplain even nomenclature in terms of something empirical - when is something a planet, star, galaxy, super cluster; the referenced utube video explains some beautifully.

Dying on Mars

If we’reever going to send humans to Mars, we’re going to need water—whether it’s for drinking and growing food for settlers, or to convert into hydrogen to fuel the trip home. Scientists have long known that the Red Planet is home to plenty of water ice, but they haven’t been able to gauge its purity or potential for mining. Until now. As science writer Robbie Gonzalez reports, researchers have discovered eight sites on Mars where, thanks to land erosion, vast quantities of ice are available. And that ice is looking incredibly pure.
It’s going to take a lot of work to drill down to the ice and analyze its composition, and we likely won’t know much more until 2020, when NASA and the European Space Agency are slated to launch new Mars rovers. But the very existence of the ice is cause for celebration: If it is indeed as pure as geologists suspect, human survival on Mars becomes a whole lot more plausible. As Gonzalez writes, “optimistic timelines put our arrival on the Red Planet sometime during the 2030s. Where we land, how long we visit, and what we bring along will all depend on the resources that await us—and how hard we’ll have to work to get them.”

Wednesday, January 10, 2018

21 century after the years of IITK fun long ago




There is one link to an internet link farm where the matter in this write up can be accessed in detail. Humanity is on an exponential curve that makes reading the future very perilous for all but me – future is not polynomial extrapolation of the past! How can one predict, even approximately? By predicting unlike authors – one cannot leave out steps but predict based on hard philosophical steps in only a reasonable implementation! The future, so foretold, must happen at the predicted time or faster if someone achieves the sub-goals faster, with brand new disruptive technology. Enough can be achieved today to even make slowest lines predicted to be exciting.

Death by desire or rare accidents: Death is a time bound event to those who take care of themselves and escape accidents. The culprit is aging and the effects are universal after 80. Several ways exist to give boost, I use all of them on self. These include religious exercise, metformin, niagen and coQ10. These give me comfortable 90 to progressively bad 100. Clearly then, I need a boost within 25 years to 35. Whatever way is found will be expensive (e.g. niagen or mitoq). One must intersperse the goal; of delayed death WITH FUNDING THE NEXT INCREASE.

How will that happen? Partly by breakthroughs in hibernation. Partly by medical breakthrough in DNA repair. But these will add to vitality while incrementing life span like 5 years! Aging is not proportional to being wild – there are rare exceptions like well-aged sedentary, fat smokers. However if one computes expensive but proper genetic profile, the realised age to genetic predisposition is in fact proportional to self-care. Smoking and fat are injurious to health despite exceptions.

True first gain in age is unlikely from telomere manipulation according to my philosophy. I believe strongly that telomere length is an indicator of cellular age and not a cause of aging. Situation is like cholesterol and heart disease, improving cholesterol numbers do not affect the disease events. In general, the curing of indicators does not benefit the patient! Hibernation seems to truly benefit simple animals only. The benefits are quite low by the time of complexity of a bear! External counter-pulsation is an excellent mode to improve vitality but has no longevity benefits. Rapamycin and friends work for simple animals like yeasts.

That does not exhaust the positive predictively! The essential ways that enable any live being to live 3000 years and whales to live 300 years is this. Almost any cellular being falls to cancer. That is because cancer is part of every live body. Cancer cells are not special. They are normal cells which refuse to die! Normally, healthy surroundings enclose this cell which dies from lack of food. When the cell survives by infecting near cells to creation of blood supply, a tumour is produced. If parts of a tumour go into blood and travel to other parts, metastases of cancer occurs and eventually the organism dies.
Why do whales and some trees live long despite being much more likely to be cancerous! When cell divides, it is very useful to have another cell available in case the division was faulty. The extraordinary density of cells in whales gives them immunity from cancer formation. In long-lived trees, the roots continuously send stem-cells, available at divide time. If the current cell is aged, the division is unlikely to survive. However not a problem since a stem cell is present!

This trick does not work in higher animals with lot more specialization. However qn Indian doctor in USA has done amazing work on transfection. A mouse leg was damaged till it dried to a stumf. A transfection was done by extracting skin cells, processing them to certain kinds of stem cells and appending them at certain distance FROM INJURY. Miraculously, the injury healed and life returned to dying limb..

So I await a transfection miracle in next 25 years.


My philosophy


Friday, January 5, 2018

Arun Arya Quantum Mechanics


http://afriedman.org/AndysWebPage/BSJ/WaveCollapse.jpg

Understanding quantum mechanics is very hard, says Feynman. If one is to think normally, then stupidities as Einstein. Another is invent a magical semantics, consistent with all known results. The worst happens when one can derive three or more normal intuitive results at the same time, which cannot be true at the same time. Bell theorem fails if local realism i.e. “no spooky action at a distance” fails. It fails experimentally. Hence need for QM interpretations. ONLY deterministic theory known to 2014 was MEW = Everett’smany universe theory in which current universe branches into many for everynon-deterministic transition. That a huge number (10”1000) universes per second. Non-parsimonious but deterministic, explains all!


Starting 2014, MIW motivated by quantum chemistry. It looks like the Everett’s worlds are not unreachable split but share space-time of each other! One needs to compute the wave functions of complex molecules in quantum chemistry. This is exponentially hard. So some approximations have entered which work. These CAN be interpreted as overlap of Everett’s worlds! So we have brand new module – the MIW or multiple interactive worlds. It looks like most MEW are simply effecting our universe! What if all are? That gives us the standard non-deterministic model!

Enters Arun Arya brand new interpretation. What if ALL MEW SHARE OUR SPACE-TIME BUT AT PARALLEL MOMENTS? Then time is not simple as now but two dimensional, second axis small, the actual value for any particle some operator of its potential VALUES! Time is not magical but 2D! Let us call thiseffort at removing ALL magical or religious elements from quantum mechanicsthrough 2D time, the heart of arun arya interpretation! Thickness of time in other axis is very small, hence not noticed in any macro system.

Let us look at 2-slit canonical experiment. If the input in single particles (electron or photon) is very slow, you still get interference pattern! It is as if the particle passed through 2-slits at once and self-interfered! MEW can explain it as the universe for each particle as distinct, the particle going to expected location in that universe! How about AAQ? The second time dimension resolved to whatever experimentally seen location! Happens naturally even with single particle!

How about Zeno QM effect? Like “No boil if watched”,unstable particles refuse to decay if watched! In effect, watching means bombardment with photons. The interaction in many cases, disturb the second time dimension of the unstable particle, preventing its decay!

It is easy to see, it is an interpretation that cannot be falsified within normal quantum mechanics. It has a value of being less magical than most, parsimonious, and not creating new points requiring more interpretation! Can one predict the resolutions of the other axis?  Then it is no longer interpretation but falsifiable science! It can derive new science just as multiverse can! In that it is between science and religion in positive way i.e. pregnant science!

Pretty large things can be entangled these days, dealing a death-blow to collapse-like classic QM interpretations like Bohr copenhagen! Entangling macroscopic diamonds at room temperature: Bounds on thecontinuous-spontaneous-localization parameters says "A recent experiment made a significant step forwardin this direction. Two millimeter-size diamonds, distantsome 15 cm one from the other, were entangled, andthe entanglement was detected, via optical techniques,at room temperature. This means that objects directlyvisible by the human eye, in standard environmental conditions,and separated by a macroscopic distance, showa quantum behavior'

Monday, January 1, 2018

Counterfactual Quantum Communication


I have never been blown out of mind, as I was when I saw this story.


Counterfactual means an interaction-free measurement Cf history for eg is where a historian says (if x then y) even when known that -x happened! .Dated Mid December last year, so veracity checking still on, but this link is good. Counterfactuality requires a quantum channel between sites, which means that there exists a tiny probability that a quantum particle will cross the channel—in that event, the run of the system is discarded and a new one begins. It works because of the wave-particle duality that is fundamental to particle physics: Particles can be described by wave function alone.

Well understood as a workable scheme by physicists, theoretical aspects of counterfactual  have appeared in journals, but until recently, there have been no practical demonstrations of the phenomenon. Read more at: https://phys.org/news/2017-05-counterfactual-quantum.html#jCp
I understand the principle – Zeno effect in quantum mechanics, my belief it is basic to FTL (Faster than Light) communications, best possible since QM no-go theorem can derive the impossibility of material objects travelling at greater than light speed. Will there be no-go for Zeno effects?

Zeno effect is not even regular quantum mechanics, QM strangeness from two things

2.       Contrary states at the same time - well-known is Schrodinger-cat joke – alive and dead same time!
Zeno effect is even more magical than QM!

It is state communication without even entanglement – provided there is a quantum channel between source and target! These may never have interacted in the past to get entangled particles! It makes QM sense (not Einstein) to imagine that entanglement remains no matter how far the partners are. If you do something to one, it happens to the other. If you measure, the entanglement is destroyed. But each entangled can become entangled BEFORE being measured to another local. So now one can destroy one entangled pair to transmit one bit, but there is another entangled pair!

Above is entanglement magic to allow me to dream of FTLcommunication someday! But Zeno is magic even by QM standards. No particle is exchanged, no entanglement is needed! You set up a bit sender at one end, and a measure apparatus at other end, no matter how far. The sending end simply displays the bits at send end. At the receive end, you just measure using a Zeno receiver. And you get the bits!

Each bit at receive end is three detectors. If two are same and third on then 0, 1 if different. If the third is zero then error!

Chinese have advanced to sending an image of zero! Theoretically possible. Claim is demonstrated experimentally, says the story. Zeno effect can probabilistically tell if a Elitzur–Vaidman light triggered bomb is live or dead without sending a photon, by QM, most of the time! A big crunch can loseentropy using QM particles and my mechanism at universe boundary can be truewithout math tricks of CCC.

Arun Viewpoint

Quantum channels drop off in fidelity as distance squared. This means this mode is great for bluetooth like connections. But the real FTL needs entangled bits.

Comogony


Means scientific theory of big bang. What is this Universe I was born in? I distrust all but science! It uses my extended semantics of science – falsifiable now or expected or derives science. If-now, it is classic definition of science. If-expected then my extension, admits NO religion, but allows me to consider pre-big bang and multi-verse theories as science and still label others not discussed here to be pseudo-science.

Only falsifiable cosmogony and issues it raises are here. Knowing it solves the problem of fine tuning of constants of physics. However it does not yield any new prediction.

This references six video that are collectively six hours. They are fun and educative. If you have the time, excellent material. In each case, I provide a brief preview. The loveliest of all is that all point to difficulties in others that are always answered. Collectively, ALL the six are considered legitimate alternatives and they are mutually non-unify able! 5 are wrong, and I can’t decide which one!
Cosmology is answers about our Universe. Scientists agree that universe began in big bang. (if you disbelieve, POINTLESS CONTINUE). What is it? What was before? What is the expected falsifiability? For these, you turn to cosmogony, somewhat like religion but not, with none but  (conventionally identified) scientists as pathfinders.

The questions I had were

1.       Mass - Where did the mass come from? Space came from growth expansion.
2.       Explosion - What caused the big bang?
3.       Science - What will falsifiable consequences be?
4.       Derivation - What falsifiable derivations happen?
5.       Entropy – of the past. What happened to it (second law)
Machine nary - Laws, constants, math-effectiveness,. time-in variance.

The references are mildly dated I have two extra vital references.

1.       Big bang is no longer an excellent derivation.The imprint of spectral lines from quantum particles are present in CMB! That can happen only if the entire universe was atom size once!

2.       Entropy can be lost by quantum particles at once high energy and low (QM needed!). The loss of entropy is not necessary through horizon point of Ashtekar in LQG or weak mechanism of CCC! In my model, singularities are not needed as matter crunches down to maximum density before exploding. Same happens to black holes which evaporate till the final explosion.

After the big bang is cosmology. Was there a before?

The order is deliberate – order of my belief.

Cyclic model to infinity, repeated big crunch then big bang. Escape crunch/bang neck by beyond science. Predict circles in CMB – controversial seen or not –in B-modes i.e. CMB with polarization, from gravity waves from large black holes merging in previous edition of universe. eLisa can tell when she flies in 30’s. I am fearful that it will be European glory, and not American, like internet!

Cyclic model to infinity, repeated big crunch then big bang. Only logical way out for mass, crunch and explosion – mass from previous edition, crunch down not to singularity but maximum density of plank scale cube with side like 10 plank length, explosion to bang once maximal density of space. Entropy lost by quantum particles, not horizon.

3 string theory variants
Loveliest of the lot, most comprehensive, known and greatest admirers and workes. Still in the middle because it predicts super-partners, not seen. A piece of matter or photon-likes are strings at the deepest levels. Simply integer number of waves means quantize d. But where are the super-partners? Silent about black matter and energy, which I believe does not exist - black energy is a constant term in Einstein, black matter is explained by Linde's work.

4 Guth’s eternal inflation theory – compatible with my method crunch/bang. Post bang inflation starts dying by half lives. Inflation image possible in past too!

The classical model, time itself starting at bang, no idea why bang happened or size of universe mass.

The most amazing model which imagines closed time loops (IE travel to past) and escapes grandfather paradox (ie killed) by alternate reality.


My philosophy
Constants - ratios of properties of geometric objects