Holoportation

Monday, April 11, 2022

Exponential technologies

I have already built an narrative that I called the second most important story of your life because it had 10+ hour of Dr. Sinclair on how to improve your age and my fond wish that you be alive for next singularity2.0. Now the most important - Exponential technologies exptech are those innovations that continue to advance exponentially, with disruptive economic and lifestyle effects, current price-performance makes it feasible to incorporate them into today’s business and social problems in new and previously impossible ways. This is how I understand Modi/Yogi despite my problems with their opium. I view myself as Conservative scientist who sees value in inherited traditions despite rejection of some as being unsupported in science and obnoxious to some, whose rights I accept. You need exptech to decode last 5 years and henceforth. How 21 century is different.

I think that the solutions to some of the world’s most urgent problems can be found at the intersection of exponential technologies below

artificial intelligence (AI),

additive manufacturing,

augmented and virtual reality (AR, VR),

digital biology and biotech,

data science,

medical tech,

nanotech,

robotics,

autonomous vehicles,

etc…

When two or more exponential technologies exptech are applied to a serious societal challenge – the chance of creating a viable and sustainable solutions increases drastically.

Why are Modi/yogi so much better than the kangaroo and the prince despite their religion opium – more honest administration absent nepotism boosted corruption, way free decentralization after decisions and enforced accountability, and use of intersection, by exponential technologies! That is the only drawback of AAP of Kejriwal, equally honest but puzzled by the amazing unusual predictions of exponential technologies not amenable to even business tools of today! Best approach, start the exptech tool and let it proceed at its pace, using the best of intersection present for solving problems.

Consider Aadhar. It is a digital identity number that can be uniformly for many things. False identities can be purchased but are difficult to manage. The abuse is miniscule, unlike the past where fake identities were in majority and exploitation enabled vast corruption in all government plans. It was created by congress but never used. Modi was smart, embraced congress jewel and used it to completely new uses with citizen accounts in banks and low corruption rations and even farmer dole.

Aadhar new uses are in doldrums. For all the likely advantages of demonetization , nothing significant happened for any significant period of time. I claim that it must be an annual affair! How knowing the massive derail last time! Trivial, all notes have an annual validity number, after which they can’t be used! You get last 3 months to exchange them in any bank. Only point is the bank uploading the aadhar number and amount of the customer. No demonetization needed! Once you have the record, lot of traps can be laid and corrupt routinely fucked! False conduits lead to massive blackmail!

Common properties of exptech

1. Major property of exptech is failure of polynomial extrapolation leading to common failure of normal existing businesses to forecast their future. Even worse is the reality of existing officers of the corporation in predicting future business based on experience that fails. You certainly do not want forecasts and plans based on dreams, not business reality. The companies that succeed are new ones, missing the tried working ways of yester years. Consider 2000. Then forecast cameras, CD, radio, press etc. Even 2010 is hard. 2020 too much. Now consider 2030. Who would forecast Microsoft, apple, Google, Musk, Amazon … But wait, these are companies before 210 and staffed with disruptive technology executives. Will new companies live?

2. Fundamental to Disruption is coincidence with a paradigm shift. That fundamentally makes the earlier scientists redundant. That does not happen to executives. Changes happen their but never in disruptive fashion. The company itself may sink like kodak, xerox, sears etc. But that is not due to management but unmanageable disruption.

3. The opacity of the future blesses people like me, as very few care to understand the science of longevity. The very first disruption by me has already happened by sheer extension of my determination to be disruptive, by my encryption, uniquely different, not

defeat able by a quantum computer and perfectly forward secure (old messages secure even if entire encryption known). First application – tamperproof email. Also health span extension with me as proof, the second disruption!

Some exptech examples for future notes

artificial intelligence (AI)

additive manufacturing,

augmented and virtual reality (AR, VR),

digital biology and biotech,

data science,

medical tech,

nanotech,

robotics,

autonomous vehicles,

etc…

Usable Anti-aging

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After 20 year side interest and major extensive interest in Aging for last 10 as I age, its biology and chemistry, blessed with sharp intellect that took me to the Unix group at Bell labs as colleague to Dennis Ritchie and two computer science seminars at Harvard, I can state as a self-styled expert in Aging that unlike my past, there are five methods of Aging reduction that are likely independent and hence composable. It is not known how effective each is, nor is needed in composing method of mine sensitive to scientific answers, enough anecdotal evidence exists for some effectiveness of each, benefits may exist that are varying for each client, still my composition is not sensitive to such variations. It is the value in parallel composition. Each addresses a responsible utterly visibly competent Est doctor!

What are the possible ways to indefinite healthy life

B Bio-evolution with limitless rejuvenation/growth of limbs and organs.

2. Bio-evolution with periodic reversion to womb-state

3. Download of Brain

4. Permanent periodic refix of stem cells and immune system

MMedicine

Only sub animals will wish you long but unhealthy life. My goal is to extend to maximum my health span, even if the resulting is life span increment is zero! The methods above will extend my healthy life, have been detailed elsewhere but may not work for me as the technology is not there. Only one method applies today - by medicine. The technologies will be developed and I call it the singularity, Once 1year postponement of death per calendar year is achieved, I will partake in appropriate Indefinite life.

What any sane person will desire in Usable Anti-ageing

The questions are

1. Why should you believe me?

2. How does one know Dr. X theory is not right for some Moron x!?

3. How does one know the recommendations are safe?

4. How do you know my recommendations are effective?

5. How should you compose?

6. How should you determine the dosage schedule?

Compatible theory unifying their methods to make them suggestions of the Arya theory

Following very dense next paragraph covers the entire field of aging.

From Hallmarks of Aging represented as a directed acyclic graph or dag one can isolate a dominating subgraph that covers activation and inhibition edges. Two methods suffice to cover 3 (Sirt, AMPK and mTOR) addressed by Dr. Sinclair and 1 by Dr. Fahy. Now one can imagine other forms of age reversion. Not doing Fahy (suggests igf-1 fix) and Sinclair (suggests NMN for Sirts, Metformin for AMPk and rapamycin for mTOR) yields senescent cells which hurt by bad chemicals and by induced senescence in neighbors. This immediately leads to senolytes and Dr. Aubrey de Grey (Spermidine, Fisetin, Quercitin, apigenin etc depending on senescent cell source). How is bioage measured? . These are not just marker but residue of DNA operation and specialization of the cell! Fixing the process not only improves the epigenome but manipulates age! Dr. Kennedy AKG comes here. How come the senescent bother the old but not youth? Because of active immune system that declines with age. Fix it by cancer developed methods like car-t fix. Finally, cells have DNA overlain by two plugs on each end that shorten in every division until the cell turns senescent from inability of division past this Hayflick limit. One can fix this by two methods - extending the limit to infinity by cell developed enzyme that uses the DNA sequence that encodes the ligase DNA present but deactivated giving rise to deathless cell line also called cancer. Or by diver-like HBOT use. Last is the famous Israel method. The manipulation of telomere length seems to have aging reduction applications. Intermittent brief Yamanaka factors arena-toxic and refresh the cell without losing specialization assuming only OSK are used. E5 likely uses exosomes and depends on the fact that these serve to be like hormones without using generation organs!

Why should you believe me?

The link of this essay can be shortened to last slash. That gives you the linkfarm of several hundred links devoted to essays relevant to this question and answers in detail why you should believe me. The main point is my glorious fact that I have only collected facts and all your objections are likely handled better by the doctor referenced.

I do provide a completeness by developing a paragraph that will likely cover every future method which will simply be a further development of some method already referenced. This kind of completeness is like Dr. de Grey style seven aging modes or 9 Hallmarks of Aging.

How does one know Dr. X theory is not right for some Moron x!?

No one is likely capable of brand new anti-aging methods and hence likely a charlatan, especially if majority of Arya-standard greats expressing opinion do consider him genuine. E5 was an unexpected add to my internal unpublished list, but was added after Dr. Horvath and Dr. Sinclair supported Dr. Katcher. It looks like cell-age is governed by external signals and not internal cell DNA only. E5 methods may use Stem cells and may be fundamentally different from and independent of Dr Sinclair aging explanation as theory of information internal to cell not dependent on external events.

Stretching my neck, I think the anti-aging modes are different, one can talk of Sinclair aging related to DNA and Katcher aging of the DNA in mitochondria.

How does one know the recommendations are safe?

I consider Self-application SA and USA FDA test FDA/Test to be gold standard. SA because FDA test may be too expensive or slow, requires consumption by recommender and family. Dr. Sinclair does that, Dr. de Grey follows FDA/Test. And I do SA. I eat medicines recommended by me since All my recos are Arya-safe and no unexpected interaction has occurred with many aging chemicals in between or with my heart medicine or brain medicine so far.

Arya-safe: increased concentrations of chemical names of contents of fruits and vegetables, chemical names of stuff already in the body, GRAS status in the USA law, doctor managed medication available OTC in some major country without prescription but requiring prescription in others, or vitamins. No concentrations are suggested to known poison levels.

How do you know my recommendations are effective?

Not my issue at all, talk to the doctor. I feel good and Aging well but that feeling can be placebo effect, full blood tests show everything measured is in limits and best will be known before November 2022 by when an aging test is due.

How should you compose? How should you determine the dosage schedule?

Depends on you and your aging doctor, to be picked from attached list here. I am committed to provide a “drug application review” and “excellent supplier” list to all members at the year mark every year you are a member, based on averages reported by all aging doctors to me for silent aggregation. In return to Dr. submitted reports, in addition to listing, they will also get the review in addition to aging drugs, doses, and schedule recommended to start with new patients. Neither patient or doctor names will ever be reported.

[AKA1]

Wednesday, April 6, 2022

Problem of plenty in Aging

After 20 year side interest and major extensive interest in Aging for last 10 as I age, its biology and chemistry, blessed with sharp intellect that took me to the Unix group at Bell labs as colleague to Dennis Ritchie and two computer science seminars at Harvard, I can state as a self-styled expert in Aging that unlike my past, there are five methods of Aging reduction that are likely independent and hence composable. It is not known how effective each is, nor is composing method of mine sensitive to scientific answers, enough anecdotal evidence exists for some effective of each, benefits may exist that are varying for each client, still my composition is not sensitive to such variations.

self-applicative and FDA test routes

That brings me to value of my knowledge. Being a top doctor or scientist means nothing. Even statements of two greats, Dr. Sinclair and Dr. Aubrey de Grey only means they will be carefully considered but not consider to be cardinal objective truth. There are precisely two methods that massively defeat all the others, all of which including evidence from a theory, religious tome, Guru, great, article etc. are all considered junk. The methods are transparent self-application or FDA directed clinical tests, since aging is distinct from all other diseases, all grow old and I have internal natural right to demand that any recommenders of anything apply it to themselves and family first. Dr. Sinclair does it to self and family. So do I. Dr Grey has followed clinical route. So has Dr. Sinclair eventually. Great past helps, is suggestive, but does not guarantee anything. Self-application is because FDA process is too slow and will unacceptably remain so, in Aging medicine for centuries, even though accurate.

self-application risk

What are the things I claim to understand well enough to risk self and family? I think Dr. Sinclair theory of Aging as progressive error in error correction in epigenome. He calls it the theory of information as the effects of errors makes that make cell senescent and essentially useless and a burden. In youth, there is no problem as the immune system is strong and such cells suffer apoptosis or forcibly are cut, garbage-collected and expelled through urine. I took a calculated risk for I grow old. My family came on board after 3 months of wait and watch.

How are you different?

All my recommendation are usually for liposomal form, unless explicitly denied. All my recommendations are for materials available as supplements.

Adoption of this discipline enables me to state that I do not play a doctor, no disease cure is suggested, no responsibility is assumed, all is for consideration of doctors, and critics suggesting otherwise are emfubar sub human. Liposome very significantly change dosage due to greatly improved bioavailability and only a doctor can suggest proper dose and titration to it.

What does your study and experience so far indicate for the theory?

Several great doctors have worked on the methods. My innovation is collecting the successful in isolation in a theory that suggests the method in a logical manner. I call it “the theory and practice of aging”. That is standard science that collects many empirical results into a whole which suggests the empirical facts. Hopefully new ideas will be suggested beyond those derived with difficulty in isolation. As I proceed, certain observation are litmus tests for any other theory! Never accept a theory that fails even 1 litmus test!

Problem of plenty

There are five distinct, independent (now) approaches to aging, meaning they are statistically independent, hence likely composable with effects that add and composable howsoever in parallel and sequential modes. These are mTOR, telomere, immune refresh, Yamanaka factors, and E5. The last 2 are in the future within 2-20 years, and it is essential that reasonable healthy persons be there when the expectation matures. My different recommendations apply to different self-assesed people.

1. Religiously inclined

2. Conservative science inclined like me

3. Liberal inclined

Religiously inclined

Included here people who consider the body divine which should not be defiled by adding untested drugs which have no doctor-blessed history. They are included because mTOR based methods have dietary restriction and time-restricted methods. No chemicals need to be used these two techniques. Empirically, mice experiments prove that best is single meal, however large and howsoever constructed. You must fast 1day a week, week-long per month, etc. Fasting does auto-phagy (junk collection) after 16 hours after a meal and a lot in long fasts. Should avoid all comforts. The mTOR paradox applies, as all mTOR methods apply and all comforts are evil!

Conservative science inclined

Science inclination means typical conservative low for religion is missing and the source of ethics if different. Human body is not considered sacred. Conservative means respect for traditions and harder acceptance of new results. Clearly FDA approval is gold standard but aging drugs are special. Here Arya-standard is used. Doctors are collected in groups based on their work so far. Only when their name is attached to a distinct element accepted by my theory, are they considered equivalent to Nobel laureates. Only when active after first work and a second Nobel-equivalent work do they rise to greats of Arya-standard.

Liberal inclined

Such a person is inclined to new things, just different, without serious consideration of the reason. Conservative shop owners and producers love him for the person loves new fashions and subscribes to the belief that tradition minded conservatives are stupid. Such persons were instrumental in the USA to destroy racial and sexual discrimmination. However being science inclined conservative gives me to oppose these discriminations as essentially for they have no scientific basis and hence are equally evil. The point here is that all science+conservative recommendations apply.

Who are greats of Arya-standard?

Name Why Where

Sinclair Resveratrol+NMN+Self-apply Harvard

Kennedy Buck+CaAKG Singapore

Horvath Bio-age/human+Bio-Age/animals UCLA

Israel Divers+ HBOT Israel places

Fahy hGH+DHEA+Metformin Stanford

Yamanaka Y factors+pluripotent cells Japan

Compatible theory unifying their methods to make them suggestions of the Arya theory

Following the very dense next paragraph covers the entire field of aging.

Remedy mTOR

mTOR is the kinase that determines the overall body state into 2 categories – comfort and adversity. It is a very important discovery of evolution and plays a similar role in all animals, including yeast. On adversity, it signals autophagy and reuse signals – destroying unfixable garbage proteins that can not be repaired. In effect, it increases age. The autophagy process is central to cancer cures and deserves its own section.

When the body determines comfort, there are no evil events to comfort of body, food is plentiful, enough sleep is missing, it loves the comfort and proceeds to shut adversity pathways, i.e. declares comfort, feels and looks healthy, but is bad for age!

Unlike animals, we are at the top of the food chain, are not cannibals, and developed environment improving technological evolution, so are no longer subject to biological evolution because tech-evolution outpaces bio-evolution by a factor of 1000 and I think that tech-evolution products make bio-evolution based success definitions easily targeted by tech-evolution products. I include brain developments given the successes in AI which render man-machine systems or cyborgs distinctly superior.

The mTOR puzzle is all comforts weaken aging processes. So, how can full-grown adults ramp up autophagy, cool the mTOR jets a bit – and ultimately age better and more slowly? Here are a few simple natural ways to get into the groove:

1. Eat a bit less: To tame mTOR activity and trigger more autophagy, simply restrict calorie intake. One safe way to do that (absolutely no starvation allowed!) is with brief periods of caloric restriction (we’re talking hours at a time, not days). You can try approaches like intermittent fasting (IF), time-restricted eating (TRE), alternate-day or modified alternate-day fasting, or the 5:2 approach.

2. Pile on plants: Animal proteins, especially red meat, contain high amounts of branched-chain amino acids like leucine, which stimulate mTOR. Plant proteins contain considerably less, so they won’t stimulate mTOR nearly as much. No need to swear off all animal protein (as in, meat, dairy, chicken, fish, eggs), but, in middle age, the average person would be wise to eat a lot less of it, ideally keeping daily protein intake in the 55-gram range, with most or even all of it coming from sources like almonds; broccoli; chickpeas; cruciferous veggies; hemp powder; lentils; onions; pea protein; nut butter; sunflower seeds; tempeh; turmeric, etc. For the 65-and-over set, it’s fine to ramp back up a bit to 70 grams daily to help minimize age-related muscle wasting or sarcopenia.

3. Add a little stress: As in the healthy, physical kind. In small doses, the healthy stress of moderate exercise – think walking or light jogging versus Ironman competitions or climbing Mt. Everest – encourages better aging via “hormesis.” Hormesis is your body’s response to small stresses—think fasting or caloric restriction for short periods; biking up a short, steep hill; or brief bouts of cold exposure. These bursts of adversity toughen up the cells and the body’s defenses against aging.

4. Embrace mTOR tamers: To help tame the mTOR beast, you may also wish to augment your plant-based diet with a few supplements that can keep it – and aging – in check. Among my favorites:

Alpha-lipoic acid – Dosage: 300 to 600 milligrams per day (non-meat-eaters should aim for the higher end).
Curcumin – Dosage: 500 to 1,000 milligrams twice a day. Take it with good fats, like avocado, so it can be properly absorbed. Add turmeric to your cooking too.
Quercetin – Dosage: 500 to 1,000 milligrams per day. Best when paired with vitamin C or digestive enzymes like bromelain to aid absorption.
Resveratrol – Dosage: 200 to 300 milligrams per day.
Fish oil – Dosage: 1 to 3 grams per day.

5. Get your sleep on Getting high-quality shut-eye, think 7 – 8 hours a night, to help stoke your autophagy engine. Studies show that sleep deprivation encourages increased mTOR, so don’t skimp on this health-maintaining activity.

6. Adjust the temperature up and down: Swim in a cool pool, then dip in the hot tub or sauna (or vice versa); add a brief cold finish to your hot shower; or simply or spend a few minutes outdoors in the cold lightly dressed. Swinging back and forth between cold and hot will lightly stress your cells enough to encourage autophagy and keep mTOR at bay.

The telomere approach to Aging

There are five distinct, independent (now) approaches to aging, meaning they are statistically independent, hence composable with effects that add and composable howsoever in parallel and sequential modes. These are mTOR, telomere, immune refresh, Yamanaka factors, and E5. The last 2 are in the future within 2-20 years.

Beyond mTor with several Approaches to Aging, there is the telomere lengthening approach, lengthened by the diver approach or hyperbaric oxygen. When I approached it six months ago after the method being there for about a year, telomere extensions were known as in professional divers, but not referenced with guisto and soon very negative things by Dr. Aubrey de Grey who I respect most. It was unclear whether the elongation reduced age, the latest says it does, a reputed Israeli scientist writes. The method is the best of the lot since HBOT short term has another well-known use by film stars to enhance their beauty and properly done. one can find many marriage applications. In fact, the Glutathione chemical has anti-aging and skin-whitening applications! I desisted as intravenous use was needed but now have discovered liposome suppliers, thus going beyond intravenous use only!

One of the more spectacular uses of HBOT, recognized even by conventional American medicine, is its powerful detoxification benefit. Thus, given that your skin is not only your single largest organ but also plays a major role in detoxification, and given that toxins in your body definitely show up as skin blemishes and discolorations. Thus removing toxins and the aesthetic benefits to your skin are shown outwardly.

Hyperbaric enhances beauty and finds applications post plastic surgery. According to Wu Jianhua, a famous Chinese doctor in the field of hyperbaric oxygen therapy， the effect of hyperbaric oxygen therapy on beauty has three aspects.

Repair after cosmetic surgery: cell tissue promotes wound healing in a high-oxygen environment; leukocyte phagocytosis under hyperbaric oxygen is enhanced, which can prevent infection, repair necrotic cell tissue after surgery, and make wounds heal faster in hyperbaric oxygen after surgery, Better, so as to achieve the purpose of beauty

2. Promote skin cell metabolism: Hyperbaric oxygen treatment promotes the synthesis of skin collagen, which can increase the elasticity of the skin; it makes the skin capillaries richer in blood oxygen, which can achieve better nourishment of the skin cells, Isreal Hyperbaric making the complexion ruddy; it is the blood and skin The nutrient exchange between tissues is sufficient, and the skin is more moisturized, smooth.

3. Fight against UV damage: A study by the University of Connecticut found that hyperbaric oxygen therapy has a very significant inhibitory effect on skin cell proliferation, cell death, and apoptosis caused by UV rays, and can significantly reduce skin wrinkles caused by UV rays. The depth and quantity increase, increasing skin elasticity. It is necessary that hyperbaric oxygen may have the effect of preventing and curing skin damage caused by ultraviolet rays, which means that hyperbaric oxygen may have cosmetic effects. Researchers believe that the root cause of UV damage is the preconditioning effect of hyperbaric oxygen.

It is available in India !!!! India. Hyperbaric Oxygen therapy (HBOT). A Natural Therapy for Anti aging, Wellness, Cosmetic Clinics & Spa.

It will cost 10-20 lakhs, I don't have it, but my mother is interested in family applications. Whether or not commercial applications fly is secondary, great if so, ok without. That is the best approach to a business, can be very strictly honest! If my aging clinical test works (looks great mid-term), completed by bio-age test before November, it is another very strict honesty and perhaps one can find synergy between two simultaneous independent anti-aging methods. So I start today on "Anti-aging and enhanced beauty shop". Delhi/Ghaziabad area. Will become global when Modi/Yogi Zaver airport is done in 2 years. Starting rentals in Greater Noida next to the airport site close to the airport ASAP.

Tuesday, April 5, 2022

mTOR puzzle remedy

mTOR is the kinase that determines the overall body state into 2 categories – comfort and adversity. It is a very important discovery of evolution and plays similar role in all animals, including yeast. On adversity, it signals autophagy and reuse signals – destroy unfixable garbage proteins that can not be repaired. In effect, it decreases age. When it determines comfort, there are no evil events to comfort of body, food is plentiful, enough sleep is missing, it loves the comfort and proceeds to shut adversity pathways, i.e. declares comfort, feels and looks healthy, but is bad for age! Unlike animals, we are the top of food chain, are not cannibals, and developed environment improving technological evolution, so are no longer subject to biological evolution because tech-evolution outpaces bio-evolution by a factor of 1000 and I think that tech-evolution products make bio-evolution based success definitions easily targeted by tech-evolution products. I include vrain developments given the successes in AI which render man-machine systems or cyborgs distinctly superior.

2. Pile on plants: Animal proteins, especially red meat, contain high amounts of branched chain amino acids like leucine, which stimulate mTOR. Plant proteins contain considerably less, so they won’t stimulate mTOR nearly as much. No need to swear off all animal protein (as in, meat, dairy, chicken, fish, eggs), but, in middle age, the average person would be wise to eat a lot less of it, ideally keeping daily protein intake in the 55 gram range, with most or even all of it coming from sources like almonds; broccoli; chickpeas; cruciferous veggies; hemp powder; lentils; onions; pea protein; nut butters; sunflower seeds; tempeh; turmeric, etc. For the 65-and-over set, it’s fine to ramp back up a bit to 70 grams daily to help minimize age-related muscle wasting or sarcopenia.

4. Embrace mTOR tamers: To help tame the mTOR beast, you may also wish to augment your plant-based diet with a few supplements that can keep it – and aging – in check. Among my favorites:

Alpha-lipoic acid – Dosage: 300 to 600 milligrams per day (non-meat-eaters should aim for the higher end).
Curcumin – Dosage: 500 to 1,000 milligrams twice a day. Take it with good fats, like avocado, so it can be properly absorbed. Add turmeric to your cooking too.
Quercetin – Dosage: 500 to 1,000 milligrams per day. Best when paired with vitamin C or digestive enzymes like bromelain to aid absorption.
Resveratrol – Dosage: 200 to 300 milligrams per day.
Fish oil – Dosage: 1 to 3 grams per day.

5. Get your sleep on: Getting high-quality shut-eye, think 7 – 8 hours a night, to help stoke your autophagy engine. Studies show that sleep deprivation encourages increased mTOR, so don’t skimp on this health-maintaining activity.

Common to all these methods is precisely join a monk in some religion! Why bother with creature comforts, great food, temperature likeness, sleep devoted comfort, when you can please the angels and increase life!