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Bio-immortality
[If you are normally intelligent] and have seen many such articles then what is new? I studied and used my own recommendations and feel 50 at 68. [What did I find and do]? Why does my aging theory significantly expand [Sinclair theory] while extending it to Arun Arya hyper function theory?
1. As a scientist and engineering scholar only rational-skeptic faithless things have been pursued
2. It covers 22 years of critical adult scholarly work starting MIT random thoughts by a self-user super-smart bell-labber
3. No Expression is contained without of stated mechanism of experimental data
4. I have used this successfully on myself and Doctor Sinclair recommends it to US Army soldiers on US Military request. He is not an MD, but still has created and run the Aging lab in medical school at Harvard, Boston, discovered and popularized resveratrol (in red grape wine), and is NASA's choice to be responsible for the health of Mars astronauts.
5. I have attempted to answer what to eat, when, the rationale for drugs with mechanisms of aging slowing and reversal, and the economics of aging.
What experience summarizes this work?
My theory, based on scholarly work on 22-year, and self-experiment experience conveys the growing pangs between bio-chemistry derived from evolution and the study of model animals versus straight protein chemistry. Mostly missing are sickness doctors, gerontologists, and geriatricians, considered irrelevant.
What is this work based on?
It is based on cells and evolution. Cells make everything like bone, hair, skin, every organ, nails, etc. Deep inside is the huge DNA in a protected sac. It is surrounded by epi-genome. Latter is responsible for making every cell kind and coiling DNA to make only some parts visible and usable for reactions. A cell dies almost in under 2 years. Prior to death, the cell DNA double helix unwinds and reattaches slowly into two double helices. This leads to a new epigenome per DNA. DNA ends are called telomeres and the whole process leads to 2 daughter cells. Telomeres shorten in any division, unless telomerase, also described in all DNA is also made. Normal cells don’t make it and live for 50-70 divisions. Cancer cells discover how to make telomerase and live forever!
The second basic concept is evolution. A few times in life, In sexual animals, mating occurs, A new DNA is formed that is a stochastic average of the two parents. The new DNA either grows in the egg or in the womb. Strange genes can be rarely produced but they will be reproduced in the future. The animal so produced either is good for the momentary situation or dies fighting, This is called survival of the fittest. Note that successful gene mixes with the less fortunate animals and may just die out. The successful gene must also be dominant! So I say modified, not understood by evolutionists “the survival of dominant fittest gene”. Another characteristic, from the very nature of evolution, is rarity expressed as time punctuation. So evolution is “the probabilistic punctuated survival of dominant fittest gene”.
All faith-based religions that think that their religion-based roots are true, even though the details may differ, are gone-cases and further study of aging as evolutions of cells is a time-waste.
Given the small time of few thousand as opposed to the human existence of hundreds of thousands, the former can be ignored and evolution biology can ignore it. Most humans share the same biology – the genes for size, looks, skin color, etc. have no aging significance, this is a scientific fact, not any liberal truth!
What is your theory consistent with your experience?
Based on what follows, my extended hyperfunction theory explicitly denies Sinclair's bottom-up theory as just one cog in hyperfunction theory with components of
1. Bottom-up theory and OSK fix
2. Top-down theory based on stem cells and fix by exosomes
3. [Immune theory based on thymus and CAR T fix]
4. Telomere theory and fix by HBOT
5. Dead cells and senolysis fix
This theory is based on provable age gains not consistent with bottom-up These include E5 and stem-cell reactivation, a general claim of doctors regarding immunity, and HBOT advantages in de-aging.
Without shame or bowing to detractors, I claim that [biological immortality] is scientifically possible and I am going toward or on it. If not me, then my children, or citizen supporters' children, will benefit from my findings and experiments. Roughly, death is decoupled from old age - you can still die from injury, poison, disease, predation, lack of available resources, or changes to the environment, but my engineering fiction can still defeat them without postulating any new science. I am both a computer Scientist and an Engineer.
What happens in aging?
Humans first grow in the womb. Then they are born and grow to adulthood around 20, characterized by growth from stem cells and good thymus-mediated immunity. Then live on to 60 with thymus becoming fat and hence degrading by involution. New T cells (white blood cells) are not produced, those already built live on to age 85. Very vulnerable to opportunistic infections like pneumonia and covid thereafter. Further life age is Poisson distributed – simply roughly halving per year to age 110.
All the while DNA breaks and is repaired. Telomeres keep shortening till a limit and the cell dies thereafter. The immune system is degrading. Stem cells are aging and longer active but for wound repair and even that is degrading. Without useful intervention or no mechanisms even experienced not-subject morons, you die from old age.
Death can happen whenever any of the processes above fail to lead to critical organ failure. Otherwise old age with degrading facilities – sight, sound, taste, skin feel, looks, strength, etc.
What matters in a cell?
A cell has many sacs surrounding organelle Some are aging-related and mentioned here. Mitochondria came from subsuming some bacteria at the start of evolution. Each has its own DNA, They vary from zero in blood cells to thousands in liver cells,
They are principally involved in ATP production in the ATP-ADP part of Krebs’s energy cycle. Reducing/failing mitochondria means strength loss. DNA is in the Nucleolus sac. Exosomes get external molecules.
Almost every cell in the body needs NAD+ of Krebs’s cycle. It is created de novae from vitamin B3 after several steps. Two useful precursors are NMN and NR.
Sinclair recommends beta-NMN. I do so. Expensive, often fake from the USA! Poor bio-availability. Hence I additionally recommend liposome form. NAD+ continuously falls with age. Even after the NMN supplement, though slowly. Can it be stabilized or even incremented, Age reset-directed research, unknown today?
Bio-Chemistry in the body relevant to Aging?
Krebs’s cycle has already been introduced, is very complex, with sub-cycles, and is central to biology. There are some central enzymes of DNA relevant to aging. These are Sirtuin, AMPK, MTOR and igf-1.Two useful ways to focus on them is to study yeasts and go to MIT as Sinclair did, [or derive them by cut in hallmarks of aging as I did, independently validating Dr. Sinclair ]! Also useful is Telomerase and its generation.
Use NMN and others like vitamin k2 and xenohormesis by resveratrol and pterostilbene, etc.
AMPK? AMP-activated protein kinase
By Metformin, Berberine.
MTOR you want to minimize. Almost all technological developments and conveniences of the last 4000 years have increased MTOR and thus have reduced age. Unscientific yet true masters do not accept any convenience. The convenience use is complex as many are time saviors, death-reducing medicine, filth-reducing, etc. Allowing kids to play in the dirt is hard! Only known chemical to reduce MTOR is uncertain low dose rapamycin, deadly if overdosed!
igf-1? Insulin-like growth factor
Better wait for Dr. Fahy's developments or my work on white cell growth in T cells with external revitalization and growth. Immune regeneration is very hard.
Telomerase? A telomere (/ˈtɛləmɪər, ˈtiːlə-/; from Ancient Greek τέλος (télos) 'end', and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes. Telomeres are a widespread genetic f
Cancer is evil, useful, and found in male sperm in the body. Restore them otherwise!
4. Await cheaper HBOT procedure for telomere growth. HBOT for me is mouse model research, which can be done inexpensively in India and one can measure mouse telomere effects coincident with dosing changes. Requires mouse carers, some small liquid oxygen pool in cages, and liquid oxygen
5 Senolysis is the garbage collection of dead cells. Cells that fail or die stay in place occupying it uselessly. What is more, they release chemicals like CD38 that kill their neighbors starting a bad positive reinforcement. This does not happen in youth as immune cells are active, dead cells get marked and cut up by cytokines, and immune-disposed through kidneys.
In old age, you must help the body. Depending on which cell died, garbage collection molecules are different. All the drugs are present in an insufficient amount of vegetables and are likely, not dangerous supplements. As only a small percentage needs to be disposed of, two chemicals spermidine and fisetin are enough. Things like quercetin, etc. come advanced. Fisetin, in particular, being like D3 soluble in fats, can be taken monthly over 2 days in larger amounts as per Rochester protocol and is extracted as needed. Some supplement sellers mix many supplements and sell a single senolysis pill under many names. You need to trust the seller and select the pill based on chemical contents, Hard but a blessing for my future company to select the supplement sellers, define the need as per patient, and select doses amount, frequency, and when. This is the ground between doctors and pharmacists, both failing, to personalized medicine.
Biology versus chemistry?
Biology is about evolution versus mechanism by chemistry. Sometimes model animal experiments are not reproducible due to subtle differences in the genetic makeup of the model animals used. Far more common are lies, inadvertent or deliberate. One can blindly ape what people did in the animal phase 4000 years ago for hundreds of thousands of years. Or one might view only chemistry as the study of model animals. Ideally, they would be consistent. But errors persist due to the pricing and functioning of markets. Even expert opinions can be wrong! The best is total fuck after one error without a convincing mechanism error response, not a court punishment. Very rarely will ignoring honest opinions happen – too bad for innocents hurt – welcome to reality. This is basic to my thinking, sometimes "must prove innocent", and sometimes "must prove guilty", is a choice of law-makers, not of analogy-toting lawyers and courts i.e.
part of the constitution.
Now the list of evolution pruning like nature does
If one views nature's situation for animals, it is amazingly comfortable after short technological evolution in the last 4000 years. I argue that the similar animal situation has been faced by my ancestors for 500,000 years and they survived by natural selection bringing forth in-built genetic solutions that emerged to fight the problems. Re-exposing to similar situations will again cause the technology-unneeded solutions to re-emerge for they are genetic and built-in. “What does not kill you makes you stronger” is the basis of my experience and is called hormesis. Dr. Sinclair has created another term called xeno-hormesis where the prefix means foreign and implied is edible-compatible when limited to plants and animals. Plants fight bugs and old age, sometimes better. Why do ayurveda, Chinese, etc. still exist, despite flaws?
Hunger?
Is called calorie restriction and happens by fasting. Beneficial fasting ( chemistry by autophagy ) as early as 16 hours with dead and badly built proteins recycled (that is what autophagy means). Lengthening fasting activates other autophagy but needs to be attempted only after 6 months. The 16-hour gap is called intermittent fasting and requires either no dinner or breakfast. In the fasting period, one can drink water, tea, diet coke, etc. but not calorie-containing things like milk, fruit juice, etc. Fasting will neither kill you i.e. is hormetic. The worst case is reducing fat!
Ever since Gandhi, fasting is a common part of politics in India. Never mind a few illegal eating cases, it seems that 50-100 days of hunger are not life-threatening. Near-starvation sadhu seems to last 10 days. There is no threat with week-long fasting under doctor supervision. Very hard but no loss. This is despite the death of my hero Prof. Dr. GD Agrawal in a river issue to-death fast against the BJP government and I still support the BJP party, as two Jain sadhu fasted recently to death to save a hill. Unlike some brave souls who died for me, I am a calculating coward who will die fasting for an issue after diagnosis of fast terminal cancer.
Sleep?
Bad idea as sleep is required for age gain. Even the elderly must force themselves to 8 hours.
Tiredness?
The best thing you can do for yourself is aerobic or anaerobic exercise. Exercise helps with quick walking or weights, dancing, and moving by vertical desks.
Sickness or age?
Don’t be bed-bound unless ordered by a doctor. Help the helps in the hospital by standing on cloth change, bed-change, excrement, etc. Perform simple foot exercises when laying sick or traveling.
Thirsty?
NO age gain by it and may hurt,
Temperature, under 70/F and over 70/F, even 99/F?
Evolution selected us for survival in cold and heat. Uncomfortable yes, die no. There are lots of saunas and an immediate ice water tub! Sinclair practices it for 3 min ice tolerance and says his son can do 15 minutes. Guys train for 3 hours shirtless on snow mountains. Or scorching trek in deserts with water only. An MD stopped me from attempting these based on my heart problems. Never do these kinds of interventions without MD advice. Change MD who fails to give a checkable reason for advice. Ignore claims on experience.
Do what I do – let supplements reduce your feelings of tiredness, gain from inverting comfort, and then use every gain to exercise more – aerobic and anaerobic.
Why does my aging theory significantly expand Sinclair?
Self-experience indicated that while Sinclair theory dramatically improved my looks, I still had noticeable strength loss. Mechanism indicated that [cellular DNA fix was not enough], one must address all others too. Sinclair theory is enough to cover all other aging theories as somehow being the root causes,
Economics of age-gain
long term?
There is already overpopulation in parts, lamented the liberal or left-wing libertarian. The world will surely collapse. Not really, say I, a scientific conservative whose science part dissolves established prejudices of the past. I am busy using my prodigy gifts to see if the philosophy can extend to cyborgs that I expect to rise, with increasing human meld with AI-directed mechanical parts. Surely, some form of state income will be needed to reward the people with the fruits of technology-evolution but a very large number of skills in support of aged populations and training in the use of new gadgets and certifying and skilling in uses of needed gadgets will slowly absorb all redundant workers, let's forget repair and selling. The long-term looks very promising. What about the short term?
https://www.lifespan.io/news/overpopulation/
short term?
It is estimated that health budget savings of several trillion dollars will greet both the current west, while advancing in Asia, Africa, and Latin America. No matter what the health progress is, citizens, want it everywhere without fail. There is no reason to prevent retirement at 50 and a second career. In fact, most economically advanced regions of the world are short of population. The tight integration of the Indian and Chinese communities extending to customs and culture in the USA is very encouraging, as is discouraging with Muslims in Europe that may need more time. In any case, science eliminates the sharp edges of conservatism that honors tradition and law in default. You need more population in USSR, most of Europe, most of Latin America, china, japan, etc.
overall?
So native population increase is needed in many parts, and changes are expected in governing all others, with controls on health expenses possible through a sharp drop in diseased parts of life as well as a sharp drop in drugs consumed. And the icing on the cake is the life extension of the most productive part of the population.
