regenerative medicine

 

 Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

https://www.sciencedaily.com/releases/2021/11/211130150456.htm

JWST science

 

Ahead of JWST’s launch, STScI had the daunting task of figuring out which of the 1,173 proposals for the observatory’s first year of life — known as Cycle 1 — should get time with the telescope. How do you prioritize what the most advanced piece of space equipment in the world should do when it first turns on? 

Well, the science has to be nothing short of revolutionary.

“What is deemed most interesting is science that is considered transformational — that will change our view of the universe,” Klaus Pontoppidan, an astronomer and JWST project scientist at STScI, tells The Verge. “We don’t want the observatory to do things a little better than what has been done before. We wanted to answer fundamental questions that cannot be answered any other way.”

That makes Webb true successor of Hubell. Like Yogi of Modi! It rubber-stamps my decision in 2001 to live on regardless, and my love for 1000 year life. Even I am astounded how much science in ageing can do, towards likely wish-death even for me.

https://www.theverge.com/22789561/nasa-jwst-james-webb-space-telescope-priorities-astronomy-astrophysics-exoplanets

solar electric generators - roof-solar

 

The following are selected responses to my roof-solar written up earlier. I am disappointed in the lack of input per the Joint-plan. There is something fundamental I do here. Every business plan requires hard work to implement. USA methods reduce to one of six types

1. Single direct investments

2. Multiple direct investments 

3. Portfolio

4. LP investments

5. Corporate investment

6. Co-practice

This is followed by several Angels. USA VC deals average 11,7 million dollars, angels average 330 thousand. It is 1/30 times. I, maybe alone, feel that I was a great hungry startup developer but never prospered because no angel dangled a win-win deal before me.

Clearly, I am not hungry enough! But I believe there are many like me, await a juicy business plan ready for limited risk. A limited risk means no cash risk and under 1-year risk at most. A pre-business plan is exactly that. The front end is a business plan leading to a business plan implemented by a careful person to deal with the plan within a year. In this idea, the success of  BP means selling to a banker. If it works, I invest a part.

If I succeed, IIT Roorkee graduates many of who will welcome my pre-BP list. I view them as my co-investor with solving angel fund problems and living up to 1 year. If someone approached me with pre-BP and angel funds for a co-investor role, I would certainly be a civil engineer, forget the USA!

=============

Writes Sir Chakresh -

This topic can be divided into two parts. One part can be devoted to rooftop solar and the second part to commercial solar power generation.

The economics for rooftop top is very simple and straightforward. Irrespective of the capacity of the rooftop, it's a very profitable investment as it starts generating electricity from the day it is installed and connected to the system. Many of my colleagues have got it installed including me and our returns are excellent. We are confident that the investment will pay off in the next five to six years. This return period will reduce further as the solar panels' cost will keep reducing and the unit cost of the electricity will keep on increasing.

Regarding commercial solar power generation, the economics is not so simple. Firstly, the investment is large depending on the capacity of the plant and secondly, the unit rates are reducing day by day because of fierce competition as very large industrial houses have entered into this field. Hence, it's too early to give any meaningful comments on this. I hope, this clarifies at least some of the issues raised in this article.

me: I agree re roof-solar. Mainly looking for data for commercial joint solar. it will be 100 times larger. My principle regret in life is "when I could digest, had no money, now have money (2 years) can't digest." The only way my life as a naastik Hindu makes any sense is to take well-considered risks. I must leave the garden marginally better than I populated. In the USA, the deepest moment came when a nurse recounted the last words on the death bed., most common was "why did I not take the risk".

"When I could risk, had no money, now have money (2 years) let someone invest in win-win deal."

----------------------------

Writes Sir VijayG -

One question about the rooftop case:

What about long-term maintenance costs? What about the loss of efficiency from dust buildup over time? What happens when the roof leaks under a solar panel? What happens when you have to replace the roof (every 20-25 years in the US)? What happens if a growing tree, a new house/building, or a house that has added a second story, starts blocking the sun to your roof?

In my area (Silicon Valley in the US), I don't see too many homes with solar panels. Probably under 10%. Or even less. If the decision were such a no-brainer, as you say, shouldn't I see many more homes using solar panels? 

answers sir Chakresh -

Firstly, let me clarify that there is virtually no maintenance or repairs for fifteen years as the warranty for pannels is given for fifteen years when the system is installed and you may think of replacing the panels if the efficiency goes down drastically. As far as collection of dust on pannels is concerned, the same can be got cleaned at some interval, although it is not a must as the efficiency is not adversely affected to a greater extent even if pannels are not cleaned. 

Generally speaking, no new buildings are constructed close to existing buildings but if it happens, one will have to get the panels raised on the steel frame to avoid any shade on the panels.

In India, solar power generation is always beneficial as the solar system is connected to the grid and we are required to pay for only net consumption i.e units consumed from the gridless the units generated from solar panels.

In case you still need some clarification on solar power generation, I will be happy to answer them to the best of my ability.

me: I consider these for joint-solar too. Says my guy - You consider two guys, one a manager. You have a bigger plot. If it works for 2 bighas. I will expand to 33! I start with self-clean, dust will come, start that as service-0n-call for Roorkeeites with roof-s0lar. An interesting aside, the top surface of the plot is bad and agriculture has to be done in huge pots anyway.

Pre-business plan - solar electric generators

 A pre-business plan is between a back of envelope calculation and a formal business plan. The idea is to read on to determine if the critical variables of a business plan have been under stood. One would call space-x chief deliberations on hyper loop and boring company as a pre-business plan. One could hire a plan maker to convert it to a formal plan.

Two related ideas are discussed here. One is a personal roof-top solar rooftop plan roof-solar. Another is joint solar-orchard plan joint-plan. roof-solar started as as way to reduce electric bill. The joint-plan as a good business plan. Both involve non-trivial business arithmetic cost ideas.

The joint plan addresses an idea that will discourage competition other than me. Government no longer buys electricity at better rates as the cost of solar panels plummets. Now the return on electric roof with enough sun hole to shoot for semi-shade agriculture below will probably be equal to cost. It is profits from agriculture below that keeps it profitable. Such a venture absent my expertise in agriculture in chemicals and planet medicine would be ruinous. No usual farmer will be smart enough to restrict crops or understand benefits of solar cover without profit - the panels will get cheaper and coverament will lose any reasons to pressure distcoms! So I expect an early mover advantage. Competion is not a problem in next few months.

Competion is not a problem in roof-solar either, every one is welcome for many months or even years.

Now the meat - solar capital costs 50,000 per kilowatt, delivers 3 kw per 10 sqm. So a 200 kw joint-plan will cost 1 crore and need 2 bigha with half covered It will require 2 people to maintain it. also free to do agriculture and cost 10 lakh per annum, paid for by sale of electricity. Agriculture will yield the profit, under 5 lakh.

Bank will finance half to 80 %. Return will be 10% to 40%, depending on financing.

The roof-solar will cost 200,000, but draw 40% subsidy in 2021. With subsidy, electric costs will be halved in months other then overcast, and few costs. Even brainless USA methods can be used but what happens when government reduces/eliminates subsidy, risk-taking companies will bankrupt! Happened in Nevada!

Comments welcome and incorporated.

Motivation for me

 

Why is the USA so important to me? Is it being fucked and is there a way out of it? Why does India thrive? Can we predict the end of this journey? Does this matter at all to me?

The first three questions is about the USA. It is a relevant truth to me, dedicated to remaining modest citizen despite what I can achieve and ready to take risks, meaningful now since I believe in wish-death and the belief that I can partake in it. It is no longer academic.

So why did the USA fail? Why did India thrive? Why does China thrive? Understanding these issues delivers to non-actor me, meaningful prediction ability. If I understand markets that well, I will be a very rich man. I do believe that prices within a decade are best handled by chaos theory i.e. every soothsayer is a fraud. But a decade-wide or larger prediction is probabilistic and doable within the wide net of investment. That applies to both the political theory and the stock market. It is asymmetric prediction, winner prediction is slow, while losers are fast.

The hardest change in me comes from rising of India and China and the reducing strengthening of the USA. The link above blame rightly the effect of size on decision speed but that is only a visible effect, the rise of Asian giants (increasing centralization) and the weakening of the USA (increasing decentralization without effective coordination) is not caused by size but the politically correct speech by a technical specialist,  thus their weakening. Both Asians reaped the benefit of effective coordination by increasing centralization. I have believed for a long in decentralization which improves political correctness. It pails before centralization benefits, Modi wins, my feelings, because he listens to key bureaucrats as opposed to elected riff-raff. Xi gets effect for free. Both are personally uncorrupt, don't tolerate corruption, and have publically damaged lower corrupt.

One consequence in India has been the marginalization of Congress even in opposition. Better luck in HP and Uttarakhand with the solid tired-government sentiment. I predict the BJP government in UP and egg on the face of sir Akhilesh.

Modi juggernaut goes on to 2024 and likely another 5-years then. The replacement of centralization is replaced by both, chosen by effective coordination and anti-corruption transparency, even if privacy-incorrect! Political correctness is way too important and must never be abandoned even if operating in opposition. It is important to shut up political correctness sellers applying way excessive analysis to determine alleged incorrectness.

Spanish me culpa

 Medicina me culpa y Computación nueva medicina

 Me culpa significa que soy culpable. En pruebas empíricas, por lo tanto inexpugnables, el 20% de los diagnósticos de los médicos estadounidenses (los mejores en la tierra) dicen que prescribimos el medicamento equivocado, repetidamente, por lo tanto, un meta-imbécil en mi idioma. No es intencional, por lo que encontrar al culpable es una mala idea, pero las víctimas sufren y parte de la responsabilidad recae sobre los perpetradores.

Para mí, la razón es trivial para entender como científico de la computación, así como las soluciones: los pacientes tienen múltiples tipos, el enfoque de la medicina de talla única es estúpido, el mejor tipo de pacientes y luego lo hace como c ++, es decir, inventa el diagnóstico de clase o la medicina de precisión; o ir a mecanografía delegada o medicina personalizada. El médico estará mejor atendido si se enumeran los biomarcadores de diversas enfermedades y el medicamento, así como la frecuencia, el entorno (como el estómago vacío o lleno, etc.) y los efectos esperados, se derivan para los biomarcadores de cada enfermedad. Uno puede comenzar a escribir en C ++ (precisión) y pasar a personal. Es probable que la idea de diferentes fármacos para la misma enfermedad sea poco intuitiva y errónea, y es mejor expulsar a todos esos médicos si no se incluye la nueva información.

La FDA es estadounidense y los votantes allí pueden arreglar la medicina, pero yo vivo en la India con un rayo de esperanza más allá de la licencia raj, el sifarish y la victimización hindú (tanto que me llamé agnóstico, no hindú naastik) de una manera verdaderamente secular (menos tushtikaran ). Estoy orgulloso de estar a favor de la elevación a través de la reserva y los escaños políticos asignados, incluso una posición minoritaria en RSS durante mucho tiempo. La troika de Modi-Yogi-Ramdev llevará a India al siguiente nivel sin violencia. Y en Gadkari, Piyush y Sarma de Assam, etc., BJP tiene una profundidad más allá de la troika.

Hace poco se extinguieron una culpa y unos gustos muy grandes, presumiblemente capitalistas. El corredor de Kasi costó 332 millones de rupias, mejor utilizado para eliminar la desnutrición de los niños de la UP, dijo un idiota de Akhilesh. La respuesta contundente fue que si el corredor atraía solo a turistas, 3 millones de turistas que gastaban 1000 dólares cada uno, la inversión en Kashi generaría 3 mil millones por año. ¡La desnutrición durante muchos años en todo UP se solucionará para siempre con solo el 10% de impuestos! ¡Siempre que esos imitadores (supuestos) imbéciles nunca hayan estudiado con Sir Akhilesh!

Vendrán a los proyectos de Modi, pero es poco probable que vengan a los proyectos de Jinnah. Marque mis palabras para 4naths, Badri, Kedar, Gangotri y Yamnotri.

FSSAI es indio y debe incrementarse para aplicar estadísticas bayesianas, efectos cruzados aprobados por FSSAI y suplementos aprobados. No debería ser un reemplazo de la FDA, sino un complemento con ensayos igualmente respetados.

Vuelve a la medicina de precisión y personalizada. Es de esperar que los lectores comprendan la diferencia entre ellos, de ambos con la actual mm (Medicina Moderna), y su superioridad e inevitabilidad en el siglo XXI.

Medicine me culpa and Computing new medicine

 Me culpa means I am guilty. In empirical, hence unassailable tests, 20% of American Doctor diagnoses (best on earth) say that we prescribe the wrong medicine, repeatedly, hence a meta-moron in my language. It is not intentional, hence finding the guilty is ill-advised, yet the victims suffer and some responsibility lies on perpetrators.

The reason is trivial for me to understand as a computer scientist as is the solutions - patients are multi-typed, one size fits all approach to medicine is stupid, best type patients and then do as c++ i.e. invent class diagnosis or precision medicine; or go to delegate typing or personalized medicine. The doctor will be better served if biomarkers of various diseases are listed and the medicine, as well as frequency, environment ( like an empty stomach, or full, etc), and expected effects, are so derived for each disease biomarkers. One can start c++ typing (precision) and proceed to personal. The idea of different drugs to the same disease is likely to be unintuitive and wrong, and all such doctors are best expelled by non-inclusion is new mm

FDA is American and voters there can fix medicine, but I live in India with a gleam of hope beyond license raj, sifarish, and Hindu victimization (so much so I called myself agnostic, not naastik Hindu) in a truly secular fashion (minus tushtikaran). I am proud to be for upliftment through reservation and assigned political seats, even a minority position in RSS for long. The troika of Modi-Yogi-Ramdev will lift India to the next level without violence. And in Gadkari, Piyush, and Sarma of Assam, etc, BJP has depth beyond the troika. 

A very great, presumably capitalist guilt and likes were extinguished recently. Kasi corridor cost 332 crores, better used for removal of ill-nutrition of children of UP, said an Akhilesh moron. Telling reply was that if the corridor attracted just Tourists, 3 crore tourists who spent 1000 bucks each, the investment in Kashi will generate 3 billion per year. The malnutrition for many years in all of UP will be solved forever just by 10% taxes! Provided that copy-cat (alleged) morons never studied with Sir Akhilesh! 

They will come to Modi projects, unlikely to come in Jinnah projects. Mark my words for 4naths, Badri, Kedar, Gangotri, and Yamnotri. 

FSSAI is Indian and must be ramped up to apply Bayesian statistics, FSSAI-approved cross-effects, and approved supplements. It should not be a replacement of FDA but a complement with equally respected trials.

Return to precision and personalized medicine. Hopefully, readers understand the difference between them, of both with current mm (Modern Medicine), and their superiority and inevitability in century 21.