Biological immortality

 The latest link

https://en.wikipedia.org/wiki/Turritopsis_dohrnii

Ameba is immortal, yet unexciting. since they reproduce by splitting into 2, so that every ameba extant is a distant child of 1.5 billion old, cannot die as long as even one lives! I am more interested in multi-cellular beings.  Turritopsis dohrnii, also a form of jellyfish are multi-cellular and biologically immortal, not immortal since a violent accident can kill them. Turritopsis dohrnii, is another cnidarian that scientists believe to be immortal.

Their strategy is simple, they become adults but revert to being a child instead of dying. We do share several thousand of their DNA elements in humans. Who knows what will be produced if the right mRNA activated them in humans,

If they were milked somehow, the question becomes the identity of me as a child. Is it death for me of then? What exactly is death? Why does restoration into an angelic form after long sleep create the same identity as the one who died? Isn't Arun of 1 sec ago dead? 60 years before death? Will I live past quantum teleportation?

Foundations of Natural Cell Medicine

 

The latest link

My Natural cell medicine NCM can be viewed as Longevity science but is designed to address incurable diseases in modern medicine Allopathy (no time waste on dated procedures, assume the best) of chronic age diseases, cancers, and Aging. The question is not on treatment, considered the best in emergency and treatment situations. The question is what to do after releasing from a hospital and a month passes, with the doctor prescribing essentially a lifelong visit and medicine schedule.

I am 66. I suffer from diabetes, heart, and osteoarthritis, also essential tremors. They are all genetic since they bothered my father and uncles too. I am exactly in the situation described above. What do I do? Without a formal medicine or chemistry background, not much. Except for 20 years ago, I decided to use the internet and educate myself in molecular chemistry, molecular biology, genetics, and immunology as required, subsequent to the enticement of claims of Dr. de Grey at MIT to scientists and engineers I respect, rational skeptics all. He talked then about SENS and extending the age of mice. He was met by skepticism and disbelief, rationally answered. He was then a married head of gerontology in Oxford in England. Happened to have deep respect and belief that professors and students at MIT and Harvard there were smart and also RS, have nothing but admiration for NHS. Followed off and on, his funding of couple pair Drs. Conboy parabiosis in 2005 and rise of Sinclair after resveratrol, Yamanaka factors and how it defeated the religious meta-morons, to Sinclair calling out for NMN, the rise of Horvath by DNAm and grimAge clocks, and the start of TAME effort,

When 65, Lowell's stealing money subhuman morons couldn't any longer fix me, a victim of disability. Meanwhile, I took a breather from my NSA-proof encryption and went full time on undoing aging, strongly buttressed by the 2020 defeat of erroneous natural conclusions from parabiosis, that doomed most California undo aging entrants. I believed then, as now, there are no current mm fixes for me, only undoing aging will help by restoring dead cells by forced autophagy, then by cell division. Those happen with exercise, but I was slipping, not just by psychological reasons but true tiredness. Only exercise will cure, too old now, accept defeat, but never! I did not acquire the greatest citizenship by birth or accident. It was hard-earned, not given. How could I submit to medicine failure?

Suppose I discovered a chemical cocktail that fixed my chronic diseases. How could I know they contained no long-term enemy chemicals? Or if I got sick, then ate a drug that conflicted with my cocktail? These concerns led me to eliminate drugs outside the safe classes, unless singular.

Most declared GRAS (generally recognized as Safe) by FDA

Phytochemicals, present widely in vegetables and fruits

Chemicals already in the body processes, principally in Krebs

Vitamins

Unless explicitly forbidden by mm doctor, they were unlikely to hurt! That includes orthomolecular medicine. The only risk henceforth is from adopted doses and interactions, then even knowing low concentrations are harmless. That remains a risk. These are considered safe in all contexts unless suffering known incompatibilities.

FDA establishes safe doses. It famously fails to establish joint risks. It is NOT made of human enemies but court-savvy intelligent humans. So are mm Doctors. What they do is determine the safety and efficacy. There is a smart way around them, show the effectiveness and safety in one disease. Thereafter, any MD can use it for any disease! They cannot consider history as a guide to safety as GRAS can. But I can in estimating my risk. Stevia is ok and the best sugar substitute, regardless of what FDA says based on Peru's experiences for 1500 years, or Japanese since 1970. And don't even get me started on vitamin K2. The point is I use Stevia and K2, independent of FDA blessing,

The problem comes when Aging is not considered a disease. WHO now recognizes aging as a disease! FDA will soon someday. Why care in India? Doctors(mm) here recognize only FDA-approved medicine.

Ayurveda might. Naturopathy will. The four safe classes are in the natural set.  So is most orthomolecular medicine. Top life scientists are not MD. The Harder the MD squeal, the harder will be their fall. One dance around injections is by taking all supplements as liposomes or under-tongue liposomes (nasal etc also okay). Rarely is injection-fast supplementation needed? No natural cell medicine requires MD permission but metformin (only in the USA etc). Liposomes are even better than injections since the cell entry problem is removed. What if liposomes are less absorbed in the intestines? Use them sublingually. 

Like RDA, an LDA should be required from Liposome makers which says how much the liposome equals regular RDA. Otherwise, it forces aware consumers like me to look up liposome efficiency by dividing the stated RDA. Efficiency varies enormously, depending on bioavailability. For NMN is 4 and ~50 for fisetin. NMN is easy, 250 mg/day equals 1gm per day Dr. Sinclair uses. Consider difficulties and errors in my applying mayo protocol using liposome fisetin. Daily doses exceed mayo lumps!

I believe that NCM will solve my ailments, try it on myself. No tension of getting sick, safety in the test. I might be wrong, but postmortem tests on me can be used to debug one bug. I consider the risks of my chronic diseases to exceed risks in my test and my path is unusual but rational. Non-death errors can be designed around. I have many MD cousins, even an ex-wife who never could live with my disability.

Tech-fi, not sci-fi

The latest link

 

The difference is in relation to physics, tech-fi if existing laws only are used, otherwise sci-fi. Star Trek, all preserving corpse to avoid death finality, most labeled sci-fi are usually not tech-fi which can only ignore costs and engineering. Such a world is not impossible.

Up to now, I have listened to the spiel of the overt or subconscious religious types, mentally waiting for a nonsense statement that I knew would come, and it always did. How can anyone know except by reading about or listening, or watching a movie, and hence non-science? The following is a beauty that collects the thoughts of many atheists.

 

https://www.facebook.com/BigThinkdotcom/videos/860373821169931/

 

None of them talk about semantic games. They at most describe the religious nonsense as a pitiful cover for the immature. Not one talks of cheating death and circumstances for living on despite mathematical certainty of continuously increasing vulnerability as age stretches longer, the probability of death approaches 1. Can I advance a rational scheme to live forever?

 

I can provided the probability of death by any physical object approaches a limit, no matter how long you live, this limit must exist in most real universes because the devastation must be limited by volume and size of threat – it cannot increase without limit.

 

Within a thousand years, download of the brain becomes routine, essential in my thinking to enable lightspeed zero lag movement between stars. Useful even within a solar system with almost a day delay between planets. Multiple copies can exist with a separation exceeding the estimated largest devastated volume, Also, the strategy of surviving the largest possible devastation can be used.

 

It is tech-fi, not sci-fi. Downloads happen with MIT technology development. Light travels fast, but does not age the photons! A simple reset cycle with very little age suppression is enough to give 1000 years. There are a huge number of chronic diseases, cancers, and aging. But I believe De-age methods will allow victory even on them and am testing them on myself.

 

What underlies my efforts is not bravado – I only test with phytochemicals and vitamins, they do have anti-aging effects, which makes the risk tolerable. As my stoicism says – what is the difference between a life of a day or three generations, both are sandwiched between infinities. At least I tried intelligently, fast death now means less to me than overcoming my ailments.

 

caAKG

 

The latest Link

It ends with CaAKG. Only mm Allopathy is recommended, people propagating, but not practicing, are considered criminal, using any non-science methods is stupid. There is no FDA or FSSAI recommended form for undoing aging, a doctor advocating is a criminal. I have identified enzymes that targetted, removal of senescent cells. I provide support for the heart (no duplicate), and bones (weakness kills by fracture). My recommendations are nutraceuticals of phytochemical kind or forms of vitamins, I call them cell medicine, fully vegan, extends orthocellular medicine, will likely not have effects on any prescription medicine, can be and should be told to any prescriber. In many cases, the prescriber himself will be in the dark about some and in that case only, one can look up the internet.

You only live once and a reasonable small risk to avoid death, permanent or any case forgetful of you, is worth taking. I am willing to answer questions or point to a paper for now. Who knows my future, neither written, not forecastable, only guessable. I consider predictable believers to be meta-morons, my Freewill is from quantum physics, there is no God, life is re throwing dice. Interestingly, cell medicine is an agnostic work that adds to whatever you believe in, far more than Allopathy full of animal extracted and tested medicine.

https://youtu.be/3I7TxBT8FmI

 Must look up and understand this short link.

Why do I consider and adopt this Chemical? The issue is belief in the video, which references Dr. Brian Kennedy. This guy was a classmate (to the extent Ph.D. guys can be) of Dr. Sinclair at MIT, director of Buck institute (only aging), and now a prof in Singapore. I consider everyone talking about aging (not trying on self) a suspect! Apart from the veracity of research, I must prove to my satisfaction the safety and effectiveness of the chemical (unless vouched by my fellow) and cross safety to my medicine and already taken chemicals, bumping less effective if needed, If Dr. Kenedy vouches for research, which removes safety and effectiveness concerns. Cross safety is hard, but my argument to myself is this - CaAKG works by mTOR, no chemical but  Rapamycin does that pathway (others SIRT and AMPk) and there is no reported interaction between CaAKG and Rapamycin. Not proof but suggested by the evidence, within the dangers with Death a certainty. Danger will be known from my hurt.

What is Fat?

There is two orthogonal dimension - nutrition ( saturated (saturated: saturated, trans) unsaturated  (poly, mono)), and anatomical (White WAT, brown BAT, beige). Trans is very bad, saturated less bad, polyunsaturated is less good, monounsaturated best. WAT is ok elsewhere but bad on the belly, though children need it. BAT occurs mostly in the back and is good, Beige is new anatomy, made from WAT, but acts like BAT. Allows one to decode (adipogenesis is fat cell genesis)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974731/

The key point is - In summary, AKG supplementation promotes beige adipogenesis and alleviates HFD‐induced obesity in middle‐aged mice, which is associated with enhanced DNA demethylation of the Prdm16 gene. CaAKY reduces methylation and reduces age markers! I believe, based on extensive reading, that turning off these markers improves error in cells and hence actually exceeds just a marker but actually reduces age! A bad test by a company still implies an 8.5 year age reduction in clinical tests on humans, better in the works! And improvements every reset (postulated)! Looks like a fix for my osteoarthritis, diabetes, heart, essential tremors, even if no lifespan benefits, resets coming by other chemicals!

CaAKG benefits are important to me, I am far less concerned by lifespan than healthspan, the defeat of my incurable chronic diseases in mm Allopathy, and very low opinion of AYUSH. So I risk beyond mm, try aging drugs, but cautiously, have a very small panel of two noble-quality types of research. Such a person did not stop to enjoy the fruits of work. Note that there have been only 4 people with real double Nobel prizes, Madam Curie(physics and chemistry, Radium/polonium,  Radioactive), Sengar (Medicine, Insulin, Read DNA), Bardeen (Physics, transistor, and superconductivity), and my master Linus Pauling (chemistry, peace(also orthomolecular medicine)). Deserving likes are Dr. Sinclair (Resveratrol, NMN), Dr. de Grey (7 hallmarks/Aging, Medical Tourism, SENS), Drs. Conboy (parabiosis,  kill blood exchange), Dr. Horvath (DNAm, grim Age), Dr. Yamanaka (OSKM, slow OSK).

My theory of undoing Aging postulates that failure of DNA repair is likely aging but useless for undoing. Instead one focuses on undoing damage (removing senescent cells and thus reducing SASP by senolytes) prosper by improving 3 targets (SIRT, AMPk, and mTOR)  by (increasing Krebs i.e. NAD+ and Resveratrol path), improving heart and bones (K2/D3), various paths (including the heart)(CoQ10), many paths (including the heart and Krebs) (CaAKG), metformin for insulin control including asymptomatics.

This means Dr. de Grey exhortation to senolytes (apigenin, quercetin, fisetin) and stemcells by Dr. Sinclair (Resveratrol, NMN, NAD+) and my collection (Coq10, K2/D3, Calcium, metformin, CaAKG). The senolytes safety is from the fact they are widely found in fruits and vegetables, Sinclair list from red wine and vitamin B3 form, my collection CoQ10, D3/K2 common improvement, Calcium safe levels only, CaAKG MTOR, metformin AMPk, Sinclair on SIRTs. Liposome all but Calcium and metformin.

Benefits of my chemical list

 

Of course, I don't take them all. In boost group is resveratrol,  In senolytes group are fisetin, quercetin and apigenin.  Also, take D3/K2, CaAKG. Not seen here are NAD+/ boost, NMN/boost, CoQ10, vitamin C, and Rapamycin. Extreme care is needed with not-in-table above!

Boost group is a subset of Dr. Sinclair's diet estimate. Senolytes group is a subset of Dr. de Grey's senolytes recommendation estimate. Not used are berberine, Glutathione, hyaluronic acid, Curcumin, or AMPK activator. Note that I reject ROS or oxidation as key aging drivers.

vitamin c liposome

 

https://organicbiomama.com/homemade-liposomal-vitamin-c-recipe

Recent Aging things

 

The latest link

 

Aging overview

https://www.youtube.com/watch?v=nnnXVUWlTkI

 

Can We Live 200 Years? 

Gives a simple overview.

WHO has declared Aging a disease!

Hence researcher funding is easier.

Impact on new aging on pensions.

One year more life means a 3.5% increase.

Extra life means an end early retirement, 1-year work extra adds 38.5 trillion income to the government. 10 years is 365 trillion in the USA!

Arguing for India ratio, why is this not top India priority, given that childish fears of an enormous population are precisely a stupid joke? The only sane answer is that the overwhelming majority of Indian doctors consider aging a natural inevitable process, regardless of mice experiments at Harvard actually reversing age, kept to new natural death. Mice whose optic nerve was crushed, reverted to young age, the eye regrew, uneventfully eye kept in the new full life! I think that my experiment, never mind lifespan benefits, will cure my chronic diseases! Square my age curve of fragility versus age, short decline at death. That motivates me to self-test using my own protocol (dosage, schedules, which chemicals, who to buy from, drug delivery system) sharpened by 20 years of doctor following.

Eliminating all cancers adds 2.5 years to life only.

Synthesis of related diseases sharply reduces cost.

Non-commie economies benefit.

Important not life but healthspan!

 

93% of health events are from your life doings and only 7% are genetic. This is true for 99% of humans. Cursing bad luck in genetics is likely a meta-moron!

Will wealth inequality increase. Can’t allow only capitalists to invest.

Developed world 1970 3.5%, 2.7%  in 1980’s, decline to under 2% last 20 years.

 

Second career everyone. Sinclair's father started onde at 78, now 82!

Welcomes 100-year anniversary, half what I take, other half senolytes.

Money saved from health into education.

A second career means no learning.

Get one mentor career1, be one in career2.

The USA has more 70+ oldies than kids 5- and sells more adult diapers than kid diapers! Will happen in India on my health span!

 

Philosophical view, Dr. Arya?

 

Aging relief is there, only a few more years to deny it.

Smart believers like me invest money, time, and effort into it. Fuck you the late entrants! How to invest? Who knows but certainly not pointed by advertisement legends! Go for the science and management sweat.

 

Professor Jhun (honored to have as class mate) talks about the 10x plan. I believe my interventions will work on me.  1000 million Indians, 500 million older is my market size. Maybe 6000 million in the world. He wants 1000 crore companies. I will be there, both by quantum computer proof encryption and also by health-based, two not one. I need the second one even more than the first. Delay to riches can wait. I am the first customer of the second. If I fail in 2, success in 1 does not excite me.

 

Where are we?

 

Traditional doctors know little about molecular chemistry and biology, genetics and immunology, and my cure to chronic aging diseases and aging, They are doomed to a new sub-specialty.  They were taught wrong in medical school about telomere length versus age!

The AKG addition to Sinclair+deGrey=Arya+Lipo

AKG is available in CaAKG which has GRAS Status, makes brown fat and reduces white fat, appears in Krebs cycles, is not made by the human body, has 10-15% health span gain, only boosted by keto diet and CR, no gains to male mice, not worth my need now, but kept as a possible health span chemical. AKG trial on humans in Singapore.

 

Politics ideology?

 

Already EU is at destruction edge, A court in Poland has just declared a Brussel. (ie EU) law constitutionally impermissible in Poland! If Poland gets away then so will everyone. But how to force Poland? Polexit after Brexit? 80% of poles love EU! The big lesson to me and my belief in SAARC-wide economic union!

 

What happens if Pakistan wants one way? Or Punjab wants it another way. What does want mean? Court judgments? Government? Citizen majority – voting or non-voting also?

 

First contrary opinion to Dr. Sinclair?

 

Aging is here, we can not wait to change the law when it arrives. We have to consider its impact before it arrives, when it does, there will be no philosophical views, just ideologies, and trending cases. India cannot push the inevitable as the USA can.