Aging bounty of Covid-19

        Only comparable picture is physicists in 1927. Center is the saint Aubrey de Grey, SENS.

 The latest link

But the scientific community doesn't know what to make of him. In July 2005, the MIT Technology Review challenged scientists to disprove de Grey's claims, offering a $20,000 prize (half the prize money was put up by de Grey's Methuselah Foundation) to any molecular biologist who could demonstrate that "SENS is so wrong that it is unworthy of learned debate." The challenge remains open; the judging panel includes TEDsters Craig Venter and Nathan Myhrvold. It seems that "SENS exists in a middle ground of yet-to-be-tested ideas that some people may find intriguing but which others are free to doubt," MIT's judges wrote. And while they "don't compel the assent of many knowledgeable scientists," they're also "not demonstrably wrong."

Without sounding mean, my life has been unspoken incessant tragedies that made me stronger by the opportunity given because they never killed me. One of the bounties of Covid-19 is mRNA technology polishing, Even a successful company is called Moderna, using RNA as a suffix. RNA is not new, likely older to even first failing DNA a billion years ago. But its use to build new proteins is new, doing it industrially and eliminating kinks, is new. It is a perfect development for Aging.

What aging is, and how does SENS fit within Gerontology and Geriatrics as an engineering approach within great sciences is my ideology of 20 years and counting.

Why is COVID-19 so deadly to the elderly?

What m,RNA is, should be crystal clear after this. The current article is about some of the myriad applications, in the near future, in Aging. That is why you must intern it to be able to judge the technology behind claims of novelty and usefulness of products.

 

Let us abbreviate greatly for new biology novices, even this simplicity was novel to me recently.  Every Eutheria body is collection of trillions of cells, all derived from a single pluripotent cell in the womb and assisted-developed to adult-hood from a single pluripotent cell, about half from both parents from DNA which duplicated by unraveling the double helix. In computer science, every action by a program is a derivation from the start symbol, here is the fertilized zygote and repeatedly derived according to the grammar rules, till all nonterminals become terminals,  the final program. In biology, complete derivation never ends and non-terminals remain as stem cells even at huge long life end. These are reactivated in wounds, just sleep after adulthood. All is done by blood carried signal molecules. It also carries some instructions from specialized organs for hormones. Growth happens by hormones and is stopped so. Hugely extended brain cells called neurons become nerves for analog signals.

For aging, important to consider single cells since the same structure, regardless of organs except brain is found in and aging happens at the cell level, a very recent find. Even if one keeps the structure perfect, aging will happen as cells age. Aging is normal at cell level, and cells avoid death by repeatedly becoming daughter cells. However, telomere at the end of DNA shorten on every division and there is a limit called Hay flick limit on number of divisions, this is about 50.  Classic doctors subscribe to this and believe that undoing aging is a matter of telomeres, expressed by gene within the cell. The first shocker is cancer cells which become infinite lived solely by learning how to use the gene in DNA to infinite divisions. One must be super-careful to avoid cancer in all telomere manipulations. The second shocker is the presence of animals whose telomeres never shorten, but they die all the same! So this possible but unreal story is wrong. Current scientifically established theory is genetic by Dr. Sinclair. It focuses on DNA repair in the nucleolus. By forcing exclusion of repair and duplication rules by error-free perfect means by repair and duplication states logical inverses, One is trivially shut when the other is active. In fact, super centenarians all have robust DNA repairs. Sinclair won the mechanism race by two  repeatable empirical tests, one aged one of a twin pair of twin mice and second by crushing the optical nerve of a mouse and restoring it by topical chemical use (NAD+).

Regardless of chemical needed, a protein is generated either by the DNA lording all, by mRNA which emerge, are grabbed by the right ribosome and protein is built and exits the cell. The messenger RNA (mRNA) is almost a copy of small part of DNA except that it is single strand and contains a U instead of a T – uracil instead of thymine. A signal molecule from outside enters the nucleus, excites the DNA, compelled to emit an mRNA which exits the nucleus. While never encountered in text, all mRNAs are known bad in Blood, immune knows all kinds are bad, (says my evolution part. Hard for nature to preset killers for just all mRNA More likely all Uracil having molecules are bad, needed natural immune complexity there! Whatever rest of the molecule is bad too and that is how the killers learn.) A lot of evolution is simple natural means to solve hard human problems! Just exclusionary DNA repair means all life on earth. Only one kind on earth DNA means likely compatible life in Universe! Many forms that failed evolution lottery on earth will exist in other planets.

The mitochondria generate and release energy in ATP-ADP cycle and have their own 13 unit DNA. Very recently by clever means, mitochondria were fixed by harvests (70%), new DNA for mitochondria, inserted, and replaced, all in living mouse! Holy crap! This technique can be extended to extraction and replacement of ribosomes and in live humans! Another giant step to defeat of aging.

The process that converts signal molecule to DNA to mRNA to protein is the foundation for how the cell functions. The mitochondria probably be segregated to other cells, or is their presence needed by evolution? Reduced NAD+ inflammation with senescent cells might be a reason.

How do mRNA vaccines work

We outlined enough to understand the sequence of steps. From above, I ask as my Socrates brain, after mRNA emerges from the nucleus.

Can it go back, say, for disposal?

Evolution imposes the rule - No going back! Grossly unsafe, all virus kinds will love it. No mRNA allowed returning!

So how disposed?

Self-destruction, minutes for high proteins, hours at most!

What if it emerges from the cell?

The change in at least one sugar is enough to allow target all RNA by immune system.  Additional benefit in Eutheria.

How does mRNA vaccine work?

An mRNA is found to unite with spike protein in Covid-19 case, the compound can't be toxic. Vaccine allow it in blood. If any viruses present, some mRNA sticks. By immunology, all RNA in blood are bad. So they get eaten. Of the rest, some remains in blood and some enter cells. They die inside by self-destruction. Fraction outside are eaten by killers, training them. Later when virus comes, spike-protein launches love to death killers. How train? Remember that mRNA had the spike protein not wanted by vaccine maker. Being partly mRNA, it was bad. Because part of the spike protein was attached, immune cells believe not only mRNA is bad, so is the attached spike protein!

Lesson learned

To kill a virus, one looks for an expressed protein on the surface for which a good mRNA can be found. Next, one uses mice and/or human cell cultures to make candidates by keeping only those which appear safe. Next theory is applied to reject candidates based on harm before. The remainder molecule are triaged to first small human tests. COMES fda-2, ELIDED BY SPUTNIK TO fda-3 AT ONCE. WORKS OFTEN BUT LOWER SAFETY. After all, safe in some humans for some time. Sinopharm, likely example of fail if fda-2 and fda-3 were there. In effect, Seychelles, UAE and many other China vaccine users did the FDA-3 and flunked the vaccine!

Arun Arya generic transform

Nice example of deep understanding of some subject is candidate ideas in Aging of new products and understanding of others. Let us apply the ArunArya transform that will be used to create new kind of programming. For aging, let us keep the protein and mRNA variable. Then the procedure is find the protein, select mRNA for it, train the killer cells and kill them.

Application in Aging

I believe it will be major and many targets. First I pose it and later consider Angel investors. To apply to aging, let us identify the villain. For now, we limit to CD38 and TGF-beta. One way to eliminate them is by filtering blood by concentration meters. A completely different novel technique is to find good mRNA that will attach to the bastards.  Imagine the beauty of the slaughter by natural immune killers trained to kill the bastards, trained by RNA attachments to the bastards. Till a vaccine is developed and tested, drugs can be used for periodic reduction in strength. In other words, new classes by vaccine or drug of senolytics. It will be great to get vaccines for expanding class of bastards - how to expand your life by vaccines and periodic revaccination (100 years?) for some, for healthy age increment purpose. For some, once is good enough, as the immune cells for them retain memory forever. Even that might need slower reactivation. If USA style fish eat fish applies to companies, then maybe we will embark on posthumen form of life even before 1000 years.

Letter seeking help

 

As recounted by Lady Conboy, before 2005, prior to their earth-shattering work, they could not move forward in parbiosis work till fix required funds for research. Beyond the other donnés, stepped up Dr de Grey and solved funding and expertise (suggested and convinced two capable technician fellows to work). Rest is history. It reminded me of Bhama shah. I don’t need one for money. But I do need capable technicians. And someone in our group to sound on by email. Best would be a new doctor uncle. Oh, I miss him.

I did write up my work to a form good enough for me.

It can be edited and extended, in fact should be. IT will be used to ignite shared help calls. The HARDEST part of being a grownup male is to admit you need help, and having doctor uncle meant I did not need help. I do now. Solving funds problem, and tech problem is a good start, that all. Maybe some better ideas. My goal is a company and my need is, a perhaps not meet (email and phone only), partners. No funds needed, best being PPP model with Yogi, or like, delay and use my NMN experience, go for clinical test over 5 people (Too expensive in the USA, NMN still lags NR), … Whose shoulders do I cry on and answer my doubts! Time to build email only groups like class-of-75 with legal statement consequences, ... My proning experience was bad and deflationary. But did fetch help from Hemant & Baldev, gratefully acknowledged,

Tech fi on life after the first thousand from now

 

Latest link

Tech-fi and consistent sci-fi are my invention neologisms. The title "Tech-fi on life after the first thousand from now" indicates that the technology applications will take unspecified time to become profitable, but no new science is postulated. Consistent sci-fi is that the series explores derived possibilities of the raw science imagined, as well as strong believers constitute consistent explored civilizations.  Star Wars and Star Trek are both consistent sci-fi. If current science postulates sufficiently widely a contrary principle, then that branch of sci-fi becomes dead. Jules Verne classics and "back to future" are bad sci-fi, to be passed sci-fantasy, because antigravity and time travel respectively are anti-science. Consistent sci-fi do not include, but do have Star Trek imaginations which while true flights of fancy, are still non-contradictory.

After the first ageless 1000 years, the sane majority of life forms will allow their brains to be blown up to huge sizes using MIT 2010 decade technology developments, transfer their brains on digital memories and weights on huge robotic nets, to enable a recreation of similar net, as nano particles on diamonds, as the brain. Once that is done, light speed travel, and safety against all types of dangers becomes possible, even true immortality assuming correctly that unlimited dangers have very local limits forever. Regardless of length of time in any matter coordinate system, the time elapse for photons is zero! So optical information needs to revert to diamond form only after unlimited travel.

What is an advanced brain?

It can be answered today with some certainty. It is many functional units composed by pipeline. Each unit can be implemented securely by read only functions operating on two kinds of data, write-once and variables, with fixed locations or pointers. The data is separate from code and organized as series of snapshots connected by lists of transactions which each keep an implicit record of what was done, why, and by whom etc. Each function begins with an event which schedules in a set of closures dynamically bound to that function. It terminates in another dynamically bound post-event to which various sanity-checking closures can attach. Closures imply coroutines which can share variables. The entire program is a process which cannot share any variables, but can share write once. The program flow can be normal or automatically instantiated from semi-context-sensitive grammars on events. The semis have singe global nullable non-terminal but nulled just once at the end. It represents time.This models coroutines and machine learning (an opaque functional coroutine) both.

I am predicting that even full first order logic will not be doable by  ml machines. There is nothing intuitive about the logic. Unlike human brain, two independent units can ML-compute a function and the difference, thus operate differently from neural brains. However, complex units will have two levels with one normal circuit level  over ML-level.

To be done.

Conclusions of my Aging research

 

            Fountain of youth

Latest link

Scientific American (for 200 years, the best American journal)

Aging Is Reversible--at Least in Human Cells and Live Mice ...

www.scientificamerican.com/article/aging-is-reversible-at-least-in-human-cells-and-live-mice/

New research suggests it is possible to slow or even reverse aging, at least in mice, by undoing changes in gene activity—the same kinds of changes that are caused by decades of life in humans.

Arun Arya View

No point reading for entertainment, documents MY plan, available for free for Cathedral and the Bazar reasons.

It is not sci-fi. The path to Bhishma-like wish-death is open to me and I will probably not die , but will a huge number aged of today since they will not do the right precondition to aging singularity and not realize it when it comes. It will not be celebrated as an event, but will simply mark a timeline event in 2050 histories and later. Prior to details, diabnetes drugs extend life of patients and non-patients. It is likely strange consequence of coincidences of two common drugs metrformin and acarbose, which have lack of age benefits from their counterpart drugs. Every one praises metformin, 1/2 gm twice a day.

Belief triage on aging?

There are three Doctor units only listened to, for own skeptical aging analysis to TRS. Each one of them have acquaintance in me to their work in 2000 to 2010. Every other opinion is likely rejected outright, not even submitting to other intellectual opinion that requires acceptable proof of accomplishment. Unless endorsed by them. These are Dr de Grey of SENS and "apigenin + quercetin" fame, Dr. Sinclair at Harvard after MIT, (nmn+pterostilbene) and massive journalist of USA fame, and Drs. Conboy at UCB of parbiosis and "Diluting blood plasma rejuvenates tissue, reverses aging in mice" fame. There are only 4 methods they advocate that are in my powers today and 2 require medical help. The singularity I await is medical professionals or bio-hackers like me, reaching that point that one extra year of life is expected in every calendar year for 20 years known. My prediction is 2030. For all steps, Dr de Gey predicts 2036. I consider age extension to then be possible with fewer extensions mentioned here.

By massive confusion I learned that Irine Conboy is no longer in UCB medical school, but now the vice-president of UCB!

The works that established these doctors as great scientists is based on pioneering work in the decade of 2000-2010 and great work done since. Dr. de Grey mentioned senolytic drugs and outlined mouse-extension challenge (2000 decade). He funded the Drs. Conboy study. He has since advocated startups and medical tourism in 2010 decade. Drs. Conboy proved experimentally by parbiosys that young mice become old by getting old partners and old become younger. Last decade, they experimentally showed that direct transfer of blood ages the young but gives minute benefits to the old. Another painffully slow but exquisite experiment showed that blood dilution was enough! Dr. Sinclair discovered resveratrol in 2004 and nmn in the decade of 2010. The decade also saw the emergence of Dr. Horvath and the Horvath bioage clock that establishes a great magic link between bioage from genetics and calendar age, also predicted remainder of life to death, the grim age! Starting the decade of 2021, the bioage tables were shown to be valid in all eutherians! New young doctors like my niece are still taught that telomere length dictates age!

Arun Arya Methods of age improvement by self decided interventions?

So far careful hypothesis formation. Based on my epistemology, conclusive scientific results by pre and post Horvath bio-age. Either it works as expected, or failure refines the next try. Getting ready for small try, welcome any one interested in own empirical try with me (own costs but none of mine either, likely to become historical, no effects beyond failure, expected small improvement in worst case).

First is aping evolution and experiments of past 50 years. These are ONLY 2 methods that guarantee healthy extension, proper fasting and exercise to all eutherians (proper is crucial since improper fasting may weaken immune nsystem). This kingdom of eutherians is invoked by me for these reasons

0. Proper is judged only by registered medical scientists in responsible situations.

1. Eutherians have similar DNA. Regardless of skeptical motherfuckers, aging, says my 20-year study, is a genetic consequence, with DNA editing basic. Proof: Horvath bio-clock works in all of them. Establishes Dr. Sinclair's aging theory solidly in  me and seems to apply to all cellular  life, even stars. It requires development of one way surround of DNA to prevent total hijack and of mRNA distinct from DNA to allow protein synthesis, but to reduce infections by immune adaptation.

2. Humans and mice are both eutherians, so are yeasts. Hence, many experiments can be done on yeasts/mice, and possible failure in human is possible but unusual, defined by proper prefix, often elided but always there. The sequence 1) (mice/.. works)|(human-cells works) 2) (First-few-volunteers works) 3) (large-number volunteers works) will work. For danger-love people, they can volunteer after 2-steps. Deliberately and knowledgeably I mention 3 sequential steps, applicable to applied chemicals, medicine and vaccines. Only FDA-2 is elided for speed reasons.

3. Theoretical derivations may suggest some results, excellent hypothesis, but my epistemology requires confirmation experiments, only allowing interpolations on continuous differential functions polynomially interpolatively. People might volunteer but can not adopt any but interpolations, and never extrapolations. Almost all Eutheria health functions known to me are interpolating able.

These principles I state as minimum required by me to accept any claims to aging cure. It is possible I miss out on some miracles, but sticking to them will certainly save me valuable time.

Second, I use NMN and Pterostilbene (instead of Sinclair recommended resveratrol, a much less bioavailable stilbene). NMN will become mib-626 to benefit from nitric oxide etc. NMN only with TNG.

Third from Dr. de Grey, I get quercetin/dhaniya combination, quercetin because it is senolytic and dhaniya because it approximates apigenin well.

Fourth from Drs. Conboy and the possibility beyond even-fix Allopathy, the long term cure for diabetes and heart problems. I am ecstatic that my osteoarthritis is lessened significantly 1 year after Allopathy fix estimated 3-5 years! I should have undergone an extensive bone check X-ray, once per life at age 60, rather than wait to be hit at 65.

The precise kind of blood dilution for me is to decide by 2030. That gives Drs. Conboy and Dr. Kirpov to develop dilution further. The hope of medical break through for Singularity and also cancers is great strides in immunotherapy in conjunction with training immune cells by command and development of virtual thymus. Three medical conclusions from my 30-year study are

 

1. virtual thymus to fix white cells and reprogram them is what will solve aging and cancers

2. cancers and aging are strongly related problems of senescent cells doing nothing to becoming infinite-life tumor cells

3. YAMANAKA FACTORS CAN, and are being used to  generate drug and supplements, as intermittent pulsing low concentration of all but M form are possible in vivo.

New genetic medicine or cell focussed micro-surgery will allow genetic update in live beings.

Central to medical interventions beyond virtual thymus will be Yamanaka factors based drugs and supplements, different from immunotherapy attacks for eliminating cancer like component of aging.

SENS

3hour read based on slow clicks. It caught me in 2001, courtesy Aubrey, and has kept me going for 20 years. What has been done since is to launch all ideas and a polished version of the ideas today. Essential month long reading by clicking. See you then. My experience says 

1. Life details and plot to defeat aging is as absorbing as the best Sherlock Holmes.

2. Biology can be very interesting

3. Defeat of aging happens if all area below were done

4. They are not needed at once

5. Cancers are only a sub-part of aging! DNA molecules end in slowly shortening telomere per copy-rebirth. Cancerous cells all learn how to become infinite lives by telomerase or ALT means, from chromosomes in all cells.

One can fix cancers by anti-telomerase drugs (after a while all cancerous cells die), except that good stem cells  badly need it too. What now? Turns out stem-cells have a decade worth of reserves. So must be reinserted every decade if genetic drugs were used to remove telomerase genes in all cells! There are good analogies, suggestive of clever solutions, but all good solutions cause problems and the process happens repeatedly. Cancers are fascinating senescent genetic trouble because they mutate all the time. Patients go into remission, but evolution is milked by cancers, and cancer is back, now unhurt by the working drug!

Collectively, fixing these 7 things is needed in a thousand years, not all at once, giving me Bhishm opportunity. Colored are all clickable. Dr de Grey has used this table since 2001 without needing a change!

Program	Rejuvenation Biotechnology	Aging Damage	Year Discovered
A AmyloSENS	Immunotherapeutic clearance	Extracellular aggregates	19078
B ApoptoSENS	Targeted ablation	Death-resistant cells	19656
C GlycoSENS	AGE-breaking molecules; tissue engineering	Extracellular matrix stiffening	19586, 19817
D LysoSENS	Novel lysosomal hydro lases	Intracellular aggregates	19419, 195910
E MitoSENS	Allotropic expression of 13 proteins	Mitochondrial mutations	19724
F OncoSENS	Removal of telomere-lengthening machinery	Cancerous cells	19592, 19823
G RepleniSENS	Stem cells and tissue engineering	Cell loss, tissue atrophy	19551

Dr. Aubrey de Grey launches vitaDAO, capable of decentralized evolution, that I expect to the devastation of existing governments, markets, economics and motivations, and basis of all enterprise within a century, What happens after the first 1000 years is fictional by necessity and is likely migration to nano life on diamonds after brain transfer!

Immediate Future work

I have a colored view of partiality for my motherland and current host. The following are not just ideas of the Conboys and their laments, which must be considered as an opportunity for medical tourism to India. 

To 2021, strongly established as improvement in the condition of aged all over world with blood exchange or MRNA drugs and vaccines,within oversight of GOI, disbursed to states. The mechanism is very easy to waste using Inspector-raj and decentralization means state funding, which will severely hurt non-BJP nearly everywhere, and unfixable democratic return post all electorate defats from <same party tiredness>. 

Note the lament, NIH funds everyone but us. says Irina! She misses the fact that FDA-equivalent clinical trials will cost 10% in India. Greatness of India as provider will follow from extensive required patient-specific data, generated for free in patient cure, in blood exchange that has to follow a narrow path henceforth becoming like dialysis. US free compiteion delivers a long-term incentive to hide data, at least of failures in massive company searches. Intrinsic feature of free competetion and IP value system!

The idea is to extract patient blood, filter it to remove CD38 or TGF-beta1, either by filter or mRNA drugs or a few more, Blood filter needed for cancers! Blood fix of cancer return the filtered tit-rated blood back to the patient! No one else enters the picture, hence guaranteed free of any rejection. By how should the concentrations reduce? Patient centric with golden data to be generated. I do assume that our scientist can develop concentration-meters fast. The list at CD38 etc will grow, 20 years inprovement expected from first 2! Self-funded exponential growth, I will invest in PPP model company! Try form one if possible.

Open Doubts

Unlike a paper, there is still possibility from my ignorance or future research. That is how ndoubts happen. I suspect my type of mRNA vaccines can be done for small sets of similarly tainted Cancers. Few hundred year program there. I also suspect that hibernation will also require cancer-fix-like return medicine.

Concentration meters for measuring proteins to be filtered out wll be needed. List of bad proteins beyond CD38 and TGF-BETA1. Life-line gains expected. All this data is vital for smart diagnosis and will be generated for free from medical tourist patients, attracted by much lower costs, even if lower quality. Two third world aged are potential beneficiaries who will not be able to pay American costs, even decade gain in life matters.

Enemy cd38 and aging

 

The Latest Link

Demise of doctor uncle, bio-hackary on self

I consider myself an unlicensed aging doctor-like, no agreement by GOI, either will change my host government's POLICY or escape to a superior destination based on my USA passport. Till then, you should never do bio-hackery unless suggested by a licensed doctor and managed by a licensed doctor later! Note that my citizenship enables me to do bio-hackery on self.

CD38 has been mentioned as the villain chemical suspected to be antagonist to NAD+. Central to reducing (genetic) age, measurable by Horvath test which remarkably works for all eutherians (hence human and mice). Strongly suggesting the correctness of earlier Dr. Sinclair of earthier DNA which took 3 billion years to make and a billion years to evolve in to all life and us. First time in planet life, evolution is supplanted by the watch-maker, genetics humans and doctors, with time frames of a century, not geologic millions and billions. It is a natural product made by senescent cells (all villains) to escape the inflammation produced by NAD+. Their survival ages their host.

There are two strategies to eliminate CD38, target senescent cells(effectively generic cure cancer). Or target CD38. The group of drugs is called senolytes, anticipated in 2001- by Dr. de Grey, interesting to us being the supplement Quercetin that is is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine, onions, green tea, apples, berries, Ginkgo biloba, St. John's wort, American elder, and others. Buckwheat tea has a large amount of quercetin. Some people use quercetin as a medicine. Quercetin is most commonly used for conditions of the heart and blood vessels and to generic prevent cancer. It is also used for arthritis, bladder infections, and diabetes, but there is limited scientific evidence to support these uses. From my perception, Quercetin is also found great for antiaging and cancers, other uses save from FDA safety test of the drug,

This is a vital point for me. FDA clinical trials establish to my trust of two properties of a chemical or procedure, safety and efficacy. Efficacy is a secondary issue in all my applications. Safety targets of trials must account for wrongly identified patients and hence are safe for all. Hence, repurposing a drug implicitly establishes safety. Long use of a chemical also assumes safe within reported effects. Quercetin is like that. Hippocratic oath says your medicine in the worst case will not increase the disease! USA courts are stupidly deficient in this case, as evident from 40 year delay in stevia even when in wide use in Peru for 1500 years! Even today, Vitamin k2 is illegal in the USA! One can not save from attorney delays but failure to punish the proponent side severely for attorneys behavior is Un-American,

There are several significant groups of flavonoids, including anthocyanidins, flavanols, flavones, flavonols, flavonones and isoflavones. Flavones: These include luteolin and apigenin. Good sources of flavones are celery, parsley, various herbs and hot peppers. apigenin is particularly interesting because it reduces the amount of CD38 too. Particularly relevant is the fact that it is found in significant quantities with enough bioavailability in dried fruits of parsley and green leaves of parsley. Not found in India, but it is intermediate between dhaniya (coriander) and ajwaain (carom). Dhaniya can be used. In other words, dhaniya and quercetin (400-500)mg completes Dr. de Grey senolytes usage without a doctor monitor!

It is a matter of joy  that traditional food masala like chilies have uses. However, do not allow a brahmin-equivalent fool you into the great foresight of our ancestors!

If you want apigenin and quercetin only  (low cost senolytics of Dr. de Grey), you should investigate N-Stac product. My cheaper way is buy quercetin and get apigenin  benefits from dhaniya (coriander).

The inhibition of CD38 has been proven in NIH-sponsored studies to increase NAD+ tissue bioavailability greater than NMN or NR alone. A vital differentiating feature compared to generic NAD precursor supplements. 

Deliberate elided are reliable manufactures, amounts and doses schedule as patient-dependent  (culture, location, individual differences etc.), never mind the impact on convinced reader. Some day, undoing-aging doctors will help in starting and management based on patient with Horvath-inspired aging clocks! I will only support evidence-based Horvath-inspired aging-clocks proven , such a person has at least some properties of a true cell-doctor for undoing-aging.

Demise of doctor uncle, bio-hackary on self

 

My uncle passed away on ventilator, despite 2 doeses of vaccine, despite my protestations of dangers, he persisted in free medication of the very poor, daily without stop. He was the great Dr. K. K. Agrawal, who freed me to weep with the beneficiaries, released me with passage from sworn statement not to mention his name. I still have an unfilled hole to fill. RIP.

I consider myself an unlicensed aging doctor-like, no agreement by GOI, either change my government or escape to a superior destination based on my USA passport. Till then, never do bio-hackery unless suggested by a licensed doctor and managed by a licensed doctor later! Note that my citizenship enables me to do bio-hackery on self.

What is law and why needed

 

Following originates as why I became a diploma holder lawyer in cyberlaw. IRRELEVANT ARE LEGAL COMMENTS AND JUDGMENTS. It simply says why I can wrap normal human beings in a web of split-the-hair issues fairly easily and why is this kind of thinking needed in any document - to anticipate such attacks and fail them or use them to defend.

Any document is made of words. Collectively, it forms a case. In order to understand its meaning, every word has to be expanded in context. Being a semanticist of formal languages, it is clear that word meanings require multiple layers of context. For simplicity, context is assumed to be independent conflict able overlap of simple contexts. These range from legal population, entire case/document with explicit meanings, section and sentence. Large sized context implicitly surrounds every word. The full frame of each word requires massive context filling, mostly solvable using contexts. What makes even theoretic process hard is that all the full contexts demanded every word are rarely exp-licitly handled but elided with the assumption that they can be properly and unambiguously reconstructed, alas not so and even distinct with the author with time and slow change of word meaning.

In formal languages, it is called binding. Meaning of any word for a particular set of bindings is obtained by disambiguate d contexts. The very frame embedding a word may depend on binding. Conservative lawyers require contemporaneous binding as the authors. It is called lexical binding. Dynamic binding happens when all the Neo-lawyers change binding to the decision time frame. No matter what the old turkeys thought, what anyone understands today is what it means today! Clearly what a law means is what it means today, not that constructed by a foggy lawyer or translator who somehow reinterprets history!

There is lot more, may not be relevant to the reason of linking. Consider a robot. If command is spoken to the machine, an easy fix is to speak back what is understood in all complex cases. Simple commands should be executed at once. In complex or ambiguous cases, accent is needed for all derived command. ALL COMMANDS THAT ARE AMBIGUOUS ARE BEST HANDLED BY LISTING THE INTERPRETATIONS. SIMPLIFICATION IS POSSIBLE BY CONSTRAINING INTERPRETATIONS BY RESTRICTING TO A DOMAIN OF ACTION BY A WORD OR TWO. In any case, ambiguity is always possible and how situations are handled is critical. The ideal solution is restricting the action domain, and use simple subsets of natural languages. There is enormous similarity between formal and natural languages by thinking of each adjective or adverb as an abstract enumeration or other type or instance.

My asli language

Not implemented yet, it is a declarative language that provides gradual typing and program refinement from standard inefficient to specialized code. In other words, a program starts with an executable specification and is refined either by better implementation or specification. Every step is executable and implementable by applying delta program for the current code. FOR THIS PURPOSE, IT WILL IMPLEMENT PROCEDURES BY PROCEDURE VARIABLES AND HAVE A UNIQUE DIFFERENT WAY OF DEBUG ON PROJECT AND PRODUCT SITES. Never mind the frustrated laments of yesterday greats.

All the past great languages implemented great standard libraries that are agonistically usable. In terms of precise distinction of asli, the most basic is built-in compiler of attributed grammars doing simple context-sensitive things, without becoming general grammars, implementing special kind of nullification.

In fact, the included attribute grammar is powerful enough to implement arbitrary constraint possible in gene edit of CRISPR cas9. THE GENERIC GENE SLICE CAN BE RESTRICTED TO JUST SPECIFIED GENE PATTERN IN ONE PART OF DNA.