Two EQUI-AGE 27 yr SIMIANS L & R, UNTREATED AND TREATED BY CALORIE-RESTRICTION MIMICKED. TWO PICS EACH, U & D, FACES AND BODY. AN AUSSIE DOC CLAIMS AGE 60 ENERGETIC LIKE 30'S, FATHER FROM 78 TO EARLY SIXTY. My goal of 2045 (expected singularity) very likely with Metformin and Niagen - just must convince doc to rid of assisted sulfonylurea medications of ziten-20M (1000mg metformin but 20 mg sulfonylurea).
Next step, I posit, is IPS stem cells, tranformed in testtubes to more specialised, delivered by injection to cell reproduction sites, extreme accuracy not needed as in trees that live for 4000 years. That is the singularity I seek. Hope to start on Niagen within a year and expect long time to quell my fears and debilitations occasioned by my TBI.
First
convince yourself that Niagen is for you and it is not another Reservetrol.
If doubtful, quit. Rest of this document is about “how?” and “whether?”.
Whether?
Arun thinking?
Cells of animals tested are about our size. Hence for intracellular processes, per kg. weight scales.
Contraindications?
Why
bother increasing NAD+?
The discharged is NAD+ but there is NO KNOWN WAY of boosting the charged ie NADH.
Hearing loss
Diabetic side
effects and lipid profiles
Obesity and weight
loss or gain
NIH researchers find
potential target for reducing obesity-related inflammation
Asthma
Cognitive decline
and Alzheimer’s
Mitochondrial and
stem cell function
How
boost nad+?
Even
though the ability to isolate and synthesize by NR is new, there has already
been a great deal of research about boost. Every agent so far (like Resevtrol) is found in foods
but quantities are minute. Every other agent is VERY sensitive to environmental
and handling damage. NR is stable unlike reservetrol.
Why
now?
Much of research within just the past 5 years.
David Sinclair (reservetrol, paid 750 million for co in 2008) has changed and is only one of many who are
researching this.
Another
reservetrol?
Unlikely.
1.
“NAD+ repletion
improves mitochondrial and stem cell function and enhances life span in mice”
2. A number of known researchers were part of it,
most coming from Switzerland along with one from Brazil and one from Canada.
The paper suggests that using the NAD+ precursor, nicotinamide riboside, protects
aging mice against muscle degeneration. Similar effect were also seen in neural
stem cells.
3. Speaking of muscles, another study from 2014
suggested that restoration of healthy NAD+ levels resulted in a partial reversal
of skeletal muscle aging in old mice (23).
4. Two papers from 2014 looked at NR and mitochondrial
myopathy (24) (25).
5. Many look at its effect on broader
mitochondrial health and behavior (26) (27).
6. A few people have asked whether Niagen is
thought to benefit hair loss or grey hair, however we are aware of no
studies – neither animal or human – on those topics.
Business aspects
Is Niagen worth
buying?
Body of evidence suggesting NR may be beneficial vastly
outweighs anything there ever was for resveratrol, that’s for sure.
But setting aside the suspected health benefits/efficacy for a
moment, one of the biggest
dietary dosage benefits of nicotinamide riboside supplements is that they
are relatively stable. Unlike resveratrol which easily and rapidly degrades
from air, heat, and light exposure, NR stability seems to be comparable to many
other vitamins and nutrients in terms of shelf life and the amount of potency preserved.
Compare
that versus resveratrol bulk powder, tablets, and even the gel caps. With all
of those, it’s highly speculative as to how much of the active ingredient are
actually in them. Even more so after you repeatedly open and close a jar of
resveratrol powder. So before even considering the nicotinamide riboside
research, at least you can take comfort in that if you buy it, you’re getting
the substance you’re paying for versus some highly oxidized and degraded
powder.
Animals vs. humans,
study conclusions vs. proof?
Will sirtuin activation be the key to
increasing longevity in humans or not?
It’s
important to remember that the vast majority of studies involved to date
involve animal models taking high dosages. As we all know, not everything that
works well in mice or even rhesus monkeys will necessarily translate to human
biology.
With
those caveats said, it appears the hype – as least as of to date – is
justified, given the many promising studies so far suggesting its ability to
increase NAD+ levels. However further research and clinical trials will be
needed to verify whether or not the benefits are what many researchers suspect
them to be.
It’s
totally understandable why many say the gamble (as in, the money spent) to buy
a nicotinamide riboside supplement or powder is well worth it based on the
research.
Even
one of the world’s richest – Mr. Li Ka-Shing who is worth an
estimated $31 billion – is so compelled in this anti-aging research, that
he bought up approximately 20% of ChromaDex in April 2017.
If
you do purchase NR, remember that all the brands selling it are buying from
ChromaDex. Therefore, you may want to choose based on price rather than your
typical go-to brands. Especially since a daily regimen of a higher Niagen
dosage will not be cheap.
Use it how?
In
terms of capsules, you have plenty of competition and therefore, you might get
a better value per mg by going that route. It appears Live
Cell Research Niagen might be the most popular, based
solely on the number of reviews we see on Amazon for each
product.
These statements have not been evaluated
by the Food and Drug Administration. This product is not intended to diagnose,
treat, cure, or prevent any disease.
Arun's add
Niagen is available on amazon, people have posted reactions, about 1 yr. About half benefitted a lot, other half think its a scam. I suspect the beneficiaries exercised, scam believer's did not. Hence I advocate undiminished exercise with this add. I am and my father is, even debilitated. I think that improved nad+ is not enough or useful in absense of exercise. Will post experiences when done. Even if a scam, still only waste of money if it is, in worst case. If useful, can revert to 'flushing' B3! Very cheap since made in india! 5* reviewers sound +ve, 3* lazy. 1* depressed!
https://www.amazon.com/product-reviews/B00L5Q951S/ref=acr_dpx_see_all?ie=UTF8&reviewerType=avp_only_reviews&showViewpoints=1
55-45 considered 50-50
[5* reviewer]
I am a 65 year old female who has had cancer twice, and have been in remission from stage 4 metastatic cancer for 11 years, due in part I believe to a regimen of supplements including resveratrol, quercetin, Vitamin C, Vitamin D3, and many others. I also walk 3 miles per day, and have tried to avoid sugar and refined carbs for much of that time.
Throughout the years I have been following anti-aging and anti-cancer research, as a curious layperson. I have explored writings and videos by David Sinclair of Harvard, Leonard Guarente of MIT, and others, leading me to the recent reports on the postulated benefits to humans of NAD precursor, Nicotinimide Riboside. Leonard Guarente himself takes it, according to his Elyseum website.
I started taking the recommended dose in early February, 2015, and can report some positive results, although I believe the dosage level is critical and probably varies widely, depending on one’s age and health status.
My experience has been that the prescribed dose of 250 mg. is simply too much. It revved me up, but the rebound effect was very noticeable--exhaustion. A suitable analogy might be constantly gunning and red-lining one’s old, inefficient engine. So I cut back to a half dose every other day. Much better. I still feel energetic--and optimistic--but am not completely exhausted hours later after the initial burst of energy has waned.
It would certainly seem logical that younger, healthy, and/or athletic folks already have sufficient amounts of NAD, so they probably wouldn't notice much if any improvement from supplementation with NR. However, old folks have NAD deficiency as a result of aging, and probably see a much greater benefit from supplementation with NR. which increases NAD.
I am guessing that most of the folks reporting little or no benefit from NR are either younger & healthy and have plenty of NAD; or, perhaps are taking far more than they need, producing some sort of negative hormesis-like response; or are not taking complementary doses of resveratrol, or other pterostilbenes, which operate in tandem with NAD as a substrate to influence anti-aging sirtuins.
[3* middle]
I think this is a good product. I did notice a slight increase in energy. I just don't think the minor results justify the price. It may work better on other people. One odd note, I got a slight bit of tooth sensitivity when taking them. I have never had sensitive teeth so it was a bit of a surprise. Could just be me.
I have not notice anything except possibly a reduction in joint pain. This does not mean though that it isn't good for me on a cellular level but I have no way to measure that. Will continue use for awhile.
[1* useless]
