Monday, March 13, 2017

Chemistry and Physics of Disease




Dr Doherty said medical researchers could use the device (diamond tip molecular beam at nanoscale) to weigh and identify complex molecules such as proteins, which drive diseases, such as cancer, and cures for those diseases.

"Every great advance for microscopy has driven scientific revolution," he said.
"Our invention will help to solve many complex problems in a wide range of areas, including medical, environmental and biosecurity research."
Molecular MRI is a form of the common medical imaging technology that is capable of identifying the chemical composition of individual molecules, while mass spectrometers measure the masses within a sample.
Current work is like quantum basis for sonic screwdriver in Dr. Who or tri-corder in star trek. Generally beyond, when possible at all, the limited irrational thinking of humanities writers, say I. For way better than sci fi is my tech fi. You don't imagine potentially impossible theory driven artifacts, but possible artifacts economically possible in current known or likely known science.

THE paper

Relevance  to  medicine




Wednesday, March 8, 2017

Hqol Longevity research



This collects views summarized from referenced papers. Rather than just “why so, says who”, interspersed are many “why not”, some times answered, some times research. Aaqgs-authoring (questions=[sub]sections). Longevity alone is not the goal; (Hqol=High quality of life) and limited predictable steps are required. Philosophy is Hqol longevity seems possible with very limited side-effects and many positive ones. So why not do a small cost (time|money) effort and listen – worst case you will know why I am wrong!

Limitations: Following pragmatic once – strictly exercise and nutrition products. The loopholes allowing plants but not chemicals. Thus pain is alleviated by cannabis plant products.

Main herb-products – stevia (for sugar), aged-garlic for reducing glycation, haldi as anti-oxidant, Glutathione (never direct for bio avail) through L-cystine. Plenty of Morons sold Gutathione supplements, soaps, cream etc. Aging view: Telomeres shortening and enemy effects long-term of once-friend chemicals. Extrapolation – absent known exceptions – Telomere shortening can be prevented without causing cancer for 200 years.

Immortality view: Not possible in bio form, but in cyborg form in 200 years including ways to transfer consciousness. The extrapolation here is on-going success in marrying senses with robotic elements for limited replacement and paralysis overcoming goals i.e. required capital is application generated. No centralized like government with war aims or venture capital sugar-daddy is needed.
200 year life-view: max needed for cyborg development; in two parts. First sixty assumes no new technology. Second 80 years by hibernation cooling. Possible to cut energy-consumption, breathing etc of human complexity by 15% max. This means time is slowed by 50% max. Humans are NOT cold-blooded, hence best is like bear with temp drop to 80;s oF and breathing cut to half rate and energy from stored form to one per 3-days. Even then 80 years max is possible, organism aging at half rate. Technology for that kind of hibernation is possible in 30 years, and requires normal life extension to 90 years using ecp, Glutathione and anti-glycation, telomere shortening prevention for anti-cancer.

A solution is assumed for all big killers – heart by anti-oxidants and anti-glycation, cancers by telomere, Alzheimer by anti-glycation, standard microbes through anti-bionics, overall by ECP directed blood flow, cheerfulness through personality changing stoicism.

I am crazy enough to believe strongly in own theories. Since 50's (age) did 100 calorie exercise and high-protein diet-control anti-glycation. Changing to 3 half hour evenly spaced 70 calorie exercise. I am right, screw the critics, proof is in my latest HgA1C (6.0), Lipid (all in range), CBC (all in range). Never have had better results. Continuation with high-protein (whey+)  mediterranean diet is easy. 
Off-nitrates so sexuality is back.

But for episodic psyche (solution - wife + adoptions, line-marriage(Moon is harsh ...)?) problems, I will live to 95 normal, perhaps 120 pushed by ECP, cancers controlled by STEM cells, normal infections by antibiotics! Possibly await hibernation just starting. And there is so much to do, crispr itself means massive targeted genetic agriculture! My niece works in a genetic-cafe in Boston – you send them a sample and they grow it! Distributed 3D print in print-cafe makes union-elimination possible, only headache of current biggies. I can happily potter around busy for next 1000 years. Time enough to think of nextthousand!





Sunday, February 26, 2017

Controversial belief


A Two hundred year life

Mind expanding humerous survey of immortality ideas

If any moron finds doubts in linking document, there is no sense in being abused. Just lay off and we are happy being ships that pass each other on dark night. This presents belief that I have and trot out to be attacked on. It does not show weakness of belief but certainly of arguments for and lack of strong arguments against.

What the hell can non-MD know? Lot, compare to top quality TED MD!

Trick is careful empirical+nogo-theorem analysis.
  1. I think that all organisms age equally and uniformly at individual rates of course, but within a factor of 3, much faster some times but never slower than the best. This is strongly supportive of telomere-like hypothesis, which is a part of DNA, hence universal across animals and shortening on cell division hence age limiting. Once the telomerEs become too small, the organism dies. Cancer is simply telomeres that refuse to shorten, hence causing boil like harm to shortening telomere  tissue. However attractive be this theology, the empirical fact is there are birds where it does not dwindle etc. Scientists are not yet sure. But they have been able to use telomerase in the lab to keep human cells dividing far beyond their normal limit, and the cells do not become cancerous.
    If we used telomerase to "immortalize" human cells, we may be able to mass produce cells for transplantation, including insulin-producing cells to cure diabetes, muscle cells for treating muscular dystrophy, cartilage cells for certain kinds of arthritis, and skin cells for healing severe burns and wounds. An unlimited supply of normal human cells grown in the laboratory would also help efforts to test new drugs and gene therapies
  2. Alternate, NOT NECESSARILY EXCUSIVE,  hypothesis is that growth factors are absolutely needed till adulthood but turn around and cause disease past adult hood species-wide. It has support in humans when insulin needed by muscles becomes a major direct killer for diabetics through strokes and diabetes B and Alzheimer effect on brain in survivors. Top three killers, when one considers why, reduce to telomere shortening (cancer) and insulin. Just control of these 2 give up 120 year life! ECP gives blood flow. Inexpensive diabetes medicines are in use and well understood. Telomere needs to be researched. ECP, exercise and good diet (calories are killed by ECP and exercise, insulin levels aggressively controlled). A recipe most doctors will not object too
  3. Hibernation is one promising avenue. A lot is possible with small animals, However, once bear complexity is reached, temperature drops of 85 from 95 fahrenheit happens. That is different from sci fi, a tech fi (i.e. mine) limit of modest increase is best believed and plenty of competent people are already doing so! Like tech fi in general, science advances can only shorten the time-line! I only posit 80 year gain over next century, based on extrapolation, not faith, hibernation is not the only shot. 
  4. So the Dr. Path pronouncement after my impressive (for then 1998) power point presentation – won't help you but can't hurt – on statins/. Now consider above – ECP, exercise, aggressive insulin control, vitamin stuffing, anti-oxidants with Glutathione bio-availability, cheerful stoic disposition, I deserve another “won't help you but can't hurt”. Telomeres are different – likely need new biotechnology and stem cells. I believe if controlled in 30 years, we are talking high quality of life 110-120. We need another 80 years. But the 60 years from now likely will solve that gap.
  5. There is a particular reason for my cheer, with electronics/computer background. The progress functions are exponential, tremendous success happens in final few years, gain of 80 years life in 60+40 is not that weird! Capital for electronic-brain interface is there as it is greatly needed in rehabilitation of limb losers and stroke patients! I complimented my EEG technician 3 years ago and BBC introduced think-change-channels only 2 years ago and all the jeddi toys 1 year old.. Next very big advance happens when avatars can feel and report back on felt as sensations. Then new meaning to "almost there" starts. You can be spaceship, car racer or driver, NBA player, movie-star, professor any one? Briefly my tech-fi elysium!
  6. So summary of immortality my tech fi way is 60 years by ECP & anti-oxidants with glycation minimization; 80 years by hibernation and unlimited by cyborgification. True sci fi can only make it faster!
  7. Another different exciting way is the deGrey method.

------------------ disussion ropund about

This is a very good talk for the devotees of allopathic medicine. (me). I agree 100% .

The answer to drawbacks of allopathic medicine is NOT to revisit the lesser effective medicines of past! Trick is distinguish acute and chronic, limit allopathic medicine to acute and trust medical grads more for chronic. One thing I say CLEARLY, also found here, contrary to most allopathic medicine, is the belief that the root causes of chronic diseases unify to very few - glycation (sugars), telomeres (cancers) and anti-oxidants. Do just these, and 200 year life yours (28 years for Kurtweil, 150 for me) to singularity.

I have undergone many specialities, have come to sugars.Never had csancers but stem opposed telomeres are answers. Ant-ocidant for in-built ant-fraigility. Tough sugar control (exercise and diet & metmorphin+Teneligliptin) will do it (green tea, custartard apple,guvava etc for anti-oxidants, stoicism for true cheer) Above was lovely for me for here was a true MD agreeing with my conclusions!

Distinction between acute disease and chronic disease is not so clear cut. Many acute diseases have similar root causes as chronic diseases. For example, last week my daughter had strep throat three days after returning to US from India. We took her to our vaidya in the US, and she treated her without the antibiotics that an allopath would have surely prescribed. More interestingly, the vaidya examined her throat without any gloves or face masks. She said that she does not catch infection from her patients because her body (immune system, if you will) is healthy.

Failure to distinguish between chronic and acute diseases can be very hurtful as can differentiation between treatment-needed and transitory diseases can be on wallet and immunities.Clear applicable  language, like constitution, that can change but only with super majority of licensed stakeholders in treatment.for differentiation

Better word than false is less-effective.

The strep-throat episode I would place in transitory - allopaths are very good as diagnosing common colds as strep, common colds are way more common. I do not question your avoidance of antibiotics - develop resistance and BAD idea to use to be on safe side. I suspect homeopath would be as good as Vaidya! placebo WILL DO, AND colds can LOOK BAD. There is NO reasonable way using anecdotal data and any statistical will have sieve-like holes!

My own thinking is based on 1. proper allopath fix of acute problems 2. No ideas on effective prevention of similar recurrence but fine on exact, exotic diseases and my disbelief I could NOT have SO MANY bad genes given my father/mother free and upbringing ok. It follows then the chronic diseases sprang from one source – found insulin and telomere.

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HqolLongevity research


Chemistryand Physics of Diseasse


Agingfoods



Tuesday, February 7, 2017

Points on mathematics of aaqgs-cryption




NSA surprised me with no reaction, even from a colleague in one of the NSA funded several places saying in effect “but sq-rt in what modular base + not all integers are squares”. The key insight I have is that man-in-the-middle is the real enemy, not the factorization of the semi-prime, best never disclosed and done well. Silence means Okay to commercialize a technology with security implications. Second insight is that IBE can be super to RSA like KEM-DEM. Once man-in-middle is killed, ordinary well-studied RSA can be used. Resulting can be argued to be excellent without decade long study since RSA and Cocks are being used.

1. A J-nearest is necessary to convert a number to logically unique square. Almost 1/2 the modular numbers are square, So the gap bigger than 1 is infrequent. It can be covered by computing the Jacobi every time, which means effort be rounded by c*log n most of the time. Precise calculations are outside my pay grade,
2. There is a trick to reduce computation to 2 in all but negligible cases. The family administrator computes in family-semi-prime, the [name//'gap' = n] [name//”semi-prime”= n] tuples . Now J-nearest is by few evaluated simple checked adds.
3. [s/”feature” = n] is currently implemented by concatenating s and feature with a string n and delimiters then SHA-3 sq-rt is given n and value of concatenating s and feature and delimiters SHA-3 sq-rt again, all in implied mod. Entire record of any node is protected by its sq-rt in implied embedding, can be found and checked.
4. The author is simply a series of numbers after an ASCII or Unicode name. Post character name are numbers, my-semi // user-semi // my-proof. My-proof is generated at family insertion time and is check-able in sq-rt in nation-wide my-permit-for-year, can be checked since my-permit-for-year for current year is fixed & published semi-prime and ensures payment to me. Note that my-* are published, also communicated every year or enroll-time in consumer public. Consumer and I talk in consumer public and my public.
5. A retraction can be undone by building a new member. The user can reuse name with higher edition suffix.
6. Retraction is done by publishing factors of my-semi. Henceforth any one can claim to be you. Every year, factors of my-* used that year are published. No previous messages become opened.
7. Only authorized names can be allowed. This is as per policy of the jurisdiction.
8. There is an easy way to prevent misspellings. A large number of functions to Boolean are allowed as f(index,name) Names considered misspellings  in some index return bad, others good. A name is looked up before switching. A consumer is allowed to select a number of indices. In effect, a name is good if good in at least one chosen index. Any number of people are allowed to buy any number of indices (16 ASCII-64 characters), at $10 each!

Monday, February 6, 2017

On Road to Richest human ever on earth


Displayed here is the plan. It revolves around modular sq-rt only I on earth can do even though the inverse is modular squaring and can be done effortlessly in hardware. That is math. How can you make money from it? How much? Answer should shock you. Don't think like Cocks! First time ever, the money part is done. After all, I am not M!

You can do before and after but not just this. What is more, if you could, then either you reinvented me or most military encryption will fail, hence very unlikely you can even if NSA. I need no research plaudits. Can or not. Easy to smoke out worst me! I return sq-rt, which you can trivially square and check. That I compute and not keep a hidden shared table is easy to prove – two unconnected sites give same square root.

Remember that this is NOT math paper and all numbers don't have sq-rt and J-nearest is implicitly assumed.

Beyond true nonsense

How much money? There is internet 2.0 now. Next is not 3.0 but Aaqgs-internet 1.0. Why strictly superior? Impossible for a link to lead you astray! The current nonsense about clicking only known reasonable goes – how can you only click only reliable ones? In Aaqgs-internet, every site is as now, but prefixed with sq-rt(digest(<author><as-before>),number(author))) <author> . IN hardware without communication can the sq-rt squared and compared to digest at hardware speeds. The sit6emaker fetches the sq-rt from me once, good for any number of users. A consumer can reject unless author in reliable table. In fact, some function of author name may be treated as reliable and a monitor required clearance to be in that function's characteristic set. That is Aaqgs-internet 2.0 which will implement like to “on government service only” with the added charm of rejecting nefarious adds!

Why the money? Other great IBE can do it, but any exponentiation on several thousand bits is unlikely to be done at blazing speeds.


Safety from criminals – Cryptography security from even one bit change and from arbitrary authors (like not criminal but as bad adsters) can be rejected. I am protected from copy cats because sq-rt is not disclosed, even though security is from cryptographic means and NO ONE has to trust me (square to check!)!

Safety from intelligences - Assume NSA has nobus policy and can protect - the square root algorithm is useless if public! I protect myself from NSA by making sqrt public on any demise! It is enormously beneficial to USA if I exercise my citizen love for the land!

Determining competence (helps me!) says the true importance of claims here is gauged only by competent!