Controlled by checks and balance democracy:
The list of such professionals, licensed by the government on the basis of some recognized body, which can be removed too, on cause with the concurrence of court system. Laws by transparent checks and balances with forced agreement with supreme court.
Abstract: I
believe that Senescence cell doctors are basically distinct from
other doctors because they do not need to become jack of all trades
and because their fundamental treatment is only related to problems
within cells, fundamentally different from physicians who need to
understand body function in all random organs effected by differently
random diseases, often more than one. Limiting the specialty to cells
and strong ties to genetics community and molecular biologists enables Senescence doctors to
deal with all eukaryotes. The subject of aging applies to dog, cats,
mice etc. as well. The nucleus sack is the basic unification that
allows the development and treatment with mRNA drugs and vaccinations
to attack cancers of all kinds and aging of all eukaryotes. We must
allow all the great scientists mentioned, Dr. de Grey, Dr Sinclair,Drs. Conby and Dr. Horvath as fundamental scientist with MD like
opinion value and ability to practice cell medicine’ applied to
cancers and aging even though in most cases, they do not have MD
credentials. The invited will themselves act responsibly.
Advanced cancers are often considered untreatable anymore, and the focus shifts to control of pain in hospice setting and permission to use any weird technology by the care-givers routinely exploited by moron criminals. This might be acceptable behavior in MD community, but will not be of any senescence cell doctors. That is because both cancers and aging have a cellular basis, and the effort to control ailment in the patient must extend to the very last, even trying theoretically good novel chemicals. Death is no longer a necessary natural event but an admitted shame on the doctors on the state of recuperative art of the time. The ailment must be cellular and that distinction has to be continually refined.
Both aging and cancers are ailments of the cell. Cancers can be researched as one, based on genetic mutation of the effected cells. There is a generalization, which converts remit, post the drugs causing remit fail. THIS MAY BE FOR THE VIRUS TO MUTATE OR TOLERANCE DEVELOPMENT. Only true cancers here.
There is no discovered unification of aging. Certain defects in cells are called hallmarks, with Balkanized work on each. Cell medicine depends on molecular biology and genetics. The unification is mRNA drugs and vaccines, with training the immune system central. There is a hallmark, cell diseases, treatable by mRNA drugs or cousins and vaccines fixing patient immunity. Alternatively, treatment and cure by strengthening immune therapy. The treatment and cure is not by external magic drugs, but by inherent immunity training. Immunotherapy is removed from Allopathy. Some professional organization admits cell medicine professionals, by examination, unless invited.
The persistent diseases of diabetes, heart, osteo-whatsoever etc. are divided into treatment and cure. For cure, all legal systems. For treatment, only Allopathy.
A completely different disruptive new paradigm path is proposed here to use the machinery (IE mechanism) for mRNA for this purpose. I call it a hypothesis for fails my notion of science theory. But there are arguments to believe it represents likely path to undoing aging. First reference (Follows this) is to learn trivial underlying biology.
Increment to NAD+ is crucial to undoing aging. One basic goal of undoing aging is to increment NAD+ levels to what are in adults. NAD+ declines continuously with age.Synthesis of nicotinamide adenine dinucleotide (NAD+) decreases during aging, which is thought to limit the activity of enzymes that require it for their catalytic activity. Studies in animals indicate that replenishment of cellular NAD+ can have beneficial effects on aging and age-related diseases, but the situation in humans is less clear. Yoshino et al. report the effects of supplementation with the NAD+ precursor nicotinamide mononucleotide in overweight or obese postmenopausal women with prediabetes (see the Perspective by Hepler and Bass). The treatment improved insulin sensitivity in muscle, although a change in NAD+ content was not detected. The treatment also increased the expression of platelet-derived growth factor b. The results support potential therapeutic action of NAD+ supplementation in humans, but how various NAD+ precursors are processed in specific tissues remains to be fully explored.(science
NAD+ is a basic material used in Krebs cycle. It decrements because senescent cells, hallmarks of aging, are inflamed by NAD+ and generate CD38 poison to reduce NAD+. Every trick to boost NAD+ will fail because eventually CD38, whose concentration increases with age, will overwhelm the trick. Clearly, CD38 levels must be reduced periodically.
One direction being pursued by Group led by Drs. Conboy at UCB is to use Blood dilution and chemical metering to reduce any evil proteins by dialysis type machine. This method will expand graciously with research expanding the evil list to include TGF-beta etc.
The current state of the art is here.
I state a new disruptive paradigm here - use mRNA vaccination idea to remove nonliving proteins much smaller than viruses. The idea here is to train the immune system to recognize the evil proteins and eliminate them in the usual way. For this purpose, we use two properties of biological evolution of DNA and cells of DNA repair and sanctity of DNA by nucleus membrane. This method applies to cancers even when not caused by virus type of things, The paradigm where vaccines work without viruses is novel to all western modern medicine, away from germ theory of causation so strongly tied to it, instead of older systems missing the theory of germs. The idea of vaccinating for cancers and undoing aging seems opposed to modern medicine, since no new germs are postulated.
First, that every evil is legislated against by preventing any direct contact with DNA molecule inside the nucleus sack in eukaryote. All other methods will be destroyed by future evolution interlopers. It is like Dr. Sinclair idea of only surviving DNA to achieve exclusion of repair and replication by making them the opposite sides of logic of epi-gene, shut or not! The signal molecules cause the copy of some part of DNA into mRNA. It is this molecule that exits the eukaryote nucleus sac and can never go back. This mRNA unites with ribosomes of the cell external to the sack, constructs the encoded protein that then exits the cell. The mRNA self-destruct for important proteins to in few hours. They can never reenter the sack, like the perfect surviving solution of Sinclair! Most subsequent evolutionary products can not penetrate and hijack the DNA!
Somehow, horizontal gene transfer happens, although I state and believe in the theory of lost intermediate eukaryote species sexually compatible with both now incompatible species. This alternate explanation is possible given the low frequency of apparent horizontal transfer, despite the similarities of neighboring sequences in sexually incompatible species. Alternatively, there is still viral transmission theory with symbiotic role.
Second, if mRNA exit the cell, immune system kills them by eating. But it has to kill only a few that survive self-destruction. The mRNA are copied segments that have a different sugar, becoming Uracil on transcription!
Now comes an irrelevant point as to the recognition by immune system of improper cells - it may be because of memory of all the mRNA. Or any molecule with U is bad. The difference is on the attachment freedom to the evil protein. Whichever, the point is that any molecule that resembles mRNA in part is bad. The immune system killers destroy mRNA analogs and are also trained to consider the rest of the molecule bad too.
This makes the functioning of mRNA vaccines easy to follow. Consider one hypothetical vaccine for Covid-19. The virus feature selected is the spike protein. A molecule is constructed that joins one mRNA with the protein that
a) is easy to manufacture
b) looks non-toxic
Set of these molecules are tested on mice, human cells or both. The set is reduced usefulness and improved non-toxicity and triaged to a list of candidate for first small human trials. It takes weeks to prepare the candidates, but year to test to convincing levels of safety and efficacy.
My idea is to treat the bad proteins like CD38 to be an expanding list of chemicals of evil for which mRNA vaccines are built and treat cancers as mRNA vaccine for 1 patient! This is possible since building the molecule is measured in weeks and the real time will go in identifying the evil proteins, which will become easier with data per patient helped by recent use principality.
Specifically, knowing the molecule considered evil is smaller than a virus and is assumed small enough to not look for expressed features, which may be shared with useful proteins not to be targeted, An mRNA/evil mix is considered for safety. It will be used for cure, hoping that theoretical predictions are sufficient. Data for several trials is saved on per-patient basis and hopefully will be reusable soon. The data can be exchanged with similar programs.
Immunity period depends on per-protein basis and per-patient basis. It may vary from once a century basis to once-year basis. In any case, some patients will have a very long immune memory. Aged have another severe problem with vaccines - their immunity system is too weak (numerically) to eat the foreign objects. Hand-in-hand with vaccine solution must be an immune multiplier. Till that time, the vaccination solutions are for younger cancers and infections.
To summarize, treating by vaccine approach is possible since I fail to see the difference between surface expressed proteins to full proteins in most cases. Sites visited by immune cells exceed that are blood connected. BBB barriers don't exist.
Only comparable picture is physicists in 1927. Center is the saint Aubrey de Grey, SENS.
But the scientific community doesn't know what to make of him. In July 2005, the MIT Technology Review challenged scientists to disprove de Grey's claims, offering a $20,000 prize (half the prize money was put up by de Grey's Methuselah Foundation) to any molecular biologist who could demonstrate that "SENS is so wrong that it is unworthy of learned debate." The challenge remains open; the judging panel includes TEDsters Craig Venter and Nathan Myhrvold. It seems that "SENS exists in a middle ground of yet-to-be-tested ideas that some people may find intriguing but which others are free to doubt," MIT's judges wrote. And while they "don't compel the assent of many knowledgeable scientists," they're also "not demonstrably wrong."
Without sounding mean, my life has been unspoken incessant tragedies that made me stronger by the opportunity given because they never killed me. One of the bounties of Covid-19 is mRNA technology polishing, Even a successful company is called Moderna, using RNA as a suffix. RNA is not new, likely older to even first failing DNA a billion years ago. But its use to build new proteins is new, doing it industrially and eliminating kinks, is new. It is a perfect development for Aging.
What m,RNA is, should be crystal clear after this. The current article is about some of the myriad applications, in the near future, in Aging. That is why you must intern it to be able to judge the technology behind claims of novelty and usefulness of products.
Let us abbreviate greatly for new biology novices, even this simplicity was novel to me recently. Every Eutheria body is collection of trillions of cells, all derived from a single pluripotent cell in the womb and assisted-developed to adult-hood from a single pluripotent cell, about half from both parents from DNA which duplicated by unraveling the double helix. In computer science, every action by a program is a derivation from the start symbol, here is the fertilized zygote and repeatedly derived according to the grammar rules, till all nonterminals become terminals, the final program. In biology, complete derivation never ends and non-terminals remain as stem cells even at huge long life end. These are reactivated in wounds, just sleep after adulthood. All is done by blood carried signal molecules. It also carries some instructions from specialized organs for hormones. Growth happens by hormones and is stopped so. Hugely extended brain cells called neurons become nerves for analog signals.
For aging, important to consider single cells since the same structure, regardless of organs except brain is found in and aging happens at the cell level, a very recent find. Even if one keeps the structure perfect, aging will happen as cells age. Aging is normal at cell level, and cells avoid death by repeatedly becoming daughter cells. However, telomere at the end of DNA shorten on every division and there is a limit called Hay flick limit on number of divisions, this is about 50. Classic doctors subscribe to this and believe that undoing aging is a matter of telomeres, expressed by gene within the cell. The first shocker is cancer cells which become infinite lived solely by learning how to use the gene in DNA to infinite divisions. One must be super-careful to avoid cancer in all telomere manipulations. The second shocker is the presence of animals whose telomeres never shorten, but they die all the same! So this possible but unreal story is wrong. Current scientifically established theory is genetic by Dr. Sinclair. It focuses on DNA repair in the nucleolus. By forcing exclusion of repair and duplication rules by error-free perfect means by repair and duplication states logical inverses, One is trivially shut when the other is active. In fact, super centenarians all have robust DNA repairs. Sinclair won the mechanism race by two repeatable empirical tests, one aged one of a twin pair of twin mice and second by crushing the optical nerve of a mouse and restoring it by topical chemical use (NAD+).
Regardless of chemical needed, a protein is generated either by the DNA lording all, by mRNA which emerge, are grabbed by the right ribosome and protein is built and exits the cell. The messenger RNA (mRNA) is almost a copy of small part of DNA except that it is single strand and contains a U instead of a T – uracil instead of thymine. A signal molecule from outside enters the nucleus, excites the DNA, compelled to emit an mRNA which exits the nucleus. While never encountered in text, all mRNAs are known bad in Blood, immune knows all kinds are bad, (says my evolution part. Hard for nature to preset killers for just all mRNA More likely all Uracil having molecules are bad, needed natural immune complexity there! Whatever rest of the molecule is bad too and that is how the killers learn.) A lot of evolution is simple natural means to solve hard human problems! Just exclusionary DNA repair means all life on earth. Only one kind on earth DNA means likely compatible life in Universe! Many forms that failed evolution lottery on earth will exist in other planets.
The mitochondria generate and release energy in ATP-ADP cycle and have their own 13 unit DNA. Very recently by clever means, mitochondria were fixed by harvests (70%), new DNA for mitochondria, inserted, and replaced, all in living mouse! Holy crap! This technique can be extended to extraction and replacement of ribosomes and in live humans! Another giant step to defeat of aging.
The process that converts signal molecule to DNA to mRNA to protein is the foundation for how the cell functions. The mitochondria probably be segregated to other cells, or is their presence needed by evolution? Reduced NAD+ inflammation with senescent cells might be a reason.
How do mRNA vaccines work
We outlined enough to understand the sequence of steps. From above, I ask as my Socrates brain, after mRNA emerges from the nucleus.
Can it go back, say, for disposal?
Evolution imposes the rule - No going back! Grossly unsafe, all virus kinds will love it. No mRNA allowed returning!
So how disposed?
Self-destruction, minutes for high proteins, hours at most!
What if it emerges from the cell?
The change in at least one sugar is enough to allow target all RNA by immune system. Additional benefit in Eutheria.
How does mRNA vaccine work?
An mRNA is found to unite with spike protein in Covid-19 case, the compound can't be toxic. Vaccine allow it in blood. If any viruses present, some mRNA sticks. By immunology, all RNA in blood are bad. So they get eaten. Of the rest, some remains in blood and some enter cells. They die inside by self-destruction. Fraction outside are eaten by killers, training them. Later when virus comes, spike-protein launches love to death killers. How train? Remember that mRNA had the spike protein not wanted by vaccine maker. Being partly mRNA, it was bad. Because part of the spike protein was attached, immune cells believe not only mRNA is bad, so is the attached spike protein!
Lesson learned
To kill a virus, one looks for an expressed protein on the surface for which a good mRNA can be found. Next, one uses mice and/or human cell cultures to make candidates by keeping only those which appear safe. Next theory is applied to reject candidates based on harm before. The remainder molecule are triaged to first small human tests. COMES fda-2, ELIDED BY SPUTNIK TO fda-3 AT ONCE. WORKS OFTEN BUT LOWER SAFETY. After all, safe in some humans for some time. Sinopharm, likely example of fail if fda-2 and fda-3 were there. In effect, Seychelles, UAE and many other China vaccine users did the FDA-3 and flunked the vaccine!
Arun Arya generic transform
Nice example of deep understanding of some subject is candidate ideas in Aging of new products and understanding of others. Let us apply the ArunArya transform that will be used to create new kind of programming. For aging, let us keep the protein and mRNA variable. Then the procedure is find the protein, select mRNA for it, train the killer cells and kill them.
Application in Aging
I believe it will be major and many targets. First I pose it and later consider Angel investors. To apply to aging, let us identify the villain. For now, we limit to CD38 and TGF-beta. One way to eliminate them is by filtering blood by concentration meters. A completely different novel technique is to find good mRNA that will attach to the bastards. Imagine the beauty of the slaughter by natural immune killers trained to kill the bastards, trained by RNA attachments to the bastards. Till a vaccine is developed and tested, drugs can be used for periodic reduction in strength. In other words, new classes by vaccine or drug of senolytics. It will be great to get vaccines for expanding class of bastards - how to expand your life by vaccines and periodic revaccination (100 years?) for some, for healthy age increment purpose. For some, once is good enough, as the immune cells for them retain memory forever. Even that might need slower reactivation. If USA style fish eat fish applies to companies, then maybe we will embark on posthumen form of life even before 1000 years.
As recounted by Lady Conboy, before 2005, prior to their earth-shattering work, they could not move forward in parbiosis work till fix required funds for research. Beyond the other donnés, stepped up Dr de Grey and solved funding and expertise (suggested and convinced two capable technician fellows to work). Rest is history. It reminded me of Bhama shah. I don’t need one for money. But I do need capable technicians. And someone in our group to sound on by email. Best would be a new doctor uncle. Oh, I miss him.
I did write up my work to a form good enough for me.
Tech-fi and consistent sci-fi are my invention neologisms. The title "Tech-fi on life after the first thousand from now" indicates that the technology applications will take unspecified time to become profitable, but no new science is postulated. Consistent sci-fi is that the series explores derived possibilities of the raw science imagined, as well as strong believers constitute consistent explored civilizations. Star Wars and Star Trek are both consistent sci-fi. If current science postulates sufficiently widely a contrary principle, then that branch of sci-fi becomes dead. Jules Verne classics and "back to future" are bad sci-fi, to be passed sci-fantasy, because antigravity and time travel respectively are anti-science. Consistent sci-fi do not include, but do have Star Trek imaginations which while true flights of fancy, are still non-contradictory.
After the first ageless 1000 years, the sane majority of life forms will allow their brains to be blown up to huge sizes using MIT 2010 decade technology developments, transfer their brains on digital memories and weights on huge robotic nets, to enable a recreation of similar net, as nano particles on diamonds, as the brain. Once that is done, light speed travel, and safety against all types of dangers becomes possible, even true immortality assuming correctly that unlimited dangers have very local limits forever. Regardless of length of time in any matter coordinate system, the time elapse for photons is zero! So optical information needs to revert to diamond form only after unlimited travel.
What is an advanced brain?
It can be answered today with some certainty. It is many functional units composed by pipeline. Each unit can be implemented securely by read only functions operating on two kinds of data, write-once and variables, with fixed locations or pointers. The data is separate from code and organized as series of snapshots connected by lists of transactions which each keep an implicit record of what was done, why, and by whom etc. Each function begins with an event which schedules in a set of closures dynamically bound to that function. It terminates in another dynamically bound post-event to which various sanity-checking closures can attach. Closures imply coroutines which can share variables. The entire program is a process which cannot share any variables, but can share write once. The program flow can be normal or automatically instantiated from semi-context-sensitive grammars on events. The semis have singe global nullable non-terminal but nulled just once at the end. It represents time.This models coroutines and machine learning (an opaque functional coroutine) both.
I am predicting that even full first order logic will not be doable by ml machines. There is nothing intuitive about the logic. Unlike human brain, two independent units can ML-compute a function and the difference, thus operate differently from neural brains. However, complex units will have two levels with one normal circuit level over ML-level.
To be done.
Arun Arya View
No point reading for entertainment, documents MY plan, available for free for Cathedral and the Bazar reasons.
It is not sci-fi. The path to Bhishma-like wish-death is open to me and I will probably not die , but will a huge number aged of today since they will not do the right precondition to aging singularity and not realize it when it comes. It will not be celebrated as an event, but will simply mark a timeline event in 2050 histories and later. Prior to details, diabnetes drugs extend life of patients and non-patients. It is likely strange consequence of coincidences of two common drugs metrformin and acarbose, which have lack of age benefits from their counterpart drugs. Every one praises metformin, 1/2 gm twice a day.
Belief triage on aging?
There are three Doctor units only listened to, for own skeptical aging analysis to TRS. Each one of them have acquaintance in me to their work in 2000 to 2010. Every other opinion is likely rejected outright, not even submitting to other intellectual opinion that requires acceptable proof of accomplishment. Unless endorsed by them. These are Dr de Grey of SENS and "apigenin + quercetin" fame, Dr. Sinclair at Harvard after MIT, (nmn+pterostilbene) and massive journalist of USA fame, and Drs. Conboy at UCB of parbiosis and "Diluting blood plasma rejuvenates tissue, reverses aging in mice" fame. There are only 4 methods they advocate that are in my powers today and 2 require medical help. The singularity I await is medical professionals or bio-hackers like me, reaching that point that one extra year of life is expected in every calendar year for 20 years known. My prediction is 2030. For all steps, Dr de Gey predicts 2036. I consider age extension to then be possible with fewer extensions mentioned here.
By massive confusion I learned that Irine Conboy is no longer in UCB medical school, but now the vice-president of UCB!
The works that established these doctors as great scientists is based on pioneering work in the decade of 2000-2010 and great work done since. Dr. de Grey mentioned senolytic drugs and outlined mouse-extension challenge (2000 decade). He funded the Drs. Conboy study. He has since advocated startups and medical tourism in 2010 decade. Drs. Conboy proved experimentally by parbiosys that young mice become old by getting old partners and old become younger. Last decade, they experimentally showed that direct transfer of blood ages the young but gives minute benefits to the old. Another painffully slow but exquisite experiment showed that blood dilution was enough! Dr. Sinclair discovered resveratrol in 2004 and nmn in the decade of 2010. The decade also saw the emergence of Dr. Horvath and the Horvath bioage clock that establishes a great magic link between bioage from genetics and calendar age, also predicted remainder of life to death, the grim age! Starting the decade of 2021, the bioage tables were shown to be valid in all eutherians! New young doctors like my niece are still taught that telomere length dictates age!
Arun Arya Methods of age improvement by self decided interventions?
So far careful hypothesis formation. Based on my epistemology, conclusive scientific results by pre and post Horvath bio-age. Either it works as expected, or failure refines the next try. Getting ready for small try, welcome any one interested in own empirical try with me (own costs but none of mine either, likely to become historical, no effects beyond failure, expected small improvement in worst case).
First is aping evolution and experiments of past 50 years. These are ONLY 2 methods that guarantee healthy extension, proper fasting and exercise to all eutherians (proper is crucial since improper fasting may weaken immune nsystem). This kingdom of eutherians is invoked by me for these reasons
0. Proper is judged only by registered medical scientists in responsible situations.
1. Eutherians have similar DNA. Regardless of skeptical motherfuckers, aging, says my 20-year study, is a genetic consequence, with DNA editing basic. Proof: Horvath bio-clock works in all of them. Establishes Dr. Sinclair's aging theory solidly in me and seems to apply to all cellular life, even stars. It requires development of one way surround of DNA to prevent total hijack and of mRNA distinct from DNA to allow protein synthesis, but to reduce infections by immune adaptation.
2. Humans and mice are both eutherians, so are yeasts. Hence, many experiments can be done on yeasts/mice, and possible failure in human is possible but unusual, defined by proper prefix, often elided but always there. The sequence 1) (mice/.. works)|(human-cells works) 2) (First-few-volunteers works) 3) (large-number volunteers works) will work. For danger-love people, they can volunteer after 2-steps. Deliberately and knowledgeably I mention 3 sequential steps, applicable to applied chemicals, medicine and vaccines. Only FDA-2 is elided for speed reasons.
3. Theoretical derivations may suggest some results, excellent hypothesis, but my epistemology requires confirmation experiments, only allowing interpolations on continuous differential functions polynomially interpolatively. People might volunteer but can not adopt any but interpolations, and never extrapolations. Almost all Eutheria health functions known to me are interpolating able.
These principles I state as minimum required by me to accept any claims to aging cure. It is possible I miss out on some miracles, but sticking to them will certainly save me valuable time.
Second, I use NMN and Pterostilbene (instead of Sinclair recommended resveratrol, a much less bioavailable stilbene). NMN will become mib-626 to benefit from nitric oxide etc. NMN only with TNG.
Third from Dr. de Grey, I get quercetin/dhaniya combination, quercetin because it is senolytic and dhaniya because it approximates apigenin well.
Fourth from Drs. Conboy and the possibility beyond even-fix Allopathy, the long term cure for diabetes and heart problems. I am ecstatic that my osteoarthritis is lessened significantly 1 year after Allopathy fix estimated 3-5 years! I should have undergone an extensive bone check X-ray, once per life at age 60, rather than wait to be hit at 65.
The precise kind of blood dilution for me is to decide by 2030. That gives Drs. Conboy and Dr. Kirpov to develop dilution further. The hope of medical break through for Singularity and also cancers is great strides in immunotherapy in conjunction with training immune cells by command and development of virtual thymus. Three medical conclusions from my 30-year study are
1. virtual thymus to fix white cells and reprogram them is what will solve aging and cancers
2. cancers and aging are strongly related problems of senescent cells doing nothing to becoming infinite-life tumor cells
3. YAMANAKA FACTORS CAN, and are being used to generate drug and supplements, as intermittent pulsing low concentration of all but M form are possible in vivo.
New genetic medicine or cell focussed micro-surgery will allow genetic update in live beings.
Central to medical interventions beyond virtual thymus will be Yamanaka factors based drugs and supplements, different from immunotherapy attacks for eliminating cancer like component of aging.
SENS
3hour read based on slow clicks. It caught me in 2001, courtesy Aubrey, and has kept me going for 20 years. What has been done since is to launch all ideas and a polished version of the ideas today. Essential month long reading by clicking. See you then. My experience says
1. Life details and plot to defeat aging is as absorbing as the best Sherlock Holmes.
2. Biology can be very interesting
3. Defeat of aging happens if all area below were done
4. They are not needed at once
5. Cancers are only a sub-part of aging! DNA molecules end in slowly shortening telomere per copy-rebirth. Cancerous cells all learn how to become infinite lives by telomerase or ALT means, from chromosomes in all cells.
One can fix cancers by anti-telomerase drugs (after a while all cancerous cells die), except that good stem cells badly need it too. What now? Turns out stem-cells have a decade worth of reserves. So must be reinserted every decade if genetic drugs were used to remove telomerase genes in all cells! There are good analogies, suggestive of clever solutions, but all good solutions cause problems and the process happens repeatedly. Cancers are fascinating senescent genetic trouble because they mutate all the time. Patients go into remission, but evolution is milked by cancers, and cancer is back, now unhurt by the working drug!
Collectively, fixing these 7 things is needed in a thousand years, not all at once, giving me Bhishm opportunity. Colored are all clickable. Dr de Grey has used this table since 2001 without needing a change!
| Program | Rejuvenation Biotechnology | Aging Damage | Year Discovered |
|---|---|---|---|
Immunotherapeutic clearance | Extracellular aggregates | 19078 | |
Targeted ablation | Death-resistant cells | 19656 | |
AGE-breaking molecules; tissue engineering | Extracellular matrix stiffening | 19586, 19817 | |
Novel lysosomal hydro lases | Intracellular aggregates | 19419, 195910 | |
Allotropic expression of 13 proteins | Mitochondrial mutations | 19724 | |
Removal of telomere-lengthening machinery | Cancerous cells | 19592, 19823 | |
Stem cells and tissue engineering | Cell loss, tissue atrophy | 19551 |
Dr. Aubrey de Grey launches vitaDAO, capable of decentralized evolution, that I expect to the devastation of existing governments, markets, economics and motivations, and basis of all enterprise within a century, What happens after the first 1000 years is fictional by necessity and is likely migration to nano life on diamonds after brain transfer!
Immediate Future work
I have a colored view of partiality for my motherland and current host. The following are not just ideas of the Conboys and their laments, which must be considered as an opportunity for medical tourism to India.
To 2021, strongly established as improvement in the condition of aged all over world with blood exchange or MRNA drugs and vaccines,within oversight of GOI, disbursed to states. The mechanism is very easy to waste using Inspector-raj and decentralization means state funding, which will severely hurt non-BJP nearly everywhere, and unfixable democratic return post all electorate defats from <same party tiredness>.
Note the lament, NIH funds everyone but us. says Irina! She
misses the fact that FDA-equivalent clinical trials will cost 10% in
India. Greatness of India as provider will follow from extensive
required patient-specific data, generated for free in patient cure,
in blood exchange that has to follow a narrow path henceforth
becoming like dialysis. US free compiteion delivers a long-term incentive to hide data, at least of failures in massive company searches. Intrinsic feature of free competetion and IP value system!
The idea is to extract patient blood, filter it to remove CD38 or TGF-beta1, either by filter or mRNA drugs or a few more, Blood filter needed for cancers! Blood fix of cancer return the filtered tit-rated blood back to the patient! No one else enters the picture, hence guaranteed free of any rejection. By how should the concentrations reduce? Patient centric with golden data to be generated. I do assume that our scientist can develop concentration-meters fast. The list at CD38 etc will grow, 20 years inprovement expected from first 2! Self-funded exponential growth, I will invest in PPP model company! Try form one if possible.
Open Doubts
Unlike a paper, there is still possibility from my ignorance or future research. That is how ndoubts happen. I suspect my type of mRNA vaccines can be done for small sets of similarly tainted Cancers. Few hundred year program there. I also suspect that hibernation will also require cancer-fix-like return medicine.
Concentration meters for measuring proteins to be filtered out wll be needed. List of bad proteins beyond CD38 and TGF-BETA1. Life-line gains expected. All this data is vital for smart diagnosis and will be generated for free from medical tourist patients, attracted by much lower costs, even if lower quality. Two third world aged are potential beneficiaries who will not be able to pay American costs, even decade gain in life matters.
