From investigator to manager

Last 30 years has led me to read and philosophize about many systems of thought. Overall, however, a scientific epistemology has guided me and saved me from many lazy-accepted or experience=OIE driven models. There is still the scientific method in me that requires me to doubt and question, even when I conform for that is the thing to do.

Three questions were basic beyond the simplistic observations – a weltanschauung – what was the reality I was bathed in, how could I prolong my and parent’s interesting lives and determine answers to relevant question without manipulation and bias.

And I obtained answers satisfactory to me, consistent to treatments of aging disease (FDA does not think it is, I do), is consistent with modern medicine and lovely growable. Modern medicine is extrapolated to be best possible for acute phases and measurements in chronic diseases but limited in chronic diseases from study method limitations in chronic diseases when acute disease-like studies work on successful treatment of short episodes but NO solution as good for underlying disease! In fact, acute episodes in chronic care are still best handled by mm care!

Aging is a chronic disease. Strongest telltale signs are measurable chemical constant decline with age! Only long studies can ascertain if the right treatment is followed. Till then, acute care studies are needed. These however have a different meaning in my aaqgs treatment. An acute study returns three values – harmful, useful, and irrelevant. All harmful effects are obeyed. Useful effects are supported. However, once useful but now useless but unhurt full things consistent with sensible theory are okay.

1 Some supplements are ok, even if useless. However, supplement-usefulness may be cultural, e.g. cur cumin makes sense in the west but not in India.

2 Some supplement add are sensible based on long experience of native medicine but may be just harmless in west, e.g. trikatu. Even if known, the patented perfection, i.e. bioPerine® may or may not be extra-effective or even worse.

3 One must distinguish between quality hypothesization and study. The latter may result in less ambiguous high-quality results but may take time. Then quick informal but independently tested studies on hypothesis make sense in parallel to formal studies. That is certainly true with Niagen™ and claim of enhanced nicotanamide riboside (unless licensed) with integral trikatu by aaqgs. As a further proof, convincing to me, trikatu coq10 enhanced regular coq10 for me and will be tried by wife and parents.

Functions as manager

Given that Niagen™, CoQ10, Metformin and ECP have passed my filters over long study of literature (have avoided Reservetrol and Glutathione, yesterday hype) it follows need to

1.    

  Decide on endurance tests

 Dosages, justifications, (NR before meals, coQ10 with meals, ECP only after 1year gap etc)

Combination and when

  Stoppage and when (Niagen™ must be stopped 3 days after bottle out etc)

5Research on purchase quality, prices, taxes & source

What to add, when and how

What to remove, when and replacement

In short, My (six week retreat + see Delhi) idea makes sense! Staying at my site ensures healthy relevant food. ECP requires that long anyway! The idea of at-cost service for friends and relatives is useful for commercial side – new scientific ideas, no religious bullshit but free to believe whatever,  to defeat age-old problem of aging.

 Motto – how to die young at very old age!

Comed Product Ideas - Trikatu Niagen and Trikatu Metformin

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Sane (= scientific anti-religion anti-political)  life extension readings are central to me.

Trikatu is a famous Ayurvedic product.

·         Trikatu literally means "three pungents," it contains the herbs Black Pepper, Indian Long Pepper and Ginger

·         Supports the body's natural cleansing process

·         Supports gastric function and digestion

·         Supports the bioavailability of other nutrients by supporting normal absorption through the gastrointestinal tract

·         Traditional practitioners also use Trikatu to support normal function of the respiratory system and normal urinary tract function

It is supposed to increase the availability of other nutrients bysupporting normal absorption through the gastrointestinal tract. It may improve Niagen absorption! Remember the 3-aaqgs-barriers - stomach-blood, blood-cell-wall and mitochondria barriers. Latter requires equivalent of wittig reaction and may not even exist in many cases. The blood barrier may require IVF, injection route or large consumption assuming that some fraction goes through. Direct blood route demands exceptional purity and post-digestion chemicals. To avoid all kinds of problems, as in Glutathione, increased amount of chemical is better, but there are digestion effects and costs to consider. Trikatu supplementation, if it works, makes sense and trikatu itself is effect-less or positive effects when there is NO reaction with components of any significance- so says Ayurveda to me.

So my idea is Trikatu Niagen. Extensive works shows that 5 gm per Niagen pill is sufficient. So the idea is 250 mg Niagen with 2 gm trikatu. Increases the cost some, but is likely to improve Niagen effect, as experimented on self. None of Trikatu ingredients seem to have any chemical reaction with nicotanamide riboside. So I can try on self – 1 month plain and one month trikatu. I have also asked bioPerine people if they get interested. Note that bioPerine is basically a patented perfected form of trikatu.

My interest in this formulation is from bioPerine coQ10 which effectively works so that 1 pill is equivalent to double dosage to me! May be trikatu or bioPerine Niagen works as if 500 mg of Niagen were taken! The Niagen dose of 250-500 mg seems to work best. For cost reasons, I experiment with 250 m. I send a copy to Patanjali as well.

 The idea behind Trikatu Metformin is similar. Along with Niagen and coQ10, this is the only product considered aaqgs-proven for age-extension.

Disclaimer: FDA does not have endorsements of any age extension products. Above is only considered aaqgs-rational, enough only for self-trial.

The Real criminals in my aaqgs-weltanschauung

Goals of a weltanschaunng are simple - have a model of universe to know reality, of aging to decide on pattern of living, and of people to decide how the collective i.e. society acts. This is continuous investigations into behavior.

The unimaginable perfect way to criminality is become unconscious responsible criminals that oversee law! Responsibility, in aaqgs weltanschauung, overrides unconscious intent, hence existing lawyers and judges are philosophically jail-worthy guilty of unleashing fine-print-devil in guise of stare decisis. It follows that even if one court successfully leashes this devil, then by stare decisis, it stands in all courts in hierarchy or mutually respectful (base of law like Indian evidence act 1872 from Britain, also see USA rules).

The aaqgs solution i.e. mine is very simple – the semantics of any text is determined not by careful legal reading, but by a jury cursorily (time decided by legal determination).  Only if the defence has taken steps to ensure understanding (decided by cursory legality), will deeper semantics prevail. If excess time is required than the defender is guilty of attempting evil advertisement! If the lawyer is judged to waste time of court by advancing arguments judged to be fail-worthy by another judge, jailed (requires videotaping but not publication of tape). If a judge allows significant illegality, then judge jailed. The entire appeal system needs to be corrected! It’s like license-raj monstrosity in India. By required videotaping and possibility of adverse judgment on same facts, everyone is forced to be vigilant and fair!

My weltanschauung fails to distinguish between incompetent and criminal. From victim’s point-of-view, what’s the difference? Upper elements in a hierarchy, particularly job-givers, must be rewarded or punished, based on performance of the selected based on votes cast confidentially, consistent with reservation scheme, over some years like 1-3. This also applies to teachers, based on taxes paid by taught, once they turn, say 25, to say 35, diminished by that paid by parents, equally compared, corrected by inflation and national growth etc.

Roughly, I believe in skin-in-the-game and systems constructed such that it can be measured and be rewarded or punished, based on objectives of the system. For me, happiness means with high probability, a robust long behaviorally-happy life and outside chance of singularity, with needs consistent with what I own. In my sense I am happy and have set up world to remain so, improving some thru software and writings, and sisters' help, barring unforeseen.

Niagen best way

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IF you know 3 Americans WELL and they are interested in your health, you are convinced by Niagen and by my arguments why it will not fail like last (Reservetrol) hype, then the cheapest by my very extensive research is six pack by alive which is six bottles good for 250 mg per day for all year. Ask someone to send two each (or directly to you from 3 people in 3 parcels with names, ask senders for money). In this case, each gift is under R10,000, hence tax-free. Each person should affix, on top of each package a note loosely saying

MUST be removed by customs

Gift from <name, address>

To <name address>

Valued at 64*80 Rs. Hence way under 10,000

Customs may or may not remove the note, but MUCH better than putting a bill inside (then very likely a sale, not gift).

You can get Niagen for $20 a month. Most prices are near $40 per month. HPN is second best at $24 per month.

Horrible trick

Regardless of production and marketing reasons advanced, I consider following thug-like evil trick, indulged by MANY sellers of supplements, each horrible! This is distinction between serving and capsules, only clear by careful perusal of ad! CONSIDER THIS AD. Each capsule is 125mg, since each serving is 2 capsules. By twisted language, fast cursory consumers are fooled. Another common trick is "up to 40 %s off" or like, where the reference set is 100 items with NO discount, and one that nobody wants discounted 40%. I consider lawyers and judges allowing that philosophically jail-deservng responsible criminals, and requires, in my weltanschauung for semantics to be deciphered by legally-decided cursory reading by a jury! All kinds of fine print subhumans can be jailed. By holding law responsible, customary abuses can be handled even if cast in stone by stare decisis. Last is, in my weltanschauung, evil, not the basis of reasonable law!

March to Singularity – Tissue Nanotransfection

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There are 4 take-home from here

1.       How to predict an exponential process

2.       Singularity I seek

3.       Why this work is revolutionary for aging

4.       Why this work is on self-funding trajectory

Prediction on an exponential process is very hard, impossible by polynomial extrapolation, hence fundamentally anti-faith, i.e. mother-fuck the believers. Problem is that all polynomial extrapolation fails. You can still aaqgs-predict

1 By extrapolating on log or log-log graph. Crucial is predicting the polymerization of the process. Crucial also is time based resource-graph which has two y (an entity and resource) compared for same x i.e. time, population or money etc.

2 Predict by required steps, inter-step development is difficult to time-predict. What is required here is to have some idea of goal-sought and a feasible process to achieve the steps eventually. The requirement of existing science makes the process tech fi, far more believable than sci fi.

Indefinite life is a goal. One can chase quixotic dreams. Or lay out a tech fi process which cqan only go faster with sci fi developments. I am waiting for a singularity for robust lifespan in thousands of years within my achievable life span, time enough to deal with mental issues in TBI.

Since robust lifespan increase I look for, to increase lifespan, one has to deal with big-killer diseases that for now are heart failures, strokes and cancers. Within 20 years can be postulated turbine pumps that can surgically provide better pumping. To that day are coQ10 and ECP techniques.

Cancers are forestalled by greatly increasing sell density in tissues. That can be done by injecting stem cells in division areas. The idea is one of the cell lives – either a copy of the division cell smarter than the more robust but less experienced stem cell. Where will proper specialized cells come from? How will that go to where needed? The singularity I await looks a lot like trees! Precise location of stem cells is not needed

The process described in this reference is a major step towards my goal! The stem cells are post-harvest skin cells specialized and allowed to migrate from the skin-point. Overtime, they divide in the proper places! Animal specialization of iPS cells is done at the skin and for free, the specialized cells will participate only where needed!

Mark my words, predicting on an exponential curve – there is a revolution in Tissue nanotransfection which relates enormously to indefinite life!

Self-funding trajectory is enormous applications in regenerative medicine and cancers which in many cases are tumors that need to be surrounded and choked to death!

For the curious, not relevant but explain my searches are east+weat approach to boosting effectiveness, and the rationale of 4 choices ECP, Niagen, coQ10 and Metformin.

March to singularity

Forward extrapolations are very hard on exponential curves, like longevity. But

Science News

from research organizations

Breakthrough device heals organs with a single touch

Device instantly delivers new DNA or RNA into living skin cells to change their function

Date:

August 7, 2017

Source:

Ohio State University Wexner Medical Center

Summary:

Researchers have developed a device that can switch cell function to rescue failing body functions with a single touch. The technology, known as Tissue Nanotransfection (TNT), injects genetic code into skin cells, turning those skin cells into other types of cells required for treating diseased conditions.

What des it have to do with singularity sought and when? Or the deep aaqs-question of how to predict sanely on exponential curves?

The sole reason I am SUPERIOR to others is NEVER by time, but by events. These are the events that MUST happen! The predicted singularity I seek is

Defeat of cancers and telomeres by very dense cells

To achieve that, irrigate the field of reproducing cells by stem cells. Surviver will be the healthier cell! Negatively impacts evolution but so what?

But for advanced animals, proper specializes stem cells

So different for different organs

Overlap or mix of need specializations

NOW the advance above makes sense. Skin cells can be transported and heal by proper divide

No precise location needed

Hence advance towards singularity sought!

From bad to worse

One might imagine a retailer like amazon very caring of its image and style. The image works, style goes from bad to worse after unforced errors – the executives must be fire-able incompetent.

1.       Bad/complaint: Documented and sent
this was the complaint.

http://aaqg-arunarya.blogspot.in/2017/08/amazon-complaint.html

2.       Worse – steps taken by amazon

From bad to worse

C1 no action.

C2 no fix for bug or compensation for money stolen - the amount updates the invoice, pointed friend, not amazon, but resolved. Others still there! Just weird documentation!

C3 i) repeat send of wrong product

ii) no return of money for undelivered products – 4000

iii) wrong return and repay for 1 – half pad, other half not!

3.Demands

The demands are

1. the usb3 power hub is now 1200+ not 300 as ordered. Amazon pay, accept R300 and deliver as ordered. Given pain & suffering demand 9 times penalty = R 8100

2. Bug be fixed, money of r71 paid back. Given pain & suffering demand 9 times penalty (resolved - one dollar less)

3. Amazon complies with its ad and find coQ10 200 mg capsules.   It was selling them 2 days later! Given pain & suffering demand 9 times penalty and repayment of R4900 = 44100

Proof: 

http://aaqg-arunarya.blogspot.in/2017/08/amazon-redress-picture.html

As pic shows, three orders were made, 2 for 950*2 = 1900, one for 2000. Wrong size was repeated in 1 order, one never refunded and third refunded in half! I want amazon to deliver what it accepted money for 3*2=6 bottles of200 mg coQ10. Upper right is successful order for 200 mg at 1100 bucks. Somehow amazon wants 150 more for my order per bottle!

4. Conduct investigation of bad executives in India

5. Act, or else will be legal next. Until settled, matter will expand as captured in true pictures on paper, written/htmled up for many mal-ad against amazon. It’s not just a dissatisfied customer, may be this approach will get attention.

4 I am PERSISTENT PATIENT CS PhD. What happens to other 99% customers? Steam-rolled? Don't understand or snowed? Amazon welcome to comment their side on blog.